M-Ficolin and MAp44 As Potential Markers of Subclinical Cardiovascular Comorbidity; Cardiac Evaluation By Coronary Computer Tomography and Myocardial Deformation of Left Ventricle in Early Rheumatoid Arthritis Patients

Ida G. Louw¹, Christian G. Ammitzböll², Brian Bridal Løgstrup³, Jesper Blegvad-Nissen⁴, Grazina Urbonaviciene⁴, Trine Bay Laurberg⁴, Mette Herly⁵, Agnete H. Nielsen⁴, Steffen Thiel⁶ and Torkell Ellingsen⁵, ¹University of Southern Denmark, Odense, DK, Odense, Denmark, ²Department of Rheumatology, Aarhus University Hospital, Aarhus, DK, Aarhus, Denmark, ³Department of Cardiology, Skejby, Aarhus University Hospital, Aarhus, DK, Aarhus, Denmark, ⁴Diagnostic Centre, University Research Clinic for Innovative Patient Pathways, Silkeborg Regional Hospital, DK, Silkeborg, Denmark, ⁵Department of Rheumatology, Odense University Hospital, Odense, DK, Odense, Denmark, ⁶Institute of Biomedicine, Aarhus University, Aarhus, DK, Aarhus, Denmark

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Cardiovascular disease and rheumatoid arthritis (RA), Pulmonary Involvement

Session Information

Date: Monday, November 14, 2016

Title: Rheumatoid Arthritis – Clinical Aspects - Poster II: Co-morbidities and Complications

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: The aim was to investigate M-ficolin and Map44, proteins from the lectin pathway, as prognostic markers of subclinical cardiovascular disease in untreated early rheumatoid arthritis (RA) patients. We evaluated the associations between M-ficolin, MAp44 and disease activity (DAS28, CRP and HAQ-score), the degree of coronary artery calcification and myocardial deformation of left ventricle in an inception cohort.

Methods: 79 DMARD-naïve RA patients with a disease duration < 6 months were included from an inception cohort. Clinical variables, plasma- and serum-M-ficolin and MAp44 levels, myocardial deformation analysis and coronary calcification were measured at baseline and after two years. M-ficolin and Map44 were measured with an in-house time-resolved flourometric immunoassay. Coronary calcification was evaluated by Agatston calcium-score using cardiac computer tomography. Left ventricle deformation imaging was determined by speckle tracking echocardiography. Level of statistical dependence and significance were determined with Spearman rank correlation test.

Results: Baseline serum M-ficolin was associated to CRP (r=0.26, p=0.02) and DAS28 (r=0.24, p=0.04). Further, baseline Map44 was associated to CRP in serum (r=0.25, p=0.03) and plasma (r=0.29, p=0.01). At the two-year follow-up patient’s global assessment, assessment of pain, fatigue and HAQ score were associated to serum MAp44 (range p=0.002; 0.04), (range r=-0.36; -0.25). We found associations between baseline fasting insulin and M-ficolin and MAp44 (range p=0.001; 0.02). No associations were found between Agatston calcium score and MAp44 or M-ficolin. Only baseline plasma MAp44 showed association to global longitudinal strain (GLS) (r=0.27, p=0.03).

Conclusion: M-ficolin and MAp44 were associated with disease activity markers and plasma insulin at baseline and at two-year follow-up. GLS and MAp44 were positively associated at baseline.

Disclosure: I. G. Louw, None; C. G. Ammitzböll, None; B. B. Løgstrup, None; J. Blegvad-Nissen, None; G. Urbonaviciene, None; T. Bay Laurberg, None; M. Herly, None; A. H. Nielsen, None; S. Thiel, None; T. Ellingsen, None.

To cite this abstract in AMA style:

Louw IG, Ammitzböll CG, Løgstrup BB, Blegvad-Nissen J, Urbonaviciene G, Bay Laurberg T, Herly M, Nielsen AH, Thiel S, Ellingsen T. M-Ficolin and MAp44 As Potential Markers of Subclinical Cardiovascular Comorbidity; Cardiac Evaluation By Coronary Computer Tomography and Myocardial Deformation of Left Ventricle in Early Rheumatoid Arthritis Patients [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/m-ficolin-and-map44-as-potential-markers-of-subclinical-cardiovascular-comorbidity-cardiac-evaluation-by-coronary-computer-tomography-and-myocardial-deformation-of-left-ventricle-in-early-rheumatoid/. Accessed .

« Back to 2016 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/m-ficolin-and-map44-as-potential-markers-of-subclinical-cardiovascular-comorbidity-cardiac-evaluation-by-coronary-computer-tomography-and-myocardial-deformation-of-left-ventricle-in-early-rheumatoid/