Abstracts Archive - Page 1145 of 2425 - ACR Meeting Abstracts

Abstract Number: 2107 • 2018 ACR/ARHP Annual Meeting
Lupus-Prone SLE1.2.3. Mice Exhibit Loss of Thymus-Derived CD4+CD25+Helios+ Tregs
Nick Huang¹, Zhi-Wei Lai¹, Gourav Choudhary², Thomas Winans³, Ryan Kelly⁴, Katalin Banki⁵, Laurence Morel⁶ and Andras Perl¹, ¹Medicine, SUNY Upstate Medical University, Syracuse, NY, ²Department of Biochemistry and Mol. Biology, SUNY Upstate Medical University, Syracuse, NY, ³SUNY Upstate Medical University, Syracuse, NY, ⁴SUNY, Syracuse, NY, ⁵Clinical Pathology, SUNY Upstate Medical University, Syracuse, NY, ⁶Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL
Background/Purpose: Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease that is characterized by the production of autoantibodies against nuclear antigens (ANA) and phospholipids…
Abstract Number: 2108 • 2018 ACR/ARHP Annual Meeting
Dock8-Positive CD4 T Cell As Autoantibody-Inducing CD4 T (aiCD4 T) Cell That Causes Systemic Lupus Erythematosus (SLE): Proof of Concept of Self-Organized Criticality Theory As a Cause of SLE
Shunichi Shiozawa¹, Ken Tsumiyama¹, Yumi Miyazaki², Keiichi Sakurai¹ and Masaaki Miyazawa³, ¹Institute for Rheumatic Diseases, Nagahama, Japan, ²Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, ³Immunology, Kinki University School of Medicine, Sayama, Japan
Background/Purpose: We found in reproducible experiments in which the mice not prone to autoimmune disease were immunized repeatedly with antigen that overstimulation of CD4 T…
Abstract Number: 2109 • 2018 ACR/ARHP Annual Meeting
Activation of T Follicular Helper Cells through Epigenetic Regulation By STAT1 and STAT4 in Lupus Patients
Shingo Nakayamada¹, Xiaoxue Ma¹, Satoshi Kubo¹, Yusuke Miyazaki¹, Kaoru Yamagata¹, Kazuhisa Nakano¹ and Yoshiya Tanaka², ¹First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: During the T cell differentiation, signal transducer and activators of transcription (STAT) family transcription factors play pivotal roles in specifying T cell lineages. T…
Abstract Number: 2110 • 2018 ACR/ARHP Annual Meeting
Association of Systemic Lupus Erythematosus (SLE) Genetic Susceptibility Loci with Lupus Nephritis in Children and Adults with SLE
Declan Webber¹, Jingjing Cao², Daniela Dominguez³, Dafna D Gladman⁴, Deborah M. Levy⁵, Lawrence Ng³, Andrew Paterson³, Zahi Touma⁶, Murray Urowitz⁷, Joan E. Wither⁸, Earl Silverman⁵ and Linda Hiraki⁹, ¹Department of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada, ³The Hospital for Sick Children, Toronto, ON, Canada, ⁴Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ⁵Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁶University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁷Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁸Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁹Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex, chronic, autoimmune disease. Genome-wide association studies (GWAS) have identified multiple risk SNPs in HLA and non-HLA gene…
Abstract Number: 2111 • 2018 ACR/ARHP Annual Meeting
Ifnβ Affects Osteogenesis-Adipogenesis Axis in SLE Bone Marrow
Lin Gao, Mary O'Connell, Jennifer Anolik and R. John Looney, Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: SLE patients are especially vulnerable to corticosteroid induced avascular necrosis. While it is appreciated that multiple factors contribute to AVN, the bone-fat axis in…
Abstract Number: 2112 • 2018 ACR/ARHP Annual Meeting
IFN-Gene Expression Is Elevated in Subacute Cutaneous Lupus Erythematous and DLE and Decreases with Treatment in DLE
Stephanie Lazar¹, Rajaie Namas², Celine C. Berthier³ and Michelle Kahlenberg⁴, ¹Internal Medicine, University of Michigan, Ann Arbor, MI, ²Rheumatology, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates, ³Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, ⁴Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Patients with SLE have increased type I IFN-regulated gene expression in peripheral blood, which has been correlated with systemic disease activity. IFN-regulated gene expression…
