Abstracts Archive - Page 1078 of 2425 - ACR Meeting Abstracts

Abstract Number: 1101 • 2018 ACR/ARHP Annual Meeting
Extracellular Vesicle-Mediated Delivery of EBV SMALL RNA (EBER1) Activates LUPUS Nephritis Related Antiviral Immunity in Tubular Epithelial CELLS VIA TLR3
R Baglio¹, M Tsang-A-Sjoe², M Eijndhoven¹, K Jordanova³, N Groenewegen¹, J van Weering⁴, S Verkuijlen¹, Irene E.M. Bultink⁵, J Middeldorp⁶, J Roelofs⁷, Alexandre Voskuyl⁸ and M Pegtel¹, ¹pathology, VU University medical center, Amsterdam, Netherlands, ²Rheumatology, Amsterdam Rheumatology and immunology Center | VU University Medical Center, Amsterdam, Netherlands, ³gynaecologic oncology, VU University medical center, Amsterdam, Netherlands, ⁴functional genomics, VU University medical center, Amsterdam, Netherlands, ⁵Rheumatology, Amsterdam Rheumatology and immunology Center | VU University Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands, ⁶pathology, VU Uninersity medical center, Amsterdam, Netherlands, ⁷pathology, Amsterdam Medical Center, Amsterdam, Netherlands, ⁸Amsterdam Rheumatology and immunology Center, Location VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: In lupus nephritis (LN), genetic and environmental factors drive the chronic activation of antiviral defenses leading to immune complex-mediated glomerular and tubular damage. Increasing…
Abstract Number: 1102 • 2018 ACR/ARHP Annual Meeting
Multi-Organ RNA-Sequencing of Patients with Systemic Sclerosis (SSc) Finds That Intrinsic Subsets Are Conserved across Organ Systems
Bhaven K. Mehta¹, Jennifer Franks², Yue Wang¹, Guoshuai Cai², Diana M. Toledo³, Tammara A. Wood², Kimberly A. Archambault¹, Noelle Kosarek¹, Kathleen D. Kolstad⁴, Marianna Stark⁵, Antonia Valenzuela⁶, David Fiorentino⁷, Nielsen Fernandez-Becker⁸, Laren Becker⁸, Linda Nguyen⁹, John Clarke¹⁰, Francesco Boin¹¹, Paul Wolters¹², Lorinda Chung¹³ and Michael L. Whitfield¹⁴, ¹Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Rheumatology, Stanford University Medical Center, Stanford, CA, ⁵Stanford University, Stanford, CA, ⁶Immunology and Rheumatology, Stanford University, Palo Alto, CA, ⁷Dermatology, Stanford University School of Medicine, Stanford, CA, ⁸Gastroenterology, Stanford University School of Medicine, Palo Alto, CA, ⁹Gastroenterology & Hepatology, Stanford University School of Medicine, Palo Alto, CA, ¹⁰Gastroenterology, Stanford University School of Medicine, Stanford, CA, ¹¹Rheumatology, University California, San Francisco, San Francisco, CA, ¹²Pulmonary Division, Department of Medicine, University of California, San Francisco, San Francisco, CA, ¹³Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ¹⁴Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Internal organ involvement is the primary cause of morbidity and mortality in systemic sclerosis (SSc). Here we tested the hypothesis generated from a meta-analysis…
Abstract Number: 1103 • 2018 ACR/ARHP Annual Meeting
Systemic Sclerosis Has a Distinct Serum Protein Profile That Correlates with Its Clinical Manifestations
Chiara Bellocchi^1,2, Jun Ying³, Ellen Goldmuntz⁴, Lynette Keyes-Elstein⁵, John Varga⁶, Monique Hinchcliff⁶, Peter McSweeney⁷, Daniel E. Furst⁸, Richard Nash⁷, Leslie Crofford⁹, Beverly Welch¹⁰, Ashley Pinckney⁵, Maureen D. Mayes^11,12, Keith Sullivan¹³ and Shervin Assassi¹², ¹University of Texas Health Science Center at Houston, Houston, TX, ²Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ³Department of Internal Medicine - Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁴NIAID, National Institutes of Health, Bethesda, MD, ⁵Rho Federal Systems, Inc., Chapel Hill, NC, ⁶Northwestern University, Chicago, IL, ⁷Colorado Blood Cancer Institute, Denver, CO, ⁸University of California Los Angeles, Los Angeles, CA, ⁹Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, ¹⁰National Institutes of Health, Bethesda, MD, ¹¹Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ¹²Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ¹³Duke University Medical Center, Durham, NC
