Abstracts Archive - Page 1127 of 2607 - ACR Meeting Abstracts

Abstract Number: 2805 • 2019 ACR/ARP Annual Meeting
Natural Killer Cells Gene Expression Can Differentiate Rheumatoid Arthritis Patients from Healthy Controls
Noha Elemam¹, Mahmood Hachim ¹, Suad Hannawi ² and Azzam Maghazachi ¹, ¹Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, Sharjah, United Arab Emirates, ²Ministry of Health and Prevention-UAE, Department of Rheumatology, Dubai, United Arab Emirates
Background/Purpose: Rheumatoid arthritis (RA) is the most prevalent autoimmune diseases (1-3% of the world’s population). RA is a prototypic inflammatory disease, being characterized by an…
Abstract Number: 2806 • 2019 ACR/ARP Annual Meeting
Single Cell RNA-sequencing Reveals Distinct Macrophage Subsets in the Joint with Differing Ontogenies During Steady-state and Arthritis
Anna Montgomery ¹, Shang-Yang Chen¹, Philip Homan ¹, Gaurav Gadhvi ¹, Deborah Winter ² and Harris Perlman ², ¹Northwestern University, Chicago, ²Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago
Background/Purpose: Macrophages in the synovial lining of the joint are critical players in the pathogenesis of rheumatoid arthritis (RA). However, their heterogeneity remains poorly characterized.Methods:…
Abstract Number: 2807 • 2019 ACR/ARP Annual Meeting
Activation of the STING Pathway Is a Shared Feature of Salivary Gland and Lung Inflammation in Sjogren’s Syndrome
Joanna Papinska ¹, Grzegorz Gmyrek ², Umesh Deshmukh¹ and Harini Bagavant ¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City
Background/Purpose: Sjögren’s syndrome is a chronic autoimmune disorder characterized by an increased type 1 interferon gene signature. The engagement of stimulator of interferon genes (STING)…
Abstract Number: 2808 • 2019 ACR/ARP Annual Meeting
Linking Toll-Like Receptor Signaling and Type I Interferons to Inflammation and Fibrosis in a Macrophage/Fibroblast Model of Congenital Heart Block
Miao Chang¹, Robert Clancy ¹ and Jill Buyon ¹, ¹NYU School of Medicine, New York
Background/Purpose: Since one of the strongest associations with antibodies (abs) to SSA/Ro (Ro60) is the development of congenital heart block (CHB), this model provides an…
Abstract Number: 2809 • 2019 ACR/ARP Annual Meeting
Single-Cell RNA Sequencing of Murine Neutrophils Identifies a Transcriptional Continuum (“Neutrotime”) Across Biological Compartments
Ricardo Grieshaber-Bouyer¹, Giuseppina Stifano ², Pierre Cunin ³, Anaïs Levescot ⁴, Nathan Nelson-Maney ⁴, Rachel Blaustein ⁵, Paul Monach ⁶, Peter Nigrovic ⁷ and ImmGen Consortium ⁸, ¹Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Department of Orthopedics, Heidelberg University Hospital, Heidelberg, Germany, Boston, MA, ²Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Boston, ³Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ⁴Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, ⁵Brigham and Women's Hospital, Boston, ⁶Brigham and Women's Hospital, Boston, MA, ⁷Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA ; Department of Medicine, Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA., Boston, ⁸Harvard Medical School, Boston
Background/Purpose: Neutrophils are key first responders of innate immunity, participating in both defense and inflammatory disease. Phenotypic heterogeneity is recognized but the existence of bone…
Abstract Number: 2810 • 2019 ACR/ARP Annual Meeting
Does Loss-of-function Variants in SAT1 Cause X-linked Pediatric Lupus?
