Abstract Number: 1986 • 2018 ACR/ARHP Annual Meeting
Adalimumab:TNF Complexes Are Cleared More Efficiently By Human Osteoclasts Than Those with Etanercept through Fcg-Receptor Binding and Internalization
Background/Purpose: TNF-alpha (TNFa) has been shown to contribute to osteoclastogenesis (OCgenesis) independently and in conjunction with M-CSF or RANKL, two key cytokines involved in osteoclast…Abstract Number: 1987 • 2018 ACR/ARHP Annual Meeting
Elucidation of the Function of Dendritic Cell-Specific Transmembrane Protein (DCSTAMP) in Osteoclast Differentiation
Background/Purpose: Osteoclasts (OC) are bone-resorbing, multinuclear cells that originate from myeloid progenitor cells through repetitive cycles of cell-cell fusion. Dendritic cell-specific transmembrane protein (DCSTAMP) is…Abstract Number: 1988 • 2018 ACR/ARHP Annual Meeting
Effect of Different Fucoidans on Pathological Pathways Activated in Osteoarthritic Chondrocytes and Synoviocytes
Background/Purpose: Osteoarthritis (OA) is a disease managed rather than cured, with a focus on alleviating its pain. Recent studies show that fucoidans, one of the…Abstract Number: 1989 • 2018 ACR/ARHP Annual Meeting
A Regulatory Role of ANTXR1 in RANKL-Induced Osteoclast Differentiation and Function
Background/Purpose: Anthrax toxin receptor 1 (ANTXR1) has been known to have relationship with extracellular transmembrane protein deeply associated with the process of bone formation and…Abstract Number: 1990 • 2018 ACR/ARHP Annual Meeting
Luteolin Modulates Glyco-Lipo-Oxidative Protein Modifications and Inhibits Inflammatory Cytokine Release in Human Osteoarthritic Articular Chondrocytes: Comparison with Colchicine
Background/Purpose: The progressive destruction of osteoarthritic articular cartilage has been attributed to multifactorial cellular events, including increased oxidative modifications in proteins, abnormal inflammatory and catabolic…Abstract Number: 1991 • 2018 ACR/ARHP Annual Meeting
Measuring Balance in an Experimental Mouse Model of Osteoarthritis
Background/Purpose: Destabilization of the medial meniscus (DMM) in mice results in experimental osteoarthritis, characterized by progressive joint damage (severe damage by week 12) and associated…Abstract Number: 1992 • 2018 ACR/ARHP Annual Meeting
The Effect of 4E-BP1 on Osteoarthritis-Related Gene Expression in TGF-β1-Stimulated Chondrocytes
Background/Purpose: Initiation of protein synthesis is regulated by a repressor of cap-dependent translation, eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), which prevents eukaryotic initiation factor…Abstract Number: 1993 • 2018 ACR/ARHP Annual Meeting
Evaluation of Cartilage Degeneration and Osteoarthritis Pain on Female and Male Mouse Model of Osteoarthritis
Background/Purpose: The prevalence of radiographic and symptomatic osteoarthritis (OA) is higher in women, but in animal study, male mice were more frequently used to explore…Abstract Number: 1994 • 2018 ACR/ARHP Annual Meeting
Osteoarthritis Severity Is Reduced By Intra-Articular Administration of Hydrogen Sulfide
Background/Purpose: Hydrogen sulphide (H2S) is recognized as a therapeutic target in osteoarthritis (OA). Exogenous supplementation with synthetic salts in in vitro models of OA has…Abstract Number: 1995 • 2018 ACR/ARHP Annual Meeting
Heparan Sulfates from Human Osteoarthritic Cartilage Display Increased Sulfation Pattern, Decrease the Protein Binding Capacity to FGF-2 and Increase the Binding to VEGF and Induce Changes of Human Mesenchymal Stem Cell Behavior
Background/Purpose: The major Glycosaminoglycan (GAGs) component of the cartilage ECM are Chondroitin Sulfates (CS) and Keratan sulfates (KS). Heparan Sulfates (HS) are also present in…Abstract Number: 1996 • 2018 ACR/ARHP Annual Meeting
Adenosine A2A Receptor (A2AR) Stimulation Enhances Mitochondrial Metabolism and Mitigates Reactive Oxygen Species-Mediated Mitochondrial Injury
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 10% of the US population. With age and injury, chondrocytes have diminished mitochondrial…Abstract Number: 1997 • 2018 ACR/ARHP Annual Meeting
Adenosine A2A Receptors Maintain Chondrocyte and Cartilage Homeostasis By Maintaining Expression of Anti-Inflammatory Regulators (Nur-77) and Suppressing Expression of Pro-Inflammatory Mediators
Background/Purpose: We have recently reported that adenosine A2A receptor (A2AR) knockout mice develop spontaneous osteoarthritis (OA) and intra-articular injection of adenosine prevents OA progression in…Abstract Number: 1998 • 2018 ACR/ARHP Annual Meeting
Autophagy-Related Molecules Detected in Blood and Cartilage Are Biomarkers of Joint Damage in OA
Background/Purpose: In osteoarthritis (OA), defects in cellular homeostasis, and in particular in autophagy, are evident and precede joint damage. We have shown that there is…Abstract Number: 1999 • 2018 ACR/ARHP Annual Meeting
Aberrant Expression of the GluN2B N-Methyl D-Aspartate Receptor Subunit in Osteoarthritic Chondrocytes Causes Disease-Associated Changes in Chondrocyte Phenotype through Altered Expression of Core Components of the Chondrocyte Circadian Clock
Background/Purpose: Circadian clocks are key regulators of cell behaviour. Disruption to cell clocks is implicated in a range of diseases. Expression of two core clock…Abstract Number: 2000 • 2018 ACR/ARHP Annual Meeting
Interleukin-1β, Oxidative Stress and Basic Calcium Phosphate Crystals Induce Osteoarthritis-like Changes in Chondrocyte Phenotype By Altering the Expression of PERIOD2, a Core Component of the Chondrocyte Circadian Clock
Background/Purpose: Almost all cells contain a circadian clock. Cell clocks are key regulators of cell activity and cell differentiation. In osteoarthritis (OA), chondrocytes inappropriately undergo…
ACR Meeting Abstracts