Abstract Number: 2113 • 2018 ACR/ARHP Annual Meeting
Identification of RNASE2 As a Novel Lupus Candidate Gene
Yang Xu, Xiaojun Tang and Xuebing Feng, Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Although many factors have been implicated to be involved in the development of systemic lupus erythematosus (SLE), the pathogenesis of this prototypical autoimmune disease…
Abstract Number: 2114 • 2018 ACR/ARHP Annual Meeting
Interferon Kappa Regulates Apoptotic Response to UVB in Control and Lupus Keratinocytes
Grace Hile¹, Mrinal Sarkar², Jianhua Liu³, Tamra J. Reed⁴, Johann Gudjonsson² and Michelle Kahlenberg⁴, ¹University of Michigan, Ann Arbor, MI, ²Dermatology, University of Michigan, Ann Arbor, MI, ³Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁴Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Photosensitivity, defined as increased cutaneous erythema and inflammation after ultraviolet light (UV) exposure, is a hallmark of patients with systemic lupus erythematosus (SLE), cutaneous…
Abstract Number: 2115 • 2018 ACR/ARHP Annual Meeting
Identification of Systemic Lupus Erythematosus Subgroups Using Electronic Health Record and Genetic Databases
Milena Gianfrancesco¹, Ishan Paranjpe², Julia Kay³, Joanne Nitiham⁴, Kimberly Taylor⁵, Cristina Lanata¹, Marina Sirota⁶, Lindsey A. Criswell⁷, Gabriela Schmajuk⁸ and Jinoos Yazdany², ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²University of California, San Francisco, San Francisco, CA, ³Medicine/Rheumatology, University of California - San Francisco, San Francisco, CA, ⁴Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ⁵University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁶Pediatrics, Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA, ⁷University of California San Francisco, San Francisco, CA, ⁸San Francisco VA Medical Center, San Francisco, CA
Background/Purpose: Systemic lupus erythematosus (SLE) is a multifactorial disease with genetic and environmental risk factors, and heterogeneous manifestations that encompass a wide range of disease…
Abstract Number: 2116 • 2018 ACR/ARHP Annual Meeting
Neutrophil Extracellular Trap Formation Is Dependent on Disease Activity in Systemic Lupus Erythematosus: Determination Using a Flow Cytometry-Based Assay
Sen Hee Tay¹, Olga Zharkova², Hui Yin Lee³, Shubhita Tripathi⁴, Wei Yee Ong⁵, Aisha Lateef⁶, Paul MacAry⁷, Lina Lim², John Edward Connolly⁸ and Anna-Marie Fairhurst³, ¹Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Singapore, ²Physiology, National University of Singapore, Singapore, Singapore, ³Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore, ⁴National University of Singapore, Singapore, Singapore, ⁵Institute for Molecular and Cellular Biology, Agency for Science, Technology and Research, Singapore, Singapore, ⁶Medicine, Division of Rheumatology, National University Hospital of Singapore, Singapore, Singapore, ⁷Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore, ⁸Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore
Background/Purpose: Neutrophil extracellular traps (NETs) are composed of decondensed DNA that is released during an active cell death program is known as NETosis. To date,…
Abstract Number: 2117 • 2018 ACR/ARHP Annual Meeting
Neuropsychiatric Systemic Lupus Erythematosus Is Attenuated By Sphingosine-1-Phosphate Receptor Modulation
Elise Mike¹, Carla M. Cuda², Hadijat M. Makinde³, Harris Perlman⁴ and Chaim Putterman⁵, ¹Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, ²Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY
Background/Purpose: About 20-40% of lupus patients suffer from diffuse neuropsychiatric manifestations of SLE, including cognitive impairment and depression. Although the pathogenesis is not well understood,…
