Abstracts Archive - Page 1070 of 2425 - ACR Meeting Abstracts

Abstract Number: 981 • 2018 ACR/ARHP Annual Meeting
New Consensus on an Updated Core Domain Set for Clinical Trials in Juvenile Idiopathic Arthritis
Esi Morgan¹, Alessandro Consolaro², Jane Munro³, Jennifer Horonjeff⁴, Brian M. Feldman⁵, Hayyah Clairman⁶, Clifton O. Bingham III⁷, Alessandra Alongi⁸, Vibeke Strand⁹, Marion A.J. van Rossum¹⁰, Richard Veselý¹¹, Hermine I. Brunner¹², Daniel Horton¹³, Daniel J Lovell¹⁴, Sarah Ringold¹⁵, Nicola Ruperto¹⁶, Suzanne Schrandt¹⁷, Natalie Jane Shiff¹⁸, Karine Toupin-April¹⁹ and Beverly Shea²⁰, ¹University of Cincinnati, Cincinnati, OH, ²Clinica Pediatrica - Reumatologia, Istituto Giannina Gaslini, Genova, Italy, ³Paediatric Rheumatology, Royal Children's Hospital, Victoria, Australia, ⁴Columbia University Medical Centre, New York, NY, ⁵Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁶Child Health Evaluative Sciences, Hospital for Sick Children, Toronto, ON, Canada, ⁷Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁸University of Genova, Genova, Italy, ⁹Stanford University, Palo Alto, CA, ¹⁰Amsterdam Rheumatology and Immunology Center / Reade, Emma Children’s Hospital Amsterdam Medical Center, Amsterdam, Netherlands, ¹¹Scientific and Regulatory Management Department, European Medicines Agency, London, United Kingdom, ¹²Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ¹³Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ¹⁴Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁵Pediatric Rheumatology, Seattle Children's Hospital, Seattle, WA, ¹⁶Universita di Genova Pediatria II, Genova, Italy, ¹⁷Arthritis Foundation, Saint Paul, MN, ¹⁸Pediatrics, University of Florida, Gainesville, FL, ¹⁹Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada, ²⁰Bruyere Research Institute, Ottawa, ON, Canada
Background/Purpose: The current JIA Core Set (ACR Pediatric 30) to assess efficacy of medications in randomized controlled trials (RCTs) was published in 1997 and developed…
Abstract Number: 982 • 2018 ACR/ARHP Annual Meeting
In the Presence of IL-18, IL-10 but Not IL-6 Induces IFN-γ Production and the Surface Expression of TRAIL on NK Cells
Kojiro Sato, Yoshimi Aizaki, Hiroaki Yazawa and Toshihide Mimura, Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose: Adult-onset Still’s disease (AOSD) is a systemic inflammatory disease, the cause of which is largely unknown. AOSD has been recently classified as one of…
Abstract Number: 983 • 2018 ACR/ARHP Annual Meeting
A MAPK Activated Kinase 2 Inhibitor Attenuates Inflammatory and Destructive Arthritis in Human Ex Vivo Models
Tue Wenzel Kragstrup^1,2, Anders Mellemkjær³, Morten Aagaard Nielsen⁴, Line Dam Heftdal², Marie Iversen³, Peter Schafer⁵ and Bent Deleuran², ¹Randers Regional Hospital, Randers, Denmark, ²Department of Biomedicine, Aarhus University, Aarhus, Denmark, ³Aarhus University, Aarhus, Denmark, ⁴Of Biomedicine, Aarhus University, Aarhus, Denmark, ⁵Celgene Corporation, Summit, NJ
Background/Purpose: Targeting intracellular pathways with oral small molecules is an attractive therapeutic approach for treating immune mediated inflammatory diseases. The mitogen-activated protein kinase (MAPK) pathway…
Abstract Number: 984 • 2018 ACR/ARHP Annual Meeting
Reduced Expression of CX3CR1 in Peripheral CD14++CD16+monocytes Is a Novel Feature of Patients with Systemic Lupus Erythematosus
Keiko Yoshimoto¹, Katsuya Suzuki¹, Shuntaro Saito², Jun Kikuchi¹ and Tsutomu Takeuchi¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama, Japan
Background/Purpose: Fractalkine (FKN, CX3CL1) and its receptor, CX3CR1, play an important role in chemotaxis of immune cells, such as cell adhesion, migration and infiltration into…
