ACR Meeting Abstracts

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  • Abstract Number: 1476 • 2018 ACR/ARHP Annual Meeting

    Implication of CXCL5 (Epithelial neutrophil-activating peptide 78) in the Development of Insulin Resistance in Patients with Rheumatoid Arthritis

    Sonia Peña1, Beatriz-Segura Tejera2, Raquel Lopez-Mejías3, De Vera-González AM4, Alejandra Gonzalez-Delgado5, Miguel Angel González-Gay6 and Iván Ferraz-Amaro7, 1Rheumatology, Servicio de Reumatología, Hospital Universitario de Canarias,Spain, La Laguna, Spain, 2Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 3Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, 4Division of Central Laboratory. Hospital Universitario de Canarias, San Cristobal de La Laguna, Spain, 5Division of Central Laboratory. Hospital Universitario de Canarias., Tenerife, Spain, 6Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL and School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain, 7Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain, Tenerife, Spain

    Background/Purpose: The chemokine molecule CXCL5 (C-X-C motif chemokine ligand 5, also known as epithelial neutrophil activating peptide 78 -ENA78-) constitutes a link between obesity, inflammation…
  • Abstract Number: 1477 • 2018 ACR/ARHP Annual Meeting

    Serum Autoantibody Multi-Analyte Testing in Rheumatoid Arthritis Can Reduce Avoidable Costs Associated from False Positive Results. a Simulation Study in the United States of America

    Barbara Mascialino1, Sascha Swiniarski2, Isabel Gehring3, Maryam Poorafshar1 and Teresa Tarrant4, 1Thermo Fisher Scientific, Uppsala, Sweden, Uppsala, Sweden, 2Thermo Fisher Scientific, Freiburg, Germany, Freiburg, Germany, 3Thermo Fisher Scientific, Freiburg, Germany, 4Division of Rheumatology and Immunology, Duke School of Medicine, Durham, NC

    Serum Autoantibody Multi-Analyte Testing in Rheumatoid Arthritis Can Reduce Avoidable Costs Associated from False Positive Results. A Simulation Study in the United States of AmericaBarbara…
  • Abstract Number: 1478 • 2018 ACR/ARHP Annual Meeting

    Factors Associated with Disability and Health-Related Quality of Life in Biologic-Treated Patients with Rheumatoid Arthritis in Persistent Moderate Disease Activity

    Ian C. Scott1,2, Julie Mount3, Jane Barry3 and Bruce Kirkham4, 1Research Institute for Primary Care & Health Sciences, Primary Care Sciences, Keele University, Keele, United Kingdom, 2Department for Rheumatology, Haywood Hospital, Stoke on Trent, United Kingdom, 3Eli Lilly and Company, Basingstoke, United Kingdom, 4Rheumatology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom

    Background/Purpose: A treat-to target (T2T) strategy is recommended for the management of rheumatoid arthritis (RA), with the target being remission or at least low disease…
  • Abstract Number: 1479 • 2018 ACR/ARHP Annual Meeting

    The Predictive Utility of Anti-Cyclic Citrullinated Peptide Antibodies to Diagnose Rheumatoid Arthritis in Patients with Hepatitis C and Polyarthralgias

    Divya Jayakumar1,2, Xinliang Huang1,2, Seth Eisen1,2, Prabha Ranganathan1,2 and Amy Joseph2,3, 1Rheumatology, VA St. Louis Health Care System, St Louis, MO, 2Rheumatology, Washington University School of Medicine, St Louis, MO, 3Rheumatology, VA St. Louis Health Care System, St. Louis, MO

    Background/Purpose: Joint pain is a common extra-hepatic manifestation of chronic hepatitis C (HCV) infection. HCV infection is often associated with the presence of autoantibodies such…
  • Abstract Number: 1480 • 2018 ACR/ARHP Annual Meeting

    Prognosis of Pneumonia in Rheumatoid Arthritis Patient: An Analysis of Using a Nationwide Administrative Database

    Eishi Uechi1,2 and Kiyohide Fushimi2, 1Division of Rheumatology, Tomishiro Central Hospital, Okinawa, Japan, 2Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School, Tokyo, Japan

    Background/Purpose: Pneumonia is the leading cause of mortality in RA patients. No research has been conducted on the prognosis of pneumonia in RA patients. This…
  • Abstract Number: 1481 • 2018 ACR/ARHP Annual Meeting

    Are ACPA Associated with More Bone Loss over Time in Patients with RA?

