Abstracts Archive - Page 1009 of 2425 - ACR Meeting Abstracts

Abstract Number: 64 • 2018 ACR/ARHP Annual Meeting
Dietary Magnesium Modulates the Intestinal Microbiome and T Cell Subsets
Teresina Laragione¹, Carolyn Harris¹ and Percio S. Gulko², ¹Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, ²Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Several studies have demonstrated that Magnesium (Mg) has a key role in the immune responses. Our previous studies showed that a short-term low Mg…
Abstract Number: 65 • 2018 ACR/ARHP Annual Meeting
Bacteria-Derived Indole Drives Autoimmune Arthritis By Altering B Cell Glycosylation of Autoantibodies
Widian Jubair¹, Erica Alexeev², Timothy Lemke³, Meagan Chriswell¹, Sean Colgan² and Kristine A Kuhn^1,2, ¹Rheumatology, University of Colorado Denver, Aurora, CO, ²Mucosal Inflammation Program, University of Colorado Denver, Aurora, CO, ³University of Colorado Denver, Aurora, CO
Background/Purpose: Ongoing studies in rheumatoid arthritis (RA) implicate intestinal dysbiosis of bacteria as a contributing factor, though the mechanism(s) by which bacteria influence disease is…
Abstract Number: 66 • 2018 ACR/ARHP Annual Meeting
Suppression of Inflammatory Arthritis, in Human Paraoxonase 1 Transgenic Mice, Correlates with Upregulation of the Hepatic Glutathione Pathway and Reduction of Bioactive Lipid Mediators
Christina Charles-Schoeman¹, Ani Shahbazian², Jennifer Wang³, Xiaoyan Wang², Ernest Brahn², Jeremy Papesh², Victor Grijalva⁴ and Srinivasa T. Reddy², ¹Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ²University of California, Los Angeles, Los Angeles, CA, ³University of California Los Angeles, Los Angeles, CA, ⁴Medicine-Cardiology, University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Paraoxonase 1 (PON1) is an HDL-associated protein, which hydrolyzes biologically active oxidized phospholipids and prevents oxidation of lipids in LDL and HDL. Increased lipid…
Abstract Number: 67 • 2018 ACR/ARHP Annual Meeting
Intestinal Inflammation and Netosis Associate with the Presence of Stool IgA ACPA in Subjects at-Risk for RA
Widian Jubair¹, Elizabeth A. Bemis², Yuko Okamoto³, Marie L. Feser³, Jennifer Seifert³, M. Kristen Demoruelle³, Jill M. Norris⁴, Kevin D. Deane³, V. Michael Holers⁵ and Kristine A Kuhn^1,6, ¹Rheumatology, University of Colorado Denver, Aurora, CO, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Division of Rheumatology, University of Colorado Denver, Aurora, CO, ⁴Department of Epidemiology, Colorado School of Public Health, Aurora, CO, ⁵Rheumatology Division, University of Colorado Denver, Aurora, CO, ⁶Mucosal Inflammation Program, University of Colorado Denver, Aurora, CO
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) and inflammation characterized by neutrophil extracellular trap (NET)osis have been detected at mucosal sites such as the lung and periodontium…
Abstract Number: 68 • 2018 ACR/ARHP Annual Meeting
A Genome-Wide Association Study Identifies rs116199914 As an Intergenic Variant Associated with Carotid Intima-Media Thickness in Spanish Patients with Rheumatoid Arthritis
Raquel Lopez-Mejías¹, Fernanda Genre¹, Sara Remuzgo-Martínez¹, David Carmona^2,3, Verónica Pulito-Cueto¹, Carlos González-Juanatey⁴, Alfonso Corrales¹, Esther Vicente⁵, Jose A. Miranda-Filloy⁶, Beatriz-Segura Tejera⁷, Marco A. Ramírez Huaranga⁸, Verónica Mijares¹, Leticia Lera-Gomez¹, Ricardo Blanco¹, Montserrat Robustillo-Villarino⁹, Javier Rodríguez-Carrio¹⁰, Ana Suárez¹⁰, Mercedes Alperi-López¹¹, Francisco Javier Ballina-García¹², Francisco Javier López Longo¹³, Francisco Javier Narváez¹⁴, Juan José Alegre⁹, Antonio Mera¹⁵, Eva Perez Pampín¹⁶, Antonio Gonzalez¹⁷, Enrique Raya Álvarez¹⁸, Chary López-Pedrera¹⁹, Carmen Gomez Vaquero¹⁴, Alejandro Balsa²⁰, Dora Pascual-Salcedo²⁰, Patricia Carreira²¹, Isidoro Gonzalez-Alvaro⁵, Luis Rodriguez Rodriguez²², Benjamin Fernandez Gutierrez²², Ivan Ferraz-Amaro²³, Santos Castañeda²⁴, Javier Martin³, Javier Llorca²⁵ and Miguel Angel González-Gay^1,26,27, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ²Departamento de Genética e Instituto de Biotecnología, Universidad de Granada, Granada, Spain, ³Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Granada, Spain, ⁴Division of Cardiology, Hospital Universitario Lucus Augusti, Lugo, Spain, ⁵Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, ⁶Rheumatology Department, Hospital Universitario Lucus Augusti, Lugo, Spain, ⁷Rheumatology Division, Hospital Insular de Gran Canaria, Las Palmas, Spain, ⁸Rheumatology Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, ⁹Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, ¹⁰Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, ¹¹Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, ¹²Department of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain, ¹³Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ¹⁴Rheumatology Department, Hospital Universitario de Bellvitge, Idibell, Barcelona, Spain, ¹⁵Rheumatology Division. Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain, ¹⁶Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain, ¹⁷Laboratorio Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ¹⁸Rheumatology, Hospital Universitario San Cecilio. Granada. Spain, Granada, Spain, ¹⁹IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²⁰Rheumatology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain, ²¹Servicio de Reumatología, Hospital Universitario, Madrid, Spain, ²²Rheumatology Department, Hospital Clínico San Carlos, Madrid, Spain, ²³Rheumatology Division, Hospital Insular de Gran Canaria, La Laguna, Spain, ²⁴Rheumatology, Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, ²⁵School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, ²⁶School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain, ²⁷Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Background/Purpose: Cardiovascular (CV) disease is the most common cause of morbidity and mortality in patients with rheumatoid arthritis (RA) [1, 2]. Traditional CV risk factors…
Abstract Number: 69 • 2018 ACR/ARHP Annual Meeting
Possible Association of Early Inflammatory Arthritis with Viral Outbreaks Such As Influenza: Time Series Analysis of the Canadian Early Inflammatory Arthritis Cohort
Fatima Kudaeva¹, Mark Speechley², Neil Klar², Orit Schieir³, Susan J. Bartlett⁴, Louis Bessette⁵, Gilles Boire⁶, Glen Hazlewood⁷, Carol A Hitchon⁸, Edward C. Keystone⁹, Diane Tin¹⁰, Carter Thorne¹¹, Vivian P. Bykerk¹² and Janet E. Pope¹³, ¹Department of Epidemiology & Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ²Epidemiology & Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ³Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ⁴Department of Medicine, Division of ClinEpi, Rheumatology, Respirology, McGill University, Montreal, QC, Canada, ⁵Division of Rheumatology, Department of Medicine, CHU de Québec-Université Laval, Québec, QC, Canada, ⁶Rheumatology Division, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, ⁷Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, AB, Canada, ⁸University of Manitoba, Winnipeg, MB, Canada, ⁹University of Toronto and Mount Sinai Hospital, Toronto, ON, Canada, ¹⁰The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ¹¹University of Toronto, Newmarket, ON, Canada, ¹²Hospital for Special Surgery, New York, NY, ¹³Department of Medicine, University of Western Ontario, London, ON, Canada
Background/Purpose: Disease clustering suggests a possible environmental cause. Rheumatoid arthritis (RA) is an autoimmune disease that may be triggered by environmental factors such as viruses.…
Abstract Number: 70 • 2018 ACR/ARHP Annual Meeting
Colocalization of Malondialdehyde-Acetaldehyde Adducts (MAA) and Extracellular Matrix Proteins in Joint and Lung Tissues from Rheumatoid Arthritis Patients
Geoffrey M. Thiele¹, Michael J. Duryee², Jacob D. McGowan¹, Logan M. Duryee¹, Lynell W. Klassen³, James R. O'Dell³, Bryant R. England⁴ and Ted R. Mikuls⁵, ¹University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁴Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, ⁵Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Malondialdehyde-acetaldehyde adducts (MAA) are products of oxidative stress that modify self-proteins and stimulate potent cellular and humoral immune responses. We have previously demonstrated…
Abstract Number: 71 • 2018 ACR/ARHP Annual Meeting
Association of Shared Epitope and Poor Prognostic Factors in RA
Evo Alemao¹, Joshua Bryson¹, Christine K Iannaccone², Michelle Frits², Nancy A. Shadick³ and Michael Weinblatt², ¹Bristol-Myers Squibb, Princeton, NJ, ²Brigham and Women’s Hospital, Boston, MA, ³Brigham and Women's Hospital, Boston, MA
Background/Purpose: There is a strong genetic association between RA and human leukocyte antigen (HLA) regions, particularly HLA-DRB1 alleles with the shared epitope (SE). SE alleles…
Abstract Number: 72 • 2018 ACR/ARHP Annual Meeting
Altered Serologic Responses to Epstein Barr Virus Precede Clinical Disease Development in Rheumatoid Arthritis
Heather M. Berens¹, Elizabeth A. Bemis², M. Kristen Demoruelle¹, John B. Harley³, Judith A. James⁴, Jess Edison⁵, Kevin D. Deane¹, Jill M. Norris⁶ and V. Michael Holers¹, ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Division of Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, ⁶Department of Epidemiology, Colorado School of Public Health, Aurora, CO
