ACR Meeting Abstracts

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  • Abstract Number: 1611 • ACR Convergence 2024

    Impact of Mepolizumab on Patient-reported Outcomes in Eosinophilic Granulomatosis with Polyangiitis by Using the ANCA-associated Vasculitis Patient-reported Outcomes (AAV-PRO) Questionnaire: A European Multicentre Prospective Study

    Paolo Delvino1, Luca Quartuccio2, Joanna Robson3, Federico Alberici4, Diego Bagnasco5, Alvise Berti6, Marco Caminati7, Marta Camoni8, Maria Cid9, Edoardo Conticini10, Giulia Costanzo11, Claire de Moreuil12, Stefano Del Giacco11, Georgina Espigol-Frigole13, Virginia V Ferretti14, Franco Franceschini15, Luca Iorio16, Anna Kernder17, Catherine Klersy14, Alberto Lo Gullo18, Laura Losappio19, Elena Manna20, Matteo Maule21, Carlomaurizio Montecucco22, Negrini Simone23, Roberto Padoan24, Francesca Regola25, Luisa Ricciardi26, Jan Schroeder19, Benjamin Terrier27, Paola Toniati28, Elena Treppo2, Maria-Letizia Urban29, Augusto Vaglio30, Giacomo Emmi31 and Sara Monti32, and European EGPA Study Group, 1University of Milano-Bicocca, Milan, Milan, Italy, 2Division of Rheumatology, Department of Medicine (DMED), University of Udine, Udine, Italy, Udine, Italy, 3UWE Bristol, Bristol, United Kingdom, 4Nephrology Unit, University of Brescia, ASST Spedali Civili, University of Brescia, Brescia, Italy, Brescia, Italy, 5Allergy and Respiratory Diseases, Department of Internal Medicine (DIMI), IRCCS Policlinico San Martino, Genoa, Italy, 6University of Trento, Rochester, Italy, 7Department of Medicine, Asthma, Allergy and Clinical Immunology Section, University of Verona, Verona, Italy, 8Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy, 9Hospital Clinic Barcelona. University of Barcelona, Barcelona, Spain, 10University of Siena, Siena, Siena, Italy, 11Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy, 12Service de médecine interne, CHU de Brest, Brest, France, 13Hospital Clinic de Barcelona, Barcelona, Spain, 14Biostatistcs & Clinical Trial Center, Fondazione IRCCS Policlinico San Matteo, Pavia, Pavia, Italy, 15Scleroderma Unit, Rheumatology and Clinical Immunology Unit, ERN ReCONNET, ASST Spedali Civili, Brescia, Italy, Brescia, Italy, 16Rheumatology Unit, Department of Medicine DIMED, University of Padua, Padova, Italy, Padova, Italy, 17HHU Dusseldorf, Dusseldorf, Germany, 18Rheumatology Unit, Papardo Hospital, Messina, Italy, 19Division of Allergy and Clinical Immunology, ASST GOM Niguarda, Milan, Milan, Italy, 20Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Pavia, Italy, 21Asthma Center and Allergy Unit, Verona Integrated University Hospital, Verona, Verona, Italy, 22IRCCS policlinico S. Matteo foundation, University of Pavia, Pavia, Italy, 23Department of Internal Medicine (DIMI), University of Genoa, Genoa, Genoa, Italy, 24Department of Medicine DIMED, Division of Rheumatology, University of Padua, Padua, Italy, 25Unit of Rheumatology and Clinical Immunology, ASST Spedali Civili Brescia and University of Brescia, Brescia, Italy, 26Allergy and Immunology Unit, Department of Clinical and Experimental Medicine, G. Martino Teaching Hospital, University of Messina, Messina, Messina, Italy, 27Service de Médecine interne, Hôpital Cochin, AP-HP, Paris, Ile-de-France, France, 28Spedali civili, 25123, Italy, 29Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, 30Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Firenze, Florence, Italy, 31University of Trieste, Trieste, Italy, 32IRCCS Istituto Auxologico Italiano, Milan, Italy

    Background/Purpose: Mepolizumab (MEPO) proved its efficacy in the treatment of eosinophilic granulomatosis with polyangiitis (EGPA) in the randomized controlled MIRRA trial. The ANCA-associated vasculitis patient-reported…
  • Abstract Number: 1567 • ACR Convergence 2024

    Systemic Sclerosis Is Associated with Sub-Clinical Abnormalities in Myocardial Energetics, Perfusion and Increased Fibrosis

