Abstracts Archive - Page 1071 of 2607 - ACR Meeting Abstracts

Abstract Number: 1963 • 2019 ACR/ARP Annual Meeting
Combining Clinical and Candidate Gene Data into a Risk Score for Azathioprine-Associated Leukopenia in Routine Clinical Practice
Prathima Anandi ¹, Alyson Dickson ², Qiping Feng ¹, Wei-Qi Wei ², William Dupont ², Dale Plummer ², Ge Liu ¹, Katherine Barker ², Vivian Kawai ², Kelly Birdwell ², Nancy Cox ¹, C. Michael Stein ², Adriana Hung ² and Cecilia Chung³, ¹Vanderbilt University Medical Center, Nashville, ²Vanderbilt University Medical Center, Nashville, TN, ³Vanderbilt University, Nashville, TN
Background/Purpose: Azathioprine is a widely-used drug for the treatment of rheumatic diseases, inflammatory bowel disease, and for organ transplantation. However, treatment is often limited by…
Abstract Number: 1964 • 2019 ACR/ARP Annual Meeting
A Role for Microbiota in the Pathophysiology of Takayasu Arteritis (TAK) and Giant Cell Arteritis (GCA)
Anne Desbois¹, Dragos Ciocan ², David Saadoun ¹, Gabriel Perlemuter ³ and Patrice Cacoub ⁴, ¹GHPS, Paris, France, ²Hôpital Antoine Beclere, Clamart, France, ³Hôpital Clamart, Paris, France, ⁴AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, F-75013, Paris, France, Paris, France
Background/Purpose: The pathogenesis of Large Vessel Vasculitis (LVV) is not well understood. There is increasing evidence of a close link between intestinal dysbiosis and systemic…
Abstract Number: 1965 • 2019 ACR/ARP Annual Meeting
Determining a Polygenic Risk Score in Pediatric Systemic Lupus Erythematosus
Laura Lewandowski¹, Michael Ombrello ¹, Ivona Aksentijevich ², Zuoming Deng ³, Linda Hiraki ⁴, Earl D. Silverman ⁵, Chris Scott ⁶, Ana Barrera-Vargas ⁷, Sarfaraz Hasni ⁸ and Mariana Kaplan ⁹, ¹NIAMS, NIH, Bethesda, MD, ²NHGRI, NIH, Bethesda, MD, ³Biomining and Discovery Section/NIAMS/NIH, Bethesda, MD, ⁴Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada, ⁵Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, ⁶University of Cape Town, Cape Town, South Africa, ⁷Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Mexico City, Mexico, ⁸NIAMS, National Institutes of Health, Bethesda, MD, ⁹National Institute of Arthritis, Musculoskeletal, and Skin diseases/ National Institutes of Health, Bethesda
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a potentially life-threatening autoimmune disease with no cure. The onset of SLE is thought to be the result of…
Abstract Number: 1966 • 2019 ACR/ARP Annual Meeting
A Genome-Wide Association Study of Copy Number Variations Identifies the Deletion Associated with Efficacy of TNF-Alpha Blocker Therapy in Korean Patients with Rheumatoid Arthritis
Ki-Nam Gu ¹, So-Young Bang², Hye-Soon Lee ³, Youngho Park ², Juyeon Kang ², Ji-Soong Kim ², Bora Nam ², Hyun-Seung Yoo ⁴, Jung-Min Shin ², Yeon-Kyung Lee ², Tae-Han Lee ², Sehwan Chun ¹, Soo-Kyung Cho ², Chan-Bum Choi ², Yoon-Kyoung Sung ⁵, Tae-Hwan Kim ², Jae-Bum Jun ², DaeHyun Yoo ², Kwangwoo Kim ¹ and Sang-Cheol Bae ², ¹Kyung Hee University, Seoul, Republic of Korea, ²Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ³Department of Internal Medicine, Hanyang University Guri Hospital,Hanyang University School of Medicine, Guri, Korea, Guri, Republic of Korea, ⁴Hanyang University Hospital, Guri, Republic of Korea, ⁵Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea
Background/Purpose: Copy number variation (CNV) is the most common structural variation defined as large ( >1 kb) genomic deletions and duplications and could yield a…
Abstract Number: 1967 • 2019 ACR/ARP Annual Meeting
Adenosine A2A Receptor Signals Through AMPK and SIRT1 to Increase Chondrocyte Homeostasis
Benjamin Friedman¹ and Bruce Cronstein ², ¹Department of Medicine, Division of Rheumatology NYUSoM, NYC, ²NYU Langone, New York
Background/Purpose: OA is characterized by loss of cartilage and chondrocyte dysfunction. Our lab has shown CGS21680 (CGS, 1µM) activation of adenosine A2AR leads to chondrocyte…
Abstract Number: 1968 • 2019 ACR/ARP Annual Meeting
A Drug Repurposing Story: New Therapeutic Tools Ready to Block Innate Immune Responses in Osteoarthritis
