Abstracts Archive - Page 1183 of 2607 - ACR Meeting Abstracts

Abstract Number: 719 • 2019 ACR/ARP Annual Meeting
Distinct Characteristics of the Gut Microbiome of Patients with Systemic Sclerosis and Small Intestinal Bacterial Overgrowth
Hanyan Zou¹, Giada De Palma ², Premysl Bercik ², Elena Verdu ², Karen Beattie ² and Maggie Larche ², ¹McMaster University, Mississauga, ON, Canada, ²McMaster University, Hamilton, ON, Canada
Background/Purpose: The gastrointestinal tract (GIT) is commonly involved in SSc with up to 98% of patients reporting GIT manifestations. Small intestinal bacterial overgrowth (SIBO) is…
Abstract Number: 720 • 2019 ACR/ARP Annual Meeting
Baseline Subject Demographics and Disease Characteristics in a Phase 3 Study of Safety and Efficacy of Lenabasum in Diffuse Cutaneous Systemic Sclerosis
Robert Spiera¹, Nancy Dgetluck ², Bradley Bloom ², Barbara White ² and Christopher Denton ³, ¹Hospital for Special Surgery, New York, NY, ²Corbus Pharmaceuticals, Norwood, MA, ³University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom
Background/Purpose: We report the baseline characteristics of a large cohort of diffuse cutaneous systemic sclerosis (dcSSc) patients enrolled in a Phase 3 trial of lenabasum,…
Abstract Number: 721 • 2019 ACR/ARP Annual Meeting
Ultrasound Measurement of the Nail Bed Matrix Thickness as a Useful Marker for Scleroderma-Related Interstitial Lung Disease
Marian Sidor¹, Roman Zuckerman ¹, Naomi Schlesinger ², Ross Sussman ³, Huma Jaleel Sabahath ⁴ and Vivien Hsu ⁵, ¹Rutgers-RWJ Medical School, New Brunswick, NJ, ²Rutgers Health- RWJ Medical School, New Brunswick, NJ, ³Rutgers-RWJ Medical School, East Brunswick, NJ 08816, NJ, ⁴AtlantiCare Regional Medical Center, Atlantic City, NJ, ⁵Rutgers- RWJ Medical School, SOUTH PLAINFIELD, NJ
Background/Purpose: Lung involvement is the leading cause of death in systemic sclerosis (SSc) (1). Pulmonary function tests (PFTs) and chest high-resolution CT scan (HRCT) are…
Abstract Number: 722 • 2019 ACR/ARP Annual Meeting
The Lymphangiogenetic Factor VEGF-C and Its Receptor VEGFR-3 Are Associated with Pulmonary Arterial Hypertension in Systemic Sclerosis
Henriette Didriksen¹, Øyvind Molberg ², Håvard Fretheim ³, Einar Gude ², Vyacheslav Palchevskiy ⁴, Suzana Jordan ⁵, Torhild Garen ², Øyvind Midtvedt ², Arne Kristian Andreassen ², Oliver Distler ⁶, John Belperio ⁷ and Anna Maria Hoffmann-Vold ⁸, ¹Oslo University Hospital, Moss, Norway, ²Oslo University Hospital, Oslo, Norway, ³University Hospital Oslo, Oslo, Norway, ⁴2University of California Los Angeles, Los Angeles, ⁵Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, Zurich, Switzerland, ⁶Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, ⁷University of California Los Angeles, Los Angeles, ⁸Department of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway
Background/Purpose: Pulmonary arterial hypertension (PAH) is a major complication in systemic sclerosis (SSc) and is characterized by abnormalities in vascular pathways. In murine models of…
Abstract Number: 723 • 2019 ACR/ARP Annual Meeting
Diagnosis of Systemic Sclerosis: How and When
Cristina Sobrino¹ and Carlos De la Puente ², ¹Rheumatology Department, Ramón y Cajal University Hospital & IRYCIS, Madrid, Spain, ²Hospital Universitario Ramon y Cajal, Madrid, Spain
Background/Purpose: Systemic sclerosis (SSc) is a heterogeneous disease regarding its clinical expression, evolution and forms of presentation. In spite of the lack of a disease…
