Abstracts Archive - Page 1075 of 2425 - ACR Meeting Abstracts

Abstract Number: 1056 • 2018 ACR/ARHP Annual Meeting
Association of Paraoxonase 1 Gene Polymorphisms and Enzyme Activity with Progression of Carotid Atherosclerosis in Rheumatoid Arthritis
Christina Charles-Schoeman¹, Jennifer Wang², Ani Shahbazian³, John Moriarty³, Tyler Dowd³, Buzand Oganesian⁴, Ilana Golub³, John Fitzgerald⁵, Veena K. Ranganath⁶, Mihaela Taylor³, Maureen A. McMahon³, Gorn Alan⁵ and Srinivasa T. Reddy³, ¹Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ²University of California Los Angeles, Los Angeles, CA, ³University of California, Los Angeles, Los Angeles, CA, ⁴University of California, Los Angeles, Los angeles, CA, ⁵Division of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁶1000 VETERAN BLVD., RM 32-59, UCLA, Los Angeles, CA
Background/Purpose: Paraoxonase 1 (PON1) is a high density lipoprotein (HDL) associated enzyme, which promotes the anti-oxidant and anti-inflammatory properties of HDL. PON1 polymorphisms and enzyme…
Abstract Number: 1057 • 2018 ACR/ARHP Annual Meeting
Autophagy Promotes Citrullination of Vimentin and Its Interaction with Major Histocompatibility Complex Class II in Synovial Fibroblasts
Eri Sugawara, Masaru Kato, Yuki Kudo, WenShi Lee, Yuichiro Fujieda, Toshiyuki Bohgaki, Olga Amengual, Kenji Oku, Shinsuke Yasuda and Tatsuya Atsumi, Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Background/Purpose: Citrullinated vimentin (cVIM) is one of the major autoantigens in patients with rheumatoid arthritis (RA), recognized by anti-citrullinated peptide antibodies. Autophagy is a self-cannibalism…
Abstract Number: 1058 • 2018 ACR/ARHP Annual Meeting
Doxycycline Directly Scavenges Reactive Oxygen Species and Inhibits the Formation of Malondialdehyde-Acetaldehyde-Protein Adducts – a Novel Mechanism of Action for an Old Drug
Andrew Chiou¹, Michael J. Duryee¹, Dahn L Clemens², Cleofes Sarmiento², Matthew Zimmerman³, Carlos D. Hunter¹, Lynell W. Klassen⁴, James R. O'Dell⁴, Daniel R. Anderson², Ted R. Mikuls⁵ and Geoffrey M. Thiele², ¹Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²University of Nebraska Medical Center, Omaha, NE, ³Cell Biology and Physiology, University of Nebraska Medical Center, Omaha, NE, ⁴Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁵Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Oxidative stress plays a role in the progression of inflammatory diseases such as Rheumatoid Arthritis (RA) due to the imbalance between levels of reactive…
Abstract Number: 1059 • 2018 ACR/ARHP Annual Meeting
Differentially-Utilized Transcription Factors and Enhancers in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes
Jonathan Mills¹, Gary S. Firestein² and Brian Pedersen², ¹Rheumatology, University of California, San Diego, San Diego, CA, ²Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: RA fibroblast-like synoviocytes (FLS) display a unique aggressive phenotype with a distinct epigenetic profile marked by altered chromatin accessibility. We hypothesized that differentially utilized…
Abstract Number: 1060 • 2018 ACR/ARHP Annual Meeting
Variation in the Synovial Fluid Metabolome According to Disease Activity in Rheumatoid Arthritis
Joong Kyong Ahn¹, Jiwon Hwang², Jaejoon Lee³, Eun-Mi Koh³ and Hoon-Suk Cha³, ¹Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South), ²Department of Internal Medicine, National Police Hospital, Seoul, Korea, Republic of (South), ³Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South)
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, inflammatory disease characterized by persistent inflammation and joint damage with a heterogeneous course and different pathogenic mechanisms. Metabolomics,…
Abstract Number: 1061 • 2018 ACR/ARHP Annual Meeting
Serum Metabolomic Profiling Predicts Synovial Gene Expression in Rheumatoid Arthritis
