ACR Meeting Abstracts

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  • Abstract Number: 621 • 2018 ACR/ARHP Annual Meeting

    Practical Optimization of Methotrexate Dose Improves Disease Control of Rheumatoid Arthritis Despite Reduction or Discontinuation of Oral Glucocorticoids

    Shintaro Hirata1, Kei Araki1, Hiroki Kohno1, Kazutoshi Yukawa1, Tadahiro Tokunaga1, Tatsuomi Kuranobu1, Katsuhiro Oi1, Yusuke Yoshida1, Tomohiro Sugimoto1, Keisuke Oda1,2, Takaki Nojima1,3 and Eiji Sugiyama1, 1Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan, 2Hiroshima Clinic, Hiroshima, Japan, 3Nojima Internal Medicine Clinic, Hiroshima, Japan

    Background/Purpose: Short-term glucocorticoids (GCs) along with methotrexate (MTX) has been recommended for newly onset patients with rheumatoid arthritis (RA) in EULAR recommendation 2016. However, it…
  • Abstract Number: 622 • 2018 ACR/ARHP Annual Meeting

    DMARD Withdrawal in RA Patients Achieving Therapeutic Response with Certolizumab Pegol Combined with Dmards: Results from a Canadian Randomized Study

    Janet E. Pope1, Emmanouil Rampakakis2, Julie Vaillancourt2, Eric Grant3, Louis Bessette4, Juris Lazovskis5, Boulos Haraoui6 and John S. Sampalis7, 1Department of Medicine, University of Western Ontario, London, ON, Canada, 2JSS Medical Research, Montreal, QC, Canada, 3Private Practice, Saint John, NB, Canada, 4Laval University, Québec, QC, Canada, 5Riverside Professional Centre, Sydney, NS, Canada, 6Institut de Rhumatologie de Montreal, Montreal, QC, Canada, 7McGill University, Montreal, QC, Canada

    Background/Purpose: The efficacy and safety of certolizumab pegol (CZP) in the treatment of adult patients with moderate to severe rheumatoid arthritis (RA), when administered either…
  • Abstract Number: 623 • 2018 ACR/ARHP Annual Meeting

    Step-Down-Bridge Versus Tight-Step-up Therapy in Patients with Early Rheumatoid Arthritis Lacking Poor Prognostic Factors: An Economic Point of View

    Sofia Pazmino1, René Westhovens2, Veerle Stouten1, Johan Joly3, Kristien Van der Elst3, Diederik De Cock4 and Patrick Verschueren3, 1KU Leuven Department of Development and Regeneration, Skeletal Biology and Engineering Research Center, Leuven, Belgium, 2Rheumatology, University Hospital KU Leuven, Leuven, Belgium, 3University Hospitals Leuven on behalf of the CareRA Study Group, Leuven, Belgium, 4Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: In the Care in early RA (CareRA) trial, COBRA Slim, a combination of methotrexate (MTX) with a moderate-dose prednisone step-down-bridge scheme, showed a positive…
  • Abstract Number: 624 • 2018 ACR/ARHP Annual Meeting

    Easy Accessibility of Biologics and Its Impact on Disease Activity and Quality of Life in Kuwaiti Patients with Rheumatoid Arthritis

    Adeeba Al-Herz1, Khulood Saleh2, Adel Al-Awadhi3, Waleed Al-Kandari2, Eman Hasan4, Aqeel Ghanem5, Yaser Ali5, Hebah Alhajeri6, Sawsan Hayat5, Ali Aldei7, Mohammad Hussain4, Ibrahim Nahar5, Fatemah Abutiban8, Ahmad Alenizi8, Khaled Mokaddem1, Ahmad Khadrawy2, Ammad Fazal2, Agaz Zaman5, Ghada Mazloum5, Youssef Bartella1, Sally Hamed1, Ramia Alsouk8 and Ahmed Al-Saber9, 1Rheumatology, Al-Amiri Hospital, Kuwait city, Kuwait, 2Rheumatology, Farwania Hospital, Farwania, Kuwait, 3Faculty of Medicine, Kuwait, Kuwait, 4Al-Amiri Hospital, Kuwait city, Kuwait, 5Rheumatology, Mubarak Al-Kabeer Hospital, Hawally, Kuwait, 6Division of Rheumatology, Mubarak Al-Kabeer Hospital, hawalli, Kuwait, 7Rheumatology, Al-Amiri Hospital, Kuwait City, Kuwait, 8Rheumatology, Jahra Hospital, Jahra, Kuwait, 9Department of Mathematics, Kuwait Technical College, Kuwait city, Kuwait

