ACR Meeting Abstracts

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  • Abstract Number: 1551 • 2018 ACR/ARHP Annual Meeting

    Anti-Drug Antibodies to Certolizumab Pegol Are Assiciated with Low Drug Levels and Reduced Clinical Response at 3 Months in Patients with Inflammatory Joint Diseases

    Johanna Gehin1, Guro Løvik Goll2, Silje Watterdal Syversen2, David J Warren1, Joseph Sexton3, Eldri Kvein Strand4, Tore Kvien5, Elisabeth Lie2 and Nils Bolstad6, 1Department of Medical Biochemistry, OUS-Radiumhospitalet, Oslo, Norway, 2Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Lillehammer Revmatismesykehus, Lillehammer, Norway, 5NOR-DMARD, EuroSpA Research Collaboration Network, Oslo, Norway, 6Department of Medical Biochemistry,, OUS-Radiumhospitalet, Oslo, Norway

    Background/Purpose: Anti-drug antibodies (ADAb) to biological drugs predispose patients (pts) to low drug levels and lack of treatment response. For certolizumab pegol (CP) knowledge about…
  • Abstract Number: 1552 • 2018 ACR/ARHP Annual Meeting

    No Effect of Concomitant Glucocorticoid Therapy on Efficacy and Safety of Tocilizumab Monotherapy Found in Rheumatoid Arthritis Clinical Trials

    Mary Safy1, Johannes W. G. Jacobs1, Michael Edwardes2, Maria JH de Hair1, Xavier M Teitsma1, Paco MJ Welsing1, Michelle EA Borm3, Yves Luder4, Jacob van Laar1, Attila Pethö-Schramm4 and Johannes W. J. Bijlsma5, 1Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands, Utrecht, Netherlands, 2Everest Clinical Research, Markham, ON, Canada, 3Roche Nederland BV, Woerden, Netherlands, 4F. Hoffmann-La Roche, Basel, Switzerland, 5Rheumatology & Clinical Immunology department University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

    No effect of concomitant glucocorticoid therapy on efficacy and safety of tocilizumab monotherapy in rheumatoid arthritis clinical trialsM. Safy1, J.W.G. Jacobs1, M. Edwardes2, M.J.H. de…
  • Abstract Number: 1553 • 2018 ACR/ARHP Annual Meeting

    An Analysis of Real-World Data on the Safety of Etanercept in Elderly Patients with Rheumatoid Arthritis

    Christopher J. Edwards1, Jack F Bukowski2, Sara Burns3, Heather Jones2, Ronald Pedersen2, Katherine Roshak2, Joan M Sopczynski2, Mazhar Thakur4 and Lisa Marshall2, 1University of Southampton, Southampton, United Kingdom, 2Pfizer, Collegeville, PA, 3Pfizer, Cambridge, MA, 4RegSafe Consulting Ltd, Wokingham, United Kingdom

    Background/Purpose: Both rheumatoid arthritis (RA) and older age are associated with a higher risk of comorbidities, and the appropriate treatment approach for older patients is…
  • Abstract Number: 1554 • 2018 ACR/ARHP Annual Meeting

    Cigarette Smoking Does Not Affect Treatment Response to Tofacitinib in Rheumatoid Arthritis

    Ahmet Karatas1, Burak Oz2, Ediz Dalkiliç3, Gerçek Can4, Yavuz Pehlivan5, Soner Senel6, Ayten Yazici7, Nevsun Inanc8, Zeynep Erturk9, Ayse Cefle7, Servet Akar10, Suleyman Serdar Koca11, Merih Birlik4 and Fatos Onen4, 1Department of Rheumatology, Firat University, School of Medicine, Rheumatology, Elazig, Turkey, 2Rheumatology, Firat University, School of Medicine, Rheumatology, Elazig, Turkey, 3Rheumatology, Uludag University Faculty of Medicine, Bursa, Turkey, 4Rheumatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey, 5Rheumatology, Uludag University, Faculty of Medicine, Bursa, Turkey, 6Rheumatology, Kayseri Erciyes University, Faculty of Medicine, Kayseri, Turkey, 7Rheumatology, Kocaeli University, Faculty of Medicine, Kocaeli, Turkey, 8Department of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, 9Department of Internal Medicine, Division of Rheumatology, Marmara University, Istanbul, Turkey, 10Department of Internal Medicine, Division of Rheumatology,, Izmir Katip Çelebi University Faculty of Medicine, Izmir, Turkey, 11Rheumatology, Firat University Faculty of Medicine, Elazığ, Turkey

