Background/Purpose: Current classification criteria for definite antiphospholipid syndrome (APS) recommend the use of one or more of three positive standardized laboratory assays, including anticardiolipin antibodies, lupus anticoagulant, and antibodies directed to β(2)glycoprotein I. Several other autoantibodies have been proposed to be relevant to APS. The aim of the study was to assess the prevalence of non-criteria anti-phospholipid antibodies (APL) in patients diagnosed with systemic lupus erythematosus (SLE) and their association with APS diagnosis and its clinical manifestations.

Methods: The 449 subjects meeting SLE ACR classification criteria were evaluated. The following non-criteria APL were assessed by ELISA using standardized techniques: anti-phosphatidyl ethanolamine (aPE), anti-prothromin (aPTR), anti-phosphatidyl serine (aPS), anti-annexin V (AnV).

Results:

Non-criteria APL included aPTR in 28.1% patients, aPS in 19.7% patients , AnV in 24.2% patients, aPE in 21.1% SLE patients. In 127 patients with SLE APS was diagnosed. The diagnosis of APS was associated with the presence of aPE (OR:5.69) and aPTR (OR: 2.51). The risk of developing thrombosis occurred in patients with presence of AnV IgG (OR 4.06), aPTR (OR 2.61) and aPS (OR 2,10).The presence of aPE IgM (OR 4.41), aPS (OR 2.27) and aPTR (OR 2.04) were risk factors for pregnancy failures. Epilepsy was significantly more common in patients with presence of aPE IgM (OR 4.75) and aPE IgG (OR 4.30).

Conclusion: Non-criteria APL are relatively common in patients with SLE and demonstrate a significant association with the diagnosis of APS, as well as its most important clinical symptoms.

« Back to 2016 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/non-%c2%adcriteria-anti%c2%ad-phospholipid-antibodies-in-sle-patients/