    Chin Yit Soo1, Nicholas Jex2, Stefano Di Donato3, Lucy Elizabeth Thornton4, Vishal Kakkar5, Riccardo Bixio6, Raluca Tomoaia1, Thomas Anderton2, May Lwin2, Christel Kamani2, Amrit Chowdhary2, Henry Procter1, Sharmaine Thirunavukarasu1, Sindhoora Kotha2, Marilena Giannoudi2, Eylem Levelt2, Sven Plein1, Francesco Delgado6 and Lesley-Anne Bissell7, 1Multidisciplinary Cardiovascular Research Centre and Biomedical Imaging Science Department, University of Leeds, Leeds, United Kingdom., Leeds, England, United Kingdom, 2Multidisciplinary Cardiovascular Research Centre and Biomedical Imaging Science Department, University of Leeds, Leeds, United Kingdom., Leeds, United Kingdom, 31. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2. NIHR Leeds Biomedical Research Centre, United Kingdom, Leeds, United Kingdom, 41. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2. NIHR Leeds Biomedical Research Centre, United Kingdom, Leeds, 5University of Leeds, Leeds, United Kingdom, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom., Leeds, United Kingdom, 7Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: Primary cardiac involvement in systemic sclerosis (SSc) is heterogenous, poorly defined and associated with significant cardiac morbidity and mortality. The underlying mechanism is not…
  • Abstract Number: 1654 • ACR Convergence 2024

    CRTAC1 in Osteoarthritis: Implications for Disease Severity and miRNA Regulation

    Aneta Prokopcová1, Jiri Baloun2, Adéla Navrátilová3, Klára Mocová2, Lucia Ondrejčáková4, Jana Juhaszova2, Tereza Kropáčková1, Hana Storkanova5, Michal Tomcik5, Jindriska Gatterova2, Olga Sleglova2, Olga Ruzickova2, Eva Kriegova6, Jiri Gallo7, Rastislav Ballay8, Petr Fulin9, Jiří Vencovský1 and Ladislav Šenolt1, 1Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 2Institute of Rheumatology, Prague, Czech Republic, 31st Faculty of Medicine, Charles University and Institute of Rheumatology in Prague, Hlavní mesto Praha, Czech Republic, 4Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, 5Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 6Department of Immunology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, Olomouc, Czechia, Olomouc, Czech Republic, 7Department of Orthopaedics, University Hospital Olomouc, Olomouc, Czech Republic, 81st Faculty of Medicine, Charles University, Prague, Czechia, Prague, Czech Republic, 91st Department of Orthopaedics, First Faculty of Medicine of Charles University and Motol University Hospital, Prague, Czechia, Prague, Czech Republic

    Background/Purpose: Cartilage acidic protein1 (CRTAC1) is a potential biomarker linked to osteoarthritis (OA) and cartilage degeneration. This study aimed to compare CRTAC1 levels in the…
  • Abstract Number: 1609 • ACR Convergence 2024

    Characteristics of a Cohort of Patients with Interstitial Lung Disease and ANCA Positivity in a University Hospital

    Cristina Valero1, Claudia Valenzuela2, Elisa Martínez-Besteiro3, Patricia Quiroga Colina4, Arantzazu Alfranca5, Esther Vicente-rabaneda6, Santos Castañeda6 and Rosario García-Vicuña7, 1Hospital de la Princesa, Madrid, Spain, 2ILD Unit, Pulmonology Department, Hospital Universitario de la Princesa, University Autonomade Madrid, Madrid, Spain, Madrid, Madrid, Spain, 3Pulmonology Service, Hospital Universitario de la Princesa, IIS-Princesa, Madrid, Spain, Madrid, Madrid, Spain, 4Division of Rheumatology, Hospital Universitario de La Princesa, Madrid, Spain, 5Immunology Service, Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain, Madrid, Madrid, Spain, 6Hospital Universitario de La Princesa, Madrid, Spain, 7Hospital Universitario de la Princesa, Madrid, Madrid, Spain

    Background/Purpose: The prevalence of ANCA positivity at diagnosis of interstitial lung disease (ILD) ranges between 4-36% for anti-MPO and 2-4% for anti-PR3. ILD is more…
  • Abstract Number: 1656 • ACR Convergence 2024

    Loss of Nr4a1 Expression Protects Cartilage During Post-traumatic Osteoarthritis

    Katherine Escalera-Rivera, Jennifer Jonason and Jennifer Anolik, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Osteoarthritis (OA) is a complex disease involving pathological processes in joint tissues such as the cartilage and synovium. Cartilage is degraded by matrix metalloproteinases…
  • Abstract Number: 1674 • ACR Convergence 2024

