Abstracts Archive - Page 1053 of 2425 - ACR Meeting Abstracts

Abstract Number: 726 • 2018 ACR/ARHP Annual Meeting
Anti-Retinoblastoma Protein Antibody Is Protective Against Lupus Nephritis
Jessica Li¹, Andreas Goules², Daniel Goldman¹, Antony Rosen³, Livia Casciola-Rosen⁴ and Michelle Petri¹, ¹Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Retinoblastoma protein (RB) regulates nucleosome/chromatin structures and is linked to tumor suppression. It regulates the cell cycle by repression of E2F transcription factor and…
Abstract Number: 727 • 2018 ACR/ARHP Annual Meeting
Increased Risk of Coronary Artery Disease Among Patients with Class III Lupus Nephritis: A Retrospective Study of Patients at the University of North Carolina at Chapel Hill
Enid Y Sun¹, Carolina Alvarez² and Saira Z Sheikh³, ¹Internal Medicine, University of North Carolina, Chapel Hill, NC, ²Thurston Arthritis Research Center, Department of Medicine, University of North Carolina, Chapel Hill, NC, ³University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Patients with systemic lupus erythematosus (SLE) are at an increased risk for developing coronary artery disease (CAD) compared to their cohorts without lupus. There…
Abstract Number: 728 • 2018 ACR/ARHP Annual Meeting
A Higher Activity Index at Initial Renal Biopsy Is Associated with Rapid Progression to Renal Failure in Patients with Refractory Lupus Nephritis
Shuwei Wang¹, Stacy Tanner², Teja Kapoor³, Thania Perez⁴, Vivette D D'Agati⁵, Anca Askanase⁴, Robert Winchester³ and Laura Geraldino-Pardilla³, ¹Rheumatology, Columbia University, College of Physicians & Surgeons, New York City, NY, ²Division of Rheumatology, Columbia University, College of Physicians & Surgeons, Winnipeg, DC, Canada, ³Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁴Columbia University, College of Physicians & Surgeons, New York, NY, ⁵Pathology & Cell Biology, Columbia University, College of Physicians & Surgeons, New York City, NY
Background/Purpose: Lupus nephritis (LN) is a major cause of morbidity and mortality affecting ~50% of systemic lupus erythematosus (SLE) patients. Up to 30% of patients…
Abstract Number: 729 • 2018 ACR/ARHP Annual Meeting
Atherosclerotic Vascular Events in SLE – an Evolving Story
Murray Urowitz¹, Jiandong Su¹ and Dafna D Gladman^1,2, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Atherosclerotic vascular events (AVEs) are a major cause of mortality and morbidity in systemic lupus erythematosus (SLE) with a prevalence of 8-12%. We aimed…
Abstract Number: 730 • 2018 ACR/ARHP Annual Meeting
Accrual of Atherosclerotic Vascular Events over 10 Years in a Multicentre Inception SLE Cohort
Murray Urowitz¹, Dafna D Gladman², Nicole Anderson² and Jiandong Su², ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: The prevalence of atherosclerotic vascular events (AVE) in published literature of an inception cohort with SLE is 10%. We aimed to investigate the annual…
Abstract Number: 731 • 2018 ACR/ARHP Annual Meeting
Clinical Characteristics and Neurophysiological Patterns of Peripheral Neuropathies in Patients with Systemic Lupus Erythematosus: A Single Center Experience
Francisco Treviño-Tello¹, Erwin Chiquete², Christopher Cabib², Ariadna Díaz-Mora¹, Mariana Lopez-Lopez¹, Ivonne Sandoval-Flores¹, Juan José Gómez-Piña² and Hilda Fragoso-Loyo¹, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Neurology and Neuropsychiatry, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
Background/Purpose: The prevalence of peripheral neurological manifestations in Systemic Lupus Erythematosus (SLE) ranges between 5% and 27% and are a major cause of morbidity. The…
Abstract Number: 732 • 2018 ACR/ARHP Annual Meeting
Impact of Disease Course on Atherosclerotic Vascular Events, Osteoporosis and Osteonecrosis in Systemic Lupus Erythematosus
Konstantinos Tselios, Dafna D Gladman, Zahi Touma, Jiandong Su, Nicole Anderson and Murray Urowitz, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: We have shown that disease course over time in systemic lupus erythematosus (SLE) follows three distinct patterns (prolonged remission, relapsing remitting and persistently active).…
Abstract Number: 733 • 2018 ACR/ARHP Annual Meeting
Advanced Chronic Kidney Disease in Lupus Nephritis: Factors Leading to Progression
Konstantinos Tselios, Dafna D Gladman, Jiandong Su and Murray Urowitz, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Advanced chronic kidney disease (CKD) carries an increased risk for progression to end-stage renal disease (ESRD) and renal replacement therapy. However, the rate of…
Abstract Number: 734 • 2018 ACR/ARHP Annual Meeting
The Role of Micro-RNA 142-3p Expression in Lupus Nephritis in an Egyptian Cohort
