ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1288

Older Adults with Osteoarthritis Do Not Have an Increased Risk of Cognitive Impairment

Bansari Gujar1, Ann Gruber-Baldini2, Mona Baumgarten3, William Hawkes2, Michael C. Nevitt4, Kristine Yaffe5, Tamara Harris6 and Marc C. Hochberg7, 1Division of Rheumatology, University of Maryland School of Medicine, Baltimore, MD, 2Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, 3University of Maryland School of Medicine, Baltimore, MD, 4Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, 5UCSF (University of California, San Francisco), San Francisco, CA, 6National Institute on Aging, National Institutes of Health, Bethesda, MD, 7Medicine, University of Maryland School of Medicine, Baltimore, MD

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords:

Session Information

Title: Osteoarthritis - Clinical Aspects: Epidemiology and Pathogenesis

Session Type: Abstract Submissions (ACR)

Background/Purpose:

 A prior study showed an association between osteoarthritis (OA) and increased mortality from dementia. Recent preclinical studies suggest a possible association between OA and the development of dementia. The objective of this analysis was to determine if older adults with OA have a higher risk of cognitive impairment (CI).

Methods:

We used data from the Health Aging and Body Composition (HABC) study, a multicenter prospective cohort study of community dwelling adults, ages 70-79, to determine if participants with OA at baseline (self-reported OA or OA defined by HABC prevalent disease algorithm) have an increased risk of developing CI. CI was defined as a Modified Mini-Mental State examination (3MS) score<80.  Participants with 3MS scores of <80 at baseline were excluded. Baseline and year 3, 5, 8, and 10 scores were analyzed.

Results:

There were 2577 participants with 3MS scores of >=80 at baseline (n=1277 with OA, n=1300 without OA). The OA group had more women (54% vs 44%, p<0.001), higher baseline CES-Depression scores (4.9 SD 5.4 vs 4.2, SD4.9, p=0.003) and hypertension (46% vs 40%, p=0.028).There was no significant difference in development of CI after 9 years amongst those with OA (n=165, 12.9%) versus without OA (n=197, 15.1%). χ 2(1, n= 2577) =2.66, p >0.10. The results of the multiple variable logistic regression analysis (adjusted for age, race, education and gender) suggest a protective effect that did not reach statistical significance (odds ratio= 0.8; 95% CI 0.6-1.0; P-value = 0.10). There was no significant association between baseline OA and the development of CI at the 3, 5, 8 and 10 year time points.  No differences were found upon sensitivity analysis using race and education adjusted cut-points for 3MS scores.

Conclusion:

These results do not support the hypothesis that there is a causal association between OA and CI.

Disclosure:

B. Gujar,
None;

A. Gruber-Baldini,
None;

M. Baumgarten,
None;

W. Hawkes,
None;

M. C. Nevitt,
None;

K. Yaffe,
None;

T. Harris,
None;

M. C. Hochberg,
None.

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