Abstracts Archive - Page 1225 of 2425 - ACR Meeting Abstracts

Abstract Number: 292 • 2017 ACR/ARHP Annual Meeting
Neutrophil Extracellular Traps Are Induced By Adenosine and Stimulate Release of TNF Alpha from Macrophages in Deficiency of Adenosine Deaminase 2 (DADA2)
Carmelo Carmona-Rivera¹, Kyawt W. Shwin², Jorge A. irizarry-Caro³, Sami S. Khaznadar⁴, Yudong Liu³, Kenneth A. Jacobson⁴, Amanda Ombrello⁵, Deborah L. Stone⁵, Wanxia Li Tsai³, Massimo G. Gadina⁶, Daniel L. Kastner⁵, Ivona Aksentijevich⁵, Mariana J. Kaplan³ and Peter C. Grayson⁷, ¹Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, MD, ²Division of Rheumatic Diseases, Dallas VA Medical Center/ UT Southwestern Medical Center, Dallas, TX, ³NIAMS/NIH, Bethesda, MD, ⁴Molecular Recognition Section, NIDDK-NIH, Bethesda, MD, ⁵Inflammatory Disease Section, NHGRI/NIH, Bethesda, MD, ⁶Translational Immunology Section, Office of Science and Technology, NIAMS/NIH, Bethesda, MD, ⁷National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD
Background/Purpose: Reduction of adenosine deaminase 2 (ADA2) activity due to autosomal recessive loss of function mutations in the CECR1 gene results in a systemic illness…
Abstract Number: 293 • 2017 ACR/ARHP Annual Meeting
Expanded Therapeutic ACPA Utility for Different NET-Driven Human (Autoimmune) Diseases
Renato G.S. Chirivi^1,2, Jos W.G. van Rosmalen¹, Kostantinos Kambas³, Gonny Schmets¹, Hans Kalisvaart¹, Galina S. Bogatkevich⁴, Tim Shaw², Helmuth van Es² and Jos M.H. Raats^1,2, ¹ModiQuest BV, Oss, Netherlands, ²Citryll BV, Nijmegen, Netherlands, ³Laboratory of Molecular Hematology, Democritus University of Thrace, Alexandroupolis, Greece, ⁴Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Aberrant Neutrophil Extracellular Trap (NET) formation contributes to the induction and propagation of inflammation and plays a key role in causing tissue damage in…
Abstract Number: 294 • 2017 ACR/ARHP Annual Meeting
DNA Area and Netosis Analysis (DANA): A High-Throughput Method to Quantify Neutrophil Extracellular Traps in Fluorescent Microscope Images
Ryan Rebernick¹, Lauren Fahmy², Christopher Glover², Nicole Rademacher², Hemanth Potluri², Mandar Bawadekar¹, Christie M. Bartels³ and Miriam A. Shelef^1,4, ¹Department of Medicine, Division of Rheumatology, University of Wisconsin - Madison, Madison, WI, ²University of Wisconsin - Madison, Madison, WI, ³Rheumatology/Medicine, University of Wisconsin - Madison, Madison, WI, ⁴William S. Middleton Memorial Veterans Hospital, Madison, WI
Background/Purpose: Neutrophil extracellular traps (NETs), extracellular structures composed of decondensed chromatin, are released in a process called NETosis. NETs, which are part of normal host…
Abstract Number: 295 • 2017 ACR/ARHP Annual Meeting
Ex Vivo Induced Neutrophil Extracellular Traps Are Intrinsically Different in Anca-Associated Vasculitis and Systemic Lupus Erythematosus
Laura van Dam¹, Tineke Kraaij¹, Sylvia Kamerling¹, Hans U. Scherer², Charles Pusey³, Ton Rabelink¹, Cees van Kooten¹ and Onno Teng¹, ¹Nephrology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Imperial College, London, United Kingdom
- Background/Purpose: Neutrophil extracellular traps (NETs) are immunogenic, extracellular DNA structures that harness important autoantigens to be recognized by the adaptive immune system. NETs are…
Abstract Number: 296 • 2017 ACR/ARHP Annual Meeting
A Module of Genes Describing Low Density Granulocytes Can be Identified and Followed in the Periphery of Lupus Patients
Brian Keggereis¹, Michelle Catalina², Nick Geraci¹, Sarah Heuer², Prathyusha Bachali², Sushma Madamanchi², Peter E. Lipsky² and Amrie Grammer², ¹AMPELBioSolutions and RILITE Research Institute, Charlottesville, VA, ²AMPEL BioSolutions and RILITE Research Institute, Charlottesville, VA
Background/Purpose: Lupus is an autoimmune disease characterized by a type I interferon signature thought to be initiated by granulocyte NETosis. The granulocyte population in the…
