Abstracts Archive - Page 1175 of 2607 - ACR Meeting Abstracts

Abstract Number: 584 • 2019 ACR/ARP Annual Meeting
Radiographic Association of Hip and SI Joints in Ankylosing Spondylitis Patients
Juyeon Kang¹, Seoung Wan Nam ², Hyo-Kyung Sung ³, Kyung Bin Joo ⁴, Bon San Koo ⁵, Seunghun Lee ⁴ and Tae-Hwan Kim ¹, ¹Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ²Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea, ³Hanyang University Hospital for Rheumatic Diseases, Seoul, ⁴Dertment of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ⁵Department of Internal Medicine, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea
Background/Purpose: The modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) is a representative tool for assessing radiographic progression in spine of ankylosing spondylitis (AS) patients. However,…
Abstract Number: 585 • 2019 ACR/ARP Annual Meeting
Effect of Testosterone on Spinal Ankylosis in Ankylosing Spondylitis : in Vivo and in Vitro
Sungsin Jo¹, Eun-Ju Lee ², Juyeon Kang ¹, Seunghun Lee ³, Jeehee Youn ⁴, Yong-Gil Kim ⁵ and Tae-Hwan Kim ¹, ¹Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ²Ulsan university, seoul, Republic of Korea, ³Dertment of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ⁴Hanyang University, seoul, Republic of Korea, ⁵Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
Background/Purpose: Ankylosing spondylitis (AS) is a predominantly male disease and spinal ankylosis more severely affect male AS1 suggesting role of testosterone on spinal ankylosis. In…
Abstract Number: 586 • 2019 ACR/ARP Annual Meeting
Drug Concentrations and Anti-drug Antibodies Influence in Response to Adalimumab: Results from the BioEfficacySpA Clinical Trial
José Marona¹, Santiago Rodrigues-Manica ², João Lagoas Gomes ¹, Carina Lopes ³, Inês Iria ⁴, Miguel Bernardes ⁵, Helena Santos ⁶, Jose Tavares-Costa ⁷, João Madruga-Dias ⁸, Patrícia Pinto ⁹, Alexandra Bernardo ¹⁰, Sara Maia ¹¹, Jaime Branco ², João Gonçalves ⁴ and Fernando Pimentel-Santos ², ¹Rheumatology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental; CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon., Lisbon, Portugal, ²CEDOC, NOVA-Medical School | Hospital Egas Moniz, CHLO, Lisbon, Lisbon, Portugal, ³Rheumatology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental; CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon, Lisbon, Portugal, ⁴Faculdade de Farmácia da Universidade de Lisboa; Portugal, Lisbon, Portugal, ⁵Rheumatology, Centro Hospitalar de São João, Porto, Portugal, Porto, Portugal, ⁶Instituto Português de Reumatologia (IPR), Lisbon, Portugal, ⁷ULSAM, Ponte de Lima, Portugal, Ponte de Lima, Portugal, ⁸CHMT, Torres Novas, Portugal, Torres Novas, ⁹Rheumatology Department, CHVNG, Vila Nova de Gaia, Portugal, ¹⁰Rheumatology Department, CHSJ, Porto, Portugal, ¹¹CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon, Lisbon, Portugal
Background/Purpose: Almost all protein-based biotherapeutics can induce immunogenicity, which may result in loss of efficacy and/or increased risk of adverse reactions. Despite all the efforts…
Abstract Number: 587 • 2019 ACR/ARP Annual Meeting
Increased Prevalence of Cardiac Disorders in Dutch Ankylosing Spondylitis Patients: The CARDAS Study
Milad Baniaamam¹, Sjoerd Heslinga ², Thelma Konings ³, Otto Kamp ³, Vokko van Halm ³, Irene van der Horst-Bruinsma ² and Mike Nurmohamed ⁴, ¹Amsterdam Rheumatology and immunology Center, Rheumatology, Reade, Amsterdam|Amsterdam Rheumatology and immunology Center, Rheumatology, Amsterdam University Medical Center location VUmc, Amsterdam, Amsterdam, Netherlands, ²Amsterdam Rheumatology and immunology Center, Rheumatology, Amsterdam University Medical Center location VUmc, Amsterdam, Amsterdam, Netherlands, ³Amsterdam University Medical Center, location VUmc, Department of Cardiology, Amsterdam, Amsterdam, Netherlands, ⁴Amsterdam Rheumatology and immunology Center location Reade and Amsterdam UMC location VU medical center, Amsterdam, Netherlands
Background/Purpose: The overall mortality rate in ankylosing spondylitis (AS) patients is increased by 60–90% compared with the general population. This higher mortality rate is predominately…
Abstract Number: 588 • 2019 ACR/ARP Annual Meeting
The Gut Enthesis Axis Coming into Focus with the Description of Enriched Entheseal Resident Mucosal Associated Invariant T-cells (MAITs) Capable of IL17A and TNF Production