Background/Purpose: Proteomic studies with an extensive panel of measured proteins are still scarce in systemic sclerosis (SSc). The Scleroderma: Cyclophosphamide or Transplantation (SCOT) trial showed…
Abstract Number: 1104 • 2018 ACR/ARHP Annual Meeting
Mass Cytometry Analysis Detects Dysregulated T Cell Complement Responses in Diffuse Cutaneous Systemic Sclerosis
Giuseppina Arbore¹, Shahram Kordasti², Claudia Kemper^3,4,5, Dennis Hourcade⁶, Benedetta Costantini², Leo Placais³, Lynne Mitchell⁶, Richard Ellis⁴, Christopher P. Denton⁷, David Abraham⁸ and Voon H. Ong⁸, ¹Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milano, Italy, ²Systems Cancer Immunology Lab, King's College London, London, United Kingdom, ³Laboratory of Molecular Immunology and the Immunology Center, National Institutes of Health, Washington, WA, ⁴School of Immunology and Microbial Sciences, King's College London, London, United Kingdom, ⁵Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany, ⁶Division of Rheumatology, Washington University School of Medicine, St Louis, WA, ⁷UCL Division of Medicine, Royal Free Campus, London, United Kingdom, ⁸Division of Medicine, University College London, London, United Kingdom
Background/Purpose: Aberrant CD4+ T cell activation is implicated in disease progression in systemic sclerosis (SSc). Activated T cells release various cytokines that may drive inflammation,…
Abstract Number: 1105 • 2018 ACR/ARHP Annual Meeting
Abatacept Is Effective in Experimental Digestive and Lung Tissue Fibrosis
Gonçalo Boleto¹, Christophe Guignabert², Sonia Pezet³, Anne Cauvet³, Jérémy Sadoine⁴, Ly Tu², Carole Nicco³, Camille Gobeaux⁵, Frederic Batteux³, Yannick Allanore³ and Jérôme Avouac¹, ¹Université Paris Descartes, Sorbonne Paris Cité, Service de Rhumatologie A, Hôpital Cochin, Paris, France, Paris, France, ²INSERM UMR_S 999, Le Plessis-Robinson, France, Le Plessis-Robinson, France, ³Université Paris Descartes, Sorbonne Paris Cité, INSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France, Paris, France, ⁴EA 2496 Pathologie, Imagerie et Biothérapies Orofaciales, UFR Odontologie, Université Paris Descartes and PIDV, PRES Sorbonne Paris Cité, Montrouge, France, Montrouge, France, ⁵Clinical Chemistry Laboratory, Cochin and Hôtel-Dieu Hospitals, Paris, France, Paris, France
Background/Purpose: A previous report showed that abatacept (IgG-CTLA-4) prevented and induced regression of inflammation-driven dermal fibrosis in two different mouse models of systemic sclerosis (SSc)…
Abstract Number: 1106 • 2018 ACR/ARHP Annual Meeting
Signal Transducer and Activator of Transcription 3 (STAT3) Activation in Peripheral Blood Mononuclear Cells of Systemic Sclerosis Patients: Correlation with Disease Specific Manifestations
Fabio Cacciapaglia¹, Simone Perniola^2,3, Livio Urso¹, Emanuela Praino⁴, Rita Bizzoca², Dorotea Natuzzi², Nunzia Lacarpia² and Florenzo Iannone⁵, ¹Department of Emergency and Organs Transplantation (DETO); University of Bari (Italy), Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy, ²Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy, ³Department of Verona - University of Verona (ITALY), Verona, Italy, ⁴DIM, Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy, ⁵D.E.T.O., Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy
Background/Purpose: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor regulated by phosphorylation of key tyrosine residues that regulates pivotal cell processes…
Abstract Number: 1107 • 2018 ACR/ARHP Annual Meeting
