ACR Meeting Abstracts

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  • Abstract Number: 383 • 2018 ACR/ARHP Annual Meeting

    Myositis Patients with Anti-U1-RNP and Anti-Ro52 Autoantibodies Are at Risk of Pericarditis, Glomerulonephritis, and Pulmonary Hypertension

    Maria Casal-Dominguez1, Iago Pinal-Fernandez2, Andrea Corse3, Julie J. Paik2, Jemima Albayda2, Livia Casciola-Rosen4, Cheilonda Johnson5, Sonye K. Danoff6, Lisa Christopher-Stine6, Eleni Tiniakou4 and Andrew Mammen7, 1Muscle Diseases Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases. National Institutes of Health, Bethesda, MD, 2Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Neurology, Johns Hopkins University, Baltimore, MD, 4Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 5Medicine/Pulmonology, Johns Hopkins University School of Medicine, Baltimore, MD, 6Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 7National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

    Background/Purpose: To define the clinical phenotype of myositis patients with anti-U1- ribonucleoprotein (RNP) autoantibodies. Methods: The clinical features of 20 anti-U1RNP-positive patients were assessed and…
  • Abstract Number: 384 • 2018 ACR/ARHP Annual Meeting

    Patients with Anti-Synthetase Syndrome Have a Similar Prevalence and Severity of Interstitial Lung Disease to Systemic Sclerosis

    Bret Sohn1, Narender Annapureddy2, Rosemarie Dudenhofer3, April Barnado1, Leslie Crofford1 and Erin Wilfong4, 1Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN, 3Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, 4Division of Rheumatology and Immunology, Vanderbilt Unversity Medical Center, Nashville, TN

    Background/Purpose: Interstitial lung disease (ILD) is a significant cause of morbidity and mortality in connective tissue diseases (CTDs). The purpose of this study is to…
  • Abstract Number: 385 • 2018 ACR/ARHP Annual Meeting

    Sexual Dysfunction in Female Patients with Idiopathic Inflammatory Myopathies

    Barbora Hermankova1,2, Maja Spiritovic1,2, Hana Smucrova2, Sabina Oreska2,3, Hana Storkanova2,3, Karel Pavelka3,4, Ladislav Šenolt2,3, Herman F Mann2,5, Jiri Vencovsky2,6 and Michal Tomcik2,3, 1Department of Physiotherapy, Faculty of Physical Education and Sports, Charles University, Prague, Czech Republic, Prague, Czech Republic, 2Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 3Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 4Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 5First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 6Department Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are characterized by inflammation and atrophy of skeletal muscles, pulmonary and articular involvement, which leads to functional impairment, reduced quality…
  • Abstract Number: 386 • 2018 ACR/ARHP Annual Meeting

    Differences in Body Composition in Myositis Patients and Healthy Controls Are Associated with Disease Activity and Duration, Inflammatory Status, Skeletal Muscle Involvement and Physical Activity

    Sabina Oreska1,2, Maja Spiritovic1,3, Petr Cesak4, Ondrej Marecek5, Hana Storkanova1,2, Hana Smucrova1, Barbora Hermankova1,3, Katerina Kubinova1,2, Martin Klein1,2, Lucia Vernerova1,2, Olga Ruzickova1,6, Karel Pavelka1,2, Ladislav Šenolt1,2, Herman F Mann1,7, Jiri Vencovsky1,8 and Michal Tomcik1,2, 1Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 2Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 3Department of Physiotherapy, Faculty of Physical Education and Sports, Charles University, Prague, Czech Republic, Prague, Czech Republic, 4Body Composition Laboratory, Faculty of Physical Education and Sports, Charles University, Prague, Czech Republic, Prague, Czech Republic, 5Physiotherapy, Faculty of Physical Education and Sports, Charles University, Prague, Czech Republic, Prague, Czech Republic, 6Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 7First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 8Department Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Skeletal muscle, pulmonary and articular involvement in idiopathic inflammatory myopathies (IIM) limit the mobility/self-sufficiency of patients, and can have a negative impact on body…
  • Abstract Number: 387 • 2018 ACR/ARHP Annual Meeting

    Increased Risk of Malignancy in Elderly Patients with Inflammatory Myositis

    Hyoungyoung Kim1, Yoon-Kyoung Sung2, Seongmi Choi3, Jinwook Kim4, Sun-Young Jung5, Eun Jin Jang6, Dae-Hyun Yoo7 and Soo-Kyung Cho1, 1Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), 2Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), 3Statistics, Kyungpook National University, Daegu, Korea, Republic of (South), 4Department of Statistics, Kyungpook National University, Daegu, Korea, Republic of (South), 5College of Pharmacy, Chung-Ang University, Seoul, Korea, Republic of (South), 6Information Statistics, Andong National University, Andong-si, Korea, Republic of (South), 7Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South)

    Background/Purpose: The association between inflammatory myositis and malignancy is well established, however, the risk of malignancy in aged patients is known to be similar with…
  • Abstract Number: 388 • 2018 ACR/ARHP Annual Meeting