    Background/Purpose: Prescribing biologics for patients with rheumatoid arthritis (RA) may be restricted by many factors other than the physician’s clinical judgment. In Kuwait, patients with…
  • Abstract Number: 625 • 2018 ACR/ARHP Annual Meeting

    Tapering of Biological Antirheumatic Drugs in Rheumatoid Arthritis Patients Is Achievable and Cost Effective in Daily Clinical Practice: DATA from the Brussels UCL RA Cohort

    Stéphanie Dierckx1, Bernard R. Lauwerys2, Tatiana Sokolova1, Laurent Meric de Bellefon1, Maria Stoenoiu1, Adrien Nzeusseu Toukap3, Frédéric A. Houssiau2, Aleksandra Avramovska1 and Patrick Durez1, 1Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, 2Pôle de pathologies rhumatismales systémiques et inflammatoires, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, 3Department of Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium

    Background/Purpose: Several studies have demonstrated that Rheumatoid Arthritis (RA) patients achieving low disease activity or remission are able to taper biological disease-modifying antirheumatic drugs (bDMARDs).…
  • Abstract Number: 626 • 2018 ACR/ARHP Annual Meeting

    The Comparative Effectiveness of Cycling Tumor Necrosis Factor Inhibitor (TNFi) Versus Swapping to a Nontnfi on Patient-Reported Functional Ability of Patients with Rheumatoid Arthritis

    Maria A. Lopez-Olivo1, Aliza Matusevich2, Scott B. Cantor3, Gregory Pratt4 and Maria Suarez-Almazor5, 1Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX, 3Department of Health Services Research, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX, 4Research Medical Library, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX, 5Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA, Houston, TX

    Background/Purpose: Data on patient-reported functional ability to evaluate the optimal strategy for patients who have failed to first TNFi is scarce. Patient-reported outcomes are a…
  • Abstract Number: 627 • 2018 ACR/ARHP Annual Meeting

    Corticosteroid Utilization before and after Initiation of Biologic Dmards between Patients with Rheumatoid Arthritis