Eloi Franco-Trepat¹, Ana Alonso-Pérez ¹, Maria Guillán-Fresco ¹, Alberto Jorge-Mora ², Ana Lois Iglesias ³, Oreste Gualillo ⁴ and Rodolfo Gómez ¹, ¹Institute IDIS - Musculoskeletal Pathology Group, Santiago de Compostela, Spain, ²Institute IDIS - Musculoskeletal Pathology Group, Santiago de Compostela, ³Institute IDIS - Musculoskeletal Pathology Group, Santiago de Compostela, Galicia, Spain, ⁴Institute IDIS - NEIRID Lab - SERGAS, Santiago de Compostela, Spain
Background/Purpose: Rheumatic diseases, also known as musculoskeletal pathologies, are steadily rising their prevalence. This worldwide phenomenon is depriving our society of their life quality and…
Abstract Number: 1969 • 2019 ACR/ARP Annual Meeting
FOXO1 Is Required for Human Osteoclast Differentiation
Sabarinadh Chilaka ¹, Yannick Degboe ¹, Iain McInnes ² and Carl Goodyear³, ¹Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Glasgow, Scotland, United Kingdom, ²Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, ³University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Dysregulation of osteoclast differentiation and function is a feature of inflammatory arthropathies (IA). Multiple genes and signalling pathways have been associated with regulation of…
Abstract Number: 1970 • 2019 ACR/ARP Annual Meeting
Mechanism of Chondroprotective Effects of 4-Methylumbelliferone and 2-Deoxyglucose
Kenya Terabe¹, Nobunori Takahashi ¹, Yoshifumi Ohashi ², Toshihisa Kojima ¹, Naoki Ishiguro ¹, Cheryl Knudson ² and Warren Knudson ², ¹Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan, ²East Carolina University, Greenville
Background/Purpose: We recently reported that the inhibitor of hyaluronan (HA) biosynthesis, 4-methylumbelliferone (4-MU) blocked IL-1β activation of MMP13 mRNA and protein expression in human osteoarthritic…
Abstract Number: 1971 • 2019 ACR/ARP Annual Meeting
CD39 Produced from Human Gingiva-Derived Mesenchymal Stem Cells Regulates the Balance of Osteoclasts and Osteoblasts Through Wnt / β-catenin Pathway in Osteoporosis
Wenbin Wu¹, Julie Wang ², feng huang ¹, limin Rong ¹ and Song Guo Zheng ³, ¹Sun Yat-sen University, Guangzhou, ²Ohio State University, columbus, ³Ohio State College of Medicine, Columbus, OH
Background/Purpose: Osteoporosis led to severe bone-related diseases and increased mortality and health care costs. Existing treatments failed to reduce the risk of fractures in patients,…
Abstract Number: 1972 • 2019 ACR/ARP Annual Meeting
Identification of Distinct Lipidomic Profiles in Synovial Membranes from Inflammatory Arthritis by Mass Spectrometry Imaging
Beatriz Rocha¹, Berta Cillero-Pastor ², Cristina Ruiz-Romero ³, Andrea Cuervo ⁴, Ron M A Heeren ², Juan Cañete ⁵ and Francisco J. Blanco ⁶, ¹Proteomics Group-ProteoRed/ISCIII, Grupo de Investigación de Reumatología (GIR), INIBIC – Hospital Universitario de A Coruña, A Coruña, Spain, A Coruña, Galicia, Spain, ²The Maastricht Multimodal Molecular Imaging Institute (M4I), Division of Imaging Mass Spectrometry, Maastricht University, The Netherlands., Maastricht, Limburg, Netherlands, ³Proteomics Group-ProteoRed/ISCIII, CIBER-BBN, Grupo de Investigación de Reumatología (GIR), INIBIC – Hospital Universitario de A Coruña, A Coruña, Spain., A Coruña, Spain, ⁴Arthritis Unit, Rheumatology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain., Barcelona, Catalonia, Spain, ⁵Rheumatology Department, Hospital Clínic and IDIBAPS,, Barcelona, Spain, ⁶Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain
Background/Purpose: Early diagnosis of inflammatory arthritis is associated with improved patient outcomes. However, accurate diagnosis can be challenging because of their complexity and heterogeneous nature.…
Abstract Number: 1973 • 2019 ACR/ARP Annual Meeting
Protective Effects of Intra-Articular Formulated Liraglutide in Osteoarthritis: Preclinical Studies