    Background/Purpose: Smoking is one of the described risk factors for rheumatoid arthritis (RA) since smoking may induce citrullination of peptide antigens and thus the trigger…
  • Abstract Number: 1555 • 2018 ACR/ARHP Annual Meeting

    Quality of Life of Rheumatoid Arthritis Patients Treated with Biologics

    Sonia Tropé1, Gérard Thibaud2, Françoise Alliot3, Didier Formont4 and Sadek Krouri5, 1149 avenue du Maine, ANDAR, Paris, France, 2ANDAR patient organisation, Paris, France, 3AFLAR, Paris, France, 4A+A Healthcare Market Research, BOULOGNE, France, 5Public affair & Advocacy Rheumatology, Sanofi, Gentilly, France

    Background/Purpose: Major advances in the management of rheumatoid arthritis (RA) have been recorded over the last decade thanks to the introduction of biologics. However, medical…
  • Abstract Number: 1556 • 2018 ACR/ARHP Annual Meeting

    How Phenotype of the Small Fibre Neuropathy in Primary Sjögren Syndrome Differs from Others Causes of Small Fibre Neuropathy ?

    Elise Descamps1, Julien Henry1, Céline Labeyrie2, David Adams2, David Aiello2, Xavier Mariette3 and Raphaele Seror3, 1Rheumatology department Assistance Publique Hôpitaux de Paris, Hôpitaux universitaires Paris-Sud, Le Kremlin-Bicêtre, Le Kremlin Bicetre, France, 2Neurology department. Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, French Referrent Center For Familial Amyloid Polyneuropathy, Paris, France, Le Kremlin Bicetre, France, 3Rheumatology department, Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique- Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, Paris, France

    Background/Purpose: Small fibre neuropathy (SFN) is a peripheral neuropathy characterized by neuropathic pain associated with normal routine nerve conduction study but rarefaction of intraepidermal nerve…
  • Abstract Number: 1557 • 2018 ACR/ARHP Annual Meeting

    Visualization of Dorsal Root Ganglionitis with Three-Tesla Magnetic Resonance Neurography in Sensory Ataxic Neuropathy Associated with Sjögren’s Syndrome

    Takeshi Yoshida1, Takeshi Sueyoshi2, Mitsuyo Kinjo3, Shugo Suwazono4 and Hiroyuki Nodera5, 1Rheumatology, Chikamori Hospital, Kochi, Japan, 2Radiology, Minei Daiichi Hospital, Urasoe, Japan, 3Rheumatology, Okinawa Chubu Hospital, Uruma, Japan, 4Brain-Nerve-Muscle Research Center, National Hospital Organization Okinawa Hospital, Uruma, Japan, 5Neurology, Tokushima University School of Medicine, Tokushima, Japan

    Background/Purpose: Sjögrenfs syndrome (SS)-associated neuropathy manifests as various forms of neuropathy, including sensory ataxic neuropathy (SAN). Dorsal root ganglionitis, pathologically defined as the lymphocytic infiltration…
  • Abstract Number: 1558 • 2018 ACR/ARHP Annual Meeting

    Intravenous Immunoglobulin Efficacy for Primary Sjögren’s Syndrome Associated Small Fiber Neuropathy

    Antoine Gaillet1, Karine Champion1, Jean-Pascal Lefaucheur2, Herve Trout3, Jean-François Bergmann1 and Damien Sène4, 1Internal Medicine Department, Lariboisière Hospital, Paris, France, 2Clinical Neurophysiology Unit,, Henri-Mondor Hospital, Créteil, France, 3Pharmacy Department, Lariboisière Hospital, Paris, France, 4Lariboisière Hospital, Paris Diderot University, Paris, France

    Background/Purpose: To analyze the efficacy and tolerance of intravenous immunoglobulin (IVIG) therapy in 11 patients with primary Sjögren's syndrome (pSS)-associated small-fiber neuropathy (SFN).Methods: Retrospective, single-center…
  • Abstract Number: 1559 • 2018 ACR/ARHP Annual Meeting

    Development of Lymphoma in Patients with Sjogren’s Syndrome

    Nicolas Lloves1, Anastasia Secco2, Marta Mamani3, Silvia Beatriz Papasidero4, Cecilia Asnal5, Lida Santiago6, Paula Pucci5 and Soledad Retamozo7, 1Rheumatology Department, Hospital Rivadavia, Buenos Aires, Argentina, 2Rheumatology Section, Hospital Bernardino Rivadavia, CABA, Argentina, 3Hospital Bernardino Rivadavia, Buenos Aires, Argentina, 4Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, CABA, Argentina, 5Rheumatology, Hospital Alemán, Buenos Aires, Argentina, 6Hospital Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Argentina, 7Rheumatology Unit, Hospital Privado Universitario de Córdoba, Institute University of Biomedical Sciences University of Córdoba (IUCBC), Cordoba, Argentina