Abstract Number: 2118 • 2018 ACR/ARHP Annual Meeting
Prevalence of Acquired Activated Protein C Resistance and Anti-Protein C Antibodies in Systemic Lupus Erythematosus
Giuseppe Alvise Ramirez^1,2,3,4, Hannah Cohen^5,6, David A. Isenberg^4,7 and Maria Efthymiou⁵, ¹Università Vita-Salute San Raffaele, Milan, Italy, ²Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, ³Unit of Immunology, Rheumatology, Allergy and Rare Diseases, San Raffaele Scientific Institute, Milan, Italy, ⁴Department of Rheumatology, University College London Hospitals NHS Foundation Trust, London, United Kingdom, ⁵Haemostasis Research Unit, Department of Haematology, University College London, London, United Kingdom, ⁶Department of Haematology, University College London Hospitals NHS Foundation Trust, London, United Kingdom, ⁷University College London, London, United Kingdom
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease characterised by increased cardiovascular risk, with a 5-20 fold increased risk for venous thromboembolism (VTE)…
Abstract Number: 2119 • 2018 ACR/ARHP Annual Meeting
Association of the Variant Form of rs17408553 at Human Leukocyte Antigen-C Supports Evidence That Hypo-Responsive Natural Killer Cells Adversely Influence the Course of Nephritis
Robert M. Clancy¹, H. Michael Belmont¹, Peter M. Izmirly², Nicole Bornkamp³, Sarah Miller⁴, Matthew Poulin⁴, Liying Yan⁴, Jill P. Buyon¹ and Ellen M. Ginzler⁵, ¹NYU School of Medicine, New York, NY, ²Rheumatology, NYU School of Medicine, New York, NY, ³Medicine, NYU School of Medicine, New York, NY, ⁴EpigenDx, Hopkinton, MA, ⁵Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY
Background/Purpose: In subjects with lupus nephritis (LN), tissue injury due to local immune activation involving persistently activated macrophages in the renal parenchyma is limited by…
Abstract Number: 2120 • 2018 ACR/ARHP Annual Meeting
CD47- Signal Regulatory Protein Alpha Interaction Potentiates Proinflammatory Response in Systemic Lupus Erythematosus
Jin Kyun Park¹, Ye Ji Lee², Ji Soo Park³, Eun Young Lee⁴, Eun Bong Lee⁴ and Yeong Wook Song⁵, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), ²Department of Immunology, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ³Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, Seoul, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁵Seoul National University College of Medicine, Seoul, Korea, Republic of (South)
CD47-Signal Regulatory Protein-Alpha Interaction Potentiates Proinflammatory Response in Systemic Lupus Erythematosus.Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease mediated by unbalanced activation of…
Abstract Number: 2121 • 2018 ACR/ARHP Annual Meeting
Serum High Type I Interferon Is Associated with Active Proliferative Lupus Nephritis in Lupus Patients Accompanied with High Interferon Signature Gene Expression and Plasmacytoid Dendritic Cell Infiltration in Lupus Nephritis Kidney
Taro Iwamoto¹, Jessica M. Dorschner², Mark A. Jensen¹, Shanmugapriya Selvaraj³, Danielle Vsetecka², Shreyasee Amin², Ashima Makol², Floranne C. Ernste², Thomas Osborn², Kevin Moder², Vaidehi R. Chowdhary², Valeria Mezzano⁴, Peter M. Izmirly⁵, H. Michael Belmont⁵, Robert M. Clancy¹, Jill P. Buyon¹, Ming Wu³, Cynthia A. Loomis³ and Timothy B. Niewold¹, ¹Colton Center for Autoimmunity, New York University, New York, NY, ²Mayo Clinic College of Medicine, Rochester, MN, ³Department of Pathology, New York University, New York, NY, ⁴Division of Cardiology, New York University, New York, NY, ⁵Division of Rheumatology, New York University, New York, NY
Background/Purpose: Despite recent advancements in immunosuppressive therapies, lupus nephritis (LN) remains one of the most severe organ manifestations in systemic lupus erythematosus (SLE). High type…

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