Higher Urate Volume Measured By Dual Energy Computed Tomography Is Associated with Unfavourable Cardiovascular Risks in Patients with Gout

Sang Heon Lee¹, Hae-Rim Kim², Kyung-Ann Lee³ and Jin Wuk Hur⁴, ¹Division of Rheumatology, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea, Republic of (South), ³Department of Nuclear medicine, Konkuk University Medical center, seoul, Korea, Republic of (South), ⁴Rheumatology, Eulji University College of Medcine, Seoul, Korea, Republic of (South)

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: Cardiovascular disease, computed tomography (CT) and gout

Session Information

Date: Tuesday, November 7, 2017

Session Title: Metabolic and Crystal Arthropathies Poster II

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

Hyperuricemia and gout are associated with increased risk of cardiovascular disease. The aim of the study was to evaluate the correlation between cardiovascular risk and total urate volumes measured by dual energy computed tomography (DECT).

Methods:

DECT datasets from 91 crystal-proven gout patients were analyzed retrospectively. The total volumes of uric acid deposition were quantified using automated volume assessment software. The 10-year cardiovascular risk using Framingham risk score (FRS) and metabolic syndrome (MS) based on National Cholesterol Education Program were estimated.

Results:

Fifty five patients with positive results on DECT and 36 patients with negative results on DECT were assessed. Patients with positive DECT showed significant higher systolic blood pressure, diastolic blood pressure, and fasting glucose and higher prevalence of chronic kidney disease, compared with those with negative DECT. The total urate volumes were significantly correlated with FRS and the number of component of metabolic syndrome (r = 0.22, P = 0.036 and r = 0.373, P < 0.001, respectively).

Conclusion:

This study demonstrated the correlation between total urate volumes on DECT and cardiovascular risk. Higher urate burden could affect unfavorable cardiovascular outcomes.

Disclosure: S. H. Lee, None; H. R. Kim, None; K. A. Lee, None; J. W. Hur, None.

To cite this abstract in AMA style:

Lee SH, Kim HR, Lee KA, Hur JW. Higher Urate Volume Measured By Dual Energy Computed Tomography Is Associated with Unfavourable Cardiovascular Risks in Patients with Gout [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/higher-urate-volume-measured-by-dual-energy-computed-tomography-is-associated-with-unfavourable-cardiovascular-risks-in-patients-with-gout/. Accessed January 19, 2021.

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