Abstracts Archive - Page 1046 of 2607 - ACR Meeting Abstracts

Abstract Number: 1588 • 2019 ACR/ARP Annual Meeting
Disease Activity and Dysregulated Iron Metabolism: A Potentially Overlooked Mechanism for Anaemia in Patients with Systemic Lupus Erythematosus?
Chris Wincup¹, Thomas McDonnell ¹, George Robinson ¹, Filipa Farinha ¹, Anna Radziszewska ¹ and Anisur Rahman ¹, ¹University College London, London, United Kingdom
Background/Purpose: Haematological manifestations of SLE are common with anaemia reported in approximately 50% of cases, yet the role of altered iron metabolism is poorly understood.…
Abstract Number: 1589 • 2019 ACR/ARP Annual Meeting
Prevalence of Cognitive Impairment in an Inception Lupus Cohort as Assessed by a Comprehensive Neuropsychological Battery
Bahar Moghaddam¹, Dorcas Beaton ², Robin Green ³, Maria Tartaglia ⁴, Lesley Ruttan ³, Mahta Kakvan ⁵, Marvin Fritzler ⁶, May Choi ⁶, Moe Zandy ⁵, Jiandong Su ⁵, Michelle Vitti ⁷, Dennisse Bonilla ⁵, Joan Wither ⁸, Sabrina Lombardi ³ and Zahi Touma ⁵, ¹University of Toronto, Toronto, ON, Canada, ²St. Michael's Hospital, Toronto, ON, Canada, ³University Health Network, Toronto, ON, Canada, ⁴University Health Network, University of Toronto, Toronto, ON, Canada, ⁵University Health Network, University of Toronto, Toronto, ON, Canada, ⁶Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁷University Health Network/University of Toronto, Toronto, NU, Canada, ⁸University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: Systemic Lupus Erythematosus (SLE) can lead to a number of neuropsychiatric manifestations including cognitive impairment (CI). Previous meta-analyses have reported the prevalence of CI…
Abstract Number: 1590 • 2019 ACR/ARP Annual Meeting
Clinical and Sociodemographic Associates of Depression and Anxiety in Systemic Lupus Erythematosus
David Eldeiry¹, Moe Zandy ², Oshrat Tayer-Shifman ², Andrew Kwan ³, Sherief Marzouk ², Jiandong Su ², Kathleen Bingham ² and Zahi Touma ², ¹Royal College of Surgeons in Ireland, Dublin, Ireland, ²University Health Network, University of Toronto, Toronto, ON, Canada, ³Queens University, Kingston, ON, Canada
Background/Purpose: In our recent systematic review, we have shown a high prevalence for depression (35%) and anxiety (25.8%) in Systemic Lupus Erythematosus (SLE)1. A better…
Abstract Number: 1591 • 2019 ACR/ARP Annual Meeting
Anti-ovarian Antibodies Are Not Associated with Premature Menopause in SLE Treated with Cyclophophosphamide
Martha Tsaliki ¹, Kristi Koelsch ¹, Ambre Chambers ¹, Mitali Talsania ², Eliza Chakravarty ³ and Robert Scofield³, ¹University of Oklahoma health Sciences Center, Oklahoma City, OK, ²University of Oklahoma Health Sciences Center, Oklahoam City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Treatment of systemic lupus erythematosus (SLE) with cyclophosphamide is associated with premature menopause, especially those at an older age of treatment and those receiving…
Abstract Number: 1592 • 2019 ACR/ARP Annual Meeting
Defining the SLE-Associated Pulmonary Arterial Hypertension Phenotype
Marisa Mizus¹, Jessica Li ¹, Daniel Goldman ² and Michelle Petri ¹, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Pulmonary arterial hypertension (PAH) is a leading cause of death in SLE patients. Hypocomplementemia, antiphospholipid antibodies, and elevated antibodies to RNP and Ro are…
Abstract Number: 1593 • 2019 ACR/ARP Annual Meeting
Heart Rate Visit-to-Visit Variability in Patients with Systemic Lupus Erythematosus Is Associated with Increased Mortality
Tyler Reese¹, Alyson Dickson ¹, Jocelyn Gandelman ¹, Sarah Bayefsky ¹, April Barnado ¹, Katherine Barker ¹, C. Michael Stein ¹, Vivian Kawai ¹ and Cecilia Chung ¹, ¹Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have increased mortality compared to the general population. Heart rate visit-to-visit variability (HRVVV) has emerged as an adverse…
Abstract Number: 1594 • 2019 ACR/ARP Annual Meeting
High Expression of CD38 on CD8 T Cells Predicts Increased Burden of Infections in Patients with SLE
Lama Mulki¹, Abel Suarez-Fueyo ², Eri Katsuyama ², Vasileios Kyttaris ² and George Tsokos ², ¹Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, ²Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: We have previously reported that CD38 gene expression in the peripheral blood T cell from patients with SLE is increased. CD8+CD38+ T cells have…
Abstract Number: 1595 • 2019 ACR/ARP Annual Meeting
Role of Aerobic Exercise in Modulating Fatigue in Women with Systemic Lupus Erythematosus
