Abstracts Archive - Page 1007 of 2607 - ACR Meeting Abstracts

Abstract Number: 1003 • 2019 ACR/ARP Annual Meeting
TNF Inhibitors Improves Arterial Stiffness with Cs DMARDs-resistant Active Psoriatic Arthritis: A Cohort Extended Study
Kensuke Kume¹, kanzo amano ¹, toshikatsu kanazawa ¹, susumu yamada ¹ and kazuhiko hatta ¹, ¹Department of Rheumatology/Hiroshima Clinic, Hiroshima, Hiroshima, Japan
Background/Purpose: Background/ Patients with psoriatic arthritis (PsA) have an increased cardiovascular (CV) risk. We should have strategies for primary cardiovascular prevention in PsA1). But there…
Abstract Number: 1004 • 2019 ACR/ARP Annual Meeting
Genetic Ablation of γδTCR Inhibits IL-23-induced Neutrophilia and Attenuates Epidermal Hyperplasia, Synovitis, Onycholysis and Enthesitis Associated with Psoriatic Arthritis
Cuong Nguyen¹, Trevor Chan ², Ilias Tagkopoulos ², Matthias Eberl ³ and Iannis Adamopoulos ¹, ¹Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Sacramento, CA, ²University of California, Davis, Department of Computer Science, California, USA, Davis, CA, ³Division of Infection and Immunity, School of Medicine and Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, United Kingdom, Cardiff, United Kingdom
Background/Purpose: γδ T cells are non-conventional lymphocytes that straddle between innate and adaptive immunity. Although γδ T cells have been implicated in psoriatic arthritis, the…
Abstract Number: 1005 • 2019 ACR/ARP Annual Meeting
Tendon T-cell Interactions as Drivers of Chronicity in Spondyloarthritis
Emma Garcia-Melchor ¹, Giacomo Cafaro ¹, Hanna Johnsson¹, Lindsay Crowe ², Michael McLean ², James Reilly ², Iain McInnes ³, Moeed Akbar ² and Neal Millar ³, ¹University of Glasgow, Glasgow, United Kingdom, ²University of Glasgow, Glasgow, ³Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Emerging evidence supports the concept that stromal cell functions extend beyond maintenance of tissue architecture, exerting a key role in choreographing immune responses and…
Abstract Number: 1006 • 2019 ACR/ARP Annual Meeting
Vaspin rs35262691 Is Associated with Atherosclerotic Disease in Axial Spondyloarthritis Patients
Fernanda Genre¹, Javier Rueda-Gotor ¹, Sara Remuzgo-Martinez ¹, Veronica Pulito-Cueto ¹, Alfonso Corrales ¹, Veronica Mijares ¹, Leticia Lera-Gomez ¹, Virginia Portilla ¹, Rosa Expósito ², Cristina Mata ², Iván Ferraz-Amaro ³, Vanesa Hernández-Hernández ³, Santos Castañeda ⁴, Esther Vicente-Rabaneda ⁵, Cristina Fernández-Carballido ⁶, M. Paz Martínez-Vidal ⁷, David Castro-Corredor ⁸, Joaquín Anino-Fernández ⁸, Juan Quevedo-Abeledo ⁹, Carlos Rodríguez-Lozano ⁹, Ricardo Blanco ¹⁰, María Luz García-Vivar ¹¹, Eva Galíndez-Agirregoikoa ¹¹, Javier Llorca ¹², Raquel López-Mejías ¹ and Miguel Angel González-Gay ¹³, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ²Rheumatology Division, Hospital Comarcal de Laredo, Laredo, Spain, Laredo, Spain, ³Rheumatology Division, Hospital Universitario de Canarias, Tenerife, Spain, Tenerife, Spain, ⁴Rheumatology Department, Hospital Universitario de la Princesa, IIS-Princesa, Madrid, Spain, Madrid, Spain, ⁵Rheumatology Department, Hospital Universitario La Princesa, Madrid, Spain, ⁶Rheumatology Division, Hospital Universitario San Juan de Alicante, Alicante, Spain, Alicante, Spain, ⁷Rheumatology Division, Hospital General Universitario de Alicante, Alicante, Spain, Alicante, Spain, ⁸Rheumatology Division, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, Ciudad Real, Spain, ⁹Rheumatology Division, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain, Las Palmas de Gran Canaria, Spain, ¹⁰Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ¹¹Rheumatology Unit, Basurto University Hospital, Bilbao, Spain, Bilbao, Spain, ¹²School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, Santander, Spain, ¹³Universidad de Cantabria and IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Spain
Background/Purpose: Vaspin is a novel adipokine with insulin-sensitizing functions that exerts anti-inflammatory actions1,2. It has been associated with cardiovascular (CV) disease, CV risk factors and…
Abstract Number: 1007 • 2019 ACR/ARP Annual Meeting
