Abstracts Archive - Page 1142 of 2425 - ACR Meeting Abstracts

Abstract Number: 2062 • 2018 ACR/ARHP Annual Meeting
Omentin-1: Potential Biomarker of Cardiovascular Risk in Axial Spondyloarthritis? a Serological and Genetic Study
Fernanda Genre¹, Javier Rueda-Gotor¹, Sara Remuzgo-Martínez¹, Verónica Pulito-Cueto¹, Alfonso Corrales¹, Verónica Mijares¹, Leticia Lera-Gómez¹, Virginia Portilla¹, Rosa Expósito², Cristina Mata², Iván Ferraz-Amaro³, M. Vanesa Hernandez-Hernandez⁴, Santos Castañeda⁵, Esther Vicente⁵, Cristina Fernández-Carballido⁶, María Paz Martínez-Vidal⁷, David Castro-Corredor⁸, Joaquín Anino-Fernández⁸, Ricardo Blanco¹, Oreste Gualillo⁹, Javier Martin¹⁰, Javier Llorca¹¹, Raquel Lopez-Mejías¹ and Miguel Angel González-Gay^1,12, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ²Rheumatology Division, Hospital Comarcal de Laredo, Laredo, Spain, ³Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, ⁴Rheumatology Division, Hospital Universitario de Canarias, La Laguna, Spain, ⁵Rheumatology Division, Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain, ⁶Rheumatology Division, Hospital General Universitario de Elda, Elda, Spain, ⁷Rheumatology Division, Hospital General Universitario de Alicante, Alicante, Spain, ⁸Rheumatology Division, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, ⁹SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), The NEIRID Group (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Santiago University Clinical Hospital, Santiago de Compostela, Spain, Santiago de Compostela, Spain, ¹⁰Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Granada, Spain., Granada, Spain, ¹¹Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ¹²School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain
Background/Purpose: Cardiovascular (CV) disease (mainly due to accelerated atherosclerosis) is one of the main causes of mortality in axial spondyloarthritis (axSpA). The higher incidence of…
Abstract Number: 2063 • 2018 ACR/ARHP Annual Meeting
Early Injection of TNF Inhibitor Prevents Spinal Inflammation and Deformity in Curdlan-Induced Spondyloarthritis Animal Model
Doo-Ho Lim¹, Eun-Ju Lee², Seokchan Hong², Yong-Gil Kim², Chang Keun Lee² and Bin Yoo², ¹Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of (South)
Background/Purpose: TNF inhibitors are highly efficient in controlling disease activity and improving functional outcomes as well as quality of life in most ankylosing spondylitis patients;…
Abstract Number: 2064 • 2018 ACR/ARHP Annual Meeting
Aberrant Distribution and Function of Plasmacytoid Dendritic Cells in Patients with Ankylosing Spondylitis Are Associated with Unfolded Protein Response
Liu Chin-Hsiu¹, Chen Chun-Hsiung¹ and Lin Kuo-I², ¹Division of Allergy, Immunology and Rheumatology, Division of Allergy, Immunology and Rheumatology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan., New Taipei city, Taiwan, ²Genomics Research Center, Academia Sinica, Taipei, Taiwan., Taipei city, Taiwan
Background/Purpose: Although human leukcocyte antigen (HLA)-B27 is strongly associated with ankylosing spondylitis (AS) and HLA-B27 misfolding induces unfolded protein response (UPR), whether UPR is associated…
Abstract Number: 2065 • 2018 ACR/ARHP Annual Meeting
Blockade of the JAK/STAT Pathway Inhibits Inflammation and Bone Formation in Two Murine Models of Spondyloarthritis
Yukiko Maeda¹, Zheni Stavre¹, Tingting Huang², Catherine Manning², Bryant Shaughn³, Michael Macoritto³, Deborah Hyland³, Wendy Waegell³ and Ellen M. Gravallese⁴, ¹Medicine, University of Massachusetts Medical School, Worcester, MA, ²Medicine, University of Massachusetts Medical School, worcester, MA, ³Abbvie Bioresearch Center, worcester, MA, ⁴Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Spondyloarthritis (SpA) results in significant pain and loss of function due to inflammation and resulting enthesial/periosteal bone formation. Inhibition of the Janus kinase (JAK)/STAT…
Abstract Number: 2066 • 2018 ACR/ARHP Annual Meeting
Serum IL-37 Is an Efficient Biomarker of Disease Activity and Treatment Response in Patients with Ankylosing Spondylitis