Marquis Chapman ¹, Sarthak Gupta², Jun Chu ¹, Mohammad Naqi ³, Zerai Manna ³, Mir Ali Mazhar ¹, Adam Munday ¹, Marybeth Stockman ⁴, Bart Dinkard ⁴, Lisa Chin ⁴, Mariana Kaplan ¹, Randall Keyser ⁵, Leighton Chan ⁴ and Sarfaraz Hasni ⁶, ¹National Institute of Arthritis, Musculoskeletal, and Skin diseases/ National Institutes of Health, Bethesda, ²Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, ³NIAMS/NIH, Bethesda, ⁴Rehabilitation Medicine Department, Clinical Center, NIH, Bethesda, ⁵Department of Rehabilitation Science, George Mason University, Bethesda, ⁶National Institute of Arthritis, Musculoskeletal, and Skin diseases/ National Institutes of Health, Bethesda, MD
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that predominantly afflicts women. One of the most debilitating symptoms experienced by SLE patients is…
Abstract Number: 1596 • 2019 ACR/ARP Annual Meeting
Assessing the Validity of QRISK3 at Predicting Cardiovascular Events in Systemic Lupus Erythematosus Patients
Lisa Zhu¹, Manpreet Singh ¹, Sonia Lele ¹, Mei Liang ², Lori Sahakian ¹, Jennifer Grossman ¹ and Maureen McMahon ¹, ¹UCLA David Geffen School of Medicine, Los Angeles, CA, ²Williams College, Williamstown, MA
Background/Purpose: It has been well established that patients with systemic lupus erythematosus (SLE) have an increased risk of developing cardiovascular disease (CVD). Traditional CVD risk…
Abstract Number: 1597 • 2019 ACR/ARP Annual Meeting
Assessing Long-term Poor Outcomes in Systemic Lupus Erythematosus Patients with Acute Coronary Syndromes
Paramjit Singh¹, ¹Kaiser Permanente Fontana, Fontana
Background/Purpose: Systemic lupus erythematosus (SLE) is a significant risk factor for coronary atherosclerosis, independent of the classic risk factors. Previous studies have found poor acute…
Abstract Number: 1598 • 2019 ACR/ARP Annual Meeting
Disability Among Subtypes of SLE
Jennifer Rogers¹, Raeann Whitney ¹, Megan Clowse ¹, Lisa Criscione-Schreiber ¹, Jayanth Doss ¹, David Pisetsky ², Rebecca Sadun ¹, Kai Sun ¹ and Amanda Eudy ¹, ¹Duke University, Durham, ²Duke University, Durham VAMC, Durham
Background/Purpose: The rate of medical disability among patient with systemic lupus erythematosus (SLE) ranges from 20-40% and is associated with a number of socioeconomic, disease-related…
Abstract Number: 1599 • 2019 ACR/ARP Annual Meeting
The Impact of Body Mass Index Variability in Systemic Lupus Erythematosus
Xuan Gao¹, Tejal Vashi ¹ and S Sam Lim ², ¹Emory University School of Medicine, Atlanta, GA, ²Emory University, Atlanta, GA
Background/Purpose: SLE is a chronic illness that carries both a physical and psychosocial burden, where the cumulative impact can lead to worse global outcomes. One…
Abstract Number: 1600 • 2019 ACR/ARP Annual Meeting
Frailty and Sarcopenia in Women with Systemic Lupus Erythematosus
Sarah Lieber¹, Stephen Paget ², Jessica Berman ¹, Medha Barbhaiya ³, Lisa Sammaritano ², Kyriakos Kirou ², John Carrino ², Dina Sheira ⁴, Jackie Finik ⁴ and Lisa Mandl ⁵, ¹Hospital for Special Surgery, New York, ²Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁴Hospital for Special Surgery, New York, NY, New York, NY, ⁵Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, New York, NY
Background/Purpose: Frailty is a clinical phenotype that increases with age. However, frailty can occur in younger patients with chronic disease, including SLE. Based on few…
Abstract Number: 1601 • 2019 ACR/ARP Annual Meeting
Prevalence of Peripheral Neuropathy and Its Electrophysiological Types in Patients with Systemic Lupus Erythematosus
Cynthia Matilda Wendo¹, George Oyoo ¹, Thomas Otieno Kwasa ¹, Marybeth Maritim ¹, Sybil Nakitare ² and Judith Kwasa ¹, ¹University of Nairobi, Nairobi, Kenya, ²Kenyatta National Hospital, Nairobi, Kenya
Background/Purpose: Peripheral neuropathy (PN), one of the neuropsychiatric syndromes of SLE, occurs in 2% to 36% of patients. It has been associated with high disease…
Abstract Number: 1602 • 2019 ACR/ARP Annual Meeting
Persistency in Platelet C4d and Thrombosis Risk Score Associate with Thrombosis in Systemic Lupus Erythematosus
Michelle Petri¹, John Conklin ², Tyler O'Malley ³, Jo-Anne Ligayon ², Leilani Wolover ² and Thierry Dervieux ², ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Exagen, Vista, CA, ³Exagen, Oceanside, CA
Background/Purpose: A thrombosis risk score containing abnormal Platelet-bound C4d (PC4d), low complement C3 and abnormal anti-phosphatidyl serine prothrombin (PS/PT) IgG antibody has been shown to…

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