Marwa Elkhalifa¹, Magdy Zehairy¹, Manal Tayel¹, Ahmed Elkeraie², Dalal Elkaffash³ and Nahed Baddour⁴, ¹Internal medicine, Rheumatology, Faculty of medicine, Alexandria University, Egypt, Alexanderia, Egypt, ²Internal medicine, Nephrology, Faculty of medicine, Alexandria University, Egypt, Alexanderia, Egypt, ³Clinical and Chemical Pathology, Faculty of medicine, Alexandria University, Egypt, Alexanderia, Egypt, ⁴Pathology, Faculty of medicine, Alexandria University, Egypt, Alexanderia, Egypt
Background/Purpose: Micro-RNAs play an important role in regulating gene expression at the posttranscriptional level. Recent data have shown that microRNAs are critical for the development…
Abstract Number: 735 • 2018 ACR/ARHP Annual Meeting
Serum Albumin at One Year Predicts Long-Term Renal Outcome
Vinicius Domingues¹, Daniel Goldman², Laurence S Magder³ and Michelle Petri², ¹Medicine, New York University School of Medicine, New York, NY, ²Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD, ³Epidemiology and Public health, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Lupus nephritis remains a major cause of morbidity/mortality in SLE. Our cohort has shown that 20% of SLE patients with lupus nephritis onset…
Abstract Number: 736 • 2018 ACR/ARHP Annual Meeting
Herpes Zoster and Disseminated Zoster in Systemic Lupus Erythematosus and Lupus Nephritis: Incidence Rates in Real-World Claims Data
Katherine Belendiuk¹, Yingjie Ding², Devika Chawla¹ and Matthew Cascino¹, ¹Genentech, Inc., South San Francisco, CA, ²Genesis Research, Hoboken, NJ
Background/Purpose: Disseminated zoster is a highly morbid complication of varicella zoster reactivation (herpes zoster) that is typically associated with immunosuppression. Systemic lupus erythematosus (SLE) and…
Abstract Number: 737 • 2018 ACR/ARHP Annual Meeting
Atherogenic Index of Plasma in Women with Systemic Lupus Erythematosus and Rheumatoid Arthritis: A 10-Year Potential Predictor of Cardiovascular Disease
Nevin Hammam^1,2 and Tamer A Gheita³, ¹University of Alberta, Edmonton, AB, Canada, ²Rheumatology and Rehabilitation Department, Assiut University, Assiut, Egypt, ³Rheumatology Department Faculty of Medicine, Cairo University, Cairo, Egypt
Background/Purpose: Patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are characterized by an increased frequency of cardiovascular diseases (CVD). Early diagnosis of these…
Abstract Number: 738 • 2018 ACR/ARHP Annual Meeting
Two Clinical Phenotypes of Chinese SLE-PAH Patients
Fangfang Sun¹, Wanlong Wu², Li Guo¹, Zhiwei Chen¹, Xiaodong Wang¹, Ting Li¹ and Shuang Ye¹, ¹Rheumatology, Ren Ji Hospital, South Campus, School of Medicine, Shanghai Jiaotong University, Shanghai, China, ²Department of Rheumatology, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Background/Purpose: Pulmonary arterial hypertension (PAH) is a severe complication of systemic lupus erythematosus (SLE), which is the most common underlying disease of CTD associated PAH.…
Abstract Number: 739 • 2018 ACR/ARHP Annual Meeting
Urine and Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) Differentially Correlates with Renal and Non-Renal Systemic Lupus Erythematosus (SLE): A Prospective, Case-Control Study
Yair Molad^1,2, Mohammad Egbaria³, Ariela Dortort-Lazar^4,5, Elisheva Pokroy-Shapira^3,5, Shirly Oren⁴, Yonatan Edel^3,5 and Vitaly Kliminski^5,6, ¹Rheumatology Unit, Rabin Medical Center - Beilinson Campus, Petah-Tiqva, Israel, ²Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel, ³Rheumatology Unit, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel, ⁴Rheumatology Unit, Beilinson Hospital, Rabin Medical Center, Petach Tikva, Israel, ⁵Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁶Laboratory of Inflammation Research, Felsenstein Medical Research Center, Rabin Medical Center, Petach Tikva, Israel
Background/Purpose: Elevated levels of sTREM-1 have been previously found in patients with SLE. A prospective, case-control, longitudinal study aimed to assess the value of urinary…
Abstract Number: 740 • 2018 ACR/ARHP Annual Meeting
Can Monocyte Chemo-Attractant Protein-1differentiate Different Histological Classes in Lupus Nephritis?
Varun Dhir¹, Ranjeeth Kumar Gone², Amit Sandhu³, Aman Sharma⁴, Shefali Sharma⁵, Ritambhra Nada², Sanjay Jain⁶ and Manish Rathi⁷, ¹Internal Medicine (Rheumatology Unit), Postgraduate Institute of Medical Education and Research, Chandigarh, India, Chandigarh, India, ²Postgraduate Institute of Medical Education and Research, Chandigarh, India, ³Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, ⁴Clinical Immunology and Rheumatology Services, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, Chandigarh, India, ⁵Postgraduate Institute of Medical Education and Research, Chandigarh, India, Chandigarh, India, ⁶Postgraduate Institute of Medical Education and Research, Chandigarh, India, CHANDIGARH, India, ⁷Department of Nephrology,, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Background/Purpose: Lupus Nephritis one of the commonest manifestations of SLE. Despite being the gold standard in Lupus nephritis, renal biopsy is an invasive procedure with…

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