Abstract Number: 1356 • 2018 ACR/ARHP Annual Meeting
Increasing Oral Doses of GLPG1972 Administered Daily for 29 Days Show a Strong Target Engagement in Patients with Knee and/or Hip OA
Background/Purpose: Osteoarthritis (OA) is characterized by structural changes of the joint, of which degradation of articular cartilage is one of the major signs1. The main…Abstract Number: 1357 • 2018 ACR/ARHP Annual Meeting
Flexion Contractures Are Associated with Worse Pain, Stiffness, and Function in Patients with Knee Osteoarthritis
Background/Purpose: Knee osteoarthritis (OA) causes pain, disability, and affects ~20% of the population in the United States [Wallace 2017]. Knee flexion contractures (FCs) are limitations…Abstract Number: 1358 • 2018 ACR/ARHP Annual Meeting
The Association of Microbial Translocation and WOMAC Function in Patients with Knee Osteoarthritis
Background/Purpose: Osteoarthritis (OA) affects 33.6% of population ≥65. Knee OA (KOA) is the most prevalent OA and it is one of five leading causes of…Abstract Number: 1359 • 2018 ACR/ARHP Annual Meeting
A Machine Learning Approach to Knee OA Phenotyping: The Johnston County Osteoarthritis Project
Background/Purpose: Knee osteoarthritis (KOA) is a heterogeneous condition characterized by changes in a variety of joint tissues and driven by a number of different potential…Abstract Number: 1360 • 2018 ACR/ARHP Annual Meeting
The Role of Personality in Patients with Knee Osteoarthritis
Background/Purpose: Knee osteoarthritis (OA) is a leading cause of disability and no effective disease-modifying treatment currently exists. Identifying factors associated with clinical outcomes may help…Abstract Number: 1361 • 2018 ACR/ARHP Annual Meeting
Predictive Modeling of Therapeutic Response in Knee Osteoarthritis
Background/Purpose: Phenotype identification in knee osteoarthritis (KOA) population could be useful for predicting drug response, allowing personalized interventions. In order to optimize therapeutic outcome in…Abstract Number: 1362 • 2018 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging Features Can Classify Adults Who Will Develop Accelerated Knee Osteoarthritis
Background/Purpose: Accelerated knee osteoarthritis (AKOA) is a painful disorder and is associated with several risk factors and pre-radiographic structural features. While no single factor can…Abstract Number: 1363 • 2018 ACR/ARHP Annual Meeting
Progression of Pain, Stiffness, Function Changes, and Ultrasound Detected Synovitis and Osteophyte Formation in Patients with Hand Osteoarthritis over Three Years
Background/Purpose: Hand osteoarthritis (HOA) is a common and frequent cause of pain. HOA is a heterogeneous group of disorders with two main subsets including non-erosive…Abstract Number: 1364 • 2018 ACR/ARHP Annual Meeting
Treatment of Knee Osteoarthritis with SM04690 Improved WOMAC A1 “Pain on Walking” – Results from a 52-Week, Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of a Novel, Intra-Articular, Wnt Pathway Inhibitor
Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, functional limitation, and physical disability due to articular cartilage degradation and bone remodeling. Wnt signaling is involved…Abstract Number: 1365 • 2018 ACR/ARHP Annual Meeting
A Phase IIa Study of Anti-GM-CSF Antibody GSK3196165 in Subjects with Inflammatory Hand Osteoarthritis
Background/Purpose: Previous data showed that neutralization of granulocyte/monocyte colony stimulating factor (GM-CSF) rapidly abolished pain in an experimental OA model suggesting GM-CSF may be a…Abstract Number: 1366 • 2018 ACR/ARHP Annual Meeting
Assessment of Health-Related Quality of Life in a 52-Week, Phase 2, Randomized, Controlled Trial of a Novel, Intra-Articular, Wnt Pathway Inhibitor (SM04690) for Treatment of Knee Osteoarthritis
Background/Purpose: SM04690, a small molecule, intra-articular (IA) Wnt pathway inhibitor, is in development for knee OA treatment. A phase 2, 52-week, trial evaluated changes in…Abstract Number: 1367 • 2018 ACR/ARHP Annual Meeting
Efficacy of Intra-Articular Cntx-4975 for Knee OA Pain Varies with Radiographic Presence of OA in the Opposite Knee
Background/Purpose: Nearly 60% of patients with knee OA have unilateral OA; most of those patients develop bilateral OA. CNTX-4975 is a highly purified, synthetic trans-capsaicin…Abstract Number: 1368 • 2018 ACR/ARHP Annual Meeting
Diabetes Mellitus Is Not a Risk Factor for Knee Osteoarthritis, a Systematic Review and Meta-Analysis
Diabetes Mellitus is Not a Risk Factor for Knee Osteoarthritis, a Systematic Review and Meta-analysisBackground/Purpose: Obesity is a strong risk factor for both osteoarthritis (OA)…Abstract Number: 1369 • 2018 ACR/ARHP Annual Meeting
The Influence of Hand Osteoarthritis on Bone Microstructure and Biomechanical Properties of Radial Bone
Background/Purpose: Primary hand osteoarthritis (HOA) is a heterogeneous disease, with erosive and osteoproliferative changes of the finger joints. [1] Due to the lack of treatment…Abstract Number: 1370 • 2018 ACR/ARHP Annual Meeting
Detection of an Autoantibody Profile to Characterize Patients with Early (Pre-symptomatic) Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Background/Purpose: Although osteoarthritis (OA) has not been considered as an autoimmune disorder, there are increased evidences of the role of the immune system in OA…
ACR Meeting Abstracts