Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: We have previously investigated the interplay between TGFβ, BMP, VEGF and endothelin in SSc using the TβRIIΔk-fib strain, a transgenic mouse model in which there is balanced upregulation of TGFβ signalling. The pivotal role of endothelin within this multifaceted pathology was confirmed using macitentan, a licensed endothelin receptor antagonist of proven efficacy, to prevent and treat pulmonary hypertension in this model. We have extended these studies to examine whether cellular pathways targeted by modern therapies currently undergoing clinical trials in SSc are altered in this model of constitutive skin fibrosis and pulmonary vasculopathy.
To cite this abstract in AMA style:Derrett-Smith EC, Xu S, Hoyles RK, Denton C. Multi-Tissue Gene Expression Pathway Analysis of Emerging Therapeutics in a TGFβ Dependent Mouse Model of Systemic Sclerosis [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/multi-tissue-gene-expression-pathway-analysis-of-emerging-therapeutics-in-a-tgf%ce%b2-dependent-mouse-model-of-systemic-sclerosis/. Accessed October 25, 2021.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/multi-tissue-gene-expression-pathway-analysis-of-emerging-therapeutics-in-a-tgf%ce%b2-dependent-mouse-model-of-systemic-sclerosis/