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  • Abstract Number: 2498 • 2018 ACR/ARHP Annual Meeting

    The Association of Vitamin D with the Lipid Profile in Rheumatoid Arthritis: An Interplay Among Genetic Polymorphisms, DHCR7 Levels and Seasonality

    Javier Rodríguez-Carrio1,2,3, Mercedes Alperi-López4, Manuel Naves-Díaz2,3, Adriana Dusso2,3, Patricia López1, Francisco Javier Ballina-García5, Jorge B. Cannata-Andía2,3 and Ana Suárez1, 1Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, 2Bone and Mineral Research Unit, Instituto Reina Sofía de Investigación Nefrológica, REDinREN del ISCIII, Hospital Universitario Central de Asturias, Oviedo, Spain, 3Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain, 4Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, 5Department of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain

    Background/Purpose: Vitamin D deficiency is a common hallmark of rheumatic diseases, and some controversy exists about its effect on rheumatoid arthritis (RA), in particular about…
  • Abstract Number: 2499 • 2018 ACR/ARHP Annual Meeting

    Predictors of Rheumatoid Arthritis Development in Patients with Early Undifferentiated Arthritis: A 2-Years Follow-up Study

    Juan Molina1, Maria Gabriela Gonzalez Álvarez2, Victoria Navarro-Compán3, Laura Nuño4, Alejandro Villalba2, Diana Peiteado2, Patricia Bogas2 and Alejandro Balsa2, 1Rheumatology, Rheumatology, La Paz University Hospital, Madrid, Spain, 2Hospital Universitario La Paz, Madrid, Spain, 3Immuno-Rheumatology research group, IdiPaz. La Paz University Hospital, Madrid, Spain, 4Rheumatology, La Paz University Hospital, Madrid, Spain

    Background/Purpose: Early treatment of RA improves longterm outcomes. However, at the beginning of the disease, some patients with RA fall within undifferentiated arthritis (UA) patients.…
  • Abstract Number: 2500 • 2018 ACR/ARHP Annual Meeting

    Association between Anti-Citrullinated Protein Antibody Status, Erosive Disease and Healthcare Resource Utilization in Patients with RA

    Leslie R Harrold1, Lin Guo2, Sean E. Connolly3, Evo Alemao3, Sabrina Rebello4, Ying Shan4 and Joel Kremer5, 1University of Massachusetts Medical School, Worcester, MA, 2Corrona, LLC, Waltham, MA, 3Bristol-Myers Squibb, Princeton, NJ, 4Corrona, LLC, Southborough, MA, 5Albany Medical College and The Center for Rheumatology, Albany, NY

    Background/Purpose: Anti-citrullinated protein antibody (ACPA) is a highly specific biomarker for RA1 and ACPA-seropositive patients have a tendency toward severe erosive disease and more rapid…
  • Abstract Number: 2501 • 2018 ACR/ARHP Annual Meeting

    Disease Activity Is the Major Discriminator When Defining Refractory Rheumatoid Arthritis

    Manuel Bécède1, Josef S. Smolen2 and Daniel Aletaha3, 1Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 2Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, 3Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Disease Activity is the Major Discriminator When Defining Refractory Rheumatoid ArthritisM Bécède, JS Smolen, D Aletaha.Medical University of Vienna, Vienna, AustriaBackground/Purpose: Rheumatoid arthritis (RA) is…
  • Abstract Number: 2502 • 2018 ACR/ARHP Annual Meeting

    Influence of the Treatment with Biologic Agents in the Viremia By the Endogenous Anelovirus Torque Teno Virus in Patients with Chronic Arthritis

    Maria Martin-Lopez1, Eliseo Albert2, Esther Rodriguez-Almaraz3, Isidoro Gonzalez-Alvaro4, Mario Fernandez-Ruiz5, Jose M. Aguado5, David Navarro2 and Jose L. Pablos6, 1Rheumatology Department, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain, 2Microbiology, Instituto de Investigación INCLIVA, Hospital Clínico, Valencia, Spain, 3Hospital Universitario 12 de Octubre, Madrid, Spain, 4Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, 5Instituto de Investigación Hospital 12 de Octubre. Unit of Infectious Diseases, Madrid, Spain, 6Rheumatology, Rheumatology Department, Hospital Universitario 12 de Octubre, Spain, Madrid, Spain

    Background/Purpose: Torque teno virus (TTV) is an endogenous anellovirus that is highly prevalent in adult healthy subjects (up to 90%) without known pathogenicity. Increased replication…
  • Abstract Number: 2503 • 2018 ACR/ARHP Annual Meeting

    Impact of Tobacco Smoking on 1-Year Mortality Following Total Hip and Total Knee Arthroplasty Among Rheumatoid Arthritis Patients – a Danish Cohort Study Using Nationwide Health Care Registers