Expression Quantitative Trait Loci -eQTL- Analysis in Systemic Sclerosis
Martin Kerick¹, David Gonzalez Serna¹, Maria Teruel², Sepideh Babaei³, Marialbert Acosta-Herrera¹, Elena Carnero-Montoro², Zuzanna Makowska³, Anne Buttgereit⁴, Guillermo Barturen², Sikander Hayat⁴, Jorge Kageyama⁴, Manuel Martínez-Bueno², PRECISESADS Clinical Consortium⁵, Ralf Lesche³, Marta Alarcón-Riquelme² and Javier Martin¹, ¹Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain, ²Medical Genomics, Center for Genomics and Oncological Research (GENYO), Granada, Spain, ³Pharmaceuticals Division, Bayer Pharma Aktiengesellschaft, Berlin, Germany, ⁴Bayer Pharma Aktiengesellschaft, Berlin, Germany, ⁵Spain
Background/Purpose: Systemic Sclerosis (SSc) is a complex systemic autoimmune disorder characterized by fibrosis of the skin and internal organs. Genetics and environmental factors contribute both…
Abstract Number: 1108 • 2018 ACR/ARHP Annual Meeting
Antibody Repertoire Dynamics in Systemic Sclerosis after Myeloablative Autologous Hematopoietic Stem-Cell Transplantation or Cyclophosphamide Treatment
Julia Z. Adamska^1,2, Leslie Crofford³, Daniel E. Furst^4,5, Ellen Goldmuntz⁶, Lynette Keyes-Elstein⁷, Maureen D. Mayes⁸, Peter McSweeney⁹, Richard Nash⁹, Ashley Pinckney¹⁰, Beverly Welch¹¹, Keith Sullivan¹² and William H. Robinson^1,2, ¹Stanford University, Stanford, CA, ²VA Palo Alto Health Care System, Palo Alto, CA, ³Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, ⁴University of California Los Angeles, Los Angeles, CA, ⁵University of Washington, Seattle, WA, ⁶NIAID, NIH, Bethesda, MD, ⁷Clinical Statistics, Rho Federal Systems, Inc., Chapel Hill, NC, ⁸Rheumatology, University of Texas McGovern Medical School, Houston, TX, ⁹Colorado Blood Cancer Institute, Denver, CO, ¹⁰Rho Federal Systems, Inc., Chapel Hill, NC, ¹¹National Institutes of Health, Bethesda, MD, ¹²Duke University Medical Center, Durham, NC
Background/Purpose: Myeloablative autologous hematopoietic stem-cell transplantation (HSCT) was recently demonstrated to provide benefit over monthly cyclophosphamide (CYC) in the treatment of diffuse cutaneous systemic sclerosis…
Abstract Number: 1109 • 2018 ACR/ARHP Annual Meeting
Gene Expressions of TMEM176A and TMEM176B Were Prominent at the Stage of Subclinical Pulmonary Vascular Disease in Systemic Sclerosis
Yoshinobu Koyama¹, Soichiro Fuke², Takashi Ohno³, Yoshiharu Sato⁴ and Toshie Higuchi¹, ¹Center for Autoimmune Diseases, Division of Rheumatology, Japan Red Cross Okayama Hospital, Okayama, Japan, ²Department of Cardiology, Japan Red Cross Okayama Hospital, Okayama, Japan, ³Management of medical safety, Okayama University Hospital, Okayama, Japan, ⁴DNA Chip Research Inc, Tokyo, Japan
Background/Purpose: Pulmonary arterial hypertension (PAH) is prominent as a vascular involvement of systemic sclerosis (SSc), which remains a leading cause of death in spite of…
Abstract Number: 1110 • 2018 ACR/ARHP Annual Meeting
Characterization of CD20+ T Cells in Patients with Systemic Sclerosis
Monica D'Orazio¹, Elisabeth Fliesser², Florentine Moazedi-Fürst³, Martin Stradner⁴, Sonja Kielhauser³, Johannes Fessler⁵ and Hans-Peter Brezinschek¹, ¹Internal Medicine/Division of Rheumatoloy and Immunology, Rheumatology and Immunology, Medical University Graz, Austria, Graz, Austria, ²Div. of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ³Rheumatology and Immunology, Medical University Graz, Austria, Graz, Austria, ⁴Department of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ⁵Department of Neurology, Harvard Medical School, Boston, MA
Background/Purpose: Recently, it has been demonstrated that a subset of T cells expresses the B-cell marker CD20. It has been postulated that in rheumatoid arthritis…
Abstract Number: 1111 • 2018 ACR/ARHP Annual Meeting
