Abstracts Archive - Page 1003 of 2607 - ACR Meeting Abstracts

Abstract Number: 943 • 2019 ACR/ARP Annual Meeting
A Phase 1b/2a Trial of Tofacitinib, an Oral Janus Kinase Inhibitor, in Systemic Lupus Erythematosus
Sarfaraz Hasni¹, Sarthak Gupta ², Michael Davis ³, Elaine Poncio ⁴, Yenealem Temesgen-Oyelakin ⁴, Phillip Carlucci ⁴, Xinghao Wang ⁴, Mohammad Naqi ⁴, Martin Playford ⁵, Rishi Goel ⁴, Xiaobai Li ⁶, Ann Biehl ⁴, Isabel Ochoa-Navas ⁴, Zerai Manna ⁴, Yinghui Shi ⁷, Don Thomas ⁸, Jinguo Chen ⁹, Angélique Biancotto ⁹, Richard Apps ⁹, Foo Cheung ⁹, Yuri Kotliarov ⁹, Ashley Babyak ⁶, Katie Stagliano ⁹, John Tsang ⁹, Wanxia Tsai ¹⁰, Laura Vian ¹⁰, Nathalia Gazaniga ⁴, Valentina Giudice ⁴, Stephen Brooks ¹¹, Meggan Mackay ¹², Peter Gregersen ¹³, Betty Diamond ¹⁴, Nehal Mehta ¹⁵, Alan Remaley ⁵, John O'Shea ¹⁶, Massimo Gadina ¹⁰ and Mariana Kaplan ¹⁶, ¹National Institute of Arthritis, Musculoskeletal, and Skin diseases/ National Institutes of Health, Bethesda, MD, ²Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, ³NIAMS/NIH, Bethesda, MD, ⁴NIAMS/NIH, Bethesda, ⁵NHLBI/NIH, Bethesda, ⁶Clinical Center/NIH, Bethesda, ⁷Office of Clinical Director, NIAMS, NIH, Bethesda, MD, ⁸Walter Reed National Military Medical Center, Bethesda, MD, ⁹NIAID/NIH, Bethesda, ¹⁰Translational Immunology Section, NIAMS, NIH, Bethesda, MD, ¹¹Biomining and Discovery Section/NIAMS/NIH, Bethesda, MD, ¹²Feinstein Institute for Medical Research, New York, ¹³Feinstein Institutes for Medical Research, Manhasset, NY, ¹⁴Feinstein Institutes of Medical Research, Manhasset, NY, ¹⁵National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA, Bethesda, MD, ¹⁶National Institute of Arthritis, Musculoskeletal, and Skin diseases/ National Institutes of Health, Bethesda
Background/Purpose: A pharmacologic intervention that modulates JAK/STAT signaling pathways represents a novel approach for the treatment of Systemic Lupus Erythematosus (SLE). In animal models of…
Abstract Number: 944 • 2019 ACR/ARP Annual Meeting
Efficacy and Safety of Dapirolizumab Pegol in Patients with Moderately to Severely Active Systemic Lupus Erythematosus: A Randomized, Placebo-Controlled Study
Richard Furie¹, Ian Bruce ², Thomas Dörner ³, Manuel Gustavo Leon ⁴, Piotr Leszczyński ⁵, Murray Urowitz ⁶, Birgit Haier ⁷, Claire Brittain ⁸, Jiajun Liu ⁹, Catherine Barbey ¹⁰ and Christian Stach ⁷, ¹Northwell Health, Great Neck, NY, ²University of Manchester, Manchester, United Kingdom, Manchester, England, United Kingdom, ³Charite Universitätsmedizin Berlin and DRFZ, Berlin, Germany, ⁴Investigaciones Clínicas, Lima, Peru, ⁵Poznań University of Medical Sciences, Poznań, Poland, ⁶University Health Network, University of Toronto, Toronto, ON, Canada, ⁷UCB Pharma, Monheim, Germany, ⁸UCB Pharma, Slough, United Kingdom, ⁹Biogen, Cambridge, MA, ¹⁰Biogen, Baar, Switzerland
Background/Purpose: Dapirolizumab pegol (DZP) is a polyethylene glycol-conjugated Fab’ fragment, which targets CD40 ligand and is in development for the treatment of systemic lupus erythematosus…
Abstract Number: 945 • 2019 ACR/ARP Annual Meeting
Comparison of Clinical Manifestations in IgG4 Related Disease Patients with/without Aortitis/Periaortitis and Periarteritis: A Prospective Cohort Study of 587 Patients with IgG4-RD Disease
