Abstract Number: 51 • 2017 ACR/ARHP Annual Meeting
Irisin Ameliorates Infrapatellar Adiposity in Knee Osteoarthritis Pathogenesis By Orchestrating Adipokine Signaling
Background/Purpose: Aberrant infrapatellar fat metabolism is a prominent feature that exacerbates inflammation and fibrosis relative to joint deterioration during osteoarthritis (OA). Irisin, a secretory subunit…Abstract Number: 52 • 2017 ACR/ARHP Annual Meeting
In Vivo Effect of Opticin Deficiency in a Surgically Induced Mouse Model of Osteoarthritis
Background/Purpose: Opticin (OPTC) is a small leucine-rich proteoglycan (SLRP) that has been previously demonstrated to be produced and degraded in osteoarthritic (OA) human cartilage. Here,…Abstract Number: 53 • 2017 ACR/ARHP Annual Meeting
Poly-γ-Glutamic Acid Inhibits RANKL- Induced Osteoclast Differentiation and Prevents Bone Destruction in Rheumatoid Arthritis: Human and CIA Mouse Model
Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory disease that is characterized by chronic inflammation and bone destruction. Osteoclasts, which are bone-resorbing cells, are generally known…Abstract Number: 54 • 2017 ACR/ARHP Annual Meeting
Maintaining Angiogenesis Prevents Glucocorticoid Induced Osteonecrosis
Background/Purpose: Atraumatic osteonecrosis (ON) results from reduced bone vascularity. Glucocorticoids (GC) are a major risk factor for ON, as GCs reduce vascular endothelial growth factor,…Abstract Number: 55 • 2017 ACR/ARHP Annual Meeting
Nrf2 Inhibits Apoptosis and Suppresses Oxidative Stress By Activating NOX4/ERK1/2/ELK1 Signaling Axis in Human Chondrocytes
Background/Purpose: Nrf2 is a redox sensitive transcription factor that regulates the expression of phase II antioxidant enzymes and cytoprotective genes and is crucial for maintaining…Abstract Number: 56 • 2017 ACR/ARHP Annual Meeting
Baicalein, a Plant-Derived Small Molecule, Activate Nrf2/Autophagy Signaling Axis Via MEK1/2-ERK1/2-Elk1 Pathway to Suppress the Expression of IL-6 in Human Osteoarthritis Chondrocytes
Background/Purpose: Inflammation is an important component of osteoarthritis (OA) pathogenesis. IL-6 is implicated in OA pathogenesis as it suppresses anabolic factors and upregulate the expression…Abstract Number: 57 • 2017 ACR/ARHP Annual Meeting
Accelerated Development of Aging-Associated and Instability-Induced Osteoarthritis in 12/15-Lipoxygenase Deficient Mice
Background/Purpose: 12/15-Lipoxygenase (12/15-LOX) catalyzes the generation of various anti-inflammatory lipid mediators, and has been implicated in several inflammatory and degenerative diseases. However, there is currently…Abstract Number: 58 • 2017 ACR/ARHP Annual Meeting
Cartilage-like Tissue Generation By 3D-Bioprinting of Induced Pluripotent Stem Cells
Background/Purpose: Cartilage lesions due to traumatic or pathological conditions slowly grow over the time and may lead to osteoarthritis (OA). As a prospective treatment for…Abstract Number: 59 • 2017 ACR/ARHP Annual Meeting
Abaloparatide, a Novel PTHrP Analog, Increased Bone Mass and Density at Cortical and Trabecular Sites in an Orchiectomized Rat Model of Male Osteoporosis
Background/Purpose: Male osteoporosis, a disease of reduced bone mass leading to an increased risk of fragility fractures, often results from androgen deficiency caused by hypogonadism…Abstract Number: 60 • 2017 ACR/ARHP Annual Meeting
Low and Moderate Intensity Exercise Suppresses Inflammatory Responses in an Acute Mouse Model of Gout and Suggests Therapeutic Efficacy
Background/Purpose: Little is known regarding the potential benefits of exercise on managing acute gout. Consequently, recent clinical practice guidelines released by the American College of…Abstract Number: 61 • 2017 ACR/ARHP Annual Meeting
Resolution of Systemic Joint Inflammatory Processes and Regeneration of Existing Bone Damage upon TNF Blockade As Monitored By In Vivo Multimodal PET-CT Imaging in Progressed Experimental Arthritis
Background/Purpose: To use in vivo multimodal [18F]FDG (fluoro-D-glucose, tracer for inflammation) and [18F]Sodium Fluoride (bone tracer) positron emission tomography/computed tomography (PET-CT) imaging for the monitoring…Abstract Number: 62 • 2017 ACR/ARHP Annual Meeting
Convergence of Joint Repair and Pain Pathways Via Nerve Growth Factor and p75 Expressing Mesenchymal Stem Cells in Established Osteoarthritis
Background/Purpose: Nerve growth factor (NGF) is a key regulator of pain and anti-NGF therapy reduces osteoarthritis (OA) associated pain. However, anti-NGF therapy is associated with…Abstract Number: 63 • 2017 ACR/ARHP Annual Meeting
MiR-146a a Key Player in Bone Metabolism
Background/Purpose: Micro RNAs (miRNAs) play a crucial role in the regulation of bone metabolism. MiR-146a, an important anti-inflammatory miRNA, was found to negatively impact osteogenesis…Abstract Number: 64 • 2017 ACR/ARHP Annual Meeting
The Effect of Adenosine A2A Receptor Stimulation on Mitochondrial Metabolism in the Pathogenesis and Treatment of Osteoarthritis
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 10% of the US population. There is no therapy to prevent the progression…Abstract Number: 65 • 2017 ACR/ARHP Annual Meeting
RA-Associated Antibodies Targeting Post Translational Modification Have Different Osteoclastogenetic Potential
Background/Purpose: Some but not all antibodies against citrullinated modified proteins (ACPA) promote osteoclastogenesis and bone destruction in vitro and in vivo. We aimed to investigate…
ACR Meeting Abstracts