Session Information
Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: Some cardiovascular risk factors (CVRF) have been associated with a lower probability of achieving a good therapeutic response in PsA1. However, the reason for this association is not known. We aimed to evaluate the potential link between the minimal disease activity (MDA)2 response and the presence of CVRF in PsA patients treated with DMARDs.
Methods: Cross-sectional study carried out at 25 rheumatology departments from Spain. All patients fulfilled CASPAR criteria, had an established disease (disease duration 9.6 ± 7.6 yr), and were receiving biological or synthetic DMARDs. The relationship between MDA and CVRF was evaluated by uni and multivariate analyses. To test the influence of CVRF on MDA achieving, an age-matched cohort of patients with recent-onset PsA (< 2 yr of evolution) not exposed to systemic treatment was selected.
Results: 227 patients were included and 133 (58.6%) achieved a MDA response. Among the classic CVRF, tobacco (crude OR: 0.54), sedentary lifestyle (crude OR: 1.95), hyperuricemia (crude OR: 2.01) and obesity (crude OR: 1.54) were related to the likelihood of MDA in the univariate model (p <0.25). The only CVRF related to the MDA response in the multivariate analysis was a sedentary lifestyle (OR 3.13, 95%CI: 1.50-6.53; p=0.002). No association was found between the number of CVRF and MDA. No differences were found in the prevalence of cardiovascular comorbidity between the two cohorts.
|
Variable |
Treated cohort N: 227 |
Not treated cohort N: 210 |
p-values |
|
Age Hypertension Diabetes Obesity Dyslipidemia Tobacco CV events |
53.2 ± 12.4 yr 27.3% 12.1% 21.1% 30.4% 27.3% 5.8% |
49.8 ± 13.9 yr 22.4% 10.5% 27.1% 30.9% 30.4% 6.2% |
NS NS NS NS NS NS NS |
Conclusion: Contrary to what has been found in other studies, in this multicenter study we could not find any relationship between CVRF (except for sedentary lifestyle) and MDA. In any case, patients with psoriatic disease should be encouraged to maintain healthy lifestyle habits.
References
1. Ogdie A, Eder L. Improving cardiovascular health and metabolic comorbidities in patients with psoriatic arthritis. Int J Clin Rheumatol 2015; 10(6):451-459.
2. Coates LC, Fransen J, Helliwell PS. Defining minimal disease activity in psoriatic arthritis: a proposed objective target for treatment. Ann Rheum Dis 2010; 69(1):48-53.
Acknowledgements: This study was funded by Pfizer. Recent-onset PsA data are from the Spanish Registry of Recent-Onset PsA (REAPSER)
To cite this abstract in AMA style:
Queiro R, Cañete JD. Influence of Cardiovascular Comorbidity on Achieving Therapeutic Goals: A Comparative Study between Recent-Onset Psoriatic Arthritis and Established Disease [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/influence-of-cardiovascular-comorbidity-on-achieving-therapeutic-goals-a-comparative-study-between-recent-onset-psoriatic-arthritis-and-established-disease/. Accessed .« Back to 2017 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/influence-of-cardiovascular-comorbidity-on-achieving-therapeutic-goals-a-comparative-study-between-recent-onset-psoriatic-arthritis-and-established-disease/