Metabolomics Analysis of Insulin Resistance in Mild/Inactive Non-Diabetic Systemic Lupus Erythematosus Women

Claudia Mendoza Pinto¹, Mario García-Carrasco², Gerardo Díaz-Merino³, Pamela Soto-Santillan⁴, Rossy Mejia-Ocampo⁵, Pamela Munguía-Realpozo³ and Alejandro Ruiz-Arguelles⁵, ¹Systemic Autoimmune Diseases Research Unit,, UMAE, HE CMN Manuel Ávila Camacho-CIBIOR, Instituto Mexicano del Seguro Social, Puebla, Mexico, ²Systemic Autoimmune Diseases Research Unit, HGR 36-CIBIOR Instituto Mexicano del Seguro Social, Puebla, Mexico, ³Systemic Autoimmune Diseases Research Unit,, Hospital de Especialidades UMAE CMN, Instituto Mexicano del Seguro Social, Puebla, Mexico, ⁴Systemic Autoimmune Diseases Research Unit, Medicine School, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico, ⁵Laboratorios Clínicos de Puebla, Puebla, Mexico

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: insulin resistance, metabolic syndrome, metabolomics and systemic lupus erythematosus (SLE)

Session Information

Date: Sunday, October 21, 2018

Title: Systemic Lupus Erythematosus – Clinical Poster I: Clinical Manifestations and Comorbidity

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: SLE patients present a higher prevalence of insulin resistance (IR) and metabolic syndrome (MetS) than age- and sex-matched healthy controls. Advances in technology are enabling evaluation for the prevention and early detection of those morbidities. Quantose IR is a simple test for IR based on a single fasting blood sample and may have value as an early indicator of risk for the development of prediabetes and type 2 diabetes mellitus (T2DM). The objective of this study was to evaluate IR in non-diabetic SLE women using metabolite markers identified using high-throughput metabolomic techniques.

Methods: SLE patients were consecutively enrolled in a cross-sectional study. A metabolomic approach using ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-HRMS) was developed in serum samples from non-diabetic SLE women. Activity (SLEDAI-2K) and damage (SLICC) index scores, as well as carotid intima-media thickness (IMT), were determined in SLE patients. Patients with a Quantose IR score of ≥ 63 were defined as IR. MetS was evaluated according to the NCEP-ATP III criteria.

Results: We enrolled 70 SLE patients with a mean ± SD age of 39.3±10.6 years and median disease duration of 11 years (IQR: 8-14). Fourty-five of 70 (64.2%) and 27 (38.5%) SLE patients were found to have IR and Mets, respectively. The median Quantose IR score was 69 (IQR 52.7-80.0). Patients with IR had a higher body mass index (BMI) than those without IR (27 vs. 23.7; p = 0.001). Hypertension was more frequently found in patients with IR (33.3% vs. 8.0%; p = 0.02). The SLICC index and disease activity were not associated with the Quantose IR Score. The prevalence of a Quantose IR score ≥ 63 was higher in patients with MetS (81.5% vs. 53.5%; p = 0.02). Quantose IR score also correlated with the number of metabolic syndrome criteria (r= 0.35, p= 0.003). Carotid IMT values were not correlated with the IR index.

Conclusion: In non-diabetic SLE women, the prevalence of IR based on Quantose IR was 64.2% using UHPLC-HRMS. Although, some traditional IR factors, such as BMI and hypertension were associated with IR in these patients, SLE-related factors were not. Moreover, Quantose IR score may related to MetS in those patients.

Disclosure: C. Mendoza Pinto, None; M. García-Carrasco, None; G. Díaz-Merino, None; P. Soto-Santillan, None; R. Mejia-Ocampo, None; P. Munguía-Realpozo, None; A. Ruiz-Arguelles, None.

To cite this abstract in AMA style:

Mendoza Pinto C, García-Carrasco M, Díaz-Merino G, Soto-Santillan P, Mejia-Ocampo R, Munguía-Realpozo P, Ruiz-Arguelles A. Metabolomics Analysis of Insulin Resistance in Mild/Inactive Non-Diabetic Systemic Lupus Erythematosus Women [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/metabolomics-analysis-of-insulin-resistance-in-mild-inactive-non-diabetic-systemic-lupus-erythematosus-women/. Accessed .

« Back to 2018 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/metabolomics-analysis-of-insulin-resistance-in-mild-inactive-non-diabetic-systemic-lupus-erythematosus-women/