Linyi Peng ¹, Wen Zhang ² and Panpan Zhang¹, ¹Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China (People's Republic), ²Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (People's Republic)
Background/Purpose: We aimed to clarify the clinical features of IgG4-related disease (IgG4-RD) with/without aortitis/periaortitis and periarteritis (PAO/PA), and evaluate the treatment efficacy of patients with…
Abstract Number: 946 • 2019 ACR/ARP Annual Meeting
Improvements in Disease Activity and Quality of Life for up to 64 Weeks in Patients with Behçet’s Syndrome: Results from a Phase III Study
Gulen Hatemi¹, Alfred Mahr ², Mitsuhiro Takeno ³, Doyoung Kim ⁴, Melike Melikoglu ⁵, Sue Cheng ⁶, Shannon McCue ⁷, Maria Paris ⁶, Mindy Chen ⁸ and Yusuf Yazici ⁹, ¹Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Behcet's Disease Research Center, Istanbul, Turkey, Istanbul, Turkey, ²Hospital Saint-Louis, University Paris Diderot, Paris, France, ³Nippon Medical School, Tokyo, Japan, ⁴Yonsei University College of Medicine and Severance Hospital, Seoul, Republic of Korea, ⁵Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul University – Cerrahpasa, Behçet’s Disease Research Center, Istanbul, Turkey, Istanbul, Turkey, ⁶Celgene Corporation, Summit, ⁷Celgene Corporation, Summit, NJ, ⁸Celgene Corporation, Berkeley Heights, NJ, ⁹New York University School of Medicine, New York
Background/Purpose: Behçet’s syndrome is a chronic, multi-system inflammatory disorder characterized by painful, recurrent oral ulcers (OU) that can impair quality of life (QoL). Apremilast (APR),…
Abstract Number: 947 • 2019 ACR/ARP Annual Meeting
TNF Inhibitor Treatment and Dramatic Stroke Risk Reduction in Patients with Deficiency of Adenosine Deaminase 2
Ryan Laird¹, Patrycja Hoffmann ², Karyl Barron ², Deborah Stone ², Michele Nehrebecky ³, Anne Jones ², Tina Romeo ², Camilo Toro ³, Arianne Soldatos ⁴, Cornelia Cudrici ³, Daniel Kastner ² and Amanda Ombrello ², ¹National Institues of Health, Bethesda, ²National Institutes of Health, Bethesda, MD, ³National Institutes of Health, Bethesda, ⁴NIH/NINDS, Bethesda
Background/Purpose: Deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive disease caused by biallelic loss-of-function mutations in the ADA2 gene . Over 60 pathogenic…
Abstract Number: 948 • 2019 ACR/ARP Annual Meeting
Relapsing Cryoglobulinemic Vasculitis Following Successful HCV Eradication by Interferon-Free Direct Acting Antivirals, an International Multicenter Study
Mohamed Tharwat Hegazy¹, Ahmed Fayed ¹, Tarek El Shabony ¹, Marcella Visentini ², David Saadoun ³, Patrice Cacoub ³ and Gaafar Ragab ¹, ¹Cairo University, Cairo, Egypt, Cairo, Egypt, ²Sapienza University of Rome, Rome, Italy, Rome, Italy, ³AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, F-75013, Paris, France, Paris, France
Background/Purpose: Interferon-free Direct Acting Antiviral (DAA) combinations proved to be effective for the treatment of HCV induced Cryoglobulinemic Vasculitis (HCV-Cryovas). Some reports showed relapses of…
Abstract Number: 949 • 2019 ACR/ARP Annual Meeting
Assessment of Femoral Vein Wall Thickness with Doppler Ultrasound Can Be a Diagnostic Tool for Behcet’s Disease
