ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2366

High Uric Acid As a Risk Factor for Cardiovascular Diseases in Rheumatoid Arthritis Patients

Adeeba Al-Herz1, Ali Aldei1, Khulood Saleh2, Adel Al-Awadhi3, Waleed Al-Kandari2, Eman Hasan4, Aqeel Ghanem5, Mohammad Hussain4, Ibrahim Nahar5, Fatemah Abutiban6, Ahmad Alenizi6, Yaser Ali5, Hebah Alhajeri5, Sawsan Hayat5, Ahmad Khadrawy2, Ammad Fazal2, Khaled Mokaddem1, Agaz Zaman5, Ghada Mazloum5, Youssef Bartella1, Sally Hamed1, Ramia Alsouk6 and Ahmed Al-Saber7, 1Rheumatology, Al-Amiri Hospital, Kuwait city, Kuwait, 2Rheumatology, Farwania Hospital, Farwania, Kuwait, 3Faculty of Medicine, Kuwait, Kuwait, 4Al-Amiri Hospital, Kuwait city, Kuwait, 5Rheumatology, Mubarak Al-Kabeer Hospital, Hawally, Kuwait, 6Rheumatology, Jahra Hospital, Jahra, Kuwait, 7Department of Mathematics, Kuwait Technical College, Kuwait city, Kuwait

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: , , ,

Session Information

Date: Tuesday, November 7, 2017

Session Title: Rheumatoid Arthritis – Clinical Aspects Poster III: Comorbidities

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Rheumatoid arthritis (RA) patients have an increased risk of cardiovascular diseases (CVD). It is unclear whether an elevated serum uric acid (UA) further increases that risk. We study CVD and their risk factors in association with UA in RA patients.

Methods: Adult patients who satisfied the ACR classification criteria for RA from The Kuwait Registry for Rheumatic Diseases (KRRD) from four major hospitals were evaluated from February 2013 through May 2017. Patients with recorded UA were identified and CVD and their risk factors were studied in those patients. To optimize classifier number and prediction accuracy, hierarchical cluster analyses for multiple factors were performed, which indicated nine possible independent CVD risk factors. A binary logistic regression was conducted to examine their significant association with CVD and the independence of UA as a risk factor.

Results: A total of 564 RA patients with available UA were identified, 353(62.6%) females. Mean age was 50.8+11.5 years and disease duration 10.5+2.9 years.

Mean UA was 271+78µmol/L. Of those patients, 31 (5.5%) were reported to have CVD. UA was significantly correlated to the presence of CVD (χ2=6.49, p=0.011). Logistic regression model indicated a 10% increase of CVD with every 10 µmol/L increase in UA (table). A correlation matrix between UA and other risk factors showed a significant association between high uric acid and a younger age at RA diagnosis (r=-0.262), hyperlipidemia (r=0.191) and diabetes mellitus (r=0.244).

B

p-value

Odds Ratio

95% C.I.

Lower

Upper

Uric acid

0.011

<0.001*

1.011

1.006

1.016

Smoking

-0.535

0.280

0.586

0.222

1.546

Anti-cyclic citrullinated peptide antibodies

-1.017

0.115

0.362

0.102

1.280

Rheumatoid factor

-0.717

0.337

0.488

0.113

2.111

Age at RA diagnosis

-0.071**

<0.001*

0.931

0.896

0.968

Hyperlipidemia

2.220

0.001*

9.210

2.606

32.548

Hypertension

1.824

<0.001*

6.199

2.470

15.556

Male gender

-1.097**

0.020*

0.334

0.132

0.844

Diabetes mellitus

2.619

<0.001*

13.724

4.665

40.372

Conclusion: Our study suggests that UA may be an independent risk factor for CVD and is associated with the presence of other risk factors. UA should be measured and carefully approached in RA patients.

Disclosure: A. Al-Herz, None; A. Aldei, None; K. Saleh, None; A. Al-Awadhi, None; W. Al-Kandari, None; E. Hasan, None; A. Ghanem, None; M. Hussain, None; I. Nahar, None; F. Abutiban, None; A. Alenizi, None; Y. Ali, None; H. Alhajeri, None; S. Hayat, None; A. Khadrawy, None; A. Fazal, None; K. Mokaddem, None; A. Zaman, None; G. Mazloum, None; Y. Bartella, None; S. Hamed, None; R. Alsouk, None; A. Al-Saber, None.

To cite this abstract in AMA style:

Al-Herz A, Aldei A, Saleh K, Al-Awadhi A, Al-Kandari W, Hasan E, Ghanem A, Hussain M, Nahar I, Abutiban F, Alenizi A, Ali Y, Alhajeri H, Hayat S, Khadrawy A, Fazal A, Mokaddem K, Zaman A, Mazloum G, Bartella Y, Hamed S, Alsouk R, Al-Saber A. High Uric Acid As a Risk Factor for Cardiovascular Diseases in Rheumatoid Arthritis Patients [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/high-uric-acid-as-a-risk-factor-for-cardiovascular-diseases-in-rheumatoid-arthritis-patients/. Accessed January 19, 2021.

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