    Comparison of Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme Α Reductase and Anti-Signal Recognition Particle Necrotising Myopathies: A Single Centre Experience

    Su-Ann Yeoh1, Rhys Thomas1, Friederike Baldeweg1, Hoda Alkoky1, Muhammad Shipa1, Fakhirah Badrulhisham2, Hasan Tahir3, Simon Donnelly1, Angela Pakozdi1, Zozik Fattah1 and Aleksandar Radunovic4, 1Department of Rheumatology, Whipps Cross University Hospital, Barts Health NHS Trust, London, United Kingdom, 2Newham University Hospital, Barts Health NHS Trust, London, United Kingdom, 3Whipps Cross University Hospital, Barts Health NHS Trust, London, United Kingdom, 4Department of Neurology, Royal London Hospital, Barts Health NHS Trust, London, United Kingdom

    Background/Purpose: Immune-mediated necrotising myopathy (IMNM) is characterised by paucity of inflammation on muscle biopsy and is associated with antibodies to signal recognition particle (SRP) and…
  • Abstract Number: 389 • 2018 ACR/ARHP Annual Meeting

    Risk Factors Associated with Mortality in Inflammatory Myositis: An Asian Perspective

    Tyng Yu Chuah1, Yu Heng Kwan2, Nai Lee Lui3 and Warren Fong4,5,6, 1Department o Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore, 2Program in Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore, 3Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore, 4Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore, 5Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 6Duke-NUS Medical School, Singapore, Singapore

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune diseases with systemic involvement and excess mortality. We aim to describe the causes and…
  • Abstract Number: 390 • 2018 ACR/ARHP Annual Meeting

    Severe Axial and Pelvifemoral Muscle Damage in Immune-Mediated Necrotizing Myopathy Evaluated By Whole-Body MRI

    Océane Landon-Cardinal1, Cedi Koumako2, Giulia Hardouin3, Benjamin Granger3, Harmen Reyngoudt2, Jean-Marc Boisserie2, Aude Rigolet1, Baptiste Hervier1, Nicolas Champtiaux1, Perrine Guillaume1, Mathieu Vautier1, Pierre Carlier2, Olivier Benveniste1 and Yves Allenbach1, 1Department of Internal Medicine and Clinical Immunology and Inflammation-Immunopathology-Biotherapy Department (I2B), Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, East Paris Neuromuscular Diseases Reference Center, Paris, France, 2Laboratoire de RMN AIM & CEA, Centre d'Explorations Fonctionnelles, Institut de Myologie, Paris, France, 3Département de Biostatistiques, Santé Publique et Information Médicale, Groupe hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France

    Background/Purpose: Immune-mediated necrotizing myopathies (IMNM) are a severe condition with early muscle damage attested by MRI of thigh muscles. Presence of damage in the other…
  • Abstract Number: 392 • 2018 ACR/ARHP Annual Meeting

    Autoantibody Profile and Clinical Characteristics in Patients with Idiopathic Inflammatory Myopathies

    Sung Hae Chang1, Sung Won Lee2, Mi-Il Kang3, Mihye Kwon4, Chung-Il Joung4, Seong-Wook Kang5, In-Seol Yoo5, Seung-Cheol Shim5, Su-Jin Yoo6, In Ah Choi7, Ji Hyoun Kim8, Seung-Jae Hong9, Yeon-Ah Lee9, Sang Wan Chung10 and Jinhyun Kim11, 1Department of Internal Medicine, Department of Internal Medicine, College of Medicine, Soonchunhyang University, Cheonan, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Department of Rheumatology, Department of Internal Medicine, College of Medicine, Soonchunhyang University, Cheonan, Korea, Republic of (South), 3Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea, Republic of (South), 4Department of Internal Medicine, Konyang University hospital, Daejeon, Korea, Republic of (South), 5Division of Rheumatology, Department of Internal Medicine, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Korea, Republic of (South), 6Rheumatology, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Korea, Republic of (South), 7Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea, Republic of (South), 8Department of Internal Medicine, Chungbuk National University College of Medicine, Cheong-ju, Korea, Republic of (South), 9Rheumatology, Kyung Hee University Hospital, Seoul, Korea, Republic of (South), 10Division of Rheumatology, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Korea, Republic of (South), 11Internal medicine, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Deajeon, Korea, Republic of (South)

    Background/Purpose: Autoimmune myositis (AIM) is a constellation of rare chronic disease with progressive muscle weakness. Several autoantibodies are found to be highly correlated with IIM…
  • Abstract Number: 393 • 2018 ACR/ARHP Annual Meeting

    Physical Activity Monitoring Using Wrist-Worn Accelerometer in the Assessment and Follow-up of Patients with Myositis