    Burcu Yagız1, Belkıs Nihan Coşkun2, Sedat Kiraz3, Ihsan Ertenli4, Orhan Kucuksahin5, Ediz Dalkiliç6, Cemal Bes7, Nilufer Alpay Kanitez8, Timucin Kasifoglu9, Hakan Emmungil10, Pamir Atagunduz11, Suleyman Serdar Koca12, Muhammet Cinar13, Aşkın Ateş14, Servet Akar15, Onay Gercik16, Duygu Ersozlu Bakirli17, Veli Yazisiz18, Gezmis Kimyon19, Nazife Sule Yasar Bilge20, Muge Aydin Tufan21, Ridvan Mercan22, Burak Oz12, Zeynel Abidin Akar12, Omer Karadag23, Bahar Kelesoglu24, Sedat Yılmaz25, Sezin Turan26, Yavuz Pehlivan2, Ender Terzioglu27, Levent Kilic23, Sukran Erten28, Koray Tascilar29 and Umut Kalyoncu30, 1Rheumatology, Uludag University, School of Medicine, Bursa, Turkey, 2Rheumatology, Uludag University Faculty of Medicine, Bursa, Turkey, 3Rheumatology, Hacettepe University, Faculty of Medicine, Ankara, Turkey, 4Hacettepe University Vasculitis Center (HUVAC), Ankara, Turkey, 5Rheumatology, Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey, 6Department of Internal Medicine, Division of Rheumatology, Uludağ University Faculty of Medicine, Bursa, Turkey, 7Department of Rheumatology, Health Sciences University Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey, 8Rheumatology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey, 9Department of Internal Medicine, Division of Rheumatology, Eskisehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey, 10Department of Internal Medicine, Division of Rheumatology, Trakya University Faculty of Medicine, Edirne, Turkey, 11Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 12Rheumatology, Firat University Faculty of Medicine, Elazığ, Turkey, 13Division of Rheumatology, Gülhane Military Medical Academy, School of Medicine, Ankara, Turkey, 14Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey, 15Department of Internal Medicine, Division of Rheumatology,, Izmir Katip Çelebi University Faculty of Medicine, Izmir, Turkey, 16Rheumatology, Izmir Katip Celebi University School of Medicine, Izmir, Turkey, 17PsART study group, Adana, Turkey, 18Rheumatology, Akdeniz University Faculty of Medicine, Antalya, Turkey, 19Rheumatology, Hatay Mustafa Kemal University Faculty of Medicine, Hatay, Turkey, 20Rheumatology, Eskisehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey, 21Rheumatology, Cukurova University School of Medicine, Adana, Turkey, 22Internal Medicine-Rheumatology, Gazi University Medical School, Ankara, Turkey, 23Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 24Rheumatology, Ankara University, Ankara, Turkey, 25Division of Rheumatology, Gülhane Military Medical Academy, Faculty of Medicine, Ankara, Turkey, 26Trakya University Medical Faculty, Edirne, Turkey, 27Division of Rheumatology, Akdeniz University Faculty of Medicine, Antalya, Turkey, 28PsART study group, Ankara, Turkey, 29Rheumatology, Okmeydani Research and Training Hospital, Istanbul, Turkey, 30Department of Internal Medicine, Divison of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory, systemic autoimmune disease that causes several health problems, such as pain, joint destruction and loss of function.…
  • Abstract Number: 628 • 2018 ACR/ARHP Annual Meeting

    Longitudinal Changes in Relative Market Share Proportions of Biologic and Targeted Synthetic Disease-Modifying Anti-Rheumatic Drugs for Treatment of Rheumatoid Arthritis: Descriptive Data from the Ontario Best-Practice Research Initiative Database

    Elliot Hepworth1, Mohammad Movahedi2, Emmanouil Rampakakis3, Reza Mirza1, Arthur Lau4, Angela Cesta5, Janet E. Pope6 and Claire Bombardier7, 1Department of Internal Medicine, McMaster University, Hamilton, ON, Canada, 2JSS Medical Research, St-Laurent, QC, Canada, 3JSS Medical Research, Montreal, QC, Canada, 450 Charlton Avenue East, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 5Ontario Best Practices Research Initiative, University Health Network, Toronto, ON, Canada, 6Department of Medicine, University of Western Ontario, London, ON, Canada, 7Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada

    Background/Purpose: For patients with Rheumatoid Arthritis (RA) who do not achieve adequate clinical response with combined conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs), the next…
  • Abstract Number: 629 • 2018 ACR/ARHP Annual Meeting

    Real-World Use of Tofacitinib Compared with Tumor Necrosis Factor Inhibitors in a Cohort of 211 Patients with Rheumatoid Arthritis: Data from a Drug-Based Registry Study in Taiwan

    Song-Chou Hsieh1, Yi-Hsing Chen2, Wei-Sheng Chen3, Wen-Chan Tsai4, Jui-Chieh Hu5, Hsiang-Cheng Chen6, Jack Mardekian7 and Chacun Lai8, 1National Taiwan University Hospital, Taipei, Taiwan, 2Taichung Veterans General Hospital, Taichung City, Taiwan, 3Taipei Veterans General Hospital, Taipei, Taiwan, 4Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, 5Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 6National Defense Medical Center & Tri-Services General Hospital, Taipei, Taiwan, 7Pfizer Global Biometrics & Data Management, NY, NY, 8Pfizer PFE Limited, New Taipei, Taiwan

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. Tofacitinib was approved in December 2014 for RA under Taiwan’s National Health…
  • Abstract Number: 630 • 2018 ACR/ARHP Annual Meeting

    Is Treatment Adherence of RA Patients to Injectable MTX Influenced By Previous MTX Route of Administration?