Abstract Number: 297 • 2017 ACR/ARHP Annual Meeting
Multiplexed Characterization of Circulating and Joint-Derived Human Neutrophils in Inflammatory Arthritis
Ricardo Grieshaber Bouyer¹, Olha Halyabar², Anais Levescot¹, Kacie Hoyt², Lauren Henderson² and Peter Nigrovic^1,2, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Neutrophils are innate immune cells that play a central role in the initiation of inflammatory arthritis as well as mediating tissue damage. We sought…
Abstract Number: 298 • 2017 ACR/ARHP Annual Meeting
Anabasum (JBT-101) Enhances Resolution of Inflammation in Humans
Madhur Motwani¹, Fran Bennett¹, Mark Tepper², Barbara White², Paul Norris³, Raymond MacAllister¹, Charles Serhan³ and Derek Gilroy¹, ¹University College London, London, United Kingdom, ²Corbus Pharmaceuticals, Norwood, MA, ³Harvard Medical School, Cambridge, MA
Background/Purpose: Certain rheumatic diseases including systemic sclerosis (SSc) are characterized by chronic activation of innate immune responses, leading to excessive fibrosis. A normal innate…
Abstract Number: 299 • 2017 ACR/ARHP Annual Meeting
Bik Plays an Important Role of Cell Proliferation Caused By Nitric Oxide in Rheumatoid Arthritis Synovium
Takeshi Ueha¹, Yoshitada Sakai¹, Kohjin Suzuki², Koji Fukuda³, Toshihisa Maeda³, Hanako Nishimoto³, Shinya Hayashi⁴, Yasushi Miura⁴, Ryosuke Kuroda³ and Akira Hashiramoto², ¹Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, ²Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan, ³Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, ⁴Orthpaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Nitric oxide (NO), a proinflammatory mediator responsible for various physiological processes, plays a central role in the pathogenesis of rheumatoid arthritis (RA). As a…
Abstract Number: 300 • 2017 ACR/ARHP Annual Meeting
The DNA-Binding Protein ARID3a Is Associated with Interferon Alpha Production in Lupus Patient Plasmacytoid Dendritic Cells and Neutrophils
Michelle Ratliff¹, Joshua Garton^1,2, Indra Adrianto³, Ambra Pastori⁴, Courtney Montgomery⁵, Patrick Gaffney⁴, Judith A. James^3,6 and Carol Webb^1,7,8, ¹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Chemistry, University of Oklahoma, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁷Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁸Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: We previously demonstrated over-expression of the DNA-binding protein ARID3a in peripheral blood B lymphocytes from patients with systemic lupus erythematosus (SLE) compared to healthy…
Abstract Number: 301 • 2017 ACR/ARHP Annual Meeting
MiR-221-3p Overexpression Impairs Anti-Inflammatory Activity of TLR4-Stimulated M2-Macrophages
Lilian Quero^1,2, Andre Tiaden^1,2 and Diego Kyburz^2,3, ¹Department of Biomedicine, Experimental Rheumatology, University of Basel, Basel, Switzerland, ²Rheumatology, University Hospital Basel, Basel, Switzerland, ³Department of Biomedicine, Experimental Rheumatology, University of Basel, 4051 Basel, Switzerland
Background/Purpose: MicroRNAs (miRNAs) have been shown to contribute to the inflammatory response in rheumatoid arthritis (RA) and several of these miRNAs have been found to…
Abstract Number: 302 • 2017 ACR/ARHP Annual Meeting
From Monocytes to Macrophages: the Pathogeneses of Spontaneous Inflammatory Arthritis in CD11c-Flip-KO (HUPO) Mice
Qi Quan Huang¹, Renee E. Doyle², Philip J. Homan¹, Harris Perlman³, Deborah R. WInter³ and Richard M. Pope², ¹Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: We have generated a CD11c-Flip-KO mouse line (HUPO) that spontaneously develops erosive arthritis with incidence 70-80% at age ≥ 20 weeks. This study aimed…
Abstract Number: 303 • 2017 ACR/ARHP Annual Meeting
Outcomes after Hip Fracture in the Elderly: Does Social Isolation Matter?
