Higher Consumption Of Sugar-Sweetened Soft Drinks Increases The Risk Of Hyperuricemia In Korean Population: The Korean Multi-Rural Communities Cohort Study

Seong-Kyu Kim¹, Jisuk Bae², Jung-Yoon Choe¹, Byung-Yeol Chun³, Pil Sook Park⁴ and Dong Hoon Shin⁵, ¹Catholic University of Daegu School of Medicine, Daegu, South Korea, ²Department of Preventive Medicine, Catholic University of Daegu School of Medicine, Daegu, South Korea, ³Kyungpook National University School of Medicine, Daegu, South Korea, ⁴Kyungpook National University, Daegu, South Korea, ⁵School of Medicine Keimyung University, Daegu, South Korea

Meeting: 2013 ACR/ARHP Annual Meeting

Keywords: hyperuricemia, population studies and uric acid

Session Information

Title: Epidemiology and Health Services I

Session Type: Abstract Submissions (ACR)

Background/Purpose: The aim of this study is to clarify the association between sugar-sweetened soft drinks and fruit drinks made from oranges and apples and the risk of hyperuricemia in the Korean Multi-Rural Communities Cohort.

Methods: A total of 9400 subjects were enrolled in the Korean Multi-Rural Communities Cohort Study. Five quintiles (Q1 to Q5) according to consumption of soft drinks and other fruit/fruit juices were classified and then categorized into three groups (Q1-Q3, Q4, Q5) to assess the risk of hyperuricemia. Information on dietary intake was collected by well-trained interviewers using validated food frequency questionnaires.

Results: Higher consumption of sugar-sweetened soft drinks (Q5) increased the risk of hyperuricemia in males (adjusted OR 1.35, 95% CI 1.07-1.71) with a linear trend (p for trend = 0.01) and in females (adjusted OR 1.40, 95% CI 1.03-1.90) with no linear trend (p for trend = 0.09), compared to lower consumption (Q1-Q3). However, there were no significant differences of serum uric acid level according to the three categories of soft drink consumption, Q1-Q3, Q3, Q5, in males (p = 0.21) or in females (p = 0.16), whereas all subjects showed statistical significance of serum uric acid level within the categories (p < 0.001). Estimated amount of soft drink intake was associated with serum uric acid level in males (b = 0.001, p = 0.01) but not in females (b = 0.0005, p = 0.10).

Conclusion: Higher consumption of sugar-sweetened soft drinks increased the risk of hyperuricemia in the Korean population, showing a differential linear trend for hyperuricemia according to gender.

Disclosure:

S. K. Kim,
None;

J. Bae,
None;

J. Y. Choe,
None;

B. Y. Chun,
None;

P. S. Park,
None;

D. H. Shin,
None.

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