Fatma Alibaz-Oner¹, RABIA ERGELEN ², YASIN YILDIZ ³, Ayten Yazici ⁴, AYDAN MUTIS ⁵, ZEYNEP ERTURK ³, MUSTAFA ALDAG ⁶, Ayşe Cefle ⁷, Bahar Artim-Esen ⁸, GONCA MUMCU ⁹, TULIN ERGUN ¹⁰ and Haner Direskeneli ¹¹, ¹Marmara University Faculty of Medicine,Department of Rheumatology,Istanbul,Turkey, Istanbul, Turkey, ²MARMARA UNIVERSITY, SCHOOL OF MEDICINE, RADIOLOGY, ISTANBUL, Turkey, ³MARMARA UNIVERSITY, SCHOOL OF MEDICINE, RHEUMATOLOGY, ISTANBUL, Turkey, ⁴Kocaeli University, Faculty of Medicine, Division of Rheumatology, Kocaeli, Kocaeli, Turkey, ⁵MARMARA UNIVERSITY, SCHOOL OF MEDICINE, RHEUMATOLOGY, ISTANBUL, Tuvalu, ⁶BAHCESEHIR UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF CARDIOVASCULAR SURGERY, ISTANBUL, Turkey, ⁷Division of Rheumatology, Kocaeli University School of Medicine, Kocaeli, Turkey, Kocaeli, Turkey, ⁸Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ⁹Marmara, University, Department of Health Management, Marmara University School of Health Sciences, Istanbul, Turkey, ISTANBUL, Turkey, ¹⁰MARMARA UNIVERSITY, SCHOOL OF MEDICINE, DERMATOLOGY, Istanbul, Istanbul, Turkey, ¹¹Marmara University, School of Medicine, Division of Rheumatology, Istanbul, Turkey
Background/Purpose: Behcet's disease(BD) is a uniqe systemic vasculitis mainly involving venous vessels in contrast to other systemic vasculitides. Diagnosing BD is a challenge, especially in…
Abstract Number: 950 • 2019 ACR/ARP Annual Meeting
Low-Dose IL-2 Effectively Restored Decreased Regulatory T Cells in Patients with Behcet’s Disease
Xiao-qing Liu¹, Xiaojie Liu ², Nalin Lai ³, Ting Cheng ¹, Chong Gao ⁴ and Xiao-feng Li ¹, ¹The Second Hospital of Shanxi Medical University, Taiyuan, China (People's Republic), ²Taiyuan University of Technology, Taiyuan, China (People's Republic), ³Shanxi Medical University, Taiyuan, China (People's Republic), ⁴Brigham and Women’s Hospital, Harvard Medical School, Boston
Background/Purpose: Behcet’s disease (BD) is a chronic multisystemic disease characterized by muco-cutaneous and ocular manifestations, with central nervous system, vascular and/or gastro-intestinal involvement. Several studies…
Abstract Number: 951 • 2019 ACR/ARP Annual Meeting
Avoidable Acute Care Use for Vaccine-Preventable Illnesses Among Medicaid Beneficiaries with Lupus: Demographic and Healthcare Utilization Differences
Candace Feldman¹, Chang Xu ¹ and Karen Costenbader ¹, ¹Brigham and Women's Hospital, Boston, MA
Background/Purpose: Nearly 25% of patients with SLE are hospitalized each year often for outcomes that may have been avoided if patients had received sustained, high…
Abstract Number: 952 • 2019 ACR/ARP Annual Meeting
Rate of Thirty-Day Readmissions in Systemic Lupus Erythematosus Rivals Congestive Heart Failure and Exceeds the General Medicare Population
Ann Chodara¹, Xing Wang ¹, Fangfang Shi ¹, Shivani Garg ¹, Ryan Powell ¹, Maria Schletzbaum ¹, Ann Sheehy ¹, Amy Kind ¹ and Christie Bartels ¹, ¹University of Wisconsin School of Medicine and Public Health, Madison, WI
Background/Purpose: Medicare measures readmissions within 30 days of hospitalization across several conditions as a marker of care quality. While not currently a reporting condition, in…
Abstract Number: 953 • 2019 ACR/ARP Annual Meeting
Treatment Patterns and Persistency Following the First Biologic DMARD in Patients with Rheumatoid Arthritis: Real-World Analysis of 2012–2016 US Medicare Data
