Session Title: Imaging of Rheumatic Diseases - Poster II: XR/CT/PET/MRI
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Magnetic resonance imaging (MRI) sensitively detects inflammation, but the clinical relevance of MRI-detected inflammation is undetermined in early arthritis. Therefore, this cross-sectional study investigated the association between MRI-detected inflammation of hands and feet and functional disability in early arthritis.
Methods: 514 early arthritis patients, consecutively included in the Leiden Early Arthritis Clinic, were studied. At baseline, unilateral 1.5T MRI of the wrist, metacarpophalangeal (MCP) and metatarsophalangeal-joints was made and functional disability was measured using the Health Assessment Questionnaire (HAQ). MRIs were scored for tenosynovitis, synovitis and bone marrow oedema (BME) by two readers. The sum of these types of MRI-inflammation yielded the total MRI-inflammation score. Linear and non-linear regression analyses were performed with HAQ as outcome.
Results: The total MRI-inflammation score was associated with the HAQ-score (β=0.014, p<0.001), as were tenosynovitis (β=0.046, p<0.001), synovitis (β=0.039, p<0.001) and BME-scores (β=0.015, p<0.001) separately. Analysing these three types of MRI-inflammation in one multivariable model, revealed that only tenosynovitis was independently associated with HAQ-score (β=0.039, p<0.001). Also when correcting for age, gender, joint counts, C-reactive protein and auto-antibodies, this association remained significant (β=0.034, p<0.001). MRI-detected inflammation at wrists or MCP-joints associated significantly with impairments in hand functioning (e.g. difficulties with opening milk cartons or jars). Exploring the relation between MRI-detected inflammation and HAQ-scores, suggested the presence of a ceiling effect, because after a certain inflammation-level, more inflammation was not associated with higher HAQ-scores.
Conclusion: MRI-detected inflammation, and tenosynovitis in particular, is associated with functional disability in early arthritis. This demonstrates the functional relevance of MRI-detected inflammation in early arthritis.
To cite this abstract in AMA style:Burgers LE, Nieuwenhuis WP, van Steenbergen HW, Newsum EC, Huizinga TW, Reijnierse M, le Cessie S, van der Helm-van Mil AH. MRI-Detected Inflammation Is Associated with Functional Disability in Early Arthritis – Results of a Cross-Sectional Study [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/mri-detected-inflammation-is-associated-with-functional-disability-in-early-arthritis-results-of-a-cross-sectional-study/. Accessed October 27, 2020.
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