Abstract Number: 724 • 2019 ACR/ARP Annual Meeting
Biomechanical Properties of Skin for Assessment of Scleroderma: A Systemic Review
Peiyun Ni¹, Lilit Garibyan ² and Rox Anderson ², ¹Harvard-MIT Health Sciences and Technology, Harvard Medical School, Boston, MA, ²Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA
Background/Purpose: Skin involvement is one of the early features of scleroderma and an important predictor of internal organ involvement and mortality. Skin fibrosis alters the…
Abstract Number: 725 • 2019 ACR/ARP Annual Meeting
Amniotic Membrane Dressings Provide an Effective Treatment for Systemic Sclerosis Digital Ulcers
Tracy Frech¹, Jan Pierce ², Greg Stoddard ³, Constance McNeill ⁴, Mislav Radic ⁵ and Jo -Anna Reems ⁶, ¹Division of Rheumatology, University of Utah and Salt Lake VAMC, Salt Lake City, UT, ²University of Utah Regenerative Medicine, Salt Lake City, United Kingdom, ³University of Utah Study Design and Biostatics Core, Salt Lake City, UT, ⁴University of Utah Hospitals and Clinics, Salt Lake City, UT, ⁵University Hospital Split, Split, Croatia, ⁶University of Utah Regenerative Medicine, Salt Lake City, UT
Background/Purpose: Systemic sclerosis (SSc)-related digital ulcers are a major burden for patients. The purpose of this study was to assess the effectiveness of amnion membrane…
Abstract Number: 726 • 2019 ACR/ARP Annual Meeting
Digital Blood Perfusion Differences Between Black Africans and Caucasians with Systemic Sclerosis
Claudia Ickinger¹, Valerie Lambrecht ², Eustasius Musenge ³, Mohammed Tikly ¹, Maurizio Cutolo ⁴ and Vanessa Smith ⁵, ¹Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Joahnnesburg, South Africa, ²Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ³School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy, ⁵Dept. of Rheumatology, Ghent University Hospital, Ghent, Belgium; Dept. of Internal Medicine, Ghent University, Ghent, Belgium; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Ghent, Belgium, Gent, Belgium
Background/Purpose: Microvascular dysfunction is a prominent feature in SSc. Laser speckle contrast analysis (LASCA) has been shown to be a reliable tool to quantify skin…
Abstract Number: 727 • 2019 ACR/ARP Annual Meeting
Mortality and Morbidity in Scleroderma Renal Crisis: A Systematic Literature Review
Hyein Kim¹, Frédéric Lefebvre ², Sabrina Hoa ³ and Marie Hudson ⁴, ¹The University of British Columbia, Vancouver, Canada, ²University of Montreal, Montreal, Canada, ³University of Montreal, Montreal, QC, Canada, ⁴Jewish General Hospital, Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, QC, Canada
Background/Purpose: The introduction of angiotensin converting enzyme (ACE) inhibitors in the early 1970s resulted in marked improvement in clinical outcomes of scleroderma renal crisis (SRC).Despite…
Abstract Number: 728 • 2019 ACR/ARP Annual Meeting
Nailfold Videocapillaroscopy Patterns and Digital Occlusive Arterial Disease on Laser Doppler Flowmetry Strongly Predicts the Diagnosis of Systemic Sclerosis and Other Connective Tissue Diseases
Yasser Radwan¹, Tina Gunderson ², Cynthia Crowson ³, David Liedl ⁴, Alicia Hinze ¹, Kenneth Warrington ⁴, Paul Wennberg ⁴ and Ashima Makol ¹, ¹Mayo Clinic Minnesota, rochester, MN, ²Mayo Clinic, Rochester, MN, ³Mayo Clinic Rochester, Rochester, ⁴Mayo Clinic Rochester, rochester, MN
Background/Purpose: Vasculopathy is a key feature of systemic sclerosis (SSc), a chronic autoimmune disease associated with widespread fibrosis and internal organ dysfunction. While structural abnormalities…