    René-Marc Flipo1, Eric Senbel2, Sonia Tropé3, Elena Zinovieva4, Agnès Courbeyrette5 and Hélène Herman-Demars4, 1Hôpital Roger Salengro, Lille, France, 2Rheumatology office, Marseille, France, 3149 avenue du Maine, ANDAR, Paris, France, 4Medical Department Nordic Pharma, Paris, France, 5Medical Departement, Nordic Pharma, Paris, France

    Background/Purpose: Previous studies have shown, that switching from oral to subcutaneous (SC) MTX can lead to improved efficacy and bioavailability (especially for doses ≥15mg/wk) as…
  • Abstract Number: 631 • 2018 ACR/ARHP Annual Meeting

    A Self-Determination Theory Based Intervention to Promote Autonomous Motivation for, and Engagement in Physical Activity in Rheumatoid Arthritis: Theoretical Process Evaluation of a Randomised Controlled Trial

    Sally A.M. Fenton1,2, Jet J.C.S. Veldhuijzen van Zanten1,2, George S. Metsios2,3, Peter C. Rouse4, Nikos Ntoumanis5, Chen-An Yu6, George D. Kitas1,2,7 and Joan L. Duda1, 1School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom, 2Department of Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom, 3Faculty of Education Health & Wellbeing, University of Wolverhampton, Walsall, United Kingdom, 4Department for Health, University of Bath, Bath, United Kingdom, 5Faculty of Health Sciences, School of Psychology, Curtin University, Perth, Australia, 6Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom, 7Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, United Kingdom

    Background/Purpose: Moderate-to-vigorous physical activity (MVPA) is recommended for the treatment and management of physical and psychological health in Rheumatoid Arthritis (RA). However, most people living…
  • Abstract Number: 632 • 2018 ACR/ARHP Annual Meeting

    Interpretation of Symptoms Should Take into Account Gender in Psoriatic Arthritis: An Analysis of 451 Patients

    Clémence Gorlier1, Laure Gossec2, Deborah Puyraimond-Zemmour1, Laura C. Coates3, Uta Kiltz4, Ying Ying Leung5, Penelope Palominos6, Juan D. Cañete7, Rossana Scrivo8, Andra Rodica Balanescu9, Emmanuelle Dernis10, Sandra Tälli11, Adeline Ruyssen-Witrand12, Martin Soubrier13, Sibel Zehra Aydın14, Lihi Eder15, Inna Gaydukova16, Ennio Lubrano17, Pascal Richette18, M. Elaine Husni19, Maarten de Wit20, Josef S. Smolen21 and Ana-Maria Orbai22, 1Sorbonne Université, PARIS, France, 2Rhumatologie, Médecine Sorbonne Université, Pitié-Salpétrière Hospital, Paris, France, 3University of Oxford, Oxford, United Kingdom, 4Rheumatology, Rheumazentrum Ruhrgebiet, Herne, and Ruhr University Bochum, Herne, Germany, 5Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore, 6Rheumatology, Hospital de Clinicas de Porto Alegre, Santa Cecilia, Brazil, 7Rheumatology, Hospital Clinic and IDIBAPS, Barcelona, Spain, 8Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy, 9Department of Internal Medicine and Rheumatology “Sf. Maria” Hospital, Bucharest, Romania, 10Service de Rhumatologie, CH du Mans, Le Mans, France, 11East-Tallinn Central Hospital, Department of Rheumatology, Tallinn, Estonia, 12Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, 13Rheumatology, Department of Rheumatology, CHU Gabriel Montpied, Clermont-Ferrand, France, 14University of Ottawa, Ottawa, ON, Canada, 15Women's College Research Institute, University of Toronto, Women's College Hospital, Toronto, ON, Canada, 16North-western state medical university n.a. II Mechnikov, St. Petersburg, Russian Federation, 17Department of Medicine and Health Sciences Vincenzo Tiberio, University of Molise, Campobasso, Italy, 18Rheumatology, Université Paris Diderot, Paris, France, 19Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, 20Dept. Medical Humanities, Amsterdam Public Health (APH), VU University Medical Centre, Amsterdam, Netherlands, 21Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, 22Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Treatments targets in psoriatic arthritis (PsA) are remission (REM) or Low Disease Activity (LDA) which are usually defined based on objective disease activity but…
  • Abstract Number: 633 • 2018 ACR/ARHP Annual Meeting

