Abstracts Archive - Page 1199 of 2425 - ACR Meeting Abstracts

Abstract Number: 2918 • 2018 ACR/ARHP Annual Meeting
Physical Activity in Canadian Children with Juvenile Idiopathic Arthritis: The LEAP Study (Linking Exercise, Activity, and Pathophysiology in Canadian Children with Arthritis)
Lori Tucker¹, Jaime Guzman¹, Kristin Houghton², Dax G. Rumsey³, Elizabeth Stringer⁴, Shirley M.L. Tse⁵, Rosie Scuccimarri⁶, Claire LeBlanc⁷, Roberta Berard⁸, Bianca Lang⁹, Karen N Watanabe Duffy¹⁰ and Ciarán M. Duffy¹¹, ¹BC Children's Hospital, Vancouver, BC, Canada, ²Rheumatology/Pediatrics, British Columbia Children's Hospital, Vancouver, BC, Canada, ³Stollery Children's Hospital, Edmonton, AB, Canada, ⁴Department of Rheumatology, IWK Health Centre, Halifax, NS, Canada, ⁵The Hospital for Sick Children, Toronto, ON, Canada, ⁶Department of Pediatrics, McGill University Health Centre, Montreal, QC, Canada, ⁷Pediatrics, Montreal Children's Hospital, Montreal, QC, Canada, ⁸Pediatrics, Children's Hospital, London Health Sciences Centre, London, ON, Canada, ⁹Pediatrics, IWK Health Centre, Halifax, NS, Canada, ¹⁰Rheumatology, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, ¹¹Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada
Background/Purpose: Physical activity (PA) is an important component of health, and is essential for optimal growth and development. Children with juvenile idiopathic arthritis (JIA) are…
Abstract Number: 2919 • 2018 ACR/ARHP Annual Meeting
An Epidemic: Severe Lung Disease in Patients with Systemic Juvenile Idiopathic Arthritis, Risk Factors and Predictors
Shima Yasin¹, Christopher Towe^2,3, Ndate Fall⁴, Alexei Grom^3,4 and Grant Schulert^1,5, ¹Rheumatology, Divisions of Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²Pulmonology, Division of Pulmonology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ³Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, ⁴Division of Rheumatology, Divisions of Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁵Pediatrics, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH
Background/Purpose: There is growing awareness of severe and often fatal chronic lung disease in patients with systemic juvenile idiopathic arthritis (sJIA). However, clinical features and…
Abstract Number: 2920 • 2018 ACR/ARHP Annual Meeting
Correlations of Type I Interferon Score and Interferon Induced Chemokines CXCL10 and CXCL9 with Cutaneous and Muscular Disease Activity in Juvenile Dermatomyositis
Gian Marco Moneta¹, Ivan Caiello¹, Lucilla Rava'², Silvia Rosina³, Luisa Bracci Laudiero^1,4, Angelo Ravelli^3,5, Fabrizio De Benedetti⁶ and Rebecca Nicolai⁷, ¹Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, ²Epidemiology Unit, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, ³University of Genova, Genova, Italy, ⁴Institute of Translational Pharmacology, CNR, Roma, Italy, ⁵Rheumatology, Giannina Gaslini Institute, Genova, Italy, ⁶IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, ⁷Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
Background/Purpose: Interferons (IFNs) seem to play an important role in the pathogenesis of juvenile dermatomyositis (JDM). We previously reported that expression of both type I…
Abstract Number: 2921 • 2018 ACR/ARHP Annual Meeting
The Performance of the Newly Proposed EULAR/Acr Classification Criteria in Juvenile-Onset Systemic Lupus Erythematosus
Sezgin Sahin¹, Sule Bektas¹, Amra Adrovic¹, Oya Koker², Kenan Barut¹ and Ozgur Kasapcopur³, ¹Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey, ²Istanbul University, Istanbul Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey, ³Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey
Background/Purpose: To avoid misclassifications, a new set of classification criteria have been developed by the collaboration of the EULAR/ACR and the draft was presented at…
Abstract Number: 2922 • 2018 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging of Sacroiliac Joints in Patients with Osteitis Condensans Ilii Reveals a Typical Pattern of Lesions Relevant for Differential Diagnosis with Axial Spondyloarthritis
