Abstracts Archive - Page 1188 of 2607 - ACR Meeting Abstracts

Abstract Number: 23 • 2018 ACR/ARHP Annual Meeting
Treatment with Immune Checkpoint Inhibitors and the Development of Autoantibodies
Emma de Moel¹, Elisa Rozeman², Ellen Kapiteijn³, Els Verdegaal³, Annette Grummels⁴, Jaap A. Bakker⁵, Tom W.J. Huizinga⁶, John Haanen², René E.M. Toes⁶ and Diane van der Woude⁶, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Netherlands Cancer Institute, Amsterdam, Netherlands, ³Oncology, Leiden University Medical Center, Leiden, Netherlands, ⁴Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Rheumatology, C1-R-41, Leiden, Netherlands, ⁵Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, Netherlands, ⁶Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The field of autoimmunity may benefit from the knowledge gained by studying immune checkpoint inhibitors (ICIs). These agents have shown enormous efficacy in oncology…
Abstract Number: 24 • 2018 ACR/ARHP Annual Meeting
Rituximab Induces an Early Re-Assessment of the Immune and Vascular Systems in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis
Chary Lopez-Pedrera¹, Irene Cecchi², Nuria Barbarroja³, Alejandra Maria Patiño-Trives¹, María Luque Tevar¹, Laura Pérez Sánchez⁴, Alejandro Ibáñez-Costa¹, Ivan Arias de la Rosa⁵, Yolanda Jiménez-Gómez³, Massimo Radin⁶, Rafaela Ortega-Castro³, M. Carmen Castro-Villegas⁷, Jerusalem Calvo-Gutierrez³, Alejandro Escudero-Contreras⁵, Maria Jose Cuadrado⁸, Savino Sciascia⁹, Eduardo Collantes Estevez¹, Maria Ángeles Aguirre Zamorano¹ and Carlos Perez-Sanchez³, ¹IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ³Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁴IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ⁵Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁶Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁷Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ⁸Clinica Universidad de Navarra, Madrid, Spain, ⁹Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy
Background/Purpose: While the role of Rituximab (RTX) in controlling the clinical manifestations of Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) has been documented, the…
Abstract Number: 25 • 2018 ACR/ARHP Annual Meeting
Circulating CD24hiCD38hi Regulatory B-Cells Influence Th17-Cell Responses in Patients with Granulomatosis with Polyangiitis
Anouk von Borstel¹, Lucas L. Lintermans², P Heeringa³, Abraham Rutgers², Coen A. Stegeman¹, Jan-Stephan F. Sanders¹ and Wayel H. Abdulahad², ¹Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: To investigate whether there is a direct relation between expanded proportions of Th17-effector memory (ThEM17) cells and diminished proportions of regulatory B-cells (Bregs) in…
Abstract Number: 26 • 2018 ACR/ARHP Annual Meeting
Hints for Catecholamine-Driven Autocrine Mechanisms to Regulate Regulatory B Cells
Nadine Honke¹, Torsten Lowin², Birgit Opgenoorth¹, Matthias Schneider¹, Georg Pongratz¹ and Katharina Krebber¹, ¹Rheumatology Policlinic & Hiller Research Unit, Medical Faculty, University Hospital, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany, ²Department and Hiller Research Center for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease affecting 1% of the worldwide population and characterized by synovial hypertrophy and chronic joint inflammation. In recent…
Abstract Number: 27 • 2018 ACR/ARHP Annual Meeting
Top-Down Proteomics Coupled with Antibody Sequencing from Single B Cells Reveals a Monoclonal Anti-Sm Clone Present in the Serum of an SLE Patient over Three Years
Zhe Wang¹, Jennifer Muther², Judith A. James³, Si Wu¹ and Kenneth Smith², ¹Chemistry and Biochemistry, University of Oklahoma, Norman, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Proteomics is becoming an increasingly powerful tool to study autoantibodies. Current bottom-up approaches are yielding a plethora of knowledge about public clonotypes and clonal…
Abstract Number: 28 • 2018 ACR/ARHP Annual Meeting
The Rho Kinase Family Member, ROCK2, Promotes Germinal Center Responses and Is Required for Optimal Humoral Immunity
Edd Ricker¹, Chao Ye², Danny Flores-Castro², Sanjay Gupta³, Michela Manni¹, Yurii Chinenov⁴, Tania Pannellini², James K. Liao⁵ and Alessandra B. Pernis⁶, ¹Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, ⁴Arthritis & Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, ⁵Cardiology Section, University of Chicago Medical Center, Chicago, IL, ⁶David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Rho GTPases, such as RhoA, are emerging as important regulators of lymphocyte biology owing to their ability to be rapidly activated downstream of a…
Abstract Number: 29 • 2018 ACR/ARHP Annual Meeting
CD70-Mediated CD27 Downregulation Contributed to Regulatory B10 Cell Impairment in Rheumatoid Arthritis
Lianjie Shi¹, Fanlei Hu², Rong Mu³ and Zhan-Guo Li⁴, ¹Peking University International Hospital, Beijing, China, ²Peking University People's Hospital, Beijing, China, ³Peking University People‘s Hospital, Beijing, China, ⁴Peking University People’s Hospital, Beijing, China
Background/Purpose: Impaired function of regulatory B10 cells has been shown in autoimmune diseases. However, the underlying mechanism is still obscure. In the present study, we…