    Background/Purpose: Non-Hodgkin lymphoma (NHL) is one of the most feared complications of primary Sjogren's syndrome (pSS). The most frequent is MALT type lymphoma, with localization…
  • Abstract Number: 1560 • 2018 ACR/ARHP Annual Meeting

    Usefulness of 18F-FDG Positron Emission Tomography for Lymphoma Diagnosis in Patients with Primary Sjögren’S Syndrome

    Jérémy Keraen1,2, Estelle Blanc3, Florent Besson4, Veronique Le Guern5, Rakiba Belkhir6, Julien Henry7, Céline Meyer4, Gaetane Nocturne8, Xavier Mariette8 and Raphaele Seror9, 1Internal Medicine, CHRU Bretonneau Tours, Tours, France, 2Rheumatology, Université Paris Sud, KREMLIN BICETRE, France, 3Nuclear Medicine, Centre Chirugical Marie Lannelongue, Plessis Robinson, France, 4Nuclear Medicine, Kremlin Bicêtre, KREMLIN BICETRE, France, 5Department of Internal Medicine, Department of Internal Medicine, Cochin University Hospital, Paris, France, 6RHEUMATOLOGY, Rheumatology, Université Paris Sud, KREMLIN BICETRE, France, 7Rheumatology department Assistance Publique Hôpitaux de Paris, Hôpitaux universitaires Paris-Sud, Le Kremlin-Bicêtre, Le Kremlin Bicetre, France, 8Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, 9Hopitaux Universitaires Paris Sud, Kremlin Bicetre, France, Rheumatology, Université Paris Sud, Le Kremlin Bicetre, France

    Background/Purpose: primary Sjögren’s syndrome (SS) is the autoimmune disease having the highest risk of lymphoma. The differential diagnosis between benign and malignant lymphoproliferation is sometimes…
  • Abstract Number: 1561 • 2018 ACR/ARHP Annual Meeting

    B Lymphocyte Depletion Therapy with Rituximab in Primary Sjögren’s Syndrome: Indications , Effectiveness and Ultrasonographic Response

    Francesco Ferro, Nicoletta Luciano, Elena Elefante, Maurizio Mazzantini, Marta Mosca and Chiara Baldini, Rheumatology Unit, University of Pisa, Pisa, Italy

    Background/Purpose: Aim of this study was to assess indications, effectiveness, clinical and ultrasonographic response to rituximab (RTX) therapy in primary Sjögren’s syndrome (pSS), focusing in…
  • Abstract Number: 1562 • 2018 ACR/ARHP Annual Meeting

    Large Granular Lymphocyte Proliferations in Primary Sjögren’s Syndrome: An Iatrogenic Manifestation

    Alistair Baber1, Gaetane Nocturne2, Xavier Mariette3 and Raphaele Seror4, 1Rheumatology, Université Paris-Sud, Le Kremlin-Bicêtre, France, 2Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, 3Rheumatology department, Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique- Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, Paris, France, 4Hopitaux Universitaires Paris Sud, Kremlin Bicetre, France, Rheumatology, Université Paris Sud, Le Kremlin Bicetre, France

    Background/Purpose: Large granular lymphocyte (LGL) proliferations can be observed in some auto-immune disorders, especially rheumatoid arthritis. However, reports of LGL proliferations in primary Sjogren’s syndrome…
  • Abstract Number: 1563 • 2018 ACR/ARHP Annual Meeting

    Risk of Overall Malignancies in Korean Patients with Primary Sjögren Syndrome

    Hyoungyoung Kim1, Juyeon Kang1, Seongmi Choi2, Jinwook Kim3, Sun-Young Jung4, Eun Jin Jang5, Soo-Kyung Cho1 and Yoon-Kyoung Sung6, 1Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), 2Statistics, Kyungpook National University, Daegu, Korea, Republic of (South), 3Department of Statistics, Kyungpook National University, Daegu, Korea, Republic of (South), 4College of Pharmacy, Chung-Ang University, Seoul, Korea, Republic of (South), 5Information Statistics, Andong National University, Andong-si, Korea, Republic of (South), 6Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South)

    Background/Purpose: A significant association has been found between primary Sjögren syndrome (pSS) and non-hodgkin's lymphoma (NHL), but few studies have been conducted to explore the…
  • Abstract Number: 1564 • 2018 ACR/ARHP Annual Meeting

