Session Information
Session Title: Osteoporosis and Metabolic Bone Disease - Clinical Aspects and Pathogenesis: Osteoporosis: Pathogenesis, Epidemiology and Diagnosis
Session Type: Abstract Submissions (ACR)
Background/Purpose:
Systemic Lupus Erythematosus (SLE) is associated with high risk of low bone mass/fractures but this risk is still controversial in premenopausal women. Our aim was to determine the one-year incidence of bone mineral density (BMD) loss in premenopausal SLE women and the value of bone turnover markers as predictors of this complication.
Methods
This study enrolled a convenience sample of 63 premenopausal SLE patients. BMD was evaluated by dual X-ray absorptiometry at lumbar spine and hip at baseline and after 12 months. BMD changes above the least significant change were considered significant. Serum levels of P1NP and CTX (electrochemiluminescence), OPG and RANKL (ELISA) were determined at baseline.
Results
Mean age was 31.1±6.8years, disease duration was 5.25±3.8years. 36.5% of patients presented BMD loss and 17.5% BMD gain at lumbar spine and/or hip. Patients were divided in three groups: BMD loss (BL), no BMD change (NC) and BMD gain (BG). Patients with BL and NC received similar cumulative/mean/maximum glucocorticoid doses during the study, but patients with BG received lower doses (p<0.05). Baseline P1NP levels were different in the groups (BL:36.95±23.37 vs. NC:54.63±30.82 vs. BG:84.09±43.85 ng/ml; p=0.031 BL vs. NC, p<0.001 BL vs. BG and p=0.039 NC vs. BG). There was no difference in CTX, OPG or RANKL levels. After multivariate analysis P1NP remained as an independent risk factor for BMD loss (p<0.03).
Conclusion
This study provides original evidence that lower levels of P1NP, the most specific bone formation marker, are predictive of BMD loss over 12 months in premenopausal SLE patients.
Disclosure:
L. Seguro,
None;
C. B. Casella,
None;
V. Caparbo,
None;
R. M. Oliveira,
None;
A. C. Bonfa,
None;
E. Bonfa,
None;
R. M. R. Pereira,
None.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/lower-p1np-serum-levels-a-predictive-marker-of-bone-loss-after-one-year-follow-up-in-premenopausal-sle-patients/