Background/Purpose:

Hyperuricemia and gout are associated with increased risk of cardiovascular disease. The aim of the study was to evaluate the correlation between cardiovascular risk and total urate volumes measured by dual energy computed tomography (DECT).

Methods:

DECT datasets from 91 crystal-proven gout patients were analyzed retrospectively. The total volumes of uric acid deposition were quantified using automated volume assessment software. The 10-year cardiovascular risk using Framingham risk score (FRS) and metabolic syndrome (MS) based on National Cholesterol Education Program were estimated.

Results:

Fifty five patients with positive results on DECT and 36 patients with negative results on DECT were assessed. Patients with positive DECT showed significant higher systolic blood pressure, diastolic blood pressure, and fasting glucose and higher prevalence of chronic kidney disease, compared with those with negative DECT. The total urate volumes were significantly correlated with FRS and the number of component of metabolic syndrome (r = 0.22, P = 0.036 and r = 0.373, P < 0.001, respectively).

Conclusion:

This study demonstrated the correlation between total urate volumes on DECT and cardiovascular risk. Higher urate burden could affect unfavorable cardiovascular outcomes.

« Back to 2017 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/higher-urate-volume-measured-by-dual-energy-computed-tomography-is-associated-with-unfavourable-cardiovascular-risks-in-patients-with-gout/