Richard Cuthbert ¹, Qiao Zhou ², Abdulla Watad ³, Robert Dunsmuir ⁴, Peter Loughenbury ⁴, Almas Khan ⁴, Peter Milner ⁴, Charles Bridgewood ⁵ and Dennis McGonagle², ¹University of Leeds, Leeds, ²University of Leeds, Leeds, United Kingdom, ³Department of Medicine “B”, Zabludowicz Center for Autoimmune Diseases Sheba Medical Center, Ramat-Gan, Israel, ⁴Leeds Teaching Hospitals NHS Trust, Leeds, ⁵Leeds Institute of Rheumatic and Muscoskeletal Medicine(LIRMM), University of Leeds, Leeds, United Kingdom
Background/Purpose: Mucosal associated invariant T-cells (MAITs) are innate-like T lymphocytes that express a semi-invariant TCR repertoire that are activated by microbial ligands or cytokines including…
Abstract Number: 589 • 2019 ACR/ARP Annual Meeting
Smoking, Alcohol Intake and Body Mass Index in Prediction of Disease Activity over Time in Early Axial Spondyloarthritis – Results from the SPondyloArthritis Caught Early (SPACE) Cohort
Sofia Exarchou ¹, Carl Turesson¹, Ulf Lindström ², Roberta Ramonda ³, Robert B.M. Landewé ⁴, Hanne Dagfinrud ⁵, Floris van Gaalen ⁶, Désirée van der Heijde ⁶ and Lennart Jacobsson ⁷, ¹Lund University, Malmö, Sweden, ²University of Gothenburg, Gothenburg, Sweden, ³University of Padova, Padova, Italy, ⁴Amsterdam University Medical Center, Amsterdam, Netherlands, ⁵University of Oslo, Oslo, Norway, ⁶Leiden University Medical Center, Leiden, Netherlands, ⁷Dept of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden,, Gothenburg, Sweden
Background/Purpose: In ankylosing spondylitis (AS), smokers have been found to have both higher disease activity and greater syndesmophyte progression, and a higher body mass index…
Abstract Number: 590 • 2019 ACR/ARP Annual Meeting
What Is the Impact of MRI on the Performance of the ASAS Classification Criteria in Patients Presenting with Undiagnosed Back Pain?
Walter P. Maksymowych¹, Raj Carmona ², Jonathan Chan ³, James Yeung ⁴, Sibel Zehra Aydin ⁵, Liam Martin ⁶, Ariel Masetto ⁷, Dianne Mosher ⁸, Olga Ziouzina ⁶, Stephanie Keeling ⁹, Sherry Rohekar ¹⁰, Rana Dadashova ¹¹, Joel Paschke ¹¹, Amanda Carapellucci ¹¹ and Robert Lambert ¹², ¹University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ²McMaster University, Hamilton, Canada, ³Artus Health Clinic, Vancouver, BC, Canada, ⁴Yeung Rheumatology, Vancouver, Canada, ⁵University of Ottawa Faculty of Medicine, Rheumatology,Ottawa Hospital Research Institute, 1967 Riverside Drive, Ottawa, ON, K1H 7W9, CANADA, Ottawa, Canada, ⁶University of Calgary, Calgary, Canada, ⁷Université de Sherbrooke, Sherbrooke, QC, Canada, ⁸University of Calgary, Calgary, AB, Canada, ⁹University of Alberta, Edmonton, AB, Canada, ¹⁰Western University, London, ON, Canada, ¹¹CARE Arthritis, Edmonton, Canada, ¹²University of Alberta, Edmonton, Canada
Background/Purpose: Classification criteria for axSpA comprise an imaging and a clinical arm, the former requiring radiographic or MRI evidence of sacroiliitis. Several cohorts have reported…
Abstract Number: 591 • 2019 ACR/ARP Annual Meeting
Longitudinal Assessment of MRI of the Sacroiliac Joints in the ASAS Classification Cohort: Evolution of Diagnostic Features and Predictive Utility for Axial Spondyloarthritis
Walter P. Maksymowych¹, Xenofon Baraliakos ², Manouk de Hooge ³, Iris Eshed ⁴, Susanne Juhl Pedersen ⁵, Ulrich Weber ⁶, Joachim Sieper ⁷, Stephanie Wichuk ⁸, Denis Poddubnyy ⁹, Martin Rudwaleit ¹⁰, Désirée van der Heijde ¹¹, Robert B.M. Landewé ¹², Joel Paschke ¹³, Robert Lambert ⁸ and Mikkel Østergaard ¹⁴, ¹University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ²Rheumatology Department, Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, ³Ghent University Hospital, Ghent, Belgium, ⁴Sheba Medical Center, Tel Aviv, Israel, ⁵Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark, ⁶Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sonderborg, Denmark, ⁷Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, ⁸University of Alberta, Edmonton, Canada, ⁹Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany, ¹⁰Klinikum Bielefeld, Charité Berlin, Gent University, Bielefeld, Germany, ¹¹Leiden University Medical Center, Leiden, Netherlands, ¹²Amsterdam University Medical Center, Amsterdam, Netherlands, ¹³CARE Arthritis, Edmonton, Canada, ¹⁴Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark
Background/Purpose: Follow up of the ASAS Classification Cohort (CC) indicated a high positive predictive value for the ASAS classification criteria derived from baseline patient and…
Abstract Number: 592 • 2019 ACR/ARP Annual Meeting
Replacement of Radiographic Sacroilitis by MRI Structural Lesions: What Is the Impact on Classification of Axial Spondyloarthritis in the ASAS Classification Cohort?