    Severe, Life-Threatening Phenotype of Primary Sjögren Syndrome: Clinical Characterization and Outcomes in 1580 Patients (GEAS-SS Registry)

    Soledad Retamozo1,2,3, Alejandra Flores-Chavez4, Belchin Kostov5, Roser Solans6, Guadalupe Fraile7, Brenda Maure8, Carlos Feijoo9, Francisco-Javier Rascón10, Roberto Pérez-Alvarez11, Mónica Zamora12, Alicia García-Pérez13, Miguel Lopez-Dupla14, Jesús Canora15, Mar Ripoll16, Eva Fonseca17, Pablo Guisado18, Blanca Pinilla19, Gloria de-la-Red20, Antonio-J. Chamorro21, César Morcillo22, Patricia Fanlo23, Mª José Soto-Cárdenas24, Manuel Ramos-Casals25 and Pilar Brito-Zerón4,22, 1Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET), Cordoba, Argentina, 2Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, 3Rheumatology Unit, Hospital Privado Universitario de Córdoba, Institute University of Biomedical Sciences University of Córdoba (IUCBC), Cordoba, Argentina, 4Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, ICMiD, Hospital Clínic, Barcelona, Spain, Barcelona, Spain, 5Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC, Barcelona, Spain., Barcelona, Spain, 6Systemic Autoimmune Diseases Unit, Hospital Vall d’Hebron, Barcelona, Barcelona, Spain, 7Systemic Autoimmune Diseases Unit, Hospital Ramón y Cajal, Madrid, Madrid, Spain, 8Department of Internal Medicine, Complejo Hospitalario Universitario, Vigo, Vigo, Spain, 9Systemic Autoimmune Diseases Unit, Hospital Parc Taulí, Sabadell, Sabadell, Spain, 10Systemic Autoimmune Diseases Unit, Hospital Son Espases, Palma de Mallorca, Palma de Mallorca, Spain, 11Department of Internal Medicine, Hospital do Meixoeiro, Vigo, Vigo, Spain, 12Systemic Autoimmune Diseases Unit, Hospital Virgen de las Nieves, Granada, Granada, Spain, 13Systemic Autoimmune Diseases Unit, Hospital Universitario Central de Asturias, Oviedo, Oviedo, Spain, 14Systemic Autoimmune Diseases Unit, Hospital Joan XXIII, Tarragona, Tarragona, Spain, 15Systemic Autoimmune Diseases Unit, Hospital de Fuenlabrada, Madrid, Madrid, Spain, 16Department of Internal Medicine, Hospital Infanta Sofía, Madrid, Madrid, Spain, 17Systemic Autoimmune Diseases Unit, Hospital de Cabueñes, Gijón, Gijón, Spain, 18Department of Internal Medicine, Complejo Hospitalario Ruber Juan Bravo, Madrid, Madrid, Spain, 19Systemic Autoimmune Diseases Unit Medicine, Hospital Gregorio Marañón, Madrid, Madrid, Spain, 20Systemic Autoimmune Diseases Unit, Hospital Esperit Sant, Santa Coloma de Gramenet, Santa Coloma de Gramenet, Spain, 21Systemic Autoimmune Diseases Unit, Hospital Universitario de Salamanca, Salamanca, Salamanca, Spain, 22Systemic Autoimmune Diseases Unit, Hospital CIMA-Sanitas, Barcelona, Barcelona, Spain, 23Systemic Autoimmune Diseases Unit, Hospital Virgen del Camino, Pamplona, Pamplona, Spain, 24Department of Medicine, University of Cadiz, Cadiz, Cadiz, Spain, 25University of Barcelona, Hospital Clínic, Barcelona, Barcelona, Spain

    Background/Purpose: To analyse the clinical features and outcomes of patients presenting with life-threatening systemic disease in a large cohort of Spanish patients with primary Sjogren…
  • Abstract Number: 1565 • 2018 ACR/ARHP Annual Meeting

    Comorbidity Burden in Primary Sjögren’s Syndrome: A Long-Term Observation in Clinical Practice

    Chiara Baldini1, Francesco Ferro1, Nicoletta Luciano1, Emanuele Calabresi1, Antonella Cecchettini2, Marta Mosca1, Enzo Grossi1 and Stefano Bombardieri1, 1Rheumatology Unit, University of Pisa, Pisa, Italy, 2IFC, CNR, Pisa, Italy

    Background/Purpose: Primary Sjögren’s syndrome (pSS) is a complex disorder that may affect any organ and system. In this new era of personalized medicine, a growing…
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