Abstracts Archive - Page 1189 of 2607 - ACR Meeting Abstracts

Abstract Number: 38 • 2018 ACR/ARHP Annual Meeting
Pre-Clinical Clonally-Expanded aggrecan89-103–Specific CD4+ T Cells Are a Target for Autoimmune Arthritis Prevention
Pascale Wehr¹, Hendrik Nel¹, Soi Cheng Law¹, Diahann Jansen¹, Nicole La Gruta², Hugh Reid², Jamie Rossjohn² and Ranjeny Thomas¹, ¹University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Australia, ²Infection and Immunity Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
Background/Purpose: In the pre-clinical rheumatoid arthritis (RA) prodrome, autoantibodies and transient symptoms may develop. Pre-clinical autoantibody development suggests concomitant expansion of autoantigen-specific CD4+ follicular helper…
Abstract Number: 39 • 2018 ACR/ARHP Annual Meeting
Allogeneic Mesenchymal Stem Cells Derived Extracellular Vesicles As a Superior Immunosuppressant in Murine Arthritis Therapy
Runci Wang^1,2, Yi Liu^3,4 and Songtao Shi⁵, ¹Department of Anatomy and cell biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, ²Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China, ³Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, China, Chengdu, China, ⁴Department of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, China, ⁵Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania,, Philadelphia, PA
Allogeneic mesenchymal stem cells derived extracellular vesicles as a superior immunosuppressant in murine arthritis therapyRunci Wang1,2, Yi Liu2, Songtao Shi1Affiliation: 1. Department of Anatomy and…
Abstract Number: 40 • 2018 ACR/ARHP Annual Meeting
IFN Regulatory Factor 3 but Not IFN Regulatory Factor 7 Contributes to Bone Erosion in Collagen Induced Arthritis
Susan Sweeney¹, David L. Boyle², Yuya Fujita³, Anthony Bui⁴, Gary S. Firestein² and Maripat Corr⁵, ¹Lilly Research Laboratories, Eli Lily, San Diego, CA, ²Medicine, University of California San Diego, La Jolla, CA, ³Medicine, University of California San Diego, La jolla, CA, ⁴Medicine, University of California San Diego, San Diego, CA, ⁵University of California San Diego, La Jolla, CA
Background/Purpose: Type I interferons and their mRNA signatures have become prominent in biomarkers of autoimmune and autoinflammatory disease activity. Two master regulators of type I…
Abstract Number: 41 • 2018 ACR/ARHP Annual Meeting
TAS5315, a Novel Bruton’s Tyrosine Kinase Inhibitor, Improves Bone Strength in Mouse Model for Rheumatoid Arthritis
Ryuusuke Kaneko, Fumihito Hosoi, Satoru Iguchi, Hiroaki Hayashi, Yohei Yoshiga, Yoshinori Nakachi, Daichi Akasaka, Kenji Tanaka, Teruhiro Utsugi, Eiji Sasaki and Yoshikazu Iwasawa, TAIHO PHARMACEUTICAL CO., LTD., Tsukuba, Japan
Background/Purpose: The erosions of bone and cartilage are a cardinal feature of rheumatoid arthritis (RA) and associated with disease severity and poor functional outcome. Although…
Abstract Number: 42 • 2018 ACR/ARHP Annual Meeting
Modulation of Autoimmune Arthritis By Protein Tyrosine Phosphatase SHP-1
Adrienn Markovics¹, Andrew B Nesterovitch², Katalin Mikecz¹, Tibor A. Rauch¹, Daniel M. Tóth¹ and Tibor T. Glant¹, ¹Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Department of Dermatology, Rush University Medical Center, Chicago, IL
Background/Purpose: The protein tyrosine phosphatase termed Src homology region 2 domain-containing phosphatase-1 (SHP-1) is known to exert negative regulatory effects on immune cell signaling. Mice…
Abstract Number: 43 • 2018 ACR/ARHP Annual Meeting
Novel Anti-Malarial Drug Derivative Inhibited Anti-Citrullinated Protein/Peptide Antibodies and Rheumatoid Factors Production in Dnaseii/Ifnr Double Knock out Mice
Jie An¹, Bhanupriya Madarampalli², Xizhang Sun², Lena Tanaka³, Erika H. Noss², Joshua Woodward⁴, Tomikazu Sasaki⁵ and Keith B. Elkon⁶, ¹Division of Rheumatology, University of Washington, Seattle, WA, ²Rheumatology, University of Washington, Seattle, WA, ³Medicine/Rheumatology, University of Washington, Seattle, WA, ⁴Department of Microbiology, University of Washington, Seattle, WA, ⁵Department of Chemistry, University of Washington, Seattle, WA, ⁶University of Washington, Seattle, WA