Abstract Number: 985 • 2018 ACR/ARHP Annual Meeting
IL-6 and TNF-a Cooperate to Modulate Cell Cycle of RA-FLS Via Cyclin Dependent Kinase 6
Kenta Kaneshiro¹, Kohsuke Yoshida¹, Koto Uchida¹, Alisa Yaekura¹, Ikumi Okumura¹, Koji Tateishi², Yasuhiro Terashima², Nao Shibanuma³, Yoshitada Sakai⁴ and Akira Hashiramoto¹, ¹Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan, ²Dept. of Orthopaedic Surgery, Konan Kakogawa Hospital, Kakogawa, Japan, ³Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, ⁴Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by a tumor-like synovial overgrowth leading to joint destructions. IL-6 and TNF-a play an important…
Abstract Number: 986 • 2018 ACR/ARHP Annual Meeting
Fucosylated Tumor Necrosis Factor α Is Expressed in Rheumatoid Arthritis Synovial Tissues and Is Involved in Monocyte Adhesion
Takeo Isozaki, Shinichiro Nishimi and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan
Background/Purpose: Glycosylation has been reported to associate with tumor invasion and metastasis. Fucosylation is involved in the biological functions of adhesion molecules and growth factor…
Abstract Number: 987 • 2018 ACR/ARHP Annual Meeting
CCL11 Is Involved in Cell Migration in Rheumatoid Arthritis
Kuninobu Wakabayashi, Takeo Isozaki, Shinichiro Nishimi and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan
Background/Purpose: Chemokine C-C motif ligand 11 (CCL11) also known as eotaxin-1 is produced by a variety of cell types. By interacting with C-C chemokine receptor…
Abstract Number: 988 • 2018 ACR/ARHP Annual Meeting
Regulatory T Cells with Skewed Responses and Propionate-Producing Gut Bacteria Increased Simultaneously in Patients with Relapsing Polychondritis
Jun Shimizu¹, Takao Kubota² and Noboru Suzuki³, ¹Department of Immunology and Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ²St. Marianna University School of Medicine, Kawasaki, Japan, ³Department of Immunology and medicine, St. Marianna University School of Medicine, Kawasaki-shi, 216-8511, Japan
Background/Purpose: Several intestinal bacteria produce short-chain fatty acids (SCFA) by the fermentation of dietary fibers. SCFA in the intestine differentiate regulatory T (Treg) cells by…
Abstract Number: 989 • 2018 ACR/ARHP Annual Meeting
Reduction of Serum IL17F and IL22 By IL23p19 Blockade with Guselkumab Is Associated with Improvement in Joint Symptoms in Psoriatic Arthritis
Qingxuan Song, Matthew Loza, Karen Leander, Brittney Scott, Patrick Branigan and Kristen Sweet, Janssen Research & Development, LLC, Spring House, PA
Background/Purpose: Guselkumab (GUS) is a fully human monoclonal antibody that binds to the p19 subunit of IL23. In a recent Phase 2 study, GUS demonstrated…
Abstract Number: 990 • 2018 ACR/ARHP Annual Meeting
Guanylate Binding Protein 5 (GBP5) Inhibits Rheumatoid Arthritis Synovial Fibroblast Mediated Inflammation and Tissue Destruction
Mahamudul Haque¹, Anil K. Singh¹ and Salahuddin Ahmed^1,2, ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ²Division of Rheumatology, University of Washington, Division of Rheumatology, School of Medicine, Seattle, WA
Background/Purpose: Guanylate binding protein 5 (GBP5), an interferon gamma (IFN-γ) inducible protein, helps to defend against invading pathogens. However, its role and properties beyond anti-viral…
Abstract Number: 991 • 2018 ACR/ARHP Annual Meeting
Critical Role of Interleukin-1α (IL-1α) in IL-1β-Induced Inflammatory Responses: Cooperation with NF-κBp65 in Transcriptional Regulation
Anil K. Singh¹, Sabrina Fechtner¹, Mukesh Chourasia², Jerry Sicalo¹ and Salahuddin Ahmed¹, ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ²Department of Pharmacoinformatics,, National lnstitute of Pharmaceutical Education and Research, Hajipur,, India
