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Abstract Number: 2767

Herpes Zoster As a Risk Factor for Polymyalgia Rheumatica: A Population-Based Study

Shafay Raheel1, Cynthia S. Crowson2 and Eric L. Matteson3, 1St. Joseph's Hospital, Chicago, IL, 2Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, 3Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: polymyalgia rheumatica, population studies and risk

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Session Information

Date: Tuesday, October 23, 2018

Session Title: Vasculitis Poster III: Immunosuppressive Therapy in Giant Cell Arteritis and Polymyalgia Rheumatica

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

The presence of varicella zoster virus (VZV) signal in the temporal arteries of patients with giant cell arteritis has suggested a possible role of VZV in triggering the immunopathology of GCA. This calls into question whether VZV may also play a role in the development of polymyalgia rheumatic (PMR). We aimed to determine whether herpes zoster (HZ) infection is a risk factor for PMR.

Methods: All incident cases of PMR in a geographically-defined area diagnosed between 1990 and 2014 were identified. For each patient with PMR, a non-PMR control subject matched on age and sex was randomly selected from the same underlying population. Each control was assigned an index date corresponding to the PMR incident date of the matched case. The medical records of all patients with codes for HZ were reviewed to confirm the incident date and diagnosis.

Results:

The study included 541 patients with PMR and 541 subjects without PMR. The average age at PMR incidence (index date for the non-PMR cohort) was 74 years, and 349 (65%) subjects were female in each cohort. Prior to index date, 61 (11%) patients with PMR and 62 (11%) non-PMR patients had HZ infection (p=0.92).

Conclusion: Herpes zoster infection was not associated with an increased risk of PMR. Further work is needed to determine the etiology of PMR.


Disclosure: S. Raheel, None; C. S. Crowson, None; E. L. Matteson, None.

To cite this abstract in AMA style:

Raheel S, Crowson CS, Matteson EL. Herpes Zoster As a Risk Factor for Polymyalgia Rheumatica: A Population-Based Study [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/herpes-zoster-as-a-risk-factor-for-polymyalgia-rheumatica-a-population-based-study/. Accessed May 25, 2022.
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