Abstract Number: 30 • 2018 ACR/ARHP Annual Meeting
CD21lo Cells Are Increased in Patients with Systemic Sclerosis and May be Associated with Interstitial Lung Disease
Erin Wilfong¹, Katherine Vowell², Leslie Crofford³ and Peggy Kendall¹, ¹Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, TN, ²Division of Rheumatology and Immunology, Vanderbilt University, Nashville, TN, ³Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Systemic sclerosis (SSc) is a severe systemic disease characterized by fibrosis of the skin and visceral organs. While the exact pathogenesis of SSc is…
Abstract Number: 31 • 2018 ACR/ARHP Annual Meeting
Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Regulates Inflammation and Joint Damage in the TNF-Tg Mouse Model
Maria de la Luz Garcia-Hernandez¹, Javier Rangel-Moreno², Ananta Paine², Benjamin D. Korman¹, Nelson Huertas² and Christopher T. Ritchlin¹, ¹Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, ²Division of Allergy, Immunology and Rheumatology and Center for Musculoskeletal Research School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY
Background/Purpose: Pathologic bone resorption in rheumatoid arthritis (RA) is mediated by multinucleated osteoclasts (OC) at the bone-pannus junction. OC differentiation (OCgenesis) is dependent on a…
Abstract Number: 32 • 2018 ACR/ARHP Annual Meeting
T Cell-Intrinsic Nod2 Protects Against Th17-Mediated Autoimmune Arthritis in SKG Mice
Ruth Napier¹, Ellen Lee¹, Emily Vance¹, Paige Snow², Clare Dawson³, Kimberly Samson⁴, Amy Moran⁵, Michael Davey⁶, Shimon Sakaguchi⁷ and Holly Rosenzweig¹, ¹Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, ²Molecular Microbiology and Immunology, VA Portland Health Care System, Portland, OR, ³Portland VA, PORTLAND, OR, ⁴Oregon Health & Science University, Portland, OR, ⁵Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR, ⁶VA Portland Health Care System, Portland, OR, ⁷Osaka University, Osaka, Japan
Background/Purpose: Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) is an innate immune receptor known primarily for its role in host protection against bacterial infections. Intriguingly, Nod2…
Abstract Number: 33 • 2018 ACR/ARHP Annual Meeting
Card9 Is a Critical Regulator of Autoimmune Arthritis in SKG Mice
Ruth Napier¹, Ellen Lee¹, Emily Vance¹, Kimberly Samson², Paige Snow³, Shimon Sakaguchi⁴ and Holly Rosenzweig¹, ¹Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, ²Oregon Health & Science University, Portland, OR, ³Molecular Microbiology and Immunology, VA Portland Health Care System, Portland, OR, ⁴Osaka University, Osaka, Japan
Background/Purpose: Caspase recruitment domain-containing protein 9 (Card9) is a C-type lectin receptor known for its function in protection against fungal infection and association with human diseases…
Abstract Number: 34 • 2018 ACR/ARHP Annual Meeting
Microbiome-Drived Aberration of Hematopoietic Stem Cell Development Facilitates Immune Deregulation on the Onset of Collagen-Induced Arthritis in Mice
Peiqing Yang¹, Lingchong Su¹, Yanhong Li¹, Yi Liu² and Yubin Luo³, ¹West China Hospital, Sichuan University, Chengdu, China, ²Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, China, Chengdu, China, ³Department of Rheumatology & Immunology,, West China Hosptial, Sichuan University, Chengdu, China
Background/Purpose: Increasing studies indicate that immune deregulation occurs prior to symptom in Rheumatoid arthritis (RA). Hematopoietic stem cell (HSC) gives rise to multipotent progenitors differentiating…
Abstract Number: 35 • 2018 ACR/ARHP Annual Meeting
Arthritis and Atherosclerosis in KRN Ag7 Mice Involve Distinct Inflammatory Cell Populations and Are Independent of CCR2
Anna B Montgomery¹, Carla M. Cuda², Salina Dominguez², Maximilian Mayr³, Deborah R. Winter² and Harris Perlman³, ¹Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory disease of the joints associated with cardiovascular disease, which accounts for 40% of RA mortality. Macrophages are implicated…
Abstract Number: 36 • 2018 ACR/ARHP Annual Meeting
The Pleiotropic Effects of TAM Signaling on Inflammatory Arthritis in Mice Using Kbxn Serum Transfer Induced Arthritis
Anna B Montgomery¹, Salina Dominguez², Maximilian Mayr³ and Harris Perlman³, ¹Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: TAM receptors are a small family of receptor tyrosine kinases comprising Tyro-3, Axl and Mer, which are activated by GAS6 and Protein-S. TAM signaling…
Abstract Number: 37 • 2018 ACR/ARHP Annual Meeting
Discovery of DWP213388, a Potent ITK and BTK Dual Target Inhibitor with Excellent Efficacy, As a Treatment for Autoimmune Diseases
Jae Hun Jung¹, Deokki Eom¹, Seong-Uk Jeon¹, Yong Dae Shin¹, Wolyoung Kim¹, Jaehyun Jung¹, Qingri Li¹, Hyaejung Hyun¹ and Joon Seok Park², ¹Daewoong pharmaceutical, Yongin-si, Korea, Republic of (South), ²Daewoong pharmaceutical, Seoul, Korea, Republic of (South)
Background/Purpose: Interleukin-2-inducible T-cell Kinase (ITK) and Bruton's tyrosine kinase (BTK) are critical for B cells and T cells activation, and dysregulation of this process has…

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