Abstracts Archive - Page 1075 of 2607 - ACR Meeting Abstracts

Abstract Number: 2023 • 2019 ACR/ARP Annual Meeting
Gene-Expression Analysis of Male and Female SLE Patients Reveals Candidate Pathogenic Pathways
MIKHAIL OLFERIEV¹, David Fernandez ², Dina Greenman ¹, Mary Peng ¹, Kyriakos Kirou ¹ and Mary Crow ¹, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, Mary Kirkland Center for Lupus Research, New York, NY
Background/Purpose: The female predisposition for development of multiple autoimmune diseases is well recognized. The female to male ratio reaches a maximum during the reproductive years…
Abstract Number: 2024 • 2019 ACR/ARP Annual Meeting
Genetics of Longitudinal Kidney Function in Children and Adults with Systemic Lupus Erythematosus
Thai-Son Tang¹, Declan Webber ², Jingjing Cao ³, Daniela Dominguez ⁴, Dafna Gladman ⁵, Andrea Knight ⁶, Deborah Levy ⁷, Lawrence Ng ⁴, Andrew D. Paterson ⁸, Earl D. Silverman ⁹, Zahi Touma ¹⁰, Murray Urowitz ¹⁰, Joan Wither ¹¹, Eleanor M. Pullenayegum ¹² and Linda Hiraki ¹³, ¹Dalla Lana School of Public Health, University of Toronto, Toronto, Canada, ²University of Toronto, The Hospital for Sick Children, Toronto, Canada, ³Genetics & Genome Biology, The Hospital for Sick Children, Toronto, Canada, ⁴Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada, ⁵Toronto Western Hospital, Toronto, Canada, Toronto, ON, Canada, ⁶Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁷Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁸Genetics & Genome Biology, The Hospital for Sick Children, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada, ⁹Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, ¹⁰University Health Network, University of Toronto, Toronto, ON, Canada, ¹¹University Health Network, Krembil Research Institute, Toronto, ON, Canada, ¹²Child Health Evaluative Sciences, The Hospital for Sick Children, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada, ¹³Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada
Background/Purpose: Genetics influences kidney function (estimated glomerular filtration rate (eGFR)), systemic lupus erythematosus (SLE) and lupus nephritis (LN) risk. Genome-wide association studies (GWAS) have identified…
Abstract Number: 2025 • 2019 ACR/ARP Annual Meeting
Ancestry Influences the Gene Expression Profile in Systemic Lupus Erythematosus and Contributes to Transcriptomic Heterogeneity in Lupus Patients
Michelle Catalina¹, Prathyusha Bachali ², Anthony Yeo ³, Nicholas Geraci ², Michelle Petri ⁴, Amrie Grammer ² and Peter Lipsky ², ¹AMPEL BioSolutions, LLC, harvard, MA, ²AMPEL BioSolutions, LLC, Charlottesville, VA, ³Rilite Foundation, Charlottesville, VA, ⁴Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with both sex and ancestral bias. Gene expression analysis has revealed complex heterogeneity between SLE…
Abstract Number: 2026 • 2019 ACR/ARP Annual Meeting
MicroRNA-27a Can Contribute to Interferon Signatures in Systemic Lupus Erythematosus via the Suppression of Tripartite Motif-containing Protein 27
Daiga Kishimoto¹, Ryusuke Yoshimi ¹, Yosuke Kunishita ¹, Yumiko Sugiyama ², Takaaki Komiya ¹, Natsuki Sakurai ³, Reikou Kamiyama ¹, Yohei Kirino ⁴ and Hideaki Nakajima ⁴, ¹Department of Stem Cell and Immune Regulation / Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Rheumatic Diseases / Yokohama City University Medical Center, Yokohama, Japan, ³Department of Stem Cell and Immune Regulation / Yokohama City University Graduate School of Medicine, Yokohama City, Japan, ⁴Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Background/Purpose: Type Ⅰ interferons (IFN) contribute to antiviral innate immune responses. Upon viral infection, pattern recognition receptors trigger TANK-binding kinase 1 (TBK1) activation and lead…