    René Cordtz1,2, Laerke Bech-Illum3, Daniel Prieto-Alhambra4, Pil Hoejgaard3,5, Kristian Zobbe3,6, Nina Imbæk3 and Lene Dreyer7, 1Center for Rheumatology and Spine Diseases, Gentofte-Rigshospitalet, Hellerup, Denmark, 2The Parker Institute, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Copenhagen, Denmark, 3Center for Rheumatology and Spine Diseases - Gentofte, Rigshospitalet, Hellerup, Denmark, 4Internal Medicine and Primary Care, URFOA-IMIM, Parc de Salut Mar; Idiap Jordi Gol i Gurina-Institut Català de la Salut; Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK, Barcelona, Spain, 5The Parker Institute, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Denmark, 6The Parker Institute, Bispebjerg and Frederiksberg Hospital, Capital Region of Denmark, Copenhagen, Denmark, 7Departments of Rheumatology and Clinical Medicine, Aalborg University Hospital and Aalborg University, 9000 Aalborg, Denmark

    Background/Purpose: Tobacco smoking and rheumatoid arthritis (RA) are independent risk factors for short-term complications following total hip and total knee arthroplasty (THA/TKA). We aimed to…
  • Abstract Number: 2504 • 2018 ACR/ARHP Annual Meeting

    A More Time Under Remission Impacts in a Better Health-Related Quality of Life in Rheumatoid Arthritis Mestizo Population

    Rocío Gamboa-Cárdenas1, Manuel Ugarte-Gil2,3, Mariela Medina-Chinchon1, Cristina Reategui-Sokolova1, Francisco Zevallos1, Victor R. Pimentel-Quiroz1, Claudia Elera-Fitzcarrald1,4, Jose Alfaro-Lozano1, Zoila Rodriguez-Bellido1,5, Risto Perich-Campos1,5 and Cesar A. Pastor-Asurza1,5, 1Rheumatology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, 2Rheumatology, Universidad Científica del Sur, Lima, Peru, 3Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, 4Universidad Científica del Sur, Lima, Peru, 5Universidad Nacional Mayor de San Marcos, Lima, Peru

    Background/Purpose: In Rheumatoid Arthritis (RA), sustained remission is associated with less disability (1,2) , and this outcome should be the goal in the RA treatment;…
  • Abstract Number: 2505 • 2018 ACR/ARHP Annual Meeting

    Sociodemographic Factors Are Predictors of Poorer Clinical Outcome Trajectories in Early Rheumatoid Arthritis: Results from the Singapore Early Arthritis Cohort

    Yuhan Zou1, Peter P.M. Cheung2,3, Lay Kheng Teoh4 and Manjari Lahiri2,3, 1Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 2Division of Rheumatology, University Medicine Cluster, National University Hospital, Singapore, Singapore, Singapore, 3Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 4National University Hospital, Division of Rheumatology, University Medicine Cluster, Singapore, Singapore

    Background/Purpose: Variable outcomes in early rheumatoid arthritis (ERA) may be explained by heterogeneous latent disease activity trajectories, the predictors of which are not well defined.…
  • Abstract Number: 2506 • 2018 ACR/ARHP Annual Meeting

    The Joint Disease Burden in Patients with Secondary Sjögren’s Syndrome and RA Compared to Patients with RA Only

    Evo Alemao1, Yogesh Saini2, Ying Bao1, Aarti Rao2, Christine K Iannaccone3, Michael E Weinblatt3 and Nancy A. Shadick3, 1Bristol-Myers Squibb, Princeton, NJ, 2Mu Sigma, Bangalore, India, 3Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Secondary Sjögren’s syndrome (sSS) is considered a poor prognostic factor in RA and is a common extra-articular manifestation of RA. We estimated prevalence of…
  • Abstract Number: 2507 • 2018 ACR/ARHP Annual Meeting

    Healthcare Resource Utilization in Patients with Secondary Sjögren’s Syndrome Associated with RA Compared with Patients with RA in an Insured Population

    Evo Alemao1, Aarti Rao2, Chidananda Samal2 and Robert Wong1, 1Bristol-Myers Squibb, Princeton, NJ, 2Mu Sigma, Bangalore, India

    Background/Purpose: Secondary Sjögren’s syndrome (sSS) is a rheumatic disease that may coexist with RA. Joint disease is more severe in patients (pts) with RA with…
  • Abstract Number: 2508 • 2018 ACR/ARHP Annual Meeting

    A First-in-Man Bioelectronic Therapy for Biologic-Refractory Rheumatoid Arthritis