Background/Purpose: EBV infects B cells and is associated with several autoimmune diseases, including RA. Prior studies have shown that patients with active classified RA…
Abstract Number: 73 • 2018 ACR/ARHP Annual Meeting
Circular RNAs Expression Profile in Chinese Rheumatoid Arthritis Patients at Different Disease Activity
Huan Liu, Qibing Xie and Geng Yin, Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China
Circular RNAs Expression Profile in Chinese Rheumatoid Arthritis Patients at Different Disease ActivityBackground/Purpose: Rheumatoid arthritis (RA) is an autoimmune-mediated chronic inflammatory joint disease, that is…
Abstract Number: 74 • 2018 ACR/ARHP Annual Meeting
DNA Methylation of the Dual Specificity Protein Phosphatase 22 (DUSP22) Gene Promoter in Plasma of Patients with Seropositive and Seronegative RA
Milena Rodriguez Alvarez¹, Lissette Delgado-Cruzata², Edgardo Guzman³, Wallis Tavarez³, Alorah Bliese², Tagir Sabirov³, Maria-Jose Jimenez³, Carmen A Oviedo Hilario³, Manuel E. Acosta⁴, Maria Albarracin², Carl Cirilli², Zuleika Parra³, Cristabel Robles Hidalgo³, Christopher Mesa³, Dominyka Bitinaite³, Sabeeda Kadavath³, Ibrahim El Husseini³, Grace Thomas³, Augustas Kavaliauskas³, Kioumars Bolourian Kashi³, Michael Gebeyehu³, Dave Samip³, Pawan Suri³, Menachem Gold³ and Shante Hinson³, ¹Rheumatology, SUNY Downstate, Brooklyn, NY, ²Sciences, John Jay College, City University of New York, New York, NY, ³Lincoln Medical and Mental Health Center, Bronx, NY, ⁴Barry University, Miami, FL
Background/Purpose: The Dual specificity protein phosphatase 22 (DUSP22) gene is aberrantly methylated in mononuclear cells in RA, and it has been associated with erosive disease.…
Abstract Number: 75 • 2018 ACR/ARHP Annual Meeting
Elevated Oxylipin Profile in Autoantibody-Positive Individuals at-Risk of Developing Rheumatoid Arthritis
Vidyanand Anaparti¹, Irene Smolik², Tanja Winter³, Xiaobo Meng⁴, Harold Aukema³ and Hani El-Gabalawy⁴, ¹Internal Medicine, University of Manitoba, Winnipeg, MB, Canada, ²Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, ³Food and Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada, ⁴University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Preclinical phase of rheumatoid arthritis (RA) is characterized by presence of autoantibodies, including anti-citrullinated protein antibodies (ACPA), years before disease onset. Epidemiological observations suggest…
Abstract Number: 76 • 2018 ACR/ARHP Annual Meeting
Whole Blood Targeted Bisulfite Pyrosequencing Identifies Differentially Methylated Regions within Major Histocompatibility Complex (MHC) of Patients with Rheumatoid Arthritis
Vidyanand Anaparti¹, Irene Smolik², Prasoon Agarwal³, Neeloffer Mookherjee¹ and Hani El-Gabalawy⁴, ¹Internal Medicine, University of Manitoba, Winnipeg, MB, Canada, ²Food and Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada, ³Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada, ⁴University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Human major histocompatibility complex (MHC) is strongly associated with rheumatoid arthritis (RA) pathogenesis. Epigenome-wide association study by Liu et al showed that differential DNA…
Abstract Number: 77 • 2018 ACR/ARHP Annual Meeting
Single Nucleotide Polymorphism in the Gene Encoding Peptidylarginine Deiminase 4 Correlates with Reduced Neutrophil Extracellular Traps and Anti-Histone Antibodies in Rheumatoid Arthritis
Aisha M. Mergaert¹, Mandar Bawadekar², Thai Q. Nguyen¹, Steven J. Schrodi^3,4 and Miriam A. Shelef^2,5, ¹University of Wisconsin - Madison, Madison, WI, ²Department of Medicine, Division of Rheumatology, University of Wisconsin - Madison, Madison, WI, ³Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, ⁴Computation and Informatics in Biology and Medicine, University of Wisconsin - Madison, Madison, WI, ⁵William S. Middleton Memorial Veterans Hospital, Madison, WI
Background/Purpose: In neutrophils, peptidylarginine deiminase 4 (PAD4) citrullinates histones allowing chromatin unraveling and neutrophil extracellular trap (NET) formation. NETs are increased and display proteins targeted…
Abstract Number: 78 • 2018 ACR/ARHP Annual Meeting
Decreased B Cell Ataxia-Telangiectasia Mutated Expression and Receptor Diversity Identify a Subset of Rheumatoid Arthritis Patients with Increased Joint Erosion Prevalence
Kofi Mensah¹, Jean-Nicolas Schickel², Isabel Isnardi² and Eric Meffre², ¹Section of Rheumatology, Yale University School of Medicine, New Haven, CT, ²Department of Immunobiology, Yale University School of Medicine, New Haven, CT
Background/Purpose: A skewed B cell receptor (BCR) repertoire was observed in some RA patients. In these patients, BCR κ light chains contain a higher percentage…

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