Memory ex-Th17 Cells Contribute to Synovial Inflammation in Spondyloarthritis
SO-HEE JIN ¹, Pu-Reum PARK ¹, Ji Hyun KANG ¹, DONG-JIN PARK ¹ and TAE-JONG KIM¹, ¹Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea
Background/Purpose: Spondyloarthritis (SpA) is characterized by inflammation of the synovium. An increase in the number of Th17cells in SpA has been reported. However, it is…
Abstract Number: 1008 • 2019 ACR/ARP Annual Meeting
C-X-C Motif Chemokine 10 (CXCL10) as a Transcriptomic Biomarker of Psoriatic Arthritis Susceptibility
Fatima Abji¹, Anastasiya Muntyanu ², Remy Pollock ¹, Rohan Machhar ¹, Justine (Yang) Ye ³, Vinod Chandran ⁴ and Dafna Gladman ⁵, ¹Krembil Research Institute, University Health Network, Toronto, Canada, ²University of Toronto, University Health Network, Toronto, Canada, ³University Health Network, University of Toronto, Toronto, ON, Canada, ⁴University Health Network, University of Toronto, Toronto, Canada, ⁵Toronto Western Hospital, Toronto, Canada, Toronto, ON, Canada
Background/Purpose: We previously identified CXCL10, NOTCH2NL, HAT1, and SETD2 as differentially expressed between psoriasis arthritis (PsA) and psoriasis patients without arthritis (PsC). This study aimed…
Abstract Number: 1009 • 2019 ACR/ARP Annual Meeting
PDE4 Inhibition Could Improve Endothelial and Adipose Tissue Dysfunction Associated with Psoriatic Arthritis, Key Processes in Cardiovascular Disease
Ivan Arias de la Rosa¹, Carmen Torres-Granados ¹, Maria del Carmen Abalos-Aguilera ², Ignacio Gomez-Garcia ², Rocio Guzman-Ruiz ³, Maria del Mar Malagon ³, Carlos Perez-Sanchez ⁴, Alejandra Patiño-Trives ², Maria Luque-Tevar ², Alejandro Ibañez-Costa ², Alejandro Escudero ⁵, Eduardo Collantes-Estevez ¹, Chary Lopez-Pedrera ², Maria Dolores Lopez-Montilla ² and Nuria Barbarroja ³, ¹University of Cordoba/IMIBIC/Reina Sofia Hospital, Cordoba, Spain, ²IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³University of Cordoba/IMIBIC/Reina Sofia Hospital and CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain, ⁴Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, Cordoba, Spain, ⁵IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain
Background/Purpose: Psoriatic arthritis (PsA) is the rheumatic disease most associated with metabolic disorders, including obesity and metabolic syndrome, where inflammation is a determinant key factor,…
Abstract Number: 1010 • 2019 ACR/ARP Annual Meeting
IL-17A Induces Distinct Functional Differences Between Two Novel Mesenchymal Stem Cell Populations Identified at the Human Enthesis
Tobias Russell¹, Abdulla Watad ², Charlie Bridgewood ³, Almas Khan ⁴, Abhay S Rao ⁴, Peter Loughenbury ⁴, Peter Milner ⁴, Robert Dunsmuir ⁴, Thomas Baboolal ³, Elena Jones ⁵, Richard Cuthbert ¹ and Dennis McGonagle ⁶, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM)University of Leeds, Leeds, England, United Kingdom, ²Department of Medicine “B”, Zabludowicz Center for Autoimmune Diseases Sheba Medical Center, Ramat-Gan, Israel, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM)University of Leeds, Leeds, United Kingdom, ⁴Leeds Teaching Hospitals NHS Trust, Leeds, ⁵University of Leeds, Leeds, England, United Kingdom, ⁶University of Leeds, Leeds, United Kingdom
Background/Purpose: Ankylosing spondylitis (AS) is associated with entheseal inflammation and new bone formation. Resident populations of lymphocytes have been identified at the enthesis that on…
Abstract Number: 1011 • 2019 ACR/ARP Annual Meeting
Single Cell RNA Sequencing of Patients with Psoriatic Disease
Rohan Machhar¹, Kun Liang ², Remy Pollock ¹ and Dafna Gladman ³, ¹Krembil Research Institute, University Health Network, Toronto, Canada, ²University of Waterloo, Waterloo, ON, Canada, ³Krembil Research Institute, U of Toronto, Toronto, ON, Canada
Background/Purpose: Delayed diagnosis of psoriatic arthritis (PsA) can lead to poor clinical outcomes. A large proportion of PsA patients remain undiagnosed due to a lack…
Abstract Number: 1012 • 2019 ACR/ARP Annual Meeting
Apremilast Inhibits Immune Cells Support of Inflammatory Osteoclastogenesis