    Emma de Moel1, Josephine Amkreutz1, Lotte Heimans2, Cornelia F. Allaart3, Tom W.J. Huizinga4 and Diane van der Woude4, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Internal Medicine, Leiden University Medical Center, Leiden, Netherlands, 3Department of Rheumatology, LUMC, Leiden, Netherlands, 4Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are one of the most important serological markers for rheumatoid arthritis (RA) and have been suggested to play a pathophysiologic…
  • Abstract Number: 1482 • 2018 ACR/ARHP Annual Meeting

    Is 14.3.3η a Predictor of Development of Rheumatoid Arthritis in Patients with Early Undifferentiated Arthritis?

    Karen Marie Carlsen1, Nina Schmidt2, Anne Duer3, Kim Hørslev-Petersen4, Cecilie Heegaard Brahe5, Merete Lund Hetland2, Norma K Biln6, Michelle L Zaharik7, Bo Jannik Ejbjerg8, Lene Bak9, Michael Sejer Hansen10, Julia Sidenius Johansen11, Hanne Merete Lindegaard12, Jakob M. Møller13 and Mikkel Østergaard14, 1Center for Rheumatology and Spine Diseases,, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Hillerød, Denmark, Hillerød, Denmark, 2Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Glostrup, Denmark, 3Department of Radiology, Rigshospitalet Glostrup, Denmark, Glostrup, Denmark, 4King Christian the Xth Hospital for Rheumatic Diseases, Denmark, Graasten, Denmark, 5Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark, 6Augurex Life Sciences Corp, Vancouver, BC, Canada, 7Augurex Life Sciences Corp, Vancouver, DC, Canada, 8Rheumatology, Department of Rheumatology, Køge Hospital, Denmark, Køge, Denmark, 9Department of Radiology, Odense University Hospital, Denmark, Odense, Denmark, 10Reuma-Klinik Roskilde, Denmark, Roskilde, Denmark, 11Dept. of Oncology, Department of Oncology, Copenhagen University Hospital, Herlev and Gentofte, Herlev, Denmark, 12Dept. of Rheumatology, Department of Rheumatology, Odense University Hospital, Denmark, Odense, Denmark, 13Department of Radiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark, 14Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Copenhagen, Denmark

    Background/Purpose: Optimal management of rheumatoid arthritis (RA) requires early diagnosis and therefore sensitive methods for early identification of RA to prevent joint damage and disability.…
  • Abstract Number: 1483 • 2018 ACR/ARHP Annual Meeting

    Comparison of Clinical Features of Seronegative and Seropositive Early Rheumatoid Arthritis: Blinded Data from the Ongoing Phase IIb Trial with the EP4 Receptor Antagonist CR6086 in DMARD-Naïve Patients

    Giampaolo Giacovelli, Beatrice Barbetta, Cristina Vitalini, Nadia Brambilla, Massimo D'Amato, Federica Girolami and Lucio C. Rovati, Clinical Research Department, Rottapharm Biotech, Monza, Italy

    Background/Purpose: Rheumatoid arthritis patients positive for rheumatoid factor (RF) or anti-cyclic citrullinated peptide antibody (ACPA) are considered to manifest an aggressive disease course compared with…
  • Abstract Number: 1484 • 2018 ACR/ARHP Annual Meeting

    Value of Anti-RA33 Isotypes in an European Rheumatoid Arthritis Patient Cohort

    Maresa Grundhuber1, Daniela Sieghart2, Günter Steiner2, Maryam Poorafshar3 and Sascha Swiniarski1, 1Thermo Fisher Scientific, Freiburg, Germany, Freiburg, Germany, 2Division of Rheumatology, Department of Internal Medicine III, Medical University Vienna, Austria, Vienna, Austria, 3Thermo Fisher Scientific, Uppsala, Sweden, Uppsala, Sweden

    Background/Purpose: Early diagnosis of rheumatoid arthritis (RA) leading to effective treatment is essential to improve prognosis and to prevent disease progression. Anti-cyclic citrullinated peptide (CCP)…
  • Abstract Number: 1485 • 2018 ACR/ARHP Annual Meeting

    Survivin Measurements Improve Prediction of Rheumatoid Arthritis Among Patients with Unexplained Arthralgia

    Malin C Erlandsson1,2, Minna Turkkila3, Rille Pullerits2,3,4 and Maria I Bokarewa2,3, 1Department of rheumatology and inflammation research, University of Gothenburg, Gothenburg, Sweden, 2Rheumatology Clinic, Sahlgrenska University Hospital, Gothenburg, Sweden, 3Department of Rheumatology, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden, 4Department of Clinical immunology and transfusion medicine, Sahlgrenska University Hospital, Gothenburg, Sweden