Rekha Narasimhan¹, Roxana Coras^1,2, Sara B Rosenthal³, Shannon R Sweeney⁴, Alessia Lodi⁵, Stefano Tiziani⁶, David L. Boyle¹, Arthur Kavanaugh⁷ and Monica Guma^1,2, ¹Medicine, University of California San Diego, La Jolla, CA, ²Medicine, Autonomous University of Barcelona, Bellatera, Spain, ³Center for Computational Biology and Bioinformatics, University of California San Diego, San Diego, CA, ⁴Department of Nutritional Sciences. The University of Texas at Austin., Austin, TX, ⁵Department of Nutritional Sciences & Dell Pediatric Research Institute, Dell Medical School, University of Texas at Austin, Austin, TX, ⁶Dell Medical School, University of Texas at Austin, Austin, TX, ⁷University of California, San Diego, School of Medicine, La Jolla, CA
Background/Purpose: Metabolomics is an emerging field of biomedical research that may offer a better understanding of mechanisms underlying conditions that could include inflammatory arthritides. Perturbations…
Abstract Number: 1062 • 2018 ACR/ARHP Annual Meeting
Linking Systemic Angiogenic Markers to Synovial Vascularization in Rheumatoid Arthritis
Agathe Leblond¹, Sonia Pezet¹, Anne priscille Trouvin², Muriel Elhai², Virginie Gonzalez¹, Yannick Allanore³ and Jérôme Avouac², ¹Université Paris Descartes, Sorbonne Paris Cité, INSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France, Paris, France, ²Université Paris Descartes, Sorbonne Paris Cité, Service de Rhumatologie A, Hôpital Cochin, Paris, France, Paris, France, ³Service de Rhumatologie A, Hôpital Cochin, Paris, France
Background/Purpose: Neoangiogenesis is a crucial event to promote the development of the hyperplasic proliferative pathologic synovium in Rheumatoid arthritis (RA). Ultrasound (US) is sensitive for…
Abstract Number: 1063 • 2018 ACR/ARHP Annual Meeting
Role of Mitochondrial-Bound HK2 in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Patricia Oliveira¹, Marta Fernandez Bustmanate², Ricard Garcia Carbonell³, Elsa Sanchez-Lopez⁴, Teresina Laragione⁵, Percio S. Gulko⁶, Gary S. Firestein⁷, Anne N Murphy³, Shigeki Miyamoto⁸ and Monica Guma^7,9, ¹Medicine, UCSD, San Diego, CA, ²Medicine, UCSD, La Jolla, CA, ³Pharmacology, UCSD, San Diego, CA, ⁴Department of Pharmacology, School of Medicine. UCSD., La Jolla, CA, ⁵Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, ⁶Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁷Medicine, University of California San Diego, La Jolla, CA, ⁸Pharmacology, UCSD, La Jolla, CA, ⁹Medicine, Autonomous University of Barcelona, Bellatera, Spain
Background/Purpose: Hexokinases (HKs) catalyze the first step in glucose metabolism. HK2 constitutes the principal inducible isoform with a restricted distribution in normal adult tissues. Fibroblast-like…
Abstract Number: 1064 • 2018 ACR/ARHP Annual Meeting
Identification of a Panel of Circulating Proteins Associated to Synovial Pathotypes in Early Rheumatoid Arthritis Patients
Cristina Ruiz-Romero¹, Florencia Picchi², Patricia Fernández³, Lucia González², Rebecca Hands⁴, Valentina Calamia², Maria Camacho², Conrad Bessant⁵, Costantino Pitzalis⁴ and Francisco J Blanco⁶, ¹Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Rheumatology Research Group, Proteomics Unit-ProteoRed/ISCIII, INIBIC-CHUAC, A Coruña, Spain, ³Proteomics group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, La Coruña, Spain, ⁴Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁵School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom, ⁶Rheumatology Divison, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain
Background/Purpose: Rheumatoid arthritis (RA) is characterized by high clinical variability and an underlying cellular and molecular heterogeneity. Efforts to find tools for the classification of…
Abstract Number: 1065 • 2018 ACR/ARHP Annual Meeting
Artesunate Can Synergize with Methotrexate on Inhibiting Migration and Invasion of Fibroblast-like Synoviocytes from Patients with Rheumatoid Arthritis
Jian-Da Ma¹, Jun Jing¹, Jun-Wei Wang¹, Tao Yan², Yun-Shan Mou², Ying-Qian Mo¹ and Lie Dai¹, ¹Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China, ²Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China
Background/Purpose: Fibroblast-like synoviocytes (FLS) play important roles on joint destruction in rheumatoid arthritis (RA). Recent reports showed that antimalaria drug artesunate presents anti-cancer potential by…
Abstract Number: 1066 • 2018 ACR/ARHP Annual Meeting
Tocilizumab Effect on Serum Angiogenic Factors in Rheumatoid Arthritis Patients