Abstract Number: 2027 • 2019 ACR/ARP Annual Meeting
Dysregulation of Granulopoiesis in Systemic Lupus Erythematosus
Neelakshi R. Jog¹, Teresa Aberle ¹, Cristina Arriens ², Stefania Gallucci ³ and Judith James ², ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Lewis Katz School of Medicine, Temple University, Philadelphia, PA
Background/Purpose: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by autoantibody production and periods of elevated disease activity. Recent studies indicate that along…
Abstract Number: 2028 • 2019 ACR/ARP Annual Meeting
Inhibited Expression of Hematopoietic Progenitor Kinase 1 in Tfh Cells Contributes to Autoimmunity in Systemic Lupus Erythematosus
Qing Zhang¹ and Huilin Zhang ², ¹Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China (People's Republic), ²Clinical Nursing Teaching and Research Section, Second Xiangya Hospital, Central South University, Changsha, Hunan, China (People's Republic)
Background/Purpose: T follicular helper cells (Tfh cells) are a newly discovered subset of CD4+ T cells, which play a mainly role in inducing B cells…
Abstract Number: 2029 • 2019 ACR/ARP Annual Meeting
Aberrant H3K9me3 Modification in Promoter Region Up-regulates cAMP Response Element Modulator Alpha in Systemic Lupus Erythematosus
Huilin Zhang ¹ and Qing Zhang², ¹Clinical Nursing Teaching and Research Section, Second Xiangya Hospital, Central South University, Changsha, Hunan, China (People's Republic), ²Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China (People's Republic)
Background/Purpose: In recent years, accumulating evidences have demonstrated that increased cAMP response element modulator α (CREMα) which can inhibit IL-2 and induce IL-17A in CD4+…
Abstract Number: 2030 • 2019 ACR/ARP Annual Meeting
Staphylococcus Aureus Colonization Is Increased on Lupus Skin Lesions and Is Promoted by Interferon-Mediated Barrier Disruption
Sirisha Sirobhushanam¹, Navya Parsa ², Tamra Reed ¹, Celine Berthier ¹, Mrinal Sarkar ¹, Grace Hile ¹, Lam Tsoi ¹, Alexander Horswill ³, Johann Gudjonsson ¹ and J Michelle Kahlenberg ¹, ¹University of Michigan, Ann Arbor, MI, ²University of Toledo, Toledo, OH, ³University of Colorado, Denver, CO
Background/Purpose: Background/Purpose: Cutaneous inflammation is recurrent in systemic lupus erythematosus (SLE) and is often triggered by exposure to ultraviolet B (UVB) light. Type I interferons…
Abstract Number: 2031 • 2019 ACR/ARP Annual Meeting
Interferon Alpha Promotes Caspase-Dependent Apoptosis Independently of Reactive Oxygen Species in Ultraviolet B-Exposed Keratinocytes
Shannon Estadt¹ and J. Michelle Kahlenberg ¹, ¹University of Michigan, Ann Arbor, MI
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by increased sensitivity to ultraviolet radiation (UVR). UVR can trigger cutaneous and systemic disease fares,…
Abstract Number: 2032 • 2019 ACR/ARP Annual Meeting
Enhanced IFN a Production and STING Pathway in Monocytes in Systemic Lupus Erythematosus Is Suppressed by the Inhibition of mTOR Activation
Goh Murayama¹, Asako Chiba ², Ayako Makiyama ³, Taiga Kuga ⁴, Ken Yamaji ⁴, Naoto Tamura ⁴ and Sachiko Miyake ², ¹Department of Internal Medicine and Rhumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan, ³Juntendo University School of Medicine, Tokyo, Japan, ⁴Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Interferona (IFNa) is increased and plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Overexpression of type I IFN regulated genes…
Abstract Number: 2033 • 2019 ACR/ARP Annual Meeting