Ga Young Ahn¹, Su Man Kang², Juyeon Kang¹, Bora Nam¹, Hyuk-Hee Kwon¹, Tae-Hwan Kim³ and Dae-Hyun Yoo¹, ¹Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ²Institute of Rheumatology, Hanyang University, Seoul, Korea, Republic of (South), ³Rheumatology, The Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea, Seoul, Korea, Republic of (South)
Background/Purpose: The measurement of disease activity is mainly dependent on the patient-reported outcome measures in ankylosing spondylitis (AS) patients. Current inflammatory biomarkers have insufficient sensitivity…
Abstract Number: 2067 • 2018 ACR/ARHP Annual Meeting
Dysbiosis-Dependent Inflammasomes Activation Drives Innate Immune Responses in Ankylosing Spondylitis Patients
Francesco Ciccia¹, Giuliana Guggino¹, Aroldo Rizzo², Stefania Raimondo³, Simon Milling⁴ and Riccardo Alessandro³, ¹Rheumatology Unit, University of Palermo, Palermo, Italy, ²Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello, Palermo, Italy, ³University of Palermo, Palermo, Italy, ⁴University of Glasgow, Glasgow, United Kingdom
Background/Purpose: A growing body of evidences indicate that the aberrant activation of innate immune systems, occurring in genetically predisposed patients, drives inflammatory processes in Ankylosing…
Abstract Number: 2068 • 2018 ACR/ARHP Annual Meeting
The Role of Extracellular Matrix Metalloproteinase Inducer Emmprin in the Pathogenesis of Psoriatic Arthritis
Devy Zisman^1,2, Mirna Saphieh², Joy Feld³, Amir Haddad³, Muna Elias³, Alina Kaganovitch³, Idit Lavi⁴ and Michal Amit Rahat^2,5, ¹Technion, Rheumatology Unit Carmel Medical Center, Haifa, Israel, ²The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel, ³Rheumatology Unit Carmel Medical Center, Haifa, Israel, ⁴Epidemiology Unit Carmel Medical Center, Haifa, Israel, ⁵Immunotherapy Laboratory Carmel Medical Center, Haifa, Israel
Background/Purpose: Angiogenesis is an essential component in the pathogenesis of psoriatic arthritis (PsA). Extracellular matrix metalloproteinase inducer (EMMPRIN) is a multifunctional protein that can enhance…
Abstract Number: 2069 • 2018 ACR/ARHP Annual Meeting
The Epigenetic Regulator Sirtuin-1 Modulates T-Helper 17 Cell Differentiation in Axial Spondyloarthritis
Sarah Unterberger¹, Patrizia Fasching², Elisabeth Fliesser¹, Angelika Lackner³, Christian Dejaco², Winfried Graninger³, Martin Stradner² and Johannes Fessler^4,5, ¹Div. of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ²Department of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ³Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ⁴Dep. of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ⁵Department of Neurology, Harvard Medical School, Boston, MA
Background/Purpose: The NAD+ -dependent protein/histone deacetylase Sirtuin 1 (SIRT1) acts as an epigenetic regulator and has recently been reported to be involved in the development…
Abstract Number: 2070 • 2018 ACR/ARHP Annual Meeting
Activated Tendon Stromal Cells Drive a Type 17 Immune Response Via CCL20: A Potential Role in the Pathogenesis of Enthesitis in Psoriatic Arthritis
Emma Garcia-Melchor¹, Giacomo Cafaro^2,3, Moeed Akbar¹, Derek Gilchrist¹, Susan M Kitson¹, Stefan Siebert⁴, Iain B. McInnes⁵ and Neal L Millar¹, ¹Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, ²Institute of Infection, Immunity and Inflammation, University of Glasgow, Glagow, United Kingdom, ³Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy, ⁴Institute of Infection, Immunity and Inflammation, University of Glasgow, Cardiff, United Kingdom, ⁵Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: While the exact pathogenesis of psoriatic arthritis (PsA) remains unclear, it is recognised that several environmental factors operate in individuals with genetic susceptibility leading…
Abstract Number: 2071 • 2018 ACR/ARHP Annual Meeting
Inflammation at Distant Immunocompetent Sites Combined with a Protocol of Forced Exercise Induces Mild Joint Inflammation
Giulia Rossana Gulino¹, Margot Van Mechelen^1,2 and Rik Lories^1,2, ¹Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium, ²Rheumatology, UZ Leuven, Leuven, Belgium
Background/Purpose: Psoriatic arthritis is a chronic joint disease clinically associated with psoriasis. Some patients also have signs of inflammatory bowel disease. Enthesitis, inflammation at the…
Abstract Number: 2072 • 2018 ACR/ARHP Annual Meeting
