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Abstract Number: 2930

Outcome of Patients with Systemic Lupus Erythematous (SLE) after Thrombotic Events

Samar Alharbi1, Jiandong Su2, Stacey E. Morrison3, Mohammed Attar4, Khawla Al-Ghanim5, Murray Urowitz6,7, Dafna Gladman2 and Jorge Sánchez-Guerrero8, 1Rheumatology, University Health Network, Toronto, ON, Canada, 2Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3Div Rheumatology Rm MP-10-304, Toronto Western Hospital, Toronto, ON, Canada, 4Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, 5Rheumatology, TWH, Toronto, ON, Canada, 6University of Toronto, Toronto, ON, Canada, 7Rheumatology, U of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 8Rheumatology, Mount Sinai Hospital and University Health Network, Toronto Canada, Toronto, ON, Canada

Meeting: ACR/ARHP Annual Meeting 2015

Date of first publication: September 29, 2015

Keywords: ,

Session Information

Date: Tuesday, November 10, 2015

Title: Systemic Lupus Erythematosus - Clinical Aspects and Treatment Poster Session III

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: To assess the impact of thrombotic events (TE) on 1) mortality, 2) SLE-related damage accrual; and 3) health-related quality of life (HRQoL) in patients with SLE.

Methods: We included patients participating in a prospective cohort (1990-2014). Demographic, SLE-related clinical and laboratory data were extracted. The TE group included patients with any venous or arterial event occurring after enrollment in the cohort. The non-TE group included those with no TE ever. Chi-Square test, t-tests, and Kaplan-Meier survival analysis were used to identify the differences between those with and without TE in terms of: 1) mortality by all causes; 2) damage accrual since TE using the SLICC/ACR Damage Index (SDI) excluding all vascular domains (mod-SDI); and 3) HRQoL using the mental (MCS) and physical (PCS) component summary scores of the SF-36 questionnaire.

Results: A total 1015 SLE patients were included in analysis. A univariate comparison of TE (n = 151) vs non-TE (n = 864) showed: older age at SLE diagnosis (33.8 ± 14.2 vs 30.9 ± 13.1 years, P = 0.01); lower proportion of females (82.8% vs 88.7%, P = 0.04); higher frequency of antiphospholipid antibody positivity (20.5% vs 14.1%, P = 0.04); no difference in time from SLE diagnosis to first visit to the clinic (13.8 ± 17.6 vs 14.9 ± 17.4 months, P = 0.45); no difference in survival time (75% survival time: 22 vs 27 years, P = 0.70); and more non-vascular damage (mod-SDI >0: 80.8% vs 56.9%, P ≤ 0.0001; mean mod-SDI: 1.8 ± 1.8 vs 1.1 ± 1.5, P ≤ 0.0001). Among 44 patients with TE, no differences in HRQoL MCS or PCS were observed between the groups. These results did not differ by type of TE. 

Conclusion: Compared to those without TE, SLE patients with TE accrued more chronic non-vascular damage.  We found no difference in mortality, and in the subgroup of TE patients assessed, HRQoL did not differ between the groups.

Disclosure: S. Alharbi, None; J. Su, None; S. E. Morrison, None; M. Attar, None; K. Al-Ghanim, None; M. Urowitz, None; D. Gladman, None; J. Sánchez-Guerrero, None.

To cite this abstract in AMA style:

Alharbi S, Su J, Morrison SE, Attar M, Al-Ghanim K, Urowitz M, Gladman D, Sánchez-Guerrero J. Outcome of Patients with Systemic Lupus Erythematous (SLE) after Thrombotic Events [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/outcome-of-patients-with-systemic-lupus-erythematous-sle-after-thrombotic-events/. Accessed .

ACR Meeting Abstracts - https://acrabstracts.org/abstract/outcome-of-patients-with-systemic-lupus-erythematous-sle-after-thrombotic-events/