Walter P. Maksymowych¹, Pedro Machado ², Robert Lambert ³, Xenofon Baraliakos ⁴, Mikkel Østergaard ⁵, Joachim Sieper ⁶, Stephanie Wichuk ³, Denis Poddubnyy ⁷, Martin Rudwaleit ⁸, Désirée van der Heijde ⁹, Robert B.M. Landewé ¹⁰, Joel Paschke ¹¹, Susanne Juhl Pedersen ¹² and Ulrich Weber ¹³, ¹University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ²University College London, London, United Kingdom, ³University of Alberta, Edmonton, Canada, ⁴Rheumatology Department, Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, ⁵Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark, ⁶Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, ⁷Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany, ⁸Klinikum Bielefeld, Charité Berlin, Gent University, Bielefeld, Germany, ⁹Leiden University Medical Center, Leiden, Netherlands, ¹⁰Amsterdam University Medical Center, Amsterdam, Netherlands, ¹¹CARE Arthritis, Edmonton, Canada, ¹²Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark, ¹³Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sonderborg, Denmark
Background/Purpose: xClassification of axial spondyloarthritis is based on the application of either an imaging or clinical arm. Radiographic or MRI evidence of sacroiliitis can be…
Abstract Number: 593 • 2019 ACR/ARP Annual Meeting
Performance of the ASAS Classification Criteria Presenting with Undiagnosed Back Pain: Data from the Screening in Axial Spondyloarthritis in Psoriasis, Iritis, and Colitis Cohort
Walter P. Maksymowych¹, Raj Carmona ², Jonathan Chan ³, James Yeung ⁴, Sibel Zehra Aydin ⁵, Liam Martin ⁶, Ariel Masetto ⁷, Dianne Mosher ⁸, Olga Ziouzina ⁶, Stephanie Keeling ⁹, Sherry Rohekar ¹⁰, Rana Dadashova ¹¹, Joel Paschke ¹¹, Amanda Carapellucci ¹¹ and Robert Lambert ¹², ¹University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ²McMaster University, Hamilton, Canada, ³Artus Health Clinic, Vancouver, BC, Canada, ⁴Yeung Rheumatology, Vancouver, Canada, ⁵University of Ottawa Faculty of Medicine, Rheumatology,Ottawa Hospital Research Institute, 1967 Riverside Drive, Ottawa, ON, K1H 7W9, CANADA, Ottawa, Canada, ⁶University of Calgary, Calgary, Canada, ⁷Université de Sherbrooke, Sherbrooke, QC, Canada, ⁸University of Calgary, Calgary, AB, Canada, ⁹University of Alberta, Edmonton, AB, Canada, ¹⁰Western University, London, ON, Canada, ¹¹CARE Arthritis, Edmonton, Canada, ¹²University of Alberta, Edmonton, Canada
Background/Purpose: Classification criteria for axial spondyloarthritis (axSpA) that capture the spectrum of disease present challenges due to the frequency of back pain, the relative infrequency…
Abstract Number: 594 • 2019 ACR/ARP Annual Meeting
Enhanced Performance of the ASAS Classification Criteria by Deletion of Non-Discriminatory Clinical Items: Data from the Screening in Axial Spondyloarthritis in Psoriasis, Iritis, and Colitis Cohort
Walter P. Maksymowych¹, Raj Carmona ², Jonathan Chan ³, James Yeung ⁴, Sibel Zehra Aydin ⁵, Liam Martin ⁶, Ariel Masetto ⁷, Dianne Mosher ⁸, Olga Ziouzina ⁶, Stephanie Keeling ⁹, Sherry Rohekar ¹⁰, Rana Dadashova ¹¹, Joel Paschke ¹¹, Amanda Carapellucci ¹¹ and Robert Lambert ¹², ¹University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ²McMaster University, Hamilton, Canada, ³Artus Health Clinic, Vancouver, BC, Canada, ⁴Yeung Rheumatology, Vancouver, Canada, ⁵University of Ottawa Faculty of Medicine, Rheumatology,Ottawa Hospital Research Institute, 1967 Riverside Drive, Ottawa, ON, K1H 7W9, CANADA, Ottawa, Canada, ⁶University of Calgary, Calgary, Canada, ⁷Université de Sherbrooke, Sherbrooke, QC, Canada, ⁸University of Calgary, Calgary, AB, Canada, ⁹University of Alberta, Edmonton, AB, Canada, ¹⁰Western University, London, ON, Canada, ¹¹CARE Arthritis, Edmonton, Canada, ¹²University of Alberta, Edmonton, Canada