    Océane Landon-Cardinal1, Damien Bachasson2, Perrine Guillaume1, Mathieu Vautier1, Nicolas Champtiaux1, Baptiste Hervier1, Aude Rigolet1, Olivier Benveniste1, Jean-Yves Hogrel2 and Yves Allenbach1, 1Department of Internal Medicine and Clinical Immunology and Inflammation-Immunopathology-Biotherapy Department (I2B), Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, East Paris Neuromuscular Diseases Reference Center, Paris, France, 2Institute of Myology, Pitié-Salpêtrière University Hospital, Paris, France

    Background/Purpose: Wrist-worn accelerometers allow the objective estimation of physical activity (PA) in daily life. Recently, the ENMC workshop on outcome measures in myositis suggested to…
  • Abstract Number: 394 • 2018 ACR/ARHP Annual Meeting

    In Patients with Suspected Idiopathic Inflammatory Myopathy, Does Pre-Biopsy Musculoskeletal MRI Result in Greater Yield of Diagnostic Biopsy Results? Summary of Data from a 10-Year Single Hospital Audit

    Julia Murdoch1, Merrilee Needham2,3 and Helen Keen3,4,5, 1Sir Charles Gairdner Hospital, Perth, Australia, 2Fiona Stanley Hospital, Perth, Australia, 3Murdoch University, Perth, Australia, 4Rheumatology, Fiona Stanley Hospital, Murdoch, Australia, 5University of Western Australia, Perth, Australia

    Background/Purpose: The idiopathic inflammatory myopathies (IIM) constitute a potentially steroid-responsive group of conditions that must be differentiated from other causes of muscle weakness. Histopathology from…
  • Abstract Number: 395 • 2018 ACR/ARHP Annual Meeting

    Systemic Lupus Erythematosus (SLE) with Inflammatory Myositis

    Nicole Bitencourt, Elizabeth (Blair) Solow and Bonnie L. Bermas, Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX

    Background/Purpose: The goal of this study was to identify specific clinical features of patients with SLE who have inflammatory myositis. Methods: A retrospective chart review…
  • Abstract Number: 396 • 2018 ACR/ARHP Annual Meeting

    Clinical, Physiologic, and Radiologic Features Associated with Severe MDA5-Associated Interstitial Lung Disease

    Tracy Doyle1, Priya Borker2, Elaine Fletcher1, David Murphy3, Rachna Madan3 and Paul F. Dellaripa4, 1Brigham and Women's Hospital, Boston, MA, 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, Boston, MA, 3Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Boston, MA, 4Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Autoantibodies against melanoma differentiation-associated protein 5 (MDA-5) have been described in patients with dermatomyositis (DM) and progressive interstitial lung disease (ILD). Previous cohorts have…
  • Abstract Number: 397 • 2018 ACR/ARHP Annual Meeting

    Myositis-Specific Autoantibodies and Their Clinical Associations

    Victor Tak Lung Wong1, Ho So1, Ricky Wai Ki Ip2, Virginia W Lao3, Steve H Pang3, Lai-Shan Tam4, Priscilla Wong5, Lydia Ho Pui Tam6, Tsz On Lam7, Mei Yan Law8, Isaac CW Yim9, Tin Lok LAI10, Patrick Man Leung Lee11 and Ronald Man Lung Yip12, 1Kwong Wah Hospital, Kowloon, Hong Kong, 2Queen Mary Hospital, Hong Kong, Hong Kong, 3Department of Medicine, Kwong Wah Hospital, Hong Kong, Hong Kong, 4Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China, Hong Kong, Hong Kong, 5Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China, Hong Kong, China, 6Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 7Prince of Wales Hospital, New Territories, Hong Kong, 8Alice Ho Miu Ling Nethersole Hospital, New Territories, Hong Kong, 9Department of Medicine, Tseung Kwan O Hospital, Hong Kong, Hong Kong, 10Medicine, Tseung Kwan O Hospital, Tseung Kwan O, Hong Kong, 11Yan Chai Hospital, Kowloon, Hong Kong, 12Tung Wah Group of Hospitals, Hong Kong, Hong Kong, Hong Kong

    Background/Purpose: Myositis-specific autoantibodies (MSAs) have been shown to predict clinical features and have prognostic implications in patients with idiopathic inflammatory myopathies (IIMs), with anti-melanoma differentiation-associated…
  • Abstract Number: 398 • 2018 ACR/ARHP Annual Meeting

    Muscle Function and Health-Related Quality of Life in Patients with Polymyositis and Dermatomyositis

    Kristofer Andreasson1, Li Alemo Munters1,2 and Helene Alexanderson3,4, 1Karolinska University Hospital, Function Area Occupational therapy and Physical therapy, Stockholm, Sweden, 2Swedish Rheumatism Association, Stockholm, Sweden, 3Department of NVS, Division of Physical Therapy, Karolinska Institutet, Huddinge, Sweden, 4Function Area Occupational therapy & Physiotherapy, Allied Health Professionals Function, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Poly- and dermatomyositis (PM/DM) are idiopathic inflammatory muscle diseases characterized by reduced muscle function. Oral glucocorticoids and DMARD’s are the usual treatment options and…
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