ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 595

Improved Patient-Reported Outcomes in Psoriatic Arthritis Patients Treated with Abatacept: Results from a Phase III Trial

Vibeke Strand1, E Alemao2, T Lehman2, A Johnsen2, S Banerjee2, HA Ahmad2 and Philip J Mease3, 1Stanford University, Palo Alto, CA, 2Bristol-Myers Squibb, Princeton, NJ, 3Swedish Medical Center and University of Washington, Seattle, WA

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: Biologics, patient-reported outcome measures and psoriatic arthritis

  • Tweet
  • Email
  • Print
Session Information

Date: Sunday, November 5, 2017

Title: Spondyloarthropathies and Psoriatic Arthritis – Clinical Aspects and Treatment Poster I

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: In the Phase III ASTRAEA study (NCT01860976), abatacept (ABA) significantly increased ACR20 responses, alleviating musculoskeletal symptoms in patients (pts) with active psoriatic arthritis (PsA).1 Here we explore the effect of ABA on pt-reported outcomes (PROs) in ASTRAEA. Methods: Pts were randomized (1:1) to SC ABA 125 mg weekly or placebo (PBO) for 24 weeks (W). At W16, pts without ≥20% improvement in joint counts escaped to open-label ABA. Adjusted mean changes from baseline to W16 (all pts) and W24 (non-escape responder analysis) in Short Form-36 (SF-36; physical and mental component summary [PCS, MCS] and individual domain scores using spydergrams), HAQ-DI, Dermatology QoL Index (DLQI), and Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scores were evaluated in total population (prespecified intent-to-treat analysis) and subgroups (post hoc) stratified by baseline CRP and prior TNF inhibitor (TNFi) use. Proportions of pts reporting improvements from baseline ≥minimal clinically important difference (MCID) in SF-36 summary (≥2.5) and domains (≥5.0), FACIT-F (≤−4.0), and HAQ-DI (≤–0.35), and scores ≥normative values in SF-36 summary (≥50) and individual domains, FACIT-F (<40), and HAQ-DI (<0.5) at W16 were analyzed in the total population. Results: In the total population, numerical improvements in most PROs were reported with ABA (n=213) vs PBO (n=211) at both time points (significant for SF-36 PCS at W16, HAQ-DI at W24, and DLQI at both time points; Table). At W16 before escape, improvements in all SF-36 domains were numerically greater with ABA (significant for physical function, bodily pain, and vitality). A higher proportion of pts receiving ABA vs PBO reported improvements ≥MCID in SF-36 PCS, SF-36 MCS, SF-36 domains, FACIT-F, HAQ-DI (Figure), and DLQI (not shown) at W16. Proportion of pts reporting scores ≥normative values at W16 was higher with ABA vs PBO for SF-36 PCS, SF-36 MCS, FACIT-F, and HAQ-DI. At W24, improvements in most SF-36 domain scores accrued in responders in both groups; numerical differences favored ABA. Improvements were observed in all PROs in the ABA vs PBO group for TNFi-naïve and -exposed subpopulations at W16. Improvements in all PROs were reported with ABA in baseline CRP >upper limit of normal (ULN) vs CRP ≤ULN subpopulation at W16 (Table). Subgroup data at W24 were difficult to interpret due to lower number of pts assessed vs W16.

Conclusion: Abatacept treatment improved many PROs in pts with active PsA, with larger benefits in the elevated CRP subpopulation and regardless of prior TNFi exposure. 1. Mease PJ, et al. Ann Rheum Dis 2017 [Epub ahead of print]


86897c_Figure


 

Disclosure: V. Strand, AbbVie, Amgen Corporation, AstraZeneca, Biogen, BMS, Boehringer Ingelheim, Celgene, Celltrion, Corrona, Crescendo / Myriad Genetic, EMD Serono, Genentech / Roche, GlaxoSmithKline, Janssen, Lilly, Merck, Novartis, Pfizer, Regeneron, Samsung, Sandoz, Sano, 5; E. Alemao, Bristol-Myers Squibb, 1,Bristol-Myers Squibb, 3; T. Lehman, Bristol-Myers Squibb, 3,Bristol-Myers Squibb, 1, 9; A. Johnsen, Bristol-Myers Squibb, 1,Bristol-Myers Squibb, 3; S. Banerjee, Bristol-Myers Squibb, 3,Bristol-Myers Squibb, 1, 9; H. Ahmad, Bristol-Myers Squibb, 3,Bristol-Myers Squibb, 1, 9; P. J. Mease, AbbVie, Amgen, BMS, Celgene, Janssen, Lilly, Novartis, Pfizer, Sun, UCB, 2,AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Corrona, Demira, Janssen, Lilly, Novartis, Pfizer, Sun, UCB, Zynerba, Speaker Bureau: AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Novartis, Pfizer, UCB, 5.

To cite this abstract in AMA style:

Strand V, Alemao E, Lehman T, Johnsen A, Banerjee S, Ahmad H, Mease PJ. Improved Patient-Reported Outcomes in Psoriatic Arthritis Patients Treated with Abatacept: Results from a Phase III Trial [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/improved-patient-reported-outcomes-in-psoriatic-arthritis-patients-treated-with-abatacept-results-from-a-phase-iii-trial/. Accessed .
  • Tweet
  • Email
  • Print

« Back to 2017 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/improved-patient-reported-outcomes-in-psoriatic-arthritis-patients-treated-with-abatacept-results-from-a-phase-iii-trial/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology