Metabolic and Inflammatory Links to Development of Rotator Cuff Tear in Hand Osteoarthritis

Young Sun Suh¹, Hyun-Ok Kim¹, Yun-Hong Cheon², Ki-Soo Park³, Rock-Bum Kim³, Hye Song Lim⁴, Hae Sook Noh⁴, Jae-Bum Na⁵, Hyung Bin Park⁶ and Sang-Il Lee⁷, ¹Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, ³Department of Preventive Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, ⁴Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, ⁵Department of Radiology, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, ⁶Department of Orthopedic Surgery, Gyeongsang National University School of Medicine, jinju, Korea, The Republic of, ⁷Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Hand disorders, Inflammation, osteoarthritis and shoulder disorders

Session Information

Date: Sunday, November 13, 2016

Title: Osteoarthritis – Clinical Aspects - Poster I

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Rotator cuff tear (RCT) and hand osteroarthritis (HOA) are commonly accompanied because they share a similar pathogenesis. However, there was no previous study investigating the relationship between RCT and HOA. The aim of this study was to estimate the prevalence and associated factors of developing RCT in patients with HOA.

Methods: In this study, we enrolled 1150 individuals who lived in Gyeongnam province in Korea from June 2013 to December 2015. Physical examinations were performed by rheumatologists and orthopedists. Plain radiography of hands and magnetic resonance imaging (MRI) of shoulders were performed in all participants. Serum levels of high sensitive C reactive protein (hsCRP) and high density lipoprotein (HDL) were checked. RCT was diagnosed by clinical examination and MRI findings. Diagnosis of HOA was made by the 1990 American College of Rheumatology classification criteria. Severity of radiographic HOA was assessed by sum of Kellgren–Lawrence (KL) grades of total involved joints on plain radiographs.

Results: The prevalence of RCT was higher in patients with HOA group (192/307, 62.5%) than those without HOA (410/827, 49.5%, p < 0.001). Among 307 with HOA, patients with RCT were older (62.69 ± 7.04 vs. 59.11 ± 7.69, p < 0.001) and showed higher hsCRP (1.51 ± 3.78 vs. 0.67 ± 0.70, p = 0.004) and lower HDL levels (55.66 ± 15.46 vs. 60.48 ± 12.45, p = 0.003) compared to those without RCT. There were no significant differences in gender, smoking, comorbidities, work period, body mass index, a number of affected joints, HOA severity, and prevalence of erosive HOA between both groups. Multiple logistic regression analysis showed significant associations of age (odds ratio [OR] 1.06; 95% confidence interval [CI] 1.02 – 1.10), serum levels of hsCRP (OR 1.37, CI 1.04 – 1.80), and HDL (OR 2.13, CI 1.14 3.98) with RCT in HOA patients.

Conclusion: The prevalence of RCT is high and age and serum levels of hsCRP and HDL have predictive roles in the development of RCT in HOA patients.

Disclosure: Y. S. Suh, None; H. O. Kim, None; Y. H. Cheon, None; K. S. Park, None; R. B. Kim, None; H. S. Lim, None; H. S. Noh, None; J. B. Na, None; H. B. Park, None; S. I. Lee, None.

To cite this abstract in AMA style:

Suh YS, Kim HO, Cheon YH, Park KS, Kim RB, Lim HS, Noh HS, Na JB, Park HB, Lee SI. Metabolic and Inflammatory Links to Development of Rotator Cuff Tear in Hand Osteoarthritis [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/metabolic-and-inflammatory-links-to-development-of-rotator-cuff-tear-in-hand-osteoarthritis/. Accessed .

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