    Background/Purpose: Early recognition of rheumatoid arthritis (RA) is believed to be the key to successful treatment of this disease. Symptoms of arthralgia often predate development…
  • Abstract Number: 1486 • 2018 ACR/ARHP Annual Meeting

    Incidence of Subclinical Signs of Inflammation in Patients with New Onset of Non-Specific Musculoskeletal Symptoms and Anti-Citrullinated Peptide Positivity: First Interims Analysis of the Panora Trial

    Michaela Koehm1,2, Ulf Henkemeier2,3, Tanja Rossmanith2, Stephanie Dauth2, Timm Oberwahrenbrock2, Ann Christina Foldenauer2, Karola Mergenthal4, Harald Burkhardt2,3,5 and Frank Behrens2,3,5, 1Division of Rheumatology Goethe-University Frankfurt, Frankfurt/Main, Germany, 2Fraunhofer IME Branch for Translational Medicine and Pharmacology TMP, Frankfurt, Germany, 3Centre of Innovative Diagnostics and Therapeutics Rheumatology / Immunology at University Hospital Goethe-University Frankfurt, Frankfurt, Germany, 4Institute for General Practice Goethe-University, Frankfurt, Germany, 5Division of Rheumatology Goethe-University Frankfurt, Frankfurt, Germany

    Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory joint disease affecting approx. 1% of the adult population of Northern Europe and North America. Strategies for…
  • Abstract Number: 1487 • 2018 ACR/ARHP Annual Meeting

    Correlation between Cytokine Levels and Power-Doppler Ultrasound Activity Is BMI Dependent, and Different in ACPA Positive and ACPA Negative RA with Wrist Arthritis

    Ottar Gadeholt1, Erin Arnold2, Corinne Gorman3, Tobias Mueller4 and William Arnold2, 1Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Wuerzburg, Germany, 2Orthopedics and Rheumatology of the North Shore, Skokie, IL, 3Orthopaedics & Rheumatology of the North Shore, Skokie, IL, 4Department of Bioinformatics, University of Wuerzburg, Wuerzburg, Germany

    Background/Purpose: Multiple cytokines are assumed to be involved in RA pathogenesis. It has been hypothesized that ACPA-negative RA with wrist affection constitutes a separate entity.…
  • Abstract Number: 1488 • 2018 ACR/ARHP Annual Meeting

    Identification of Joint Locations That Are Poor Prognostic in an Early Seropositive Erosive RA Cohort

    Patrick Durez1, Sofie Robert2, Alexandra Thiry3 and Harris A Ahmad3, 1Cliniques Universitaires Saint-Luc, Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, 2Bristol-Myers Squibb, Braine L’Alleud, Belgium, 3Bristol-Myers Squibb, Princeton, NJ

    Background/Purpose: Patients (pts) with early RA often present with multiple and different areas of joint involvement. While the ACR and EULAR guidelines specify high disease…
  • Abstract Number: 1489 • 2018 ACR/ARHP Annual Meeting

    “Continuous Reduction” in Serum RF Titers Predicts Low Disease Activity and Good Therapeutic Response in RA Patients Treated with TNF Inhibitors, but Does Not Relate to Clinical Outcomes during ABT Treatment

    Takayoshi Owada1, Kazuhiro Kurasawa1, Yuta Takamura1, Tomoyuki Miyao1, Ayae Tanaka1, Ryutaro Yamazaki2, Satoko Arai1, Reika Maezawa1 and Masafumi Arima3, 1Rheumatology, Dokkyo Medical University, Mibu, Tochigi, Japan, 2Rheumatology, Dokkyo Medical University, Mibu, tochigi, Japan, 3Rheumatology, Dokkyo Medical University, mibu-gun, Tochigi, Japan

    Background/Purpose: Relative change of serum RF titer has been reported to correlate with those of RA disease activity. However, it is debatable whether serum RF…
  • Abstract Number: 1490 • 2018 ACR/ARHP Annual Meeting

    Effects of Biologic Drugs on Prognosis of Rheumatoid Arthritis Among Patients with Poor Glycated Hemoglobic A1c (HbA1c) Control

    Yusuke Miwa1 and Tsuyoshi Kasama2, 1Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Shinagawa-ku Tokyo, Japan, 2Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan

    Background/Purpose: Poor control of glycated hemoglobic A1c (HbA1c) worsens prognosis for diabetes mellitus and various complicated diseases. Corticosteroids exacerbate poor HbA1c control. This study, investigated…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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