Session Information
Title: Systemic Lupus Erythematosus - Clinical Aspects and Treatment: Treatment and Management Studies
Session Type: Abstract Submissions (ACR)
Background/Purpose Despite the fact that sleep disorders are poorly studied, they´re a frequent complain by patients with SLE (62 to 80% related) and others found their influence over morning fatigue. Aim of study: To assess the impact of sleep disorders in quality of life, pain, fatigue and disease activity in female with SLE.
Methods Patients and methods: The actigraphy and sleep diary was used to measure sleep habits during 15 days in 34 female with SLE and who achieve Pittsburgh Sleep Quality Index (PSQI) equal or above 5. Quality of life was assessed through Short form health survey questionnaire (SF-36). Disease activity was measured with SLEDAI. Patients were divided into two groups, according categorical variables of PSQI scoring: less than 10 and more than 10 points. Mann-Whitney U test was used to compare SF-36 domains and the relationship between disease activity and sleep latency were analyzed with Pearson´s correlation coefficient. Significance level adopted was 5%
Results Thirty-four (34) female with SLE was analyzed (n=34; mean=43±10 years), disease time 9,5 ± 6,7 years. It was found some disabilities on SF-36 domain. Results of PSQI>10 had less points for Body pain (BP) (p-value=0,016) and role emotional (RE) (p-value=0,056). There wasn´t significant difference in physical functioning (PF) (p-value=0,730), role physical (RP) (p=0,131), general health (GH) (p = 0,769), vitality (p = 0,219), social functioning (SF) (p = 0,187) and mental health (MH) (p = 0,334). Furthermore the patients with PSQI>10 had longer sleep latency time when it was compared with the patients with PSQI<10 (p = 0,050). There was correlation between disease activity and sleep latency (r = 0,356; p = 0,046).
Conclusion: Our results suggest that the patients with PSQI>10 and disease activity are important factors that can affect the quality of life in patients with SLE.
Table 1. Comparison between SF-36 domains and PSQI categorical groups:
|
SF-36 domain |
PSQI |
|
|
|
< 10 points |
> 10 points |
p-value |
|
|
PF |
67,9 (4,4) |
64,4 (5,5) |
0,73 |
|
RP |
47,1 (9,8) |
27,9 (8,0) |
0,131 |
|
BP |
52,8 (3,2) |
35,5 (4,9) |
0,016 |
|
GH |
40,7 (3,5) |
43,9 (6,7) |
0,769 |
|
V |
60,6 (3,2) |
54,1 (4,4) |
0,219 |
|
SF |
70,6 (4,8) |
63,3 (4,8) |
0,187 |
|
RE |
74,5 (7,8) |
47,1 (10,3) |
0,056 |
|
MH |
68,7 (4,1) |
62,6 (4,4) |
0,334 |
Teste de Mann-Whitney U
|
1 |
Physical functioning |
(PF) |
|
2 |
Role physical |
(RP) |
|
3 |
Bodily pain |
(BP) |
|
4 |
General health |
(GH) |
|
5 |
Vitality |
( V ) |
|
6 |
Social functioning |
(SF) |
|
7 |
Role emotional |
(RE) |
|
8 |
Mental health |
(MH) |
Table 2. Comparison between actigraphy results and PSQI categorical groups:
|
Actigraphy |
PSQI |
|
|
|
< 10 points |
> 10 points |
p-value |
|
|
S_LAT_MEAN |
25,8 (4,6) |
43,0 (6,0) |
0,05 |
|
SMIN_MEAN |
372,7 (13,2) |
383,7 (17,3) |
0,624 |
|
SEFF_MEAN |
91,5 (1,3) |
89,7 (1,5) |
0,396 |
|
WASO_MEAN |
38,9 (6,6) |
47,2 (6,2) |
0,309 |
|
|
|
|
|
Teste de Mann-Whitney U
|
S_LAT_MEAN |
sleep latency mean |
|
SMIN_MEAN |
sleep minutes mean |
|
SEFF_MEAN |
sleep efficiency mean |
|
WASO_MEAN |
wake up after sleep onset mean |
Disclosure:
L. Reis,
None;
M. Tulio de Mello,
None;
V. M. Trevisani,
None.
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