Session Information
Session Type: Abstract Submissions (ACR)
Background/Purpose: To determine the influence of early onset (≤ 16 years) on the clinical characteristics and prognosis of ankylosing spondylitis (AS).
Methods: We revised patients diagnosed with AS according to the New York criteria included in our database. Age at symptom onset was taken from the patient’s clinical history. Other data recorded were current: age, time of evolution, gender, form of onset, form of evolution, HLA B27, BASRI (cervical, lumbar column, sacroiliacs and hips), metrology (Schober test, modified Schober test, thoracic expansion and occipuci-wall distance), VSG and PCR (last measurements), uveitis development, surgery of the locomotive apparatus and treatment provided with special attention to the need for biological drugs in order to establish prognosis.
To ensure that the differences were no solely related to the time of evolution of the disease, we created a Control Group (CG) comprising, two randomly paired patients for each patient with early onset (EO), with an age of onset between 20 and 30 years and a time of evolution of the disease (± 5 years) similar to those with EO. The results were analyzed by means of the SPSS 15.0 statistical package. The differences between EO and CG were studied by means of χ2 and ANOVA or Fisher’s test depending on the characteristics of the variables.
Results: We revised 324 patients with EA; 35 (10.8%) had an age of onset ≤ 16 years. The chart shows the main characteristics of the patients from both groups. Significant differences in the development of uveitis and HLA B27 positivity were observed, as well as a tendency towards greater hip involvement and indication for hip prosthesis in the EO group.
Conclusion: AS patients with early onset were more likely to be positive for HLA B27 and to present more ocular involvement (uveitis). AS patients with EO also presented trend towards more serious radiological damage in the hips and a higher indication for hip prosthesis, although the differences were not significant.
|
|
≤ 16 years (n= 35) |
>16 years (n = 66) |
p |
|
≤ 16 years (n= 35) |
< 16 years (n = 66) |
p |
|
Age of onset (years) |
14.9 ± 2.2 |
27.1 ± 9.1 |
<0.000 |
Form axial onset |
77% |
84% |
ns |
|
Male gender |
89% |
81% |
ns |
Form axial evolution |
60% |
72% |
ns |
|
Time of evolution (years) |
34.6 ± 13.4 |
31 ± 12.7 |
ns |
HLA B27 positive |
100% |
85% |
< 0.05 |
|
Axial BASRI (cm) |
6.4 ± 3.4 |
7 ± 3.3 |
ns |
Uveitis |
40% |
17% |
< 0.05 |
|
Hips BASRI (cm) |
1.38 |
0.87 |
ns |
Prosthesis indication |
14% |
5% |
ns |
|
Schober (cm) |
2.7 ± 2.5 |
2.6 ± 1.6 |
ns |
AINE use continuos |
49% |
49% |
ns |
|
Modified Schober (cm) |
4.2 ± 2.1 |
3.8 ±3.1 |
ns |
FAME use |
29% |
23% |
ns |
|
Thoracic expansion (cm) |
4.7 ± 2 |
3.7 ± 1.6 |
ns |
AntiTNF actual o pass use |
29% |
23% |
ns |
|
Occip-wall (cm) |
5.2 ± 8.1 |
7.1 ± 7.6 |
ns |
|
|||
Disclosure:
M. Aparicio,
None;
J. Rodríguez-Moreno,
None;
P. Estrada,
None;
I. Martín-Esteve,
None;
L. López-Vives,
None;
V. Torrente,
None;
J. Anton,
None;
J. M. Nolla,
None;
X. Juanola,
None.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/influence-of-early-onset-on-the-clinical-characteristics-and-prognosis-of-ankylosing-spondylitis/