Denis Poddubnyy^1,2, Torsten Diekhoff³, Nino Gobejishvili³, Henning Weineck³, Maria Llop Vilaltella³, Valeria Rios Rodriguez³, Joachim Sieper² and Kay-Geert Hermann³, ¹German Rheumatism Research Centre, Berlin, Germany, ²Charité Universitätsmeidzin Berlin, Berlin, Germany, ³Charité Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Osteitis condensans ilii (OCI) is regarded to as a non-inflammatory disorder induced by mechanical stress and mechanical instability of the sacroiliac joints (SIJ). OCI…
Abstract Number: 2923 • 2018 ACR/ARHP Annual Meeting
Is All MRI-SIJ Inflammation the Same? Gradient of Structural Damage with Increasing Cumulative Inflammation at the SIJ Quadrant Level in Axial Spondyloarthritis – 5-Year Data from the DESIR Cohort
Santiago Rodrigues Manica^1,2, Alexandre Sepriano^1,3, Sofia Ramiro^3,4, Robert B.M. Landewé⁵, Pascal Claudepierre⁶, Anna Moltó⁷, Maxime Dougados⁸, Miranda van Lunteren³ and Désirée van der Heijde⁹, ¹CEDOC, NOVA Medical School, Lisbon, Portugal, ²Rheumatology, Hospital de Egas Moniz - Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Rheumatology, Zuyderland Medical Center, Heerlen, Netherlands, ⁵Amsterdam Rheumatology & Clinical Immunology Center and Zuyderland Medical Center, Amsterdam; Heerlen, Netherlands, ⁶Hôpital Henri Mondor, Créteil, France, ⁷Paris Descartes University, Cochin Hospital, Paris, France, ⁸Department of Rheumatology, Paris Descartes University and Cochin Hospital, Paris, France, ⁹Leiden University Medical Centre, Leiden, Netherlands
Background/Purpose: Axial inflammation is a key feature in axial spondyloarthritis (axSpA). An (overall) definition of bone marrow oedema (BMO) on the MRI of the SIJ…
Abstract Number: 2924 • 2018 ACR/ARHP Annual Meeting
Spinal Radiographic Progression in Early Axial Spondyloarthritis: 5-Year Data from the DESIR Cohort
Sofia Ramiro¹, Désirée van der Heijde², Alexandre Sepriano³, Miranda van Lunteren⁴, Anna Molto⁵, Maria Antonietta D'Agostino⁶, Damien Loeuille⁷, Maxime Dougados⁸, M. Reijnierse⁹ and Pascal Claudepierre¹⁰, ¹Zuyderland Medical Center, Heerlen & Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Centre, Leiden, Netherlands, ³Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, ⁶Department of Rheumatology, Assistance publique-Hôpitaux de Paris Ambroise Paré Hospital, Boulogne-Billancourt , Université Versailles Saint Quentin en Yvelines, Paris, France, ⁷Rheumatology, University Hospital of Nancy, NANCY, France, ⁸Department of Rheumatology, Paris Descartes University and Cochin Hospital, Paris, France, ⁹Radiology, Leiden University Medical Center, Leiden, Netherlands, ¹⁰Hôpital Henri Mondor, Créteil, France
Background/Purpose: Spinal radiographic progression has been investigated in patients with r-axSpA, but not yet as thoroughly in early axSpA. We aimed to analyse the progression…
Abstract Number: 2925 • 2018 ACR/ARHP Annual Meeting
Fatty Lesions Detected on MRI Scans in Patients with Ankylosing Spondylitis Are Based on the Deposition of Fat in the Vertebral Bone Marrow
Xenofon Baraliakos¹, Heinrich Boehm², Ahmed Samir³, Georg Schett⁴, Jürgen Braun⁵ and Andreas Ramming⁶, ¹Ruhr-University Bochum, Herne, Germany, ²Clinic for spinal surgery, Bad Berka, Germany, ³Orthopedic and Traumatology Department, Cairo University, Cairo, Egypt, ⁴Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany, ⁵Ruhr Universität Bochum, Bochum, Germany, ⁶Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany
Background/Purpose: Fatty lesions (FL), similar to bone marrow edema (BME) and sclerosis (SCL), are characteristic findings in MRI examinations of patients with ankylosing spondylitis (AS)…
Abstract Number: 2926 • 2018 ACR/ARHP Annual Meeting
Which MRI Lesions in the Sacroiliac Joint Are Associated with the Diagnosis of Axial Spondyloarthritis after 2 Years Follow up in the Echography in Spondyloarthritis Cohort?