IRAK4 Inhibition Suppresses TLR7, TLR9, and SLE Serum-Induced IFNA Production in Primary Human Plasmacytoid Dendritic Cells
Angie Hammond¹, Sean Parghi ¹, Nathan Wright ¹, Ethan Grant ¹, James Taylor ¹ and Matthew Warr ¹, ¹Gilead Sciences, Inc., Foster City, CA
Background/Purpose: A hallmark of lupus is the presence of antinuclear autoantibodies, including those against RNA-protein complexes and double-stranded DNA (dsDNA).1,2 FcγR-mediated internalization of these nucleic…
Abstract Number: 2034 • 2019 ACR/ARP Annual Meeting
Identification of IL-17+ and IL-10+ TCRαβ+ CD4- CD8- Double Negative (DN) T Cell Subsets in Lupus-prone Mice and Patients with SLE and Their Significance in Predicting Renal Involvement
Yi Li¹, Hao Li ², Shui Lian Yu ³, Vasileios Kyttaris ⁴ and George Tsokos ⁴, ¹BIDMC, Boston, MA, ²Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, ³The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China (People's Republic), ⁴Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: We have previously shown that DN T cells are expanded in both lupus-prone mice and patients with SLE and we have demonstrated that this…
Abstract Number: 2035 • 2019 ACR/ARP Annual Meeting
Systemic Lupus Erythematosus (SLE) Is Caused by Expanded DOCK8-Positive Autoantibody-Inducing CD4 T (aiCD4 T) Cell
Shunichi Shiozawa¹, Ken Tsumiyama ¹, Yumi Miyazaki ², Keiichi Sakurai ³, Takahiko Horiuchi ⁴, Motohiro Oribe ⁵, Takashi Yamane ⁶, Hidetoshi Kagawa ⁷ and Kazuko Shiozawa ⁸, ¹Institute for Rheumatic Diseases, Ashiya, Japan, ²Kyushu University Beppu Hospital, Tokyo, Japan, ³Rheumatology and Allergology, St. Marianna University School of Medicine, Tokyo, Japan, ⁴Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, Beppu, Japan, ⁵Oribe Rheumatology Clinic, Oita, Japan, ⁶Department of Rheumatology, Kakogawa Central City Hospital, Kakogawa, Japan, ⁷Rheumatology, Red Cross Society Himeji Hospital, Himeji, Japan, ⁸Rheumatic Diseases Center, Hyogo Prefectural Kakogawa Medical Center, Ashiya, Japan
Background/Purpose: We previously found in reproducible experiments in which the mice not prone to autoimmune disease were immunized repeatedly with antigen that overstimulation of CD4…
Abstract Number: 2036 • 2019 ACR/ARP Annual Meeting
Mitochondrial DNA: A Potential Trigger of Cyclic GMP-AMP Synthase Activation in Systemic Lupus Erythematosus
Jie An¹, Bhargavi Duvvuri ¹, Xizhang Sun ¹, Lena Tanaka ¹, Christian Lood ¹ and Keith Elkon ¹, ¹University of Washington, Seattle
Background/Purpose: Approximately 70% of patients with Systemic Lupus Erythematosus (SLE) show a striking Type I Interferon (IFN-I) signature in peripheral blood. Although we have some…
Abstract Number: 2037 • 2019 ACR/ARP Annual Meeting
Understanding Langerhans Cell ADAM17 Levels in Systemic Lupus Erythematosus: Potential Contributor to Photosensitivity
Theresa Lu ¹, Noa Schwartz ², Thomas Li ², William Shipman ³, Dragos Dasoveanu ³, Yong Liu ⁴, Niroshana Anandasabapathy ⁴, Henry Lee ⁴, Ali Jabbari ⁵, James Krueger ⁵, Bebak Mehrara ⁶, Keila Veiga², Kira Minkis ⁴ and David Oliver ², ¹Hospital for Special Surgery, Weill Cornell Medicine (Microbiology and Immunology), New York, ²Hospital for Special Surgery, New York, ³Hospital for Special Surgery; Weill Cornell Medicine, New York, ⁴Weill Cornell Medicine (Dermatology), New York, ⁵Rockefeller University, New York, ⁶Memorial Sloan Kettering Cancer Center, New York
Background/Purpose: Photosensitivity resulting in inflammatory skin lesions is a hallmark of cutaneous lupus. Lesions can be disfiguring and have a negative impact on patients’ quality…

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