    Variability in Pain and Depression Measures Between Adolescent Patients with Rheumatic Disease and Caregivers

    Sarah Baluta1, Homaira Rahimi2, Michelle Swanger-Gagne3, Susan Yussman3 and Christina Schutt3, 1University of Rochester Medical Center, Syracuse, NY, 2University of Rochester, Rochester, NY, 3University of Rochester Medical Center, Rochester, NY

    Background/Purpose: The Patient Reported Outcome Measures Information System (PROMIS) has been validated for pediatric rheumatology conditions in several domains including, physical ability, mental health, and…
  • Abstract Number: 1629 • ACR Convergence 2024

    Subclinical Giant Cell Arteritis in Polymyalgia Rheumatica Has a Different Vascular Ultrasound Phenotype Than Giant Cell Arteritis

    Sharon Cowley1, Patricia Harkins2, Colm Kirby3, Richard Conway4, David Kane5, Rositsa Karalilova6, Pierluigi Macchioni7, Christina Ponte8, Edoardo Conticini9, Alessandro Tomelleri10, Sara Monti11, irene monjo12, Zguro Batalov13, Giulia Klinowski7, Paolo Falsetti14, Corrado Campochiaro15, Alojzija Hocevar16 and Eugenio De Miguel17, 1Tallaght University Hospital, Dublin, Dublin, Dublin, Ireland, 2Trinity College Dublin, Dublin 8, Dublin, Ireland, 3Tallaght University Hospital, DUBLIN, Dublin, Ireland, 4Trinity College Dublin, Dublin, Ireland, 5Tallaght University Hospital & Trinity College Dublin, D24, Ireland, 6Clinic of Rheumatology, Medical University Plovdiv, Plovdiv, Bulgaria, Plovdiv, Bulgaria, 7Rheumatology Department, Ospedale S Maria Nuova, Reggio Emilia, Italy, Emilia, Italy, 8Rheumatology, Centro Hospitalar Universitario Lisboa Norte EPE, Lisboa, Portugal, Lisboa, Portugal, 9Università di Siena, Siena, Italy, 10Unit of Immunology, Allergology and Rare Diseases, IRCCS Ospedale San Raffaele, Milano, Italy, 11IRCCS Istituto Auxologico Italiano, Milan, Italy, 12University Hospital La Paz, Madrid, Spain, 13Rheumatology, University Hospital Kaspela, Plovdiv, Bulgaria, Plovdiv, Bulgaria, 14Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, University of Siena, Siena, Italy, Siena, Italy, 15IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University, Milan, Milan, Italy, 16University Medical Center Ljubljana, LJUBLJANA, Slovenia, 17Hospital Universitario La Paz, Madrid, Spain

    Background/Purpose: Subclinical GCA in PMR has been estimated to affect 1 in 5 patients as assessed by vascular ultrasound [1, 2]. This study compared the ultrasound…
  • Abstract Number: 1574 • ACR Convergence 2024

    ­­­Therapeutic Strategy in Patients with Mixed Connective Tissue Disease: A Multicenter Retrospective Study in the French MCTD Cohort