CBS004, a Novel Monoclonal Antibody Against Bdca-2 Inhibits TLR-Induced Activation of Human pDC in Vitro and In Vivo. a Novel Therapeutic Target for Systemic Sclerosis
Clarissa Corinaldesi¹, Yasser M El-Sherbiny², Gemma Migneco³, Rebecca Ross¹, Steve Holmes⁴, Clive McKimmie⁵ and Francesco Del Galdo¹, ¹Leeds Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals, NHS Trust, Leeds, United Kingdom, ³Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom, ⁴Capella Biosciences, LTD, London, United Kingdom, ⁵Virus Host Interactions Team, Section of Infection and Immunity, University of Leeds, Leeds, United Kingdom
Background/Purpose: Human plasmacytoid dendritic cells (pDCs) have been implicated in the pathogenesis of Systemic Sclerosis (SSc) through their ability to infiltrate the skin and secrete…
Abstract Number: 1112 • 2018 ACR/ARHP Annual Meeting
Downregulated Expression of Interferon Regulatory Factor 8 in Circulating Monocytes Exhibits Pro-Fibrotic Phenotype in Patients with Systemic Sclerosis
Yasushi Ototake¹, Yukie Yamaguchi¹, Miho Asami¹, Noriko Ikeda¹, Daisuke Kurotaki², Tomohiko Tamura² and Michiko Aihara¹, ¹Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Background/Purpose: Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by autoimmunity, vasculopathy, and excessive organ fibrosis. Although the etiology of the disease is…
Abstract Number: 1113 • 2018 ACR/ARHP Annual Meeting
Distinct Pathways in Anti-RNP-Associated Pulmonary Hypertension and Anti-RNP-Associated Raynaud’s Phenomenon
Lisa Harlow¹, Ying Wang², YunJuan Zang², Vineet Gupta³, Karen Young⁴, Jian Huang⁴, Bethly Aubourg² and Eric Greidinger⁵, ¹Rheumatology and Clinical Immunology, University of Miami Miller School of Medicine, Miami, FL, ²Rheumatology, University of Miami, Miami, FL, ³Rush University, Chicago, IL, ⁴Pediatrics, University of Miami, Miami, FL, ⁵Miami VA Medical Center, Miami, FL
Background/Purpose: Anti-RNP Autoimmunity is associated with multiple manifestations of vasculopathy, including Raynaud’s Phenomenon (RP) and Pulmonary Hypertension (PH). We have previously linked anti-K10 antibodies to…
Abstract Number: 1114 • 2018 ACR/ARHP Annual Meeting
Proteomic Aptamer Analysis Reveals a Distinct Profile of Very Early Systemic Sclerosis (SSc) Patients at Risk for Progression Toward Definite SSc
Chiara Bellocchi¹, Shervin Assassi², Jun Ying³, Chandra Mohan⁴, Alessandro Santaniello¹ and Lorenzo Beretta¹, ¹Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ²University of Texas McGovern Medical School, Houston, TX, ³Department of Internal Medicine - Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁴Department of Biomedical Engineering, University of Houston, Houston, Texas, USA, Houston, TX
Background/Purpose: To determine via SOMAscan aptamer proteomic analysis (>1200 proteins analyzed) the factors associated with disease transition from very early systemic sclerosis (EaSSc) to definite…
Abstract Number: 1115 • 2018 ACR/ARHP Annual Meeting
In Vivo Assessment of Prevention of Lung Fibrosis Using the Pan-PPAR Agonist Lanifibranor in the Tβriiδk-Fib Mouse Model of Systemic Sclerosis
Emma C. Derrett-Smith^1,2, Shiwen Xu¹, David Abraham³, Olivier Lacombe⁴, Pierre Broqua⁴, Jean-Louis Junien⁴, Irena Konstantinova⁵ and Christopher P. Denton⁶, ¹Division of Medicine, University College London, London, United Kingdom, ²Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ³Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁴Inventiva, DAIX, France, ⁵Inventiva, Daix, France, ⁶University College London, London, United Kingdom
Background/Purpose: The TbRIIDk-fib transgenic (TG) mouse model of scleroderma carries a fibroblast-specific transforming growth factor β (TGFβ) receptor II mutation resulting in balanced up-regulation of…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].