Francis Berenbaum¹, Coralie Meurot ², Margot Vieubled ², Laure Sudre ³, carole bougault ⁴, revital rattenbach ², celine martin ² and claire jacques ⁵, ¹Sorbonne Université-Inserm CDR Saint-Antoine, AP-HP, Paris, France, ²4P Pharma, Lille, France, ³Sorbonne Université-Inserm CDR Saint-Antoine, paris, France, ⁴Université de Lyon - CNRS, lyon, France, ⁵Sorbonne Université-Inserm CDR Saint-Antoine, Paris
Background/Purpose: Osteoarthritis (OA) is a degenerative joint disease affecting millions of individuals worldwide. Its development has been reported to be associated with cartilage degradation and…
Abstract Number: 1974 • 2019 ACR/ARP Annual Meeting
The Rat Homolog to FX201, a Gene Therapy in Development for the Treatment of Osteoarthritis, Demonstrates Dose-Dependent Decreases in the Severity of Cartilage and Bone Lesions Following Anterior Cruciate Ligament Transection
Rebecca Senter ¹, Rogely Boyce², Monika Chabicovksy ³, Emily Walsh Martin ¹, Geneviève Langevin-Carpentier ⁴ and Neil Bodick ¹, ¹Flexion Therapeutics, Burlington, ²Beechy Ridge ToxPath LLC, Clay, ³MC Toxicology Consulting, Vienna, Austria, ⁴Charles River Laboratories, Senneville, Canada
Background/Purpose: Acute injury to the anterior cruciate ligament (ACL) is a common cause of posttraumatic OA in humans, and ACL transection (ACLT) in rats is…
Abstract Number: 1975 • 2019 ACR/ARP Annual Meeting
Fibrates as Drugs with Senolytic and Autophagic Activity for Osteoarthritis Treatment
Uxia Nogueira-Recalde¹, Irene Lorenzo-Gomez ², Francisco J. Blanco ³, María I. Loza ⁴, Diego Grassi ⁵, Valery Shirinsky ⁶, Ivan Shirinsky ⁶, martin lotz ⁷, Paul D. Robbins ⁸, Eduardo Domínguez ⁴ and Beatriz Carames ², ¹Grupo de Biología del Cartílago, Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain, A Coruña, Spain, ²Grupo de Biología del Cartílago, Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain, A Coruna, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁴Biofarma Research Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Santiago de Compostela, Spain, ⁵Institute for Interdisciplinary Neuroscience (IINS), Bordeaux, Nouvelle-Aquitaine, France, Bordeaux, France, ⁶Scientific Research Institute of Clinical immunology, Novosibirsk, Rusia, Novosibirsk, Russia, ⁷Department of Molecular Medicine. Scripps Research, La Jolla, CA, USA, La Jolla, CA, ⁸Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN
Background/Purpose: . Increasing evidence suggest that osteoarthritis (OA) is associated with hallmarks of ageing, including cellular senescence or defective autophagy, that could promote disease onset.…
Abstract Number: 1976 • 2019 ACR/ARP Annual Meeting
Regulation of Interleukin-1β (IL-1β)-induced COX-2 Expression and IL-6 and MMP-1 Production in Human OA Synovial Fibroblasts by Guanylate Binding Protein 5
Mahamudul Haque¹, Madeline McDougal ¹, Anil Singh ¹ and Salahuddin Ahmed ², ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, SPOKANE, WA, ²Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA. Division of Rheumatology, University of Washington School of Medicine, Seattle, WA, Spokane, WA
Background/Purpose: Osteoarthritis (OA) is a chronic degenerative joint disease caused by synovial inflammation and cartilage degradation primarily driven by interleukin-1beta (IL-1β). Studies suggest that TNF-stimulated…
Abstract Number: 1977 • 2019 ACR/ARP Annual Meeting
The Synthesis of Hydrogen Sulfide Is Impaired in Osteoarthritic Chondrocytes from Diabetic Patients and in Vitro in Cells Under High Glucose Environment
Carlos Vaamonde-García¹, Tamara Hermida-Gómez ², Francisco J. Blanco ³, Elena F Burguera ³ and Rosa Meijide-Faílde ¹, ¹Tissue Engineering and Regenerative Medicine Group. University of A Coruña, A Coruña, Spain, ²Unidad de Bioingeniería Tisular y Terapia Celular (GBTTC-CHUAC). Grupo de Investigación en Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC). Sergas. Centro de Investigaciones Científicas Avanzadas (CICA), A Coruña, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain
Background/Purpose: A growing number of findings indicates that type 2 diabetes is an independent risk factor of osteoarthritis (OA). However, the mechanisms underlying the connection…

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