    Kevin Chevalier1, Benjamin Thoreau2, Marc Michel3, Bertrand Godeau4, Christian AGARD5, Thomas Papo6, Karim Sacré6, Raphaele Seror7, Xavier Mariette8, Patrice Cacoub9, Ygal Benhamou10, Hervé Levesque10, Cécile Goujard11, Olivier Lambotte11, Bernard Bonnotte12, Maxime SAMSON13, Felix Ackermann14, Jean Schmidt15, Pierre Duhaut16, Jean-Emmanuel Kahn17, Thomas Hanslik17, Nathalie Costedoat-chalumeau18, Benjamin Terrier19, Alexis Régent20, bertrand Dunogue2, Pascal cohen21, Veronique LE GUERN22, Eric Hachulla23, Luc Mouthon2 and Benjamin Chaigne24, 1Department of Internal Medicine, National Reference Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France, Paris, France, 2Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes et Autoinflammatoires Rares d'Ile de France de l’Est et de l’Ouest, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, 32. Department of Internal Medicine, Henri-Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Est Créteil (UPEC), Créteil, France., Créteil, France, 4Department of Internal Medicine, Henri-Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Est Créteil (UPEC), Créteil, France., Créteil, France, 5Nantes University Hospital, Nantes, France, 6Université Paris Cité, Paris, France, 7Service de Rhumatologie, Hôpital Bicêtre, AP-HP, le Kremlin Bicetre, Ile-de-France, France, 8Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin Bicetre, France, 9Sorbonne Université, Paris, 10Department of Internal Medicine, CHU de Rouen, UniRouen, Rouen, France., Rouen, France, 11Université Paris Saclay, Department of Internal Medicine and clinical immunology, Bicêtre hospital, Assistance Publique-Hôpitaux de Paris, UMR1184 Inserm, CEA, Le Kremlin Bicêtre, France, Kremlin-Bicêtre, France, 12Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France., Dijon, France, 13Dijon University Hospital, Dijon, France, 14Department of Internal Medicine, Foch Hospital, Suresnes, France., Suresnes, France, 15Department of Internal Medicine and RECIF, Amiens University Hospital, Université Picardie Jules Verne, Amiens, France., Amiens, France, 16Department of Internal Medicine and RECIF, Amiens-Picardie University Hospital, AMIENS, France, 17Department of Internal Medicine, Ambroise Paré Hospital, Assistance Publique - Hôpitaux de Paris, Université de Versailles Saint-Quentin-en-Yvelines, Boulogne-Billancourt, France, Boulogne Billancourt, France, 18University Paris Cité, Paris, France, 19Service de Médecine interne, Hôpital Cochin, AP-HP, Paris, Ile-de-France, France, 20National Referral Center For Rare Systemic Autoimmune Diseases, Paris, France, 21National Referral Center For Rare Systemic Autoimmune Diseases, Paris, Ile-de-France, France, 22Cochin hospital, Paris, France, 23Department of Internal Medicine and clinical immunology, North-West National Reference Center for Rare Systemic Autoimmune Diseases iques et Auto-Immunes Rares du Nord-Ouest, Hôpital Claude Huriez, Université de Lille, France, Lille, France, 24Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes et Autoinflammatoires Rares d'Ile de France de l’Est et de l’Ouest, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, Ile-de-France, France

    Background/Purpose: Mixed connective tissue disease (MCTD) is a rare systemic disorder that belongs to connective tissue diseases (CTD). Few studies are available on MCTD treatment.…
  • Abstract Number: 1660 • ACR Convergence 2024

    Systemic Inflammation and Transcriptional Reprogramming Contribute to Progression to Active Rheumatoid Arthritis in ACPA+ Individuals

    Mark Gillespie1, Ziyuan He1, Adam Savage1, Pravina Venkatesan1, Marla Glass1, Lauren Okada2, Nhung Tran2, Yudong He2, Samir Rachid Zaim1, Padmapriyadarshini Ravisankar2, Christy Bennett1, Julian Reading2, Jessica Garber2, Palak Genge2, Veronica Hernandez2, Alexander Heubeck2, Erin Kawelo2, Upaasana Krishnan2, Kevin Lee2, Regina Mettey2, Blessing Musgrove2, Vaishnavi Parthasarathy2, Cole Phalen2, Charles Roll2, Tyanna Stuckey2, Morgan Weiss1, Claire Gustafson2, Qiuyu Gong2, Emma Kuan2, Tao Peng2, Lucas Graybuck2, Kristen Demoruelle3, Kristine Kuhn4, David Boyle5, Fan Zhang4, Thomas Bumol6, Ananda Goldrath2, Xiaojun Li1, V. Michael Holers7, Peter Skene1, Gary Firestein8, Kevin Deane9 and Troy Torgerson10, 1Allen Institute for Immunology, Seattle, WA, 2Allen Institute for Immunology, Seattle, 3University of Colorado Anschutz Medical Campus, Golden, CO, 4University of Colorado, Aurora, CO, 5UCSD, La Jolla, CA, 6Allen Institute for Immunology, San Diego, CA, 7University of Colorado, Denver, CO, 8University of California, San Diego, San Diego, CA, 9University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 10Allen Institute for Immunology, Enumclaw, WA

    Background/Purpose: Elevated levels of RA-associated autoantibodies (ACPA, RF) prior to the clinical onset of inflammatory arthritis (IA) define a state of risk for future development…
  • Abstract Number: 1673 • ACR Convergence 2024

    Assessing the Feasibility of a Mediterranean-Style Diet for Patients with Rheumatoid Arthritis in a Racially and Culturally Diverse Population Across the United States

    Chelsea Thompson1, iazsmin Ventura1, Cuoghi Edens2, Tamiko Katsumoto3 and Sowmya Popuri4, 1Section of Rheumatology, University of Chicago, Chicago, IL, 2Section of Pediatric Rheumatology, Section of Rheumatology, University of Chicago, Chicago, IL, 3Division of Immunology and Rheumatology, Stanford University Medical Center, Palo Alto, CA, 4Section of Internal Medicine, Loyola Medicine MacNeal, Maywood, IL