Robin Dore¹, Lawrence Chang ², Yuanyuan Ji ³, Suying Li ³, Jenya Antonova ² and Mark Genovese ⁴, ¹Private practice, Tustin, CA, ²Gilead Sciences, Foster City, CA, ³Chronic Disease Research Group, Minneapolis, MN, ⁴Stanford University, Stanford, CA
Background/Purpose: In RA patients not meeting treat-to-target goals despite treatment with a biologic (b)DMARD, ACR guidelines1 recommend using other targeted immunomodulators (TIM): TNF-α inhibitor (TNFi),…
Abstract Number: 954 • 2019 ACR/ARP Annual Meeting
Physical Therapy and Opioid Use in Knee Osteoarthritis
Deepak Kumar¹, Christine Peloquin ², Andrew Stokes ³, Lee Marinko ⁴, James Camarinos ⁴, David Felson ⁵ and Maureen Dubreuil ², ¹Boston University, Boston, MA, ²Boston University School of Medicine, Boston, ³Boston University School of Public Health, Boston, ⁴Boston University, Boston, ⁵Boston University School of Medicine, Department of Rheumatology, Boston
Background/Purpose: Knee osteoarthritis (OA) is a leading cause of chronic pain in older adults. Physical therapy (PT) decreases OA pain and consequently may reduce burden…
Abstract Number: 955 • 2019 ACR/ARP Annual Meeting
Adherence to Statin Therapy in Rheumatoid Arthritis Patients: A Population-Based Cohort Study
Tom Hahn ¹, Eric Sayre ², Maria Victoria Goycochea-Robles ³ and Diane Lacaille⁴, ¹Department of Medicine, University of British Columbia, Vancouver, Canada, ²Arthritis Research Canada, Vancouver, BC, Canada, ³Unidad de Investigación en Epidemiologia HGR 1, Mexican Institute of Social Security -, Mexico City, Mexico, ⁴Arthritis Research Canada and University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Cardiovascular diseases (CVD) are increased in RA and lead to premature mortality. Statins are effective at preventing incidence of, and mortality from, CVD; yet,…
Abstract Number: 956 • 2019 ACR/ARP Annual Meeting
The Impact of Psychiatric Comorbidity on Health Care Utilization and Preventive Health Care in Rheumatoid Arthritis: A Population Based Study
Carol Hitchon¹, Charles Bernstein ¹, James Bolton ¹, Renée El-Gabalawy ¹, John Fisk ², Alan Katz ¹, Lisa Lix ³, James Marriott ¹, Scott Patten ⁴, Christine Peschken ³, Jitender Sareen ¹, Alexander Singer ¹, Randy Walld ¹ and Ruth Ann Marrie ¹, ¹University of Manitoba, Winnipeg, MB, Canada, ²Dalhousie University, Halifax, NS, Canada, ³University of Manitoba, Winnipeg, Canada, ⁴University of Calgary, Calgary, AB, Canada
Background/Purpose: Psychiatric comorbidity is increased in rheumatoid arthritis (RA) and may complicate medical care, increasing the risk of adverse health outcomes and health care utilization…
Abstract Number: 957 • 2019 ACR/ARP Annual Meeting
Alterations in Cholesterol Homeostasis Regulate Autoimmunity/Age-associated B Cells
Zhu Chen¹, Michela Manni ¹, Danny Flores-Castro ¹, Tania Pannellini ¹ and Alessandra Pernis ², ¹Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, ²1.Autoimmunity and Inflammation Program, Hospital for Special Surgery. 2.David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery. 3.Department of Medicine, Weill Cornell Medical College, Cornell University, New York
Background/Purpose: Age-associated B cells (ABCs) are a novel B cell subset, which expands with age in non-autoimmune mice but accumulates prematurely in autoimmune-prone strains. ABCs…

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