    David Chernoff1, Yaakov Levine1, Charles Peterfy2 and Mark C. Genovese3, 1SetPoint Medical, Inc., Valencia, CA, 2Spire Sciences LLC, Boca Raton, FL, 3Department of Medicine, Stanford University, Palo Alto, CA

    Background/Purpose: Rheumatoid arthritis (RA) is a debilitating chronic disease with an unmet need for additional therapeutic approaches. Bioelectronic therapy (BET), such as electrical neurostimulation of…
  • Abstract Number: 2509 • 2018 ACR/ARHP Annual Meeting

    Long-Term Treatment with Sarilumab Plus Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs): Pooled Safety and Efficacy with over 4 Years’ Treatment

    Mark C. Genovese1, Hubert van Hoogstraten2, Gregory St. John3, Qunming Dong2, Juan José Gómez-Reino4, José A. Maldonado-Cocco5, Juan Carlos Salazar6, Tom W.J. Huizinga7 and Gerd R. Burmester8, 1Stanford University Medical Center, Palo Alto, CA, 2Sanofi Genzyme, Bridgewater, NJ, 3Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 4Complejo Hospitalario Universitario de Santiago de Compostela, Santiago, Spain, 5School of Medicine, Buenos Aires University, Buenos Aires, Argentina, 6Riesgo de Fractura S.A - CAYRE, Bogotá, Colombia, 7Leiden University Medical Center, Leiden, Netherlands, 8Charité – University Medicine Berlin, Berlin, Germany

    Background/Purpose: EXTEND (NCT01146652) is an ongoing open-label extension study enrolling patients completing five sarilumab originator studies (MOBILITY [NCT01061736]; TARGET [NCT01709578]; ASCERTAIN [NCT01768572]; ACT11575 [NCT01217814]; ONE…
  • Abstract Number: 2510 • 2018 ACR/ARHP Annual Meeting

    A Phase IIa Mechanistic Study of Anti-GM-CSF (GSK3196165) with Methotrexate Treatment in Patients with Rheumatoid Arthritis (RA) and an Inadequate Response to Methotrexate

    Mark C. Genovese1, Mario Berkowitz2, Philip G. Conaghan3, Katherine Davy4, David Inman5, Elena Fisheleva6,7, Anubha Gupta6, Robert Janiczek6, Mark Layton8, Nina Mitchell6,7, Jatin Patel9, Julia E. Smith10, Russell Williamson5 and Paul-Peter Tak11, 1Stanford University Medical Center, Palo Alto, CA, 2Leon Medical Research, Lauderdale Lakes, FL, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 4Statistics, GlaxoSmithKline, Stevenage, UK, Stevenage, United Kingdom, 5GlaxoSmithKline, Stockley Park, United Kingdom, 6GlaxoSmithKline, Stevenage, United Kingdom, 7Currently at Biomarin UK Ltd, London, United Kingdom, 8ImmunoInflammation, ImmunoInflammation, GlaxoSmithKline, Stevenage, UK, Stevenage, United Kingdom, 9ImmunoInflammation, GlaxoSmithKline, Stevenage, UK, Stevenage, United Kingdom, 10Immunoinflammation TA, GSK Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom, 11GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom

    Background/Purpose: GSK3196165 is a high-affinity anti-GM-CSF cytokine IgG mAb currently in development for RA, with reported efficacy using IV dosing.  This study evaluated the effects…
  • Abstract Number: 2511 • 2018 ACR/ARHP Annual Meeting

    Benepali Switches in Clinical Practice – a Positive Single Centre Experience

    Hoda Alkoky, Angela Pakozdi and Hasan Tahir, Rheumatology, Barts Health NHS Trust, London, United Kingdom

    Background/Purpose: Benepali (SB4) an etanercept (ETN) biosimilar, has demonstrated comparable efficacy in randomised controlled trials. Switching patients to biosimilars has cost benefits to the national…
  • Abstract Number: 2512 • 2018 ACR/ARHP Annual Meeting

    Treatment Continuation on the Etanercept Original in Comparison with a Biosimilar

    Lisa Baganz1, Yvette Meißner1, Perter Herzer2, Jürgen Braun3, Anett Gräßler4, Anja Strangfeld5 and Angela Zink6, 1Programme Area Epidemiology, German Rheumatism Research Center, Berlin, Germany, 2Scientific Advisory Board, Munich, Germany, 3Ruhr-University Bochum, Bochum, Germany, 4Rheumatologist, Pirna, Germany, 5Epidemiology, German Rheumatism Research Center, Berlin, Germany, 6Epidemiology Unit / Rheumatology and Clinical Immunology, German Rheumatism Research Centre (DRFZ) / Charité University Hospital, Berlin, Germany

    Background/Purpose: The number of biosimilars approved for the treatment of rheumatoid arthritis (RA) is constantly increasing. Until now, there are just a few analyses investigating…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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