    Background/Purpose: In 2023, the American College of Rheumatology published a conditional recommendation for patients living with Rheumatoid Arthritis to follow a “Mediterranean style” diet. However,…
  • Abstract Number: 1680 • ACR Convergence 2024

    Reporting Quality of Non-inferiority and Equivalence Rheumatoid Arthritis Randomized Clinical Trials: A Systematic Review

    Osama Alalwan1 and Majeed Haider2, 1Salmaniya Medical Complex, Bahrain, Bahrain, 2Salmaniya Medical Complex, Manama, Bahrain

    Background/Purpose: The number of non-inferiority/equivalence randomized clinical trials (NI/EQ-RCTs) in the rheumatoid arthritis (RA) field has recently increased for various reasons. These designs require special…
  • Abstract Number: 1694 • ACR Convergence 2024

    One-Year Survival Following Single versus Double Lung Transplantation in Adults with Systemic Autoimmune Rheumatic Disease-related Interstitial Lung Disease: A Nationwide Cohort Study

    Harry Hurley1, Luke Benvenuto2 and Elana Bernstein3, 1Albert Einstein College of Medicine, Maplewood, NJ, 2Columbia University, New York, NY, 3Division of Rheumatology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY

    Background/Purpose: Lung transplantation (LT) is a potentially life-saving treatment for patients with systemic autoimmune rheumatic diseases (SARDs) who have developed end-stage lung disease due to…
  • Abstract Number: 1581 • ACR Convergence 2024

    Neutrophil-to- lymphocyte Ratio: A Possible Biomarker for Clinical Response After Autologous Hematopoietic Stem Cell Transplantation

    shiri keret1, Lisa Kaly2, Georg Schett3, Christina Bergmann4, Joerg Henes5, Gleb Slobodin2 and Doron Rimar2, 1Rheumatology unit, Bnai-Zion medical center and the faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel., Atlit, Israel, 2Rheumatology unit, Bnai-Zion medical center and the faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel., Haifa, Israel, 3Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 4Department Internal Medicine III, Friedrich-Alexander-University (FAU) Erlangen-Nurnber, Frankfurt, Germany, 5University Hospital Tuebingen, Tuebingen, Germany

    Background/Purpose: Baseline high Neutrophil- to- lymphocyte ratio (NLR) (higher than 2.95) is associated with severe progressive skin and lung disease and with reduced 5-year survival…
  • Abstract Number: 1687 • ACR Convergence 2024

    IgG and IgA anti-LIN28A Outperform Anti-dsDNA and anti-Sm in Distinguishing SLE from Health and Other Autoimmune Diseases

    Ioannis Parodis1, Dionysis Nikolopoulos2, Julius Lindblom3, Denis Lagutkin3, Lorenzo Beretta4, Maria Orietta Borghi5, Janique Peyper6, Guillermo Barturen7, Per-Johan Jakobsson3, Marta Alarcon-Riquelme8, Natalia Sherina3 and Helena Idborg9, and PRECISESADS Clinical Consortium, 1Karolinska Institutet, Karolinska University Hospital; Örebro University, Solna, Sweden, 2Karolinska Institutet and Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden, 3Karolinska Institutet, Stockholm, Sweden, 4Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di MIlano, Milan, Milan, Italy, 5Università degli Studi di Milano Statale, Milano, Italy, 6Sengenics Corporation Pte Ltd, Singapore, Singapore, 7Center for Genomics and Oncological Research (GENYO), Andalusia, Spain, 8Fundación Progreso y Salud, Andalusian Government, Granada, Spain, 9Karolinska Institutet, Solna, Sweden

    Background/Purpose: Systemic lupus erythematosus (SLE) is characterised by the production of a multitude of autoantibodies (abs). The diagnosis of SLE is supported by the presence…
  • Abstract Number: 1529 • ACR Convergence 2024

    Systemic Lupus Erythematous and Neuromyelitis Optica Overlap and Risk of Infection in Hospitalized Patients

    Elizabeth Fagin1, Wei Chapman2, fares Saliba3 and Eugenio Capitle4, 1Staten Island University Hospital, Teaneck, 2Staten Island University Hospital, Staten Island, 3Staten Island University Hospital, Staten Island, NY, 4University Hospital, Newark

    Background/Purpose: Neuromyelitis optica (NMO) is an autoimmune inflammatory disorder that can coexist with systemic lupus erythematous (SLE). Given the immunosuppressive nature of SLE, it is…
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