Lisa A. Mandl¹, Omar Halawa², Jackie Szymonifka³, Kirsten Grueter⁴ and Joseph Lane⁵, ¹Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, ⁵Orthopaedic Surgery, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY
Background/Purpose: Hip fractures are a serious public health issue with a significant population burden, especially among those over 65 years old. Social isolation—how integrated a…
Abstract Number: 304 • 2017 ACR/ARHP Annual Meeting
Usefulness of Consecutive Doppler Ultrasound Examinations for Detecting Deep Venous Thrombosis during the Perioperative Period in Patients with Osteoporotic Fractures of the Proximal Femur
Ken Nakaseko and Norihiro Mayumi, Department of Orthopaedic Surgery and Rheumatology, Kuwana City Medical Center, Kuwana Mie, Japan
Background/Purpose: Deep venous thrombosis (DVT) can lead to a venous thromboembolism and increase the risk of a pulmonary thromboembolism (PE). PE is one of the…
Abstract Number: 305 • 2017 ACR/ARHP Annual Meeting
Ultrasonographic Evaluation of the Femoral Cartilage, Achilles Tendon and Plantar Fascia in Young Women Wearing High-Heeled Shoes
Ayşen Akinci¹, Kamal Mezian², Ayşe Merve Ata¹, Murat Kara¹, Şule Şahin Onat³, Eda Gürçay⁴, Aslı Çalışkan¹, Maria Ines Taboas Simoes⁵ and Levent Özçakar¹, ¹Hacettepe University Medical School Department of Physical Medicine and Rehabilitation, Ankara, Turkey, ²Czech Technical University in Prague, Faculty of Biomedical Engineering, Department of Health Care Disciplines and Population Protection, Kladno, Czech Republic, ³Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey, ⁴Gaziler Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey, ⁵PMR hospitalar assistant in Centro Hospitalar Entre Douro e Vouga, E.P.E, Portugal
Background/Purpose: Wearing high-heeled shoes (HHS) may include structural and functional abnormalities due to repetitive stress particularly in the knee and forefoot. The aim of this…
Abstract Number: 306 • 2017 ACR/ARHP Annual Meeting
Relationship between Inflammatory Anterior or Posterior Arch MRI Abnormalities and Clinical Data in Low Back Pain Patients
Helene Braun¹, Clement Geniez¹, Yannick Degboe², Arnaud Constantin³, Alain Cantagrel⁴, Delphine Nigon⁵, Marie Faruch-Bilfeld¹ and Adeline Ruyssen-Witrand⁴, ¹Purpan Hospital, Toulouse, France, ²Department of Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, Toulouse, France, ³Purpan Hospital, toulouse, France, ⁴Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, ⁵CHU Purpan, Toulouse, France
Background/Purpose: To compare demographic characteristics, characteristics of pain and functional status according to the presence of inflammatory anterior or posterior arch MRI abnormalities in low…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].