Beneficial Effect of Combination Therapy of Etanercept with Non-Steroidal Anti-Inflammatory Drugs Compared to Etanercept Monotherapy in a Spondyloarthritis Animal Model
Seung-Cheol Shim¹, Ji-Young Kim², Seung Taek Song³, Jin-Sun Choi², Chan Keol Park⁴ and In-Seol Yoo¹, ¹Division of Rheumatology, Department of Internal Medicine, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Korea, Republic of (South), ²Division of Rheumatology, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Korea, Republic of (South), ³Department of Rheumatology, Cheongju St. Mary's Hospital, Cheongju, Korea, Republic of (South), ⁴Internal medicine, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Korea, Republic of (South)
Background/Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended as first-line drug treatment of spondyloarthritis (SpA) which is frequently associated with inflammatory bowel disease. Biologic disease modifying…
Abstract Number: 2073 • 2018 ACR/ARHP Annual Meeting
Role of miRNA-21-5p As a Potential Biomarker for the Inflammation Pathway in Psoriatic Disease and Response to Methotrexate Treatment
Rohan Machhar¹, Justine Y. Ye², Vinod Chandran² and Dafna D Gladman³, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Toronto Psoriatic Arthritis Research Program, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory arthritis occurring in patients with psoriasis. miRNAs are small non coding RNAs whose main function, at a post…
Abstract Number: 2074 • 2018 ACR/ARHP Annual Meeting
Micrornas Deregulation in Monocytes and T CD4 Lymphocytes from Patients with Axial Spondyloarthritis
Olivier Fogel¹, Andreas Bugge Tinggaard², Maud Fagny¹, Nelly Sigrist³, Elodie Roché³, Laurence Leclère³, Jean-François Deleuze⁴, Maxime Dougados⁵, Corinne Miceli-Richard^6,7 and Jorg Tost¹, ¹Centre National de Recherche en Génomique Humaine, Institut François Jacob, CEA, Laboratory for Epigenetics and Environment, Evry, France, ²Aarhus University, Department of Biomedicine, Aarhus, Denmark, ³Laboratory for Epigenetics and Environment, Evry, France, ⁴Centre National de Recherche en Génomique Humaine, Evry, France, ⁵Paris Descartes University, Hôpital Cochin, Paris, France, ⁶Department of Immunology, Pasteur Institute, Immunoregulation Unit, Paris, France, ⁷Department of Rheumatology, Paris Descartes University, Hôpital Cochin, Paris, France
Background/Purpose: MicroRNAs have been shown to play a crucial role during innate or adaptive immune response. Deregulation of miRNAs has been described in several autoimmune…
Abstract Number: 2075 • 2018 ACR/ARHP Annual Meeting
Vascular Endothelial and Inflammatory Differences in Psoriasis and Psoriatic Arthritis Patients
Michael Gashick¹, Todd Wechter², Tessa Barrett¹, Sarah Azarchi², Stuart Katz³, Andrea L. Neimann⁴, James Krueger⁵, Sanja Jelic⁶, Edward Fisher¹, Jose U. Scher⁷ and Jeffrey S. Berger⁸, ¹Medicine/Cardiology, New York University School of Medicine, New York City, NY, ²Dermatology, New York University School of Medicine, New York City, NY, ³Medicine/Cardiology, New York University School of Medicine, New York, NY, ⁴Department of Dermatology, New York University School of Medicine, New York, NY, ⁵The Rockefeller University, New York, NY, ⁶Medicine/Pulmonary, Columbia University Medical Center, New York City, NY, ⁷New York University School of Medicine, New York, NY, ⁸Medicine, Division of Cardiology, New York University School of Medicine, New York, NY
Background/Purpose: Psoriatic arthritis (PsA) and Psoriasis (PsO) are chronic inflammatory diseases associated with vascular inflammation and increased CVD risk. Few studies have examined vascular inflammatory…
Abstract Number: 2076 • 2018 ACR/ARHP Annual Meeting
Transmembrane TNF (tmTNF) Transgenic Mice Exhibit Enlarged Lymph Nodes and Elevated Numbers of High Endothelial Cells Associated with Increased Lymphocyte Recruitment
Kim Jeucken¹, Jan Piet van Hamburg², Merlijn Kaaij³, Leonie van Duivenvoorde³, Dominique Baeten³ and Sander W. Tas², ¹2Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department of Clinical Immunology & Rheumatology and Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: The NF-κB family of transcription factors plays a crucial role in chronic inflammatory diseases and can be activated via two distinct pathways. Non-canonical NF-κB…

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