Abstract Number: 729 • 2019 ACR/ARP Annual Meeting
Modelled Patient Level Skin Score Trajectory Predicts Risk of Death or Major Organ-Based Complications in Diffuse Cutaneous Systemic Sclerosis
Svetlana Nihtyanova¹, Emma Derrett-Smith ¹, Carmen Fonseca ¹, Voon Ong ² and Christopher Denton ³, ¹UCL Medical School, Royal Free Campus, London, United Kingdom, ²UCL Medical School, Royal Free Campus, London, ³University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom
Background/Purpose: For most patients with diffuse cutaneous systemic sclerosis (dcSSc), skin thickness improves over time, especially with background immunosuppressive treatment. This has reduced confidence in…
Abstract Number: 730 • 2019 ACR/ARP Annual Meeting
Energy Levels: An Overlooked Element in Patient Assessment in Scleroderma
Yossra Suliman¹, Suzanne Kafaja ², Mohamed Alemam ³ and Daniel Furst ⁴, ¹Rheumatology and Rehabilitation Department. Faculty of Medicine. Assiut University, Assiut, Egypt, ²Department of Medicine. Rheumatology Division. UCLA, Los Angeles, CA, ³Clinical Pathology and Chemistry Department. Qena Faculty of Medicine. South Valley University, Assiut, Egypt, ⁴University of California, Los Angeles, CA
Background/Purpose: Scleroderma (SSc) is a debilitating multi-system chronic disease which directly affects patient related Quality of Life. We wanted to identify how the patient interprets…
Abstract Number: 731 • 2019 ACR/ARP Annual Meeting
A Systemic Review of Factors Associated with Systemic Sclerosis-associated Pulmonary Arterial Hypertension (SSc-PAH)
Yuxuan Jiang ¹, Matthew Turk ¹ and Janet Pope², ¹University of Western Ontario, London, ON, Canada, ²Western University, London, ON, Canada
Background/Purpose: Pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) is a lethal complication affecting approximately 8-15% of patients. Screening methods including echocardiography and pulmonary function…
Abstract Number: 732 • 2019 ACR/ARP Annual Meeting
Risk of Heart Valve Disease in Systemic Sclerosis
Rodolfo Alvarado¹, Marina Scolnik ², Nicolas Marin Zucaro ¹, Gelsomina Alle ¹, María Trasante Borches ³, Luis Catoggio ¹ and Enrique Soriano ⁴, ¹Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina., Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, ²Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, ³Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina., Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, ⁴Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina., Buenos Aires, Buenos Aires, Argentina
Background/Purpose: Cardiac valve involvement in patients with Systemic Sclerosis (SSc) is uncommon, except for tricuspid regurgitation associated with pulmonary hypertension, and data regarding its frequency…
Abstract Number: 733 • 2019 ACR/ARP Annual Meeting
Vonoprazan, a Novel Potassium-competitive Acid Blocker, for Treatment of Proton Pump Inhibitor-resistant Reflux Esophagitis in Patients with Systemic Sclerosis
Yuichiro Shirai¹, Noriyuki Kawami ², Katsuhiko Iwakiri ² and Masataka Kuwana ¹, ¹Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, Bunkyo-ku, Tokyo, Japan, ²Department of Gastroenterology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, Bunkyo-ku, Tokyo, Japan
Background/Purpose: Esophageal involvement is one of the most frequent organ manifestations in patients with systemic sclerosis (SSc). Gastroesophageal reflux disease (GERD) is associated with reflux…

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