Ling-Xiao Xu ¹, Jian Zhao ², Qing Sun ², Lin-Yu Geng ², Yun Deng ², Diane Kamen ², Jim Oates ³, Prithvi Raj ⁴, Edward Wakeland ⁴, R.Hal Scofield ⁵, Joel Guthridge ⁶, Judith James ⁶, Deborah McCurdy ⁷ and Betty Tsao⁸, ¹Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charelston, SC, ²Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston, SC, ³Division of Rheumatology & Immunology/Medical University of South Carolina, Charleston, SC, ⁴Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Dallas, ⁵Arthritis & Clinical Immunology Research Program, Division of Genomics and Data Sciences, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA, Los Angeles, ⁶Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁷University of California, MDCC 12-430, 10833 Le Conte Ave, Los Angeles, 90095, CA, USA, Los Angeles, ⁸Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston
Background/Purpose: Mendelian inheritances of highly penetrant single gene variants have been reported as monogenic forms of SLE. To explore novel risk variants, we carried out…
Abstract Number: 2811 • 2019 ACR/ARP Annual Meeting
The IRE1α Pathway Mediates Neutrophil Stress and NETosis in Lupus
Gautam Sule¹, Basel Abuaita ¹, Paul Steffes ¹, Kristen Gilley ¹, Andrew Fernandes ¹, Mary O’Riordan ¹ and Jason Knight ², ¹University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI
Background/Purpose: Immune complex (IC)-activated neutrophils appear to amplify inflammation in lupus through the release of neutrophil extracellular traps (NETosis). There is presently no consensus as…
Abstract Number: 2812 • 2019 ACR/ARP Annual Meeting
A New Role for Selectins in Systemic Lupus Erythematosus
Marc SCHERLINGER¹, Vivien Guillotin ², Pierre Vacher ³, Vanja Sisirak ⁴, isabelle Douchet ⁴, Nathalie Merillon ⁴, Pierre Duffau ⁵, Estibaliz Lazaro ⁶, Emmanuel Ribeiro ⁷, Christophe Richez ⁸ and Patrick BLANCO ⁹, ¹CHU de Bordeaux, Immunoconcept, Bordeaux, France, ²CHU de Bordeaux, Bordeaux, France, ³INSERM ACTION U1218, Bordeaux, France, ⁴Immunoconcept, Bordeaux, France, ⁵Department of Internal Medicine and Clinical Immunology , Hôpital Saint-André, CHU de Bordeaux , Bordeaux , France., Bordeaux, Aquitaine, France, ⁶FHU ACRONIM, Department of Internal Medecine, Centre Hospitalier Universitaire, Bordeaux, France, Pessac, France, ⁷CHU de Bordeaux, Bordeaux, ⁸Pellegrin Hospital, University Hospital of Bordeaux, Bordeaux, France, ⁹CNRS-UMR 5164 - ImmunoConcEpt, Bordeaux University - Immunology and Immunogenetic Department Bordeaux University Hospital, Bordeaux, Aquitaine, France
Background/Purpose: In systemic lupus erythematosus (SLE), blood platelets have an activated phenotype, and express high levels of CD40L and P-selectin. Our group demonstrated that SLE…
Abstract Number: 2813 • 2019 ACR/ARP Annual Meeting
Pentameric, but Not Monomeric C-reactive Protein, Limits the SnRNP-immune Complex Triggered Type I Interferon Response: Implications for Lupus Pathogenesis
Cecilia Svanberg ¹, Helena Enocsson ¹, Klara Martinsson ¹, Lawrence Potempa ², Ibraheem Rajab ², Jonas Wetterö ¹, Marie Larsson ¹ and Christopher Sjöwall³, ¹Linköping University, Linköping, Sweden, ²Roosevelt University, Chicago, IL, ³Department of Clinical and Experimental Medicine, Rheumatology/Division of Neuro and Inflammation Sciences, Linköping University, Linköping, Sweden
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune systemic disease affecting multiple organs and which is characterized by autoantibodies directed against nuclear constituents. Common autoantibody…
Abstract Number: 2814 • 2019 ACR/ARP Annual Meeting
Methionine Commits Immunometabolism and Epigenetic Regulation of BACH2 Loci in B Cells, Resulting in Biases Toward Plasmablast Differentiation in the Pathogenesis of SLE
