Date: Sunday, November 8, 2020
Session Type: Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: Background: The eye is a common and potential severe complication of sarcoidosis. Topical and systemic corticosteroids are the first-line treatment. Conventional and biological immunosuppressants are frequently needed.
Objectives: To assess the frequency, clinical and treatment of ocular involvement of sarcoidosis.
Methods: Study of a large cohort (n=383) of systemic sarcoidosis from a single university hospital. All consecutive patients diagnosed with sarcoidosis from January 1, 1999 to January 1, 2019 according the ATS/ERS/WASOG criteria (Eur Respir J 1999;14:735–737) were included.
Results: 41 (22 women/19 men) of 383 (10.7%) patients had ocular involvement, mean age 44.8±16 years. Uveitis (n=34; 82.9%) was the most common ocular manifestation, especially anterior uveitis (n=18; 52.9%). Ocular surface and eye orbit may also be affected (table 1).
In addition to topical and systemic corticosteroids, conventional (n=23; 56.1%) and biologic (n=14; 34.1%) immunosuppressive drugs were required. Adalimumab and Infliximab were the most used biologic treatments (table 2).
Cystoid macular edema (CME) and Retinal Vasculitis was observed in both cases in 3 (7.3%) patients, 2 of them (66.7%) required biological treatment. Papilitis appeared in 7 (17.1%) cases, biological treatment was needed in 3 (42.9%) patients.
The most frequent sequels were cataract (n=9, 21.9%), intraocular hypertension (n=5; 12.2%) and pupil alterations (n=4; 9.7%). The average of the best corrected visual acuity was 0.6±0.3 at diagnosis and 0.7±0.3 after one year follow up.
Conclusion: Ocular involvement of sarcoidosis is a relative frequent and potential severe complication, especially if panuveitis is presented.
To cite this abstract in AMA style:Martinez-Lopez D, Gaitan-Valdizan J, Fernandez-Ramon R, Demetrio-Pablo R, Sanchez-Bilbao L, Gonzalez-Mazon I, Martín-Varillas J, González-Gay M, Blanco R. Ocular Involvement and Treatment in Sarcodosis. Study of 41 Patients of a Series of 383 Patients from a Single University Hospital [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/ocular-involvement-and-treatment-in-sarcodosis-study-of-41-patients-of-a-series-of-383-patients-from-a-single-university-hospital/. Accessed January 15, 2021.
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