Session Information
Date: Monday, October 22, 2018
Title: Vasculitis Poster II: Behҫet’s Disease and IgG4-Related Disease
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Lower extremity vein thrombosis (LEVT) is the key feature of vascular involvement in Behçet’s syndrome (BS).Vein wall thickness (VWT) is proposed to be a surrogate marker of venous disease. A pilot MR study done in 7 BS patients and controls, had demonstrated increased VWT and signal enhancement in the lower extremity veins of BS patients without vascular disease. Another study, using USG, found that VWT was increased among BS patients without vascular disease compared to patients with ankylosing spondylitis and healthy controls. We reassessed VWT in proximal lower extremity veins in BS patients with LEVT and suitable controls in a formal, masked protocol.
Methods: We studied 47 (40 M/ 7 F) BS patients with LEVT, 50 (43 M/ 7 F) BS patients without any vascular involvement and 38 (31 M/ 7 F) age and gender matched apparently healthy controls. Two independent radiologists, blinded to the diagnosis of BS, used USG to measure VWT of common femoral vein (CFV), superficial femoral vein (SFV) and vena saphena magna (VSM) in both legs.
Results: As shown in Table 1, mean age at disease onset and the disease duration were similar between BS study groups. The mean age at thrombosis onset of the patients with LEVT was 26.4 ± 5.8 years. There was good concordance between the 2 observers (kappa: 0.9) The mean VWT was significantly increased among both BS patients with LEVT and those without any vascular involvement when compared to the healthy controls while those with LEVT had the thickest veins.
Table 1. Disease duration and VWT
| BS with vascular involvement | BS without vascular involvement | Healthy controls | P value | |
| (n=47; 40 M/ 7 F) | (n=50; 43 M/ 7 F) | (n=38; 31 M/ 7 F) | ||
| Age, years | 37.06 ± 5.26 | 36.98 ± 4.47 | 34.87 ± 7.22 | 0.296 |
| Disease duration | 10.96 ± 6.45 | 9.68 ± 5.89 | – | 0.31 |
| Vein wall thickness, mean ± SD, mm | ||||
| Right CFV 1st observer | 0.91± 0.67 | 0.69 ± 0.15 | 0.57 ± 0.11 | 0.001 |
| Right CFV 2nd observer | 0.93 ± 0.76 | 0.70 ± 0.18 | 0.58 ± 0.09 | <0.001 |
| Left CFV 1st observer | 1.04 ± 0.85 | 0.66 ± 0.11 | 0.56 ± 0.07 | <0.001 |
| Left CFV 2nd observer | 1.09 ± 0.83 | 0.69 ± 0.16 | 0.57 ± 0.07 | <0.001 |
| Right SFV 1st observer | 0.79 ±0.38 | 0.60 ± 0.11 | 0.51 ± 0.9 | <0.001 |
| Right SFV 2nd observer | 0.80 ± 0.42 | 0.62 ± 0.13 | 0.52 ± 0.07 | <0.001 |
| Left SFV 1st observer | 0.88 ± 0.38 | 0.62 ± 0.12 | 0.49 ± 0.09 | <0.001 |
| Left SFV 2nd observer | 0.90± 0.40 | 0.63 ± 0.13 | 0.51 ± 0.07 | <0.001 |
| Right VSM 1st observer | 0.60 ± 0.22 | 0.52 ± 0.11 | 0.43 ± 0.07 | <0.001 |
| Right VSM 2nd observer | 0.64 ± 0.25 | 0.53 ± 0.13 | 0.46 ± 0.08 | <0.001 |
| Left VSM 1st observer | 0.67 ± 0.23 | 0.53 ± 0.11 | 0.42 ± 0.09 | <0.001 |
| Left VSM 2nd observer | 0.65 ± 0.27 | 0.53 ± 0.11 | 0.43± 0.07 | <0.001 |
CFV: common femoral vein, SFV: superficial femoral vein, VSM: vena saphena magna
Conclusion: VWT of proximal deep and superficial lower extremity veins was found to be increased among BS patients without any clinical and radiological vascular involvement.
To cite this abstract in AMA style:
Gjoni M, Akbaş S, Durmaz EŞ, Dikici AS, Mihmanlı İ, Yazici H, Seyahi E. Increased Vein Wall Thickness in Behçet’s Syndrome [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/increased-vein-wall-thickness-in-behcets-syndrome/. Accessed .« Back to 2018 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/increased-vein-wall-thickness-in-behcets-syndrome/