Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose:To observe the clinical efficacy of metformin in the treatment of SLE and regulation of CD4+ Treg and Th17 cells.
Methods:Thirty-one patients with SLE, fulfilled the ACR 1997 standard, were enrolled in this study. Their average age was37.21±15.65 years, and disease duration was 58.33±56.48 months. They were administered with metformin£¨MET£©£¨250mg Bid£©combined with conventional therapy for 12 weeks. At week 0, week 6 and week 12, the absolute numbers of Th17 and Treg cells were assayed by flow cytometry and SLEDAI score and drug doses were collected.
Results:At week 0, 6 or 12 after metformin treatment combined with conventional therapy, the absolute number of Treg cells in 31 patients was 25.41£¨19.13£©,25.78£¨25.89£©(P=0.054), or 21.09,while that of Th17 cells was 5.96£¨7.52£©,5.60£¨5.87£©, or 4.56£¨5.38£©. The dosage of prednisone in SLE patients was decreased from 16(28.0)mg/d to 11.15(28.10) mg/d (P=0.019) or6.5(19.5)mg/d (P=0.003).
Conclusion:Our findings suggest that metformin can effectively up-regulate Treg cells as well as increase Th17 cells in a short time and can reduce the usage of prednisone.
To cite this abstract in AMA style:Hao M, Liang Z, Jing X, Gao C, Li XF, Chen J. Metformin Combined with Conventional Therapy Increases Absolute Number of Regulatory T Cells in Patients with Systemic Lupus Erythematosus [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/metformin-combined-with-conventional-therapy-increases-absolute-number-of-regulatory-t-cells-in-patients-with-systemic-lupus-erythematosus/. Accessed July 4, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/metformin-combined-with-conventional-therapy-increases-absolute-number-of-regulatory-t-cells-in-patients-with-systemic-lupus-erythematosus/