ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 761

Neurometabolic Alterations in Korean Lupus Patients with Chronic Daily Headache

Ji-Min Kim1, Tae-Han Lee1, Chang-Nam Son1, Sung Soo Kim2, Hyuk Won Chang3 and Sang-Hyon Kim1, 1Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Ulsan University School of Medicine, GangNeung Asan Hospital, Gangneung, South Korea, 3Department of Radiology, Keimyung University School of Medicine, Daegu, South Korea

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: ,

Session Information

Date: Sunday, November 8, 2015

Title: Systemic Lupus Erythematosus - Clinical Aspects and Treatment Poster Session I

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose:

Neuropsychiatric systemic lupus erythematosus (SLE) includes a broad spectrum of neurologic and psychiatric manifestations. One of the most commonly observed neuopsychiatric symptoms is headache. However, the lack of specific clinical distinctions for headache in SLE has made it difficult to elucidate its pathophysiology. Proton magnetic resonance spectroscopy (1H-MRS) permits the detection of neuronal metabolic alterations noninvasively. Most studies used 1H-MRS to compare patients with minor NPSLE vs patients with major NPSLE or they compared the SLE patients according to the existence of NPSLE. However, no study has been conducted using 1H-MRS with a focus on specific symptoms, such as headache. The aim of this study is to evaluate the neurometabolic changes in patients with SLE who suffer from chronic daily headache (CDH).

Methods:

SLE patients with CDH (primary headache occurring at least 15 days per month for longer than 3 months), fibromyalgia patients with CDH, and healthy controls were recruited. Subjects were all Korean. 1H-MRS metabolite ratios were evaluated in bilateral basal ganglia (BG) and bilateral peritrigonal white matter (PWM).

Results:

1H-MRS showed a significantly decreased N-acetylaspartate (NAA)/creatine (Cr) ratios in right BG in SLE patients with CDH compared to fibromyalgia patients with CDH and healthy controls (p=0.029 and p=0.020, respectively). Left PWM NAA/Cr and Choline (Cho)/Cr ratios of SLE patients with CDH were lower than those of fibromyalgia patients with CDH (p=0.019 and p=0.029, respectively). NAA/Cr and Cho/Cr ratios were similar between fibromyalgia patients with CDH and healthy controls.

 Conclusion:

This study suggests the clues that CDH in patients with SLE might be associated with neuronal dysfunction and neurometabolic changes. The distinctive neurometabolic features found in patients with SLE suggest the possible existence of different mechanisms in the development of CDH.

Disclosure: J. M. Kim, None; T. H. Lee, None; C. N. Son, None; S. S. Kim, None; H. W. Chang, None; S. H. Kim, None.

To cite this abstract in AMA style:

Kim JM, Lee TH, Son CN, Kim SS, Chang HW, Kim SH. Neurometabolic Alterations in Korean Lupus Patients with Chronic Daily Headache [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/neurometabolic-alterations-in-korean-lupus-patients-with-chronic-daily-headache/. Accessed .

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