Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) involves a wide range of peripheral and central neuropsychiatric manifestations. Depression is one of those and is very common in patients with SLE. The aim of this study was to determine if depression increases the risk of lupus flare in our patient population at Temple University Hospital, which is predominantly African American, and also to determine if therapy for Depression impacts SLE flares.
Results: Out of 209 patients present in the lupus cohort, 38 patients had a diagnosis of depression in their medical history. On review of these patient charts, 32 patients were included (6 excluded for having only 2 visits). 34 patients with diagnoses of lupus randomly selected from our cohort and without depression acted as control. The majority of our patients with concurrent lupus and depression were in the 40th and 50th decade of life. Only 62.5% (20/32) of patients were on antidepressants. SLEDAI analysis revealed that 62.5% (20/32) patients had at least a lupus flare and 75% (9/12) of these patients were not on any antidepressants, whereas those on antidepressants 55%(11/20) had lupus flare. The two groups were not statistically different (chi-square, p= 0.083). Interestingly lupus patients with depression compared to patients without depression, had statistically more flares (chi-square, p= 0.027). On our analysis though higher SLICC scores were common in lupus patients with depression, it did not reach significance (chi-square, p= 0.392). Also on comparing other comorbidities including HTN, diabetes, infections and social factors such as smoking, these were more common in lupus with depression (chi-square, p=0.041).
To cite this abstract in AMA style:Rathi S, Zavitsanos A, Goh KS, Caricchio R, Freid L. Impact of Depression on SLE Flares [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/impact-of-depression-on-sle-flares/. Accessed October 25, 2021.
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