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Abstract Number: 67

Higher Levels of Pro-Inflammatory and Lower Levels of Anti-Inflammatory Cytokines Are  Present in Fibromyalgia Patients

Robert S. Katz1, Hannah Leavitt2 and Daniel Pickrell2, 1Rush University Medical Center, Chicago, IL, 2Rheumatology Associates, Chicago, IL

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: cytokines, fibromyalgia and laboratory tests

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Session Information

Date: Sunday, November 8, 2015

Title: Fibromyalgia, Soft Tissue Disorders, Regional and Specific Clinical Pain Syndromes Poster I

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Abnormalities in the central
processing of pain may play a role in fibromyalgia and cytokines could be
targets for new therapies. We measured cytokine levels in the blood of patients
with fibromyalgia.

Methods: 35 Fibromyalgia patients followed in a
rheumatology office practice had their blood analyzed for cytokine levels by
the University of Miami Immunology Lab. Normal levels were established in
healthy controls by the lab.  The following cytokines were
measured: Pro-inflammatory:  TNF alpha, TNF beta, TNF receptor I, TNF
receptor II, interferon gamma , IL 1 alpha, IL 1 beta, IL 6.
Anti-inflammatory: IL 4, IL 5, IL 10, IL 13.  IL 17, IL 23.

Results:   Abnormally high and low
cytokine levels were:

Conclusion: Higher levels
of certain pro-inflammatory cytokines and lower levels of
anti-inflammatory cytokines were found in these fibromyalgia patients. The
significance of abnormal cytokine levels in fibromyalgia is unclear but
cytokines could be important in the etiology of the disorder.

 


Disclosure: R. S. Katz, None; H. Leavitt, None; D. Pickrell, None.

To cite this abstract in AMA style:

Katz RS, Leavitt H, Pickrell D. Higher Levels of Pro-Inflammatory and Lower Levels of Anti-Inflammatory Cytokines Are  Present in Fibromyalgia Patients [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/higher-levels-of-pro-inflammatory-and-lower-levels-of-anti-inflammatory-cytokines-are-present-in-fibromyalgia-patients/. Accessed .
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