Walter P. Maksymowych^1,2, Damien Loeuille³, Stephanie Wichuk⁴, Joel Paschke⁵, Olivia Judet⁶, Maxime Breban³, Maria-Antonietta D'Agostino⁷ and Robert G. Lambert⁸, ¹University of Alberta, Edmonton, AB, Canada, ²CaRE Arthritis, Edmonton, AB, Canada, ³Ambroise Paré Hospital, Boulogne-Billancourt, France, ⁴Medicine, Medicine, University of Alberta, Edmonton, AB, Canada, ⁵CaRE Arthritis, Edmonton, Canada, Edmonton, AB, Canada, ⁶CHRU Vandoeuvre les Nancy, Vandœuvre-lès-Nancy, France, ⁷CHRU Vandoeuvre les Nancy, Vandoeuvre les Nancy, France, ⁸Radiology, Radiology, University of Alberta, Edmonton, AB, Canada
Background/Purpose: MRI of the sacroiliac joint (SIJ) is emerging as an important prognostic tool for assessment of patients presenting with axSpA. A major challenge in…
Abstract Number: 2927 • 2018 ACR/ARHP Annual Meeting
What Are the Optimal MRI Lesion Cut-Offs That Define Active and Structural Lesions in the Sacroiliac Joint As Being Typical of Axial Spondyloarthritis By Expert Readers?
Walter P. Maksymowych^1,2, Pedro Machado³, Ulrich Weber⁴, Xenofon Baraliakos⁵, Joachim Sieper⁶, Stephanie Wichuk¹, Denis Poddubnyy⁶, Mikkel Østergaard⁷, Joel Paschke², Robert G. Lambert¹ and Susanne J Pedersen⁷, ¹University of Alberta, Edmonton, AB, Canada, ²CaRE Arthritis, Edmonton, AB, Canada, ³University College London, London, United Kingdom, ⁴University of Southern Denmark, Odense, Denmark, ⁵Rheumazentrum Ruhrgebiet Herne, Herne, Germany, ⁶Charité Universitätsmeidzin Berlin, Berlin, Germany, ⁷COPECARE University of Copenhagen, Copenhagen, Denmark
Background/Purpose: Defining what constitutes a definite MRI lesion in the SIJ typical of axSpA has been hampered by lack of international consensus for standardized lesion…
Abstract Number: 2928 • 2018 ACR/ARHP Annual Meeting
Validation of New Systemic Lupus Erythematosus Classification Criteria
Martin Aringer¹, Karen Costenbader², Ralph Brinks³, Dimitrios Boumpas⁴, David Daikh⁵, David Jayne⁶, Diane L. Kamen⁷, Marta Mosca⁸, Rosalind Ramsey-Goldman⁹, Josef S. Smolen¹⁰, David Wofsy¹¹, Betty Diamond¹², Søren Jacobsen¹³, W. Joseph McCune¹⁴, Guillermo Ruiz-Irastorza¹⁵, Matthias Schneider¹⁶, Murray Urowitz¹⁷, George Bertsias¹⁸, Bimba Hoyer¹⁹, Nicolai Leuchten¹, Chiara Tani²⁰, Sara K. Tedeschi²¹, Zahi Touma²², Branimir Anic²³, Florence Assan²⁴, Tak Mao Chan²⁵, Ann E. Clarke²⁶, Peggy Crow²⁷, László Czirják²⁸, Andrea Doria²⁹, Winfried Graninger³⁰, Bernadett Halda-Kiss²⁸, Sarfaraz A. Hasni³¹, Peter M. Izmirly³², Michelle Jung³³, Gabor Kumanovics²⁸, Xavier Mariette²⁴, Ivan Padjen²³, JM Pego-Reigosa³⁴, Juanita Romero-Díaz³⁵, Iñigo Rúa-Figueroa³⁶, Raphaele Seror³⁷, Georg Stummvoll³⁸, Yoshiya Tanaka³⁹, Maria Tektonidou⁴⁰, Carlos Vasconcelos⁴¹, Edward M Vital⁴², Daniel J. Wallace⁴³, Sule Yavuz⁴⁴, Raymond P. Naden⁴⁵, Thomas Dörner⁴⁶ and Sindhu Johnson⁴⁷, ¹Medicine III, University Medical Center and Faculty of Medicine TU Dresden, Dresden, Germany, ²Rheumatology, Immunology and All, Brigham & Women's Hospital, Boston, MA, ³Department of Rheumatology & Hiller Research Unit, Heinrich-Heine University, Düsseldorf, Germany, ⁴University of Athens, Athens, Greece, ⁵Rheumatology, UCSF and VA Medical Center, San Francisco, CA, ⁶Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ⁷Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁸Rheumatology Unit, University of Pisa, Pisa, Italy, ⁹FSM, Northwestern University, Chicago, IL, ¹⁰Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, ¹¹University of California San Francisco, San Francisco, CA, ¹²Autoimmune Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, ¹³University of Copenhagen, Copenhagen, Denmark, ¹⁴Int Med/ Rheum, University of Michigan, Ann Arbor, MI, ¹⁵Autoimmune Diseases Research Unit, BioCruces, Hospital Universitario Cruces, Baracaldo, Spain, ¹⁶Department and Hiller Research Center for Rheumatology, Heinrich-Heine University, Duesseldorf, Germany, ¹⁷University of Toronto Lupus Research Program, Toronto Western Hospital, Toronto, ON, Canada, ¹⁸Department of Rheumatology, Clinical Immunology and Allergy, University of Crete, School of Medicine, Heraklion, Greece, ¹⁹University of Schleswig-Holstein, Kiel, Germany, ²⁰University of Pisa, Pisa, Italy, ²¹Rheumatology Immunology & Allergy, Brigham & Women's Hospital, Boston, MA, ²²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²³Department of Internal Medicine, University Hospital Zagreb and University of Zagreb School of Medicine, Zagreb, Croatia, ²⁴Université Paris Sud, Paris, France, ²⁵University of Hong Kong, Hong Kong, Hong Kong, ²⁶Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²⁷Department of Medicine, Hospital for Special Surgery, New York, NY, ²⁸Rheumatology and Immunology, University of Pécs, Pécs, Hungary, ²⁹University and Azienda Ospedaliera of Padova, Padova, Italy, ³⁰Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ³¹Lupus Clinical Research Program, Office of the Clinical Director, NIH/NIAMS, Bethesda, MD, ³²NYU Langone Health, New York, NY, ³³University of Calgary, Calgary, AB, Canada, ³⁴Complexo Hospitalario Universitario de Vigo, Vigo, Spain, ³⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ³⁶Rheumatology Division, Hospital Doctor Negrin, Las Palmas GC, Spain, ³⁷Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, Paris, France, ³⁸Rheumatology, Medical University Vienna, Vienna, Austria, ³⁹University of Occupational and Environmental Health, Kitakyushu, Japan, ⁴⁰Rheumatology Unit, 1st Dept. of Propaedeutic Internal Medicine, Joint Academic Rheumatology Program, Athens University Medical School, Athens, Greece, ⁴¹Centro Hospitalar do Porto, University of Porto, Porto, Portugal, ⁴²University of Leeds, Leeds, United Kingdom, ⁴³Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁴⁴Department of Rheumatology, Marmara University, Istanbul, Turkey, ⁴⁵New Zealand Ministry of Health, New Zealand Ministry of Health, Auckland, New Zealand, ⁴⁶Charité Universitätsmedizin Berlin, Berlin, Germany, ⁴⁷Rheumatology, Mount Sinai Hospital and University Health Network, Toronto, ON, Canada
Background/Purpose: Correct classification of patients with systemic lupus erythematosus (SLE) is critical for clinical trials and clinical and translational science. The ACR 1997 criteria were…
Abstract Number: 2929 • 2018 ACR/ARHP Annual Meeting
Validation of Remission and Lupus Low Disease Activity State As Predictors of Organ Damage in SLE
Michelle Petri¹, Daniel Goldman¹ and Laurence S Magder², ¹Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD, ²Epidemiology and Public health, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Outcome measures that combine control of SLE activity and prednisone reduction are clinically relevant. A clinical goal in SLE is to reduce risk of…
Abstract Number: 2930 • 2018 ACR/ARHP Annual Meeting
Prospective Comparison of Remission and Lupus Low Disease Activity State – Effect on Disease Outcomes in Systemic Lupus Erythematosus
Vera Golder¹, Rangi Kandane-Rathnayake², Molla Huq³, Worawit Louthrenoo⁴, Shue-Fen Luo⁵, Yeong-Jian Wu⁶, Aisha Lateef⁷, Sargunan Sockalingam⁸, Susan Morton⁹, Sandra V. Navarra¹⁰, Leonid Zamora¹¹, Laniyati Hamijoyo¹², Yasuhiro Katsumata¹³, Masayoshi Harigai¹⁴, Madelynn Chan¹⁵, Sean O'Neill¹⁶, Fiona Goldblatt¹⁷, Chak Sing Lau¹⁸, Zhan-Guo Li¹⁹, Alberta Y. Hoi², Mandana Nikpour²⁰ and Eric Morand²¹, ¹School of Clinical Sciences at Monash Health, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia, ²School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia, ³The University of Melbourne at St Vincent's Hospital, Melbourne, Australia, ⁴Division of Rheumatology, Department of Internal Medicine, Chiang Mai University, Chiang Mai, Thailand, ⁵Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁶Chang Gung University, Taoyuan County, Taiwan, ⁷Medicine, Division of Rheumatology, National University Hospital of Singapore, Singapore, Singapore, ⁸University of Malaya, Kuala Lumpur, Malaysia, ⁹Monash Health, Melbourne, Australia, ¹⁰University of Santo Tomas Hospital, Manila, Philippines, ¹¹Rheumatology, University of Santo Tomas Hospital, Manila, Philippines, ¹²University of Padjadjaran, Bandung, Indonesia, ¹³Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ¹⁴Tokyo Women's Medical University, Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo, Japan, ¹⁵Tan Tock Seng Hospital, Singapore, Singapore, ¹⁶University of New South Wales, Sydney, Australia, ¹⁷Royal Adelaide Hospital, Adelaide, Australia, ¹⁸Medicine, The University of Hong Kong, Hong Kong, Hong Kong, ¹⁹Rheum/Immunology, Peking University People's Hospital, Beijing, China, ²⁰The University of Melbourne, Melbourne, Australia, Melbourne, Australia, ²¹Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia
Background/Purpose: The Definitions of Remission in SLE (DORIS) group has proposed multiple definitions of remission, but these are infrequently attained and have not previously been…
Abstract Number: 2931 • 2018 ACR/ARHP Annual Meeting
Missing Outcomes in SLE Clinical Trials: Impact on Estimating Treatment Effects
Mimi Kim¹, Joan T. Merrill², Kenneth C. Kalunian³, Leslie Hanrahan⁴ and Peter M. Izmirly⁵, ¹Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ⁴Lupus Foundation of America, Washington DC, DC, ⁵NYU Langone Health, New York, NY
Background/Purpose: Missing data due to drop-out and loss to follow-up is a common problem in SLE trials. The usual approaches for handling this issue include…
Abstract Number: 2932 • 2018 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus Biomarkers Identified Using Multi-Omic and Artificial Intelligence Analysis through Interrogative Biology
Eric Grund¹, Lixia Zhang¹, Leonardo Rodrigues¹, Viatcheslav Akmaev¹, Rangaprasad Sarangarajan¹, Michael Kiebish¹, Niven Narain¹ and Gary S. Gilkeson², ¹BERG, LLC, Framingham, MA, ²Department of Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Biomarkers for use in developing treatments and diagnostics for Systemic Lupus Erythematosus (SLE) are a large unmet need. The wide differential in patient progression…

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