Background/Purpose: xThe ASAS classification criteria for axial spondyloarthritis (axSpA) have overall sensitivity/specificity of 82.9%/84.4% but component imaging and clinical arms differ in performance (66.2%/97.3% and…
Abstract Number: 595 • 2019 ACR/ARP Annual Meeting
What Is the Impact of Discrepancy Between Central and Local Readers in Evaluation of MRI Scans on the Classification of Axial Spondyloarthritis? Data from the ASAS Classification Cohort Study
Walter P. Maksymowych¹, Susanne Juhl Pedersen ², Ulrich Weber ³, Pedro Machado ⁴, Xenofon Baraliakos ⁵, Joachim Sieper ⁶, Stephanie Wichuk ⁷, Denis Poddubnyy ⁸, Martin Rudwaleit ⁹, Désirée van der Heijde ¹⁰, Robert B.M. Landewé ¹¹, Joel Paschke ¹², Mikkel Østergaard ¹³ and Robert Lambert ⁷, ¹University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ²Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark, ³Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sonderborg, Denmark, ⁴University College London, London, United Kingdom, ⁵Rheumatology Department, Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, ⁶Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, ⁷University of Alberta, Edmonton, Canada, ⁸Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany, ⁹Klinikum Bielefeld, Charité Berlin, Gent University, Bielefeld, Germany, ¹⁰Leiden University Medical Center, Leiden, Netherlands, ¹¹Amsterdam University Medical Center, Amsterdam, Netherlands, ¹²CARE Arthritis, Edmonton, Canada, ¹³Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark
Background/Purpose: Active MRI lesions typical of axSpA were reported in 61.6% and 2.2% of axSpA and not-axSpA patients, respectively, from the ASAS classification cohort (ASAS-CC)1.…
Abstract Number: 596 • 2019 ACR/ARP Annual Meeting
Prostaglandin Receptor EP4 Drives Pathogenic Th17 Cell Development in Ankylosing Spondylitis and Is a New Marker of Disease Activity
Anja Meyer¹, Charlotte Klasen ¹, Pauline Wittekind ¹, Iris Waqué ¹, Schafiq Nabhani ¹ and David Kofler ¹, ¹University of Cologne, Cologne, Germany
Background/Purpose: Th17 cells are involved in the pathogenesis of ankylosing spondylitis (AS). However, the mechanism underlying enhanced Th17 cell accumulation in AS remains unknown. The…
Abstract Number: 597 • 2019 ACR/ARP Annual Meeting
High Prevalence of Sacroiliac Bone Marrow Edema on MRI in Post Partum Women: A Temporary Phenomenom
Thomas Renson¹, Ann-Sophie De Craemer ¹, Liselotte Deroo ¹, Anaïs Depicker ¹, Manouk de Hooge ¹, Nele Herregods ¹, Lennart Jans ¹, Kristien Roelens ¹, Isabelle Dehaene ¹, Philippe Carron ¹, Filip Van den Bosch ¹ and Dirk Elewaut ¹, ¹Ghent University Hospital, Ghent, Belgium
Background/Purpose: Magnetic Resonance Imaging (MRI) is a sensitive method for detection of sacroiliitis. However, recently, concerns have been raised about its specificity. In contrast to…
Abstract Number: 598 • 2019 ACR/ARP Annual Meeting
Identification of Potential Risk Factors for Spinal Structural Damage in Chinese Patients with Ankylosing Spondylitis
Weiping Kong¹, Caroline Jefferies ², Tom Learch ², Feng Zhu ¹, Nan Zhang ¹, Dier Jin ¹, Yingze Zhang ¹, Qingwen Tao ¹, Xiaoping Yan ¹, Michael Weisman ³ and Mariko Ishimori ², ¹China-Japan Friendship Hospital, Beijing, China (People's Republic), ²Cedars-Sinai Medical Center, Los Angeles, CA, ³David Geffen School of Medicine at UCLA, Los Angeles, CA
Background/Purpose: Spinal structural damage can lead to physical dysfunction and decline of spinal mobility in patients with ankylosing spondylitis (AS). Although great progress has been…

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