Yannick Degboe ¹, Flavia Sunzini ¹, Iain McInnes ² and Carl Goodyear¹, ¹University of Glasgow, Glasgow, United Kingdom, ²Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: PsA is associated with bone erosion and inflammation-induced bone loss. This process is mediated by osteoclasts, and modulated by inflammatory cytokines (i.e. TNF, IL-1,…
Abstract Number: 1013 • 2019 ACR/ARP Annual Meeting
Effects of Anti-TNF on MiR Expression in Monocytes and CD4+ T-Lymphocytes in Spondyloarthritis
Olivier Fogel¹, Maud Fagny ², Elodie Roche ³, Nelly Sigrist ³, Jean-François Deleuze ⁴, Maxime Dougados ⁵, Corinne Miceli-Richard ¹ and Jorg Tost ³, ¹Paris Descartes University, Department of Rheumatology - Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, ²CEA-CNRGH-Institut François Jacob- Laboratoire Epigenetique et Envrironnement, Evry, Ile-de-France, France, ³CEA-CNRGH-Institut François Jacob- Laboratoire Epigenetique et Envrironnement, Evry, France, ⁴CEA-CNRGH-Institut François Jacob, Evry, France, ⁵Cochin Hospital, Paris, France
Background/Purpose: TNFα inhibitors are an effective treatment for many inflammatory diseases. However, their mechanism of action is more complicated than just blocking the targeted cytokine.…
Abstract Number: 1014 • 2019 ACR/ARP Annual Meeting
Regulatory Role of IL-23 and Its Receptor System in Spondyloarthritis and Its Therapeutic Relevance in anti-IL-17 Failure Patients
Siba Raychaudhuri¹ and Smritikana Raychaudhuri ², ¹UC Davis School of Medicine, Sacramento, CA, ²UC Davis School of Medicine, Davis, CA
Background/Purpose: Here we hypothesized that (i) IL-23/IL-23R system more specifically the specific IL-23p19 subunit mediated signaling system regulates expansion/maintenance and functional maturation in respect to…
Abstract Number: 1015 • 2019 ACR/ARP Annual Meeting
Evidence for Substantial Immune Activation in Asymptomatic ANA Positive Individuals
Emma Van Lieshout¹, Dennisse Bonilla ², Zahi Touma ³, Arthur Bookman ⁴, Linda Hiraki ⁵, Zareen Ahmad ⁶, Sindhu Johnson ⁷, Earl D. Silverman ⁸ and Joan Wither ⁹, ¹University of Toronto, Toronto, ON, Canada, ²University Health Network, University of Toronto, Toronto, ON, Canada, ³University Health Network, University of Toronto, Toronto, Canada, ⁴University Health Network - Toronto Western Hospital, Toronto, Canada, ⁵The Hospital for Sick Children, Toronto, Canada, ⁶Mount Sinai Hospital, Toronto, Canada, ⁷Toronto Scleroderma Program, Department of Medicine, Toronto Western and Mount Sinai Hospitals, University of Toronto, Toronto, Canada, Toronto, Canada, ⁸Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, ⁹University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: Systemic autoimmune rheumatic diseases (SARD) including Sjogren’s Disease (SjD), Systemic Sclerosis (SSc) and Systemic Lupus Erythematosus (SLE) are characterized by the production of anti-nuclear…
Abstract Number: 1016 • 2019 ACR/ARP Annual Meeting
Identification of Differentially Expressed Genes and Signaling Pathways in Systemic Lupus Erythematosus by Integrated Bioinformatics Analysis
Wei Liu¹, Yuanhao Wu ¹ and Wenjia Zhao ¹, ¹First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China (People's Republic)
Background/Purpose: Systemic lupus erythematosus (SLE) is a common autoimmune disease. The occurrence and development of SLE is a result of multiple factors, but its exact…
Abstract Number: 1017 • 2019 ACR/ARP Annual Meeting
The Integration of Genetic Data, Molecular Pathway Analysis and Differential Expression to Delineate the Impact of Ancestral Differences on Lupus
Katherine Owen¹, Bryce Aidukaitis ¹, Adam Labonte ¹, Michelle Catalina ¹, Prathyusha Bachali ¹, Nicholas Geraci ², Miranda Marion ³, Hannah Ainsworth ⁴, kip Zimmerman ³, Timothy Howard ⁴, Carl Langefeld ⁴, Peter Lipsky ² and Amrie Grammer ⁵, ¹AMPEL Biosolutions and the RILITE research institute, Charlottesville, VA, ²AMPEL BioSolutions, LLC, Charlottesville, VA, ³Wake Forest School of Medicine, Winston-Salem, NC, ⁴Wake Forest School of Medicine, Winston-Salem, ⁵AMPEL BioSolutions and RILITE Research Institute, Charlottesville, VA
Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder with a prominent genetic component. Evidence has shown that individuals of African-Ancestry (AA) experience the…

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