Background/Purpose: Interleukin-1β (IL-1β) and IL-1α are cytokines of IL-1 family that orchestrate acute and chronic inflammatory diseases. However, their distinct role or the extent of…
Abstract Number: 992 • 2018 ACR/ARHP Annual Meeting
Epigallocatechin-3-Gallate (EGCG) Suppresses Systemic Inflammation By Inhibiting IL-6-Induced STAT3 Activation in Cultured Hepatocytes and in Liver Tissue of Adjuvant-Induced Arthritis (AIA) Rats
Anil K. Singh¹, Sabrina Fechtner², Dorothy Wang², Mukesh Chourasia³ and Salahuddin Ahmed^2,4, ¹Washington State University, College of Pharmacy, Spokane, WA, ²Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ³Department of Pharmacoinformatics,, National lnstitute of Pharmaceutical Education and Research, Hajipur,, India, ⁴Division of Rheumatology, University of Washington, Division of Rheumatology, School of Medicine, Seattle, WA
Background/Purpose: In rheumatoid arthritis (RA), the pro-inflammatory cytokine interleukin-6 (IL-6) induces systemic inflammation by activating hepatocytes through IL-6 receptor (IL-6R)- mediated JAK/STAT3 signaling pathway. The…
Abstract Number: 993 • 2018 ACR/ARHP Annual Meeting
Elucidating the Role of the Lymphatic System in the Pathogenesis of Psoriasis and Psoriatic Arthritis
H. den Braanker^1,2, A Otten-Mus³, P Asmawidjaja⁴, N Davelaar⁵, A.A.E.A. de Smet⁶, G.P. Akkersdijk⁶, B. Fioole⁶, J.B. Jaquet⁷, A. Hofman⁸, O.P. Schuitema⁸, Sander W. Tas⁹, R. Mebius¹⁰, Erik Lubberts⁴, M.R. Kok¹¹ and R.J. Bisoendial¹¹, ¹Rheumatology, Maasstad hospital, Rotterdam, Netherlands, ²Immunology and Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁵Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁶Vascular surgery, Maasstad hospital, Rotterdam, Netherlands, ⁷Maasstad hospital, Rotterdam, Netherlands, ⁸Plastic Surgery, Maasstad hospital, Rotterdam, Netherlands, ⁹Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ¹⁰Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, Netherlands, ¹¹Clinical Immunology and Rheumatology, Maasstad hospital, Rotterdam, Netherlands
Background/Purpose: Psoriasis is a common T-cell driven inflammatory skin disorder that is featured by immune cell infiltration, and vasculopathy of both blood and lymphatic vasculature.…
Abstract Number: 994 • 2018 ACR/ARHP Annual Meeting
Platelet Derived Growth Factor Receptors (PDGFRs) and Their Implication in Inflammatory Arthritis
Bhanupriya Madarampalli¹, Joon Kyung Kim², Paul Panipinto¹, Hannah Labinsky¹ and Vineet Mahajan¹, ¹Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Rheumatoid arthritis (RA) is inflammatory joint disease characterized by immune infiltration and synovial hyperplasia. Hyperplastic synovium contains increased numbers of activated synovial fibroblasts, which…
Abstract Number: 995 • 2018 ACR/ARHP Annual Meeting
Anti-Fractalkine Monoclonal Antibody Inhibits Joint Destruction through Suppression of Osteoclast Precursor Migration and Induces Synovial Cell Death in Collagen-Induced Arthritis Model Mice
Kana Hoshino-Negishi¹, Masayoshi Ohkuro², Tomoya Nakatani¹, Wataru Ikeda¹, Yoshikazu Kuboi¹, Naoto Ishii¹, Nobuyuki Yasuda¹ and Toshio Imai³, ¹KAN Research Institute, Inc., Kobe, Japan, ²Research Project Promotion Group, EA Pharma Co., Ltd., Kawasaki, Japan, ³President & CEO, Chief Scientific Officer, KAN Research Institute, Inc., Kobe, Japan
Background/Purpose: In the Phase 1/2 clinical study, E6011, a novel humanized anti-fractalkine (FKN) mAb demonstrated a promising efficacy in active RA patients who were inadequately…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].