Background/Purpose: Rheumatoid Arthritis (RA) is a highly prevalent autoimmune disease affecting ~1% of the world population and can lead to permanent joint damage and severe…
Abstract Number: 44 • 2018 ACR/ARHP Annual Meeting
Histone Deacetylase 1 (HDAC1): A Novel Therapeutic Target in Patients with Rheumatoid Arthritis
Lisa Goschl¹, Victoria Saferding², Johan Bäcklund³, Clemens Scheinecker⁴, Josef S. Smolen⁵, Günter Steiner⁶, Wilfried Ellmeier¹ and Michael Bonelli⁷, ¹Medical University of Vienna,Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Vienna, Austria, ²Medical University of Vienna, Austria, Vienna, Austria, ³Karolinska Institute,Department of Medical Biochemistry and Biophysics, Stockholm, Sweden, ⁴Medical University of Vienna, Divison of Rheumatology, Vienna, Austria, ⁵Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, ⁶Division of Rheumatology, Department of Internal Medicine III, Medical University Vienna, Austria, Vienna, Austria, ⁷Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Despite enormous efforts to develop new therapeutic strategies for treatment of rheumatoid arthritis (RA), the large number of non responding patients to currently available…
Abstract Number: 45 • 2018 ACR/ARHP Annual Meeting
CKD-506, First-in-Class Histone Deacetylase (HDAC) 6 Inhibitor, Ameliorates Rheumatoid Arthritis through Regulation of Inflammation and T Cell Function
Jieun Shin¹, Nina Ha¹, Daekwon Bae¹, Dong-Hyeon Suh¹, Ji-yeon Baek¹, Jae Hyun Jun¹, Yong Jae Lee¹, Changsik Lee¹, Sei-Hwan Kim¹, Young Il Choi¹, Keun Ho Ryu¹, Yu Jin Jang², Sehui Shon², Yeong Wook Song³, Gi Soo Youn⁴ and Jinseu Park⁴, ¹Research Institute of Chong Kun Dang Pharmaceutical Corporation, Yongin, Korea, Republic of (South), ²Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Korea, Republic of (South), ³Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁴Department of Biomedical Science, Hallym University, Chuncheon, Korea, Republic of (South)
Background/Purpose: Broad-spectrum histone deacetylase inhibitors are well known for immunomodulatory functions. However, due to their toxicity, HDAC subtype specific inhibition has been proposed as therapeutic…
Abstract Number: 46 • 2018 ACR/ARHP Annual Meeting
Organic Dust Inhalants Shift Immune Responses and Extracellular Matrix Balance between Synovium and Lung in the Collagen-Induced Arthritis Mouse Model
Michael J. Duryee¹, Jill Poole², Amy Nelson³, Katherine Janike², Lynell W. Klassen⁴, James R. O'Dell⁴, Bryant R. England⁵, Ted R. Mikuls⁶ and Geoffrey M. Thiele⁷, ¹Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Medicine, University of Nebraska Medical Center, Omaha, NE, ³Department of Medicine, University of Nebrasa Medical Center, Omaha, NE, ⁴Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁵Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, ⁶Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁷University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Emerging evidence suggests that the lungs may be an initiating site of autoimmunity leading to RA with organic inhalant exposures such as those…
Abstract Number: 47 • 2018 ACR/ARHP Annual Meeting
Analysis of the Role of RORγt+Foxp3+ T Regulatory 17 (Tr17) Cells in Murine Autoimmune Arthritis Model
Kotona Furuyama¹, Yuya Kondo¹, Masaru Shimizu², Iizuka Akira¹, Masahiro Yokosawa¹, Seiji Segawa¹, Hiroto Tsuboi¹, Isao Matsumoto¹ and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Internal Medicine, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: RORγt+Foxp3+ regulatory T (Treg) cells, designated as Tr17 is one of the new subset of Treg cells, having the potential to regulate the development…
Abstract Number: 48 • 2018 ACR/ARHP Annual Meeting
In Vivo Demonstration of Tmtnf Reverse Signaling: Significance in the Therapeutic Response to Anti-TNF Agents during Murine Arthritis