Muna Elias¹, Michal Amit Rahat², Joy Feld¹, Itzhak Rosner³, Lisa Kaly⁴, Idit Lavi⁵, Tal Gazitt⁶ and Devy Zisman⁷, ¹Rheumatology Unit Carmel Medical Center, Haifa, Israel, ²Immunotherapy laboratory, Carmel medical center, Haifa, Israel, ³Rheumaoloy Unit, Bnai Zion Medical Center, Haifa, Israel, ⁴Rheumatology unit, Bnai-Zion Medical Center, Haifa, Israel, ⁵Epidemiology Unit Carmel Medical Center, Haifa, Israel, ⁶Rheumatology unit, Carmel medical center, Haifa, Israel, ⁷Rheumatology Unit, Carmel Medical Center, Haifa, Israel
Background/Purpose: Several inducers of angiogenesis have been shown to play a central role in rheumatoid arthritis (RA) pathogenesis: VEGF (Vascular Endothelial Growth Factor), EMMPRIN (Extracellular…
Abstract Number: 1067 • 2018 ACR/ARHP Annual Meeting
Simulating the Pathogenesis of Arthritis in Vitro By Developing a Human-Based Multicomponent 3D Joint Model
Alexandra Damerau^1,2, Annemarie Lang^1,2, Moritz Pfeiffenberger^1,2, Timo Gaber^1,3 and Frank Buttgereit^1,2, ¹Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, ³Deutsches Rheuma Forschungszentrum (DRFZ) Berlin, Berlin, Germany
Background/Purpose: Although arthritis is a matter of research since more than 140 years, there is currently no valid 3D model available, which is able to…
Abstract Number: 1068 • 2018 ACR/ARHP Annual Meeting
Characterization of the Role of Endocannabinoid System Using Jwh-133, a Selective Cannabinoid CB2 Receptor Agonist, in IL-1β-Induced Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts
Sabrina Fechtner¹, Anil K. Singh¹ and Salahuddin Ahmed^1,2, ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ²Division of Rheumatology, University of Washington, Division of Rheumatology, School of Medicine, Seattle, WA
Background/Purpose: The endocannabinoid system (ECS) is comprised of two evolutionary conserved cannabinoid receptors 1 and 2 (CB1 and CB2) which participate in pain management through…
Abstract Number: 1069 • 2018 ACR/ARHP Annual Meeting
Non-Receptor Protein Tyrosine Phosphatase 14 (PTPN14) Promotes YAP-Dependent Tgfbeta Signaling in RA FLS
Angel Bottini¹, Dennis J. Wu², Rizi Ai³, Michelle LeRoux⁴, Beatrix Bartok¹, Michele Bombardieri⁵, Vida Zhang⁶, Karen M. Doody⁷, Cristiano Sacchetti¹, Martina Zoccheddu¹, Ana Lonic⁸, David L. Boyle⁹, Deepa Hammaker⁹, Tzu-Ching Meng¹⁰, Maripat Corr³, Stephanie M. Stanford³, Myles J. Lewis¹¹, Wei Wang¹², Gary S. Firestein⁹, Yeesim Khew-Goodall⁸, Costantino Pitzalis¹³ and Nunzio Bottini¹⁴, ¹Rheumatology, University of California San Diego, La Jolla, CA, ²University of California San Diego, San Diego, CA, ³University of California San Diego, La Jolla, CA, ⁴La Jolla Institute for Allergy and Immunology, LA JOLLA, CA, ⁵Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kindgdom, London, United Kingdom, ⁶La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁷Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁸SA Pathology and University of South Australia, Adelaide, Australia, ⁹Medicine, University of California San Diego, La Jolla, CA, ¹⁰Academia Sinica, Taipei, Taiwan, ¹¹Barts Health NHS Trust & Barts and the London School of Medicine & Dentistry, London, United Kingdom, London, United Kingdom, ¹²Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, ¹³Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ¹⁴Medicine/Rheumatology, University of California San Diego, La Jolla, CA
Background/Purpose: Non-Receptor Protein Tyrosine Phosphatase 14 (PTPN14) was identified in a phosphatase expression profile survey to be highly expressed in synovial fibroblasts derived from patients…
Abstract Number: 1070 • 2018 ACR/ARHP Annual Meeting
Seroreactivity Against Recombinant Citrullinated Myosin Is Associated with Measures of Diastolic Dysfunction in Patients with Rheumatoid Arthritis
Christian Geier¹, Justyna Fert-Bober², Jon T. Giles¹, Cesare Russo¹, Sabahat Bokhari³, Aylin Tugcu¹, Jenny Van Eyk² and Joan Bathon¹, ¹Columbia University, New York, NY, ²Cedars-Sinai Medical Center, Los Angeles, CA, ³Cardiology, Columbia University, New York, NY
Background/Purpose: Diastolic dysfunction and heart failure with preserved EF are more prevalent in RA. We have previously shown increased staining for citrullinated substrates in necropsied…

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