Mingzeng Zhang¹, Shigeru Iwata ¹, Maiko Hajime ¹, Naoaki Ohkubo ¹, Yasuyuki Todoroki ², Hiroko Miyata ², Jie Fan ², Shingo Nakayamada ¹, Kaoru Yamagata ¹ and Yoshiya Tanaka ³, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, Kitakyushu, Japan, ²The First Department of Internal Medicine, University of Occupational & Environmental Health Kitakyushu, Japan, Kitakyushu, Japan, ³University of Occupational and Environmental Health Japan, Kitakyushu, Japan
Background/Purpose: Amino acids play an important role in various metabolic processes. However, the role of amino acid metabolism in the regulation of human B cell…
Abstract Number: 2815 • 2019 ACR/ARP Annual Meeting
Lower IL-4R in IgD+ Naïve B Cells Is a Pre-disposing Factor for Development of T-bet+ DN2 B Cells in Systemic Lupus Erythematosus
John Mountz¹, Min Gao ², Qi Wu ³, PingAr Yang ², Alex Essman ⁴, Oluwagbemiga Ojo ⁴, Shanrun Liu ², Jake Chen ², Iñaki Sanz ⁵, W. Winn Chatham ² and Hui-Chen Hsu ², ¹University of Alabama at Birmingham and Birmingham VAMC, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, ⁵Emory University, ATLANTA, GA
Background/Purpose: Studies to date have primarily focused on stimulators that are overexpressed and activate B cells in SLE subjects. Factors that can maintain B cells…
Abstract Number: 2816 • 2019 ACR/ARP Annual Meeting
An Expanded Granzyme K+ CD8 T Cell Population Induces Inflammatory Responses in Rheumatoid Arthritis Synovium
Anna Helena Jonsson¹, Fan Zhang ², Gerald Watts ², Kevin Wei ¹, Deepak Rao ², Soumya Raychaudhuri ² and Michael Brenner ³, ¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Brigham and Women’s Hospital:, Boston
Background/Purpose: CD8 T cells represent nearly half of T cells in inflamed synovium from patients with rheumatoid arthritis (RA). Research to date has focused on…
Abstract Number: 2817 • 2019 ACR/ARP Annual Meeting
Lysosomal Placement of the Energy Sensors AMPK and mTORC1 Controls Tissue Inflammation in Rheumatoid Arthritis
Zhenke Wen ¹, Ke Jin ¹, Yinyin Li ¹, Bowen Wu ¹, Jorg Goronzy ¹ and Cornelia Weyand¹, ¹Stanford University, Stanford, CA
Background/Purpose: CD4 T cells from patients with rheumatoid arthritis (RA) are metabolically reprogrammed, diverting glucose away from glycolysis towards the production of biosynthetic precursors. Several…
Abstract Number: 2818 • 2019 ACR/ARP Annual Meeting
Differences in the Phenotypic Landscape and Antigen Specificity of CD4+ T Cells Are Present in CCP+ Subjects Before the Onset of Rheumatoid Arthritis
Virginia Muir ¹, Cliff Rims ¹, Kevin Deane ², Jeffrey Carlin ³, Sylvia Posso ¹, Sunil Nagpal ⁴, Navin Rao ⁴, Frédéric Baribaud ⁵, George Vratsanos ⁶, William Robinson ⁷, Gary Firestein ⁸, V. Michael Holers ⁹, Peter Linsley ¹, Eddie James¹ and Jane Buckner ¹, ¹Benaroya Research Institute, Seattle, WA, ²University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, ³Virginia Mason Medical Center, Seattle, WA, ⁴Janssen R&D, Spring House, PA, ⁵Janssen Research & Development, LLC, Spring House, PA, ⁶JNJ, Raritan, NJ, ⁷Stanford University, Palo Alto, CA, ⁸University of California, San Diego, San Diego, ⁹University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver
Background/Purpose: The “Targeting Immune Responses for Prevention of RA” (TIP-RA) collaboration studies individuals at high risk for developing rheumatoid arthritis (RA) because of serum anti-citrullinated…
Abstract Number: 2819 • 2019 ACR/ARP Annual Meeting
The Transcription Factor MAF Controls the Ability of T Peripheral Helper (Tph) Cells to Help B Cells
Alexandra Bocharnikov¹, Vanessa Wacleche ¹, Ye Cao ¹ and Deepak Rao ², ¹Brigham and Women's Hospital, Boston, ²Brigham and Women's Hospital, Boston, MA
Background/Purpose: Pathologic T cell-B cell interactions are hallmark features of many autoimmune diseases. PD-1hi CXCR5- T peripheral helper (Tph) cells are B cell-helper T cells…

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