    The Effect of Guselkumab on Dactylitis: Results from a Phase 2 Study in Patients with Active Psoriatic Arthritis

    Dafna D Gladman1, Wolf-Henning Boehncke2, Alice B Gottlieb3, Philip Helliwell4, Peter Nash5, Xie L. Xu6, Stephen Xu6, Yuhua Wang6, Elizabeth C Hsia6,7, Chetan S Karyekar6 and Atul A. Deodhar8, 1Krembil Research Institute, U of Toronto, Toronto, ON, Canada, 2U of Geneva, Geneva, Switzerland, 3NY Medical College, Metropolitan Hospital, NY, NY, 4U of Leeds, Leeds, United Kingdom, 5U of Queensland, Brisbane, Australia, 6Janssen Research & Development, LLC, Spring House, PA, 7U Penn School of Medicine, Phila, PA, 8Oregon Health & Science University, Portland, OR

    Background/Purpose: In a Ph2 study, GUS was shown to be safe&effective in pts w/active PsA. We evaluated effect of GUS on dactylitis in subset of…
  • Abstract Number: 634 • 2018 ACR/ARHP Annual Meeting

    Spinal Mobility Measures Allow Discrimination of Subgroups of Different Activity and Severity in Early Axial Spondyloarthritis

    Mary Lucy Marques1,2, Sofia Ramiro2,3, Floris van Gaalen2, Philippe Goupille4, Maxime Dougados5 and Désirée van der Heijde6, 1Rheumatology, Centro Hospitalar e Universitário de Coimbra, Portugal & Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Zuyderland Medical Center, Heerlen & Leiden University Medical Center, Leiden, Netherlands, 4Université François-Rabelais, Tours, France, 5Department of Rheumatology, Paris Descartes University and Cochin Hospital, Paris, France, 6Leiden University Medical Centre, Leiden, Netherlands

    Background/Purpose: Spinal mobility has been mostly investigated in cohorts of patients with established AS. However, it was scarcely studied in the early phases of the…
  • Abstract Number: 635 • 2018 ACR/ARHP Annual Meeting

    Measuring Spinal Mobility over Time in Early Axial Spondyloarthritis: Can We Do It Reliably?

    Mary Lucy Marques1,2, Sofia Ramiro3,4, Floris van Gaalen2, Philippe Goupille5, Maxime Dougados6 and Désirée van der Heijde7, 1Rheumatology, Centro Hospitalar e Universitário de Coimbra, Portugal & Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, 4Zuyderland Medical Center, Heerlen & Leiden University Medical Center, Leiden, Netherlands, 5Université François-Rabelais, Tours, France, 6Department of Rheumatology, Paris Descartes University and Cochin Hospital, Paris, France, 7Leiden University Medical Centre, Leiden, Netherlands

    Background/Purpose: The use of spinal mobility measures (SMMs), at the individual level and in the follow-up of patients with early axSpA has not yet been…
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