Numa Simons¹, Andrey Kruglov², Yannick Degboe³, Arnaud Constantin³, Sergei Nedospasov⁴, Alain Cantagrel⁵, Jean-Luc Davignon⁶ and Benjamin Rauwel⁶, ¹Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, ²German Rheumatism Research Centre, Berlin, Germany, ³Department of Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, Toulouse, France, ⁴4Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation, ⁵Center of Rheumatology of CHU, Toulouse, France, ⁶CPTP, INSERM UMR 1043, Toulouse, France
In vivo demonstration of tmTNF reverse signaling: significance in the therapeutic response to anti-TNF agents during murine arthritis. N. Simons1,2, A. Kruglov 3, Y. Degboé 1,2, A.…
Abstract Number: 49 • 2018 ACR/ARHP Annual Meeting
Tofacitinib Facilitates the Expansion of Myeloid-Dirived Suppressor Cells and Ameliorates Interstitial Lung Disease in SKG Mice
Sho Sendo¹, Jun Saegusa¹, Yoshihide Ichise², Hirotaka Yamada², Ikuko Naka³, Yo Ueda¹, Tadashi Okano² and Akio Morinobu⁴, ¹Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ³Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁴Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: SKG mice, which are rheumatoid arthritis (RA) model, develop not only arthritis but interstitial lung disease (ILD) resembling RA-ILD. Myeloid-derived suppressor cells (MDSCs) are…
Abstract Number: 50 • 2018 ACR/ARHP Annual Meeting
Intra-Articularly Delivering Lentivirus-Based CRISPR Interference Targeting Long Non-Coding RNA H19 in Synovial Fibroblasts Ameliorates Experimental Arthritis
Chrong-Reen Wang¹, Shih-Yao Chen², Yu-Ting Lo³, Yu-Chi Chou⁴, Ming-Fei Liu¹, Chao-Liang Wu⁵ and Ai-Li Shiau³, ¹Internal Medicine, National Cheng Kung University Hospital and Medical College, Tainan, Taiwan, ²Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ³Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁴Core Facility for Manipulation of Gene Function, Academia Sinica, Taipei, Taiwan, ⁵Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan
Background/Purpose: Aberrantly higher expression of long non-coding RNAs (lncRNAs) in synovial fibroblasts (SFs) plays pathogenic roles in rheumatoid joint. Studying the effects on knocking down…
Abstract Number: 51 • 2018 ACR/ARHP Annual Meeting
Genetic Ablation of Inducible Nitric Oxide Synthase in TNF Transgenic Mice with Inflammatory-Erosive Arthritis Prevents Lymph Node Expansion and Decreases Synovial Infiltrates
Richard Bell¹, Emily Wu², Lianping Xing³, Christopher T. Ritchlin⁴ and Edward Schwarz⁵, ¹Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ²Department of Immunology, Microbiology, and Virology, University of Rochester, Rochester, NY, ³University of Rochester Medical Center, Rochester, NY, ⁴Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, ⁵Orthopedeatrics, University of Rochester, Rochester, NY
Background/Purpose: Recent studies in the TNF-Tg mouse model of rheumatoid arthritis (RA) demonstrated a critical role of lymphatic vessel (LV) function in joint homeostasis and…
Abstract Number: 52 • 2018 ACR/ARHP Annual Meeting
Interferon-Alpha Protects Against Pain and Joint Damages in Experimental Arthritis and Is Associated with Expansion of Highly Suppressive Regulatory T Lymphocytes in Protected Mice and in Tocilizumab-Treated Rheumatoid Arthritis Patients
Matthieu Ribon¹, Roxane Hervé², Delphine Lemeiter², Katarzyna Matyja¹, François Santinon¹, Darragh Duffy³, Ken Tsumiyama⁴, Shunichi Shiozawa⁵, Marie-Christophe Boissier⁶, Natacha Bessis² and Patrice Decker¹, ¹Inserm UMR 1125, Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ²Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ³Institut Pasteur, Paris, Paris, France, ⁴Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, ⁵Institute for Rheumatic Diseases, Nagahama, Japan, ⁶Rheumatology Department, AP-HP, Avicenne Hospital, Bobigny, France
Background/Purpose: Type I interferons (IFN-I) can be both anti- and pro-inflammatory. Among them, IFN-α inhibits